Abstract:
:Increased antibody production and hypergammaglobulinaemia in cirrhosis are probably to a large extent due to decreased hepatic extraction of antigens. The deceased extraction is presumably related to changed microcirculation caused by damaged anatomical structure of the liver. It is therefore to be expected that immunoglobulin and antibody levels in serum in cirrhotic patients are related to the degree of certain morphological changes of the liver. This hypothesis has been tested. In 50 patients with cirrhosis, 28 alcoholics and 22 non-alcoholics, the degree of architectural destruction, the degree of fibrosis, the degree of fatty infiltration, and the degree of "activity" were compared with immunoglobulins G, A, and M and E. coli O antibody levels. The comparison was carried out within each of the aetiological groups. Identical relationships were found in both groups. Patients with completely destroyed lobular architecture had higher levels of E. coli O antibodies than patients with partly destroyed architecture. Patients with severe fibrosis had higher IgA and E. coli O antibody levels than patients with moderate or slight fibrosis. Patients with moderate and severe steatosis and patients with no or slight steatosis had the same immunoglobulin and E. coli O antibody levels. Patients with active cirrhosis had higher IgG levels than patients with inactive cirrhosis. When architectural destruction and fibrosis were combined significantly higher IgG, IgA, IgM, and E. coli antibodies were found in the group with the most severe changes. These findings support the hypothesis that immunoglobulin and antibody levels are related to the degree of morphological changes in the liver--namely, destruction of lobular architecture, fibrosis, and "activity".
journal_name
Gutjournal_title
Gutauthors
Prytz H,Bjorneboe M,Christoffersen P,Poulsen H,Orskov Fdoi
10.1136/gut.18.1.28subject
Has Abstractpub_date
1977-01-01 00:00:00pages
28-32issue
1eissn
0017-5749issn
1468-3288journal_volume
18pub_type
杂志文章相关文献
GUT文献大全abstract:OBJECTIVE:Conventional colonoscopy (CC) is considered the reference standard for detection of colorectal neoplasia, but it can still miss a substantial number of adenomas. The use of a transparent plastic cap may improve colonic visualisation. Cap-assisted colonoscopy (CAC) was compared with CC for adenoma detection. S...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2011-301327
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:A high prevalence of osteoporosis is reported in Crohn's disease. The pathogenesis is not completely understood but is probably multifactorial. Longstanding Crohn's disease is associated with a deficiency of fat soluble vitamins, among them vitamin K. Vitamin K is a cofactor in the carboxylation of osteocalc...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.4.473
更新日期:2001-04-01 00:00:00
abstract::To investigate factors which predispose to relapse in patients with ulcerative colitis, we conducted a survey to compare the events occurring in the four weeks preceding the clinic attendance of 62 outpatients in remission with those taking place in the same period before the onset of relapse in 21 patients attending ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.3.187
更新日期:1983-03-01 00:00:00
abstract::The role of lamina propria cells in regulating human colonic ion transport was investigated in vitro. Normal human colonic mucosae were mounted in Ussing chambers, and short circuit current changes (delta SCC) were monitored in response to immune cell activation. Anti-human immunoglobulin E (anti-IgE) and formyl-Methi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.3.395
更新日期:1995-03-01 00:00:00
abstract::Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrati...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.2.99
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND/AIM:To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis. METHODS:HBV genotypes, 1653/1753/core promoter (CP)/precore MT and HBV DNA levels were determined in 248 HBV patients with HCC an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.119859
更新日期:2008-01-01 00:00:00
abstract::A method is described for measuring transit time through the gut which requires the collection of only one stool. A dose of 20 radio-opaque markers is given to the subject on each of three consecutive days with breakfast, each dose of marker being of a different type. The first stool passed after rising on the fourth ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.3.219
更新日期:1976-03-01 00:00:00
abstract::The faecal blood loss of six alcoholic subjects with normal gastric mucosa, six with superficial gastritis, and six with atrophic gastritis was studied before and during ingestion of 40% v/v ethanol using (51)Cr-tagged red blood cells. No significant change in faecal blood loss was observed in the normal mucosa and su...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.4.289
更新日期:1973-04-01 00:00:00
abstract::This trial was undertaken to establish the long term biochemical and serological outcome of patients with acute post-transfusion hepatitis C virus infection after treatment with interferon alfa-2b. After 12 months, 12 patients (eight treated, four controls) had self limited disease and 16 patients (seven treated, nine...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.2_suppl.s62
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To investigate the success rate of cold snare polypectomy (CSP) for complete resection of 4-9 mm colorectal adenomatous polyps compared with that of hot snare polypectomy (HSP). DESIGN:A prospective, multicentre, randomised controlled, parallel, non-inferiority trial conducted in 12 Japanese endoscopy units....
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2017-314215
更新日期:2018-11-01 00:00:00
abstract::The effects of luminal instillation of 16,16 dimethyl PGE2 (dmPGE2) on gastric acid secretion and back diffusion of H+ were studied in anaesthetised dogs which were prepared with a segment of the greater curvature of the stomach mounted in a double lumen chamber. This model permitted simultaneous evaluation of two seg...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.9.775
更新日期:1978-09-01 00:00:00
abstract::Calcium palmitate occurred in 20% of the gallstones studied in this laboratory by x-ray diffraction and was the most important crystalline constituent after the different forms of cholesterol and calcium carbonate. Only one calculus contained alpha-palmitic acid. The gallstones came from America, England, Australia, S...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.7.618
更新日期:1970-07-01 00:00:00
abstract::To investigate the basis of subclinical alveolitis in patients with primary biliary cirrhosis, 10 primary biliary cirrhosis patients were studied by bronchoalveolar lavage. Both bronchoalveolar lavage lymphoid and non-lymphoid cell populations were analysed using immunocytological methods to determine their proportion...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.2.208
更新日期:1990-02-01 00:00:00
abstract::Patients with Crohn's disease commonly develop ileal and less commonly colonic strictures, containing various degrees of inflammation and fibrosis. While predominantly inflammatory strictures may benefit from a medical anti-inflammatory treatment, predominantly fibrotic strictures currently require endoscopic balloon ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-318081
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Multiple cancers may occur in an individual because of a genetic predisposition, environmental exposure, cancer therapy, or immunological deficiency. Colorectal cancer is one of the most commonly diagnosed cancers, and inherited factors play an important role in its aetiology. AIMS:To characterise the occur...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.5.647
更新日期:2002-05-01 00:00:00
abstract::The sample population in this initial case control study of the adenosine diphosphate ribosyl transferase (ADPRT) response of inflammatory bowel disease patients included: 23 patients with ulcerative colitis (UC)-active and inactive, 13 patients with Crohn's disease (CD)-active and inactive, 14 first degree relatives ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.12.1680
更新日期:1988-12-01 00:00:00
abstract::The distribution of the endoplasmic reticulum in human hepatocytes is defined in quantitative terms using the techniques of morphometry. The subjects of the study are liver biopsies from normal, untreated subjects and patients being treated with various drugs. In contrast to rat hepatocytes, the amount of smooth endop...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.9.737
更新日期:1974-09-01 00:00:00
abstract::Glucosamine synthetase, the first enzyme in glycoprotein synthesis, has been measured in serial rectal biopsies in four patients with membranous colitis. In two of the patients the levels of the enzyme were very high initially and in the other two patients the enzyme levels rose to a peak above the normal range after ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.3.229
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND:The "topical" effect of non-steroidal anti-inflammatory drugs (NSAIDs) seems to be an important cause of NSAID induced gastrointestinal damage. AIM:To examine the possible mechanism of the "topical" phase of damage in the small intestine. METHODS:Electron microscopy and subcellular organelle marker enzyme ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.3.344
更新日期:1997-09-01 00:00:00
abstract::We have previously shown that rats fed raw soya flour (RSF) for more than four months develop hyperplastic foci of pancreatic acinar cells, which undergo malignant change if feeding RSF is continued throughout the life of the animals. The tendency to undergo malignant change is augmented by the additional use of a gen...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.suppl.207
更新日期:1987-01-01 00:00:00
abstract::Strains of E. coli from the faeces of patients with active ulcerative colitis and with colitis in remission were examined for haemolysin and necrotoxin production. Cultures from 63 patients with active colitis grew haemolytic E. coli in 23 (37%) as compared with 24 (21%) from 115 patients whose disease was in remissio...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.2.143
更新日期:1974-02-01 00:00:00
abstract:BACKGROUND:Wilson's disease is a rare inborn disease related to copper storage, leading to liver cirrhosis and neuropsychological deterioration. Clinical data on larger cohorts are limited owing to low disease frequency. OBJECTIVE AND METHODS:We performed a retrospective analysis of 163 patients with Wilson's disease,...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.087262
更新日期:2007-01-01 00:00:00
abstract::The treatment is described of 17 patients with presumed viral hepatitis who developed hepatic coma unresponsive to standard conservative measures. Five patients were considered for treatment by exchange transfusion. Four were treated, with transient improvement in two, but all died. Nine patients were considered for t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.10.11.898
更新日期:1969-11-01 00:00:00
abstract::Chronic idiopathic constipation may be the result of an autonomic neuropathy. This hypothesis was tested in 23 constipated patients and 17 age matched controls, using the acetylcholine sweat spot test devised to test autonomic integrity in diabetes. Acetylcholine (0.01%) was injected in the dorsum of the foot painted ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.11.1539
更新日期:1992-11-01 00:00:00
abstract::In a prospective survey positive antimitochondrial antibodies have been detected in 69/4200 (1.64%) of all sera submitted to a routine immunology laboratory. Of the 69, only nine patients had uniquivocal primary biliary cirrhosis, six others had chronic active hepatitis, 10 had abnormal liver function tests without ev...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.10.814
更新日期:1982-10-01 00:00:00
abstract::The effects on gastric emptying of a solid meal of the specific 5-HT3-receptor antagonist ICS 205-930, 10 mg and 20 mg intravenously were assessed with a scintigraphic technique in 12 normals. The 50% emptying time was less, the lag phase was shorter and the post lag emptying rate was faster after 20 mg ICS 205-930 (p...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.29.9.1249
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Coeliac disease (CD) is triggered by an abnormal reaction to gluten. Peptides resulting from partially digested gluten of wheat, barley or rye cause inflammation of the small intestinal mucosa. Previous contradictory studies suggest that oats may trigger the abnormal immunological response in patien...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.225268
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is associated with cardiovascular risk. The aim of this study was to determine the role of fatty liver in predicting coronary artery disease and clinical outcomes in patients undergoing coronary angiogram. METHOD...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2011.242016
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Whole body catabolism as the result of intrahepatic metabolic derangement is common in liver transplant candidates. However, individual nutritional assessment parameters lack sensitivity and specificity in determining energy status of these patients. Recently, serum hepatocyte growth factor (HGF) has been sh...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.6.862
更新日期:1999-06-01 00:00:00
abstract:INTRODUCTION:Barrett's oesophageal epithelium (BE) is clinically important due to the associated inflammatory and malignant complications which are unevenly distributed throughout the BE segment. As the immunoregulatory environment may influence disease manifestations, we analysed the inflammatory and cytokine response...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.3.316
更新日期:2002-09-01 00:00:00