Abstract:
:A method is described for measuring transit time through the gut which requires the collection of only one stool. A dose of 20 radio-opaque markers is given to the subject on each of three consecutive days with breakfast, each dose of marker being of a different type. The first stool passed after rising on the fourth day is collected and its marker content analysed. The method has been validated in 15 subjects by comparing it on 36 occasions with mean transit time measured by a continuous marker technique (MTT-C). In 35 of these studies transit measured from a single stool (SST) and MTT-C were significantly correlated R = 0.78 P less than 0.001. In one study the designated stool contained none of the SST markers. An alternative way of validating the SST method is described by comparing it with the average of the three mean transit times from three separate doses of marker (MTT-S). The average MTT-S agreed very closely with MTT-C in 36 studies R = 0.94 P less than 0.001 and proved a satisfactory alternative method for validating transit techniques. In a total of 66 studies in 22 subjects average MTT-S correlated significantly with SST, R = 0.85 P less than 0.001.
journal_name
Gutjournal_title
Gutauthors
Cummings JH,Wiggins HSdoi
10.1136/gut.17.3.219keywords:
subject
Has Abstractpub_date
1976-03-01 00:00:00pages
219-23issue
3eissn
0017-5749issn
1468-3288journal_volume
17pub_type
杂志文章相关文献
GUT文献大全abstract::A 45 year old man is described with Whipple's disease who presented with weight loss, lethargy, and ascites. He subsequently developed fever and a mass in the neck, but died despite antibiotic treatment and nutritional support. Necropsy showed extraintestinal lymphoma. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.11.1627
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Intestinal metaplasia, whether in the cardia or the distal oesophagus, has been uniformly defined as specialised columnar epithelium, suggesting a relation with Barrett's oesophagus. It is, however, not clear whether the risk factors associated with intestinal metaplasia are identical at both sites. AIMS:To...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.1.17
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-311970
更新日期:2017-11-01 00:00:00
abstract::Dysphagia in a 79 year old lady was caused by a giant polypoid tumour in mid-oesophagus. Surgery was not appropriate. Shrinkage of the tumour and its eventual detachment were achieved by stopping its blood supply by YAG laser photocoagulation of the tumour stalk. Good, temporary palliation of the dysphagia was achieve...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.8.1146
更新日期:1992-08-01 00:00:00
abstract:OBJECTIVE:Intestinal permeability and psychological stress have been implicated in the pathophysiology of IBD and IBS. Studies in animals suggest that stress increases permeability via corticotropin-releasing hormone (CRH)-mediated mast cell activation. Our aim was to investigate the effect of stress on intestinal perm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-305690
更新日期:2014-08-01 00:00:00
abstract::A 60 year old man developed steatorrhoea, weight loss, mild diabetes mellitus, labile hypertension and limb cramps. Raised plasma concentrations of catecholamines, particularly noradrenaline and a computed tomography-scan showing an adrenal tumour strongly suggested a pheochromocytoma. Adrenoreceptor blockade reversed...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.10.1298
更新日期:1987-10-01 00:00:00
abstract::To investigate further the cause of the pancreatic enlargment induced by orally ingested soybean trypsin inhibitor (STI), antibodies raised against STI and purified by affinity chromatography were used to localise dietary STI in the rat gut by fluorescent immunocytochemical methods. This technique permitted the clear ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.4.260
更新日期:1978-04-01 00:00:00
abstract::To determine whether primary biliary cirrhosis differed in men and women we reviewed the presenting features and clinical course of 39 men and 191 women with primary biliary cirrhosis followed at this unit between 1970 and 1984. Age and severity of disease at time of diagnosis were similar in both groups. Pruritus was...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.11.1373
更新日期:1986-11-01 00:00:00
abstract::To investigate factors which predispose to relapse in patients with ulcerative colitis, we conducted a survey to compare the events occurring in the four weeks preceding the clinic attendance of 62 outpatients in remission with those taking place in the same period before the onset of relapse in 21 patients attending ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.3.187
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate whether patients with increased or decreased gastric motility can be differentiated from healthy volunteers by means of real time magnetic resonance imaging (MRI). PATIENTS AND METHODS:Ten healthy volunteers, 10 patients with gastroparesis, and 10 patients with function...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.038588
更新日期:2004-09-01 00:00:00
abstract::This report presents a patient with proximal small bowel cystic pneumatosis associated with poorly controlled coeliac disease and pseudo-obstruction. Cystic pneumatosis is rare in the proximal small bowel and we can find no report of its occurrence in association with coeliac disease. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.6.852
更新日期:1988-06-01 00:00:00
abstract::Heartburn is a common symptom affecting 21-44% of the adult population on a monthly basis. Oesophagitis is less common, affecting 2% of individuals. Epidemiological studies have shown that patients with gastro-oesophageal reflux disease (GORD) have similar incidence rates of Helicobacter pylori infection as do control...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.45.2008.i13
更新日期:1999-07-01 00:00:00
abstract::The behaviour of basal and stimulated acid secretion, gastrin release, serum pepsinogen I, and gastric emptying of liquids was studied in 19 consecutive patients with Helicobacter pylori positive duodenal ulcer, over a follow up period of six months. Eleven patients were studied before and at three and six months afte...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.2.210
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Some cirrhotic patients with tense ascites who undergo paracentesis develop a circulatory dysfunction syndrome, manifested by an increase in plasma renin activity. Recently, a significant inverse correlation between postparacentesis changes in plasma renin activity and systemic vascular resistance has been d...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.3.384
更新日期:2001-03-01 00:00:00
abstract::A simple technique for measuring gastrointestinal transit times using radioopaque pellets of barium-impregnated polythene has been developed and validated. A normal range has been established by studying 25 normal subjects; all passed the first marker within three days and most passed 80% of the markers within five da...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.10.10.842
更新日期:1969-10-01 00:00:00
abstract:INTRODUCTION:CD248 (endosialin) is a stromal cell marker expressed on fibroblasts and pericytes. During liver injury, myofibroblasts are the main source of fibrotic matrix. OBJECTIVE:To determine the role of CD248 in the development of liver fibrosis in the rodent and human setting. DESIGN:CD248 expression was studie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308325
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Although polypoid lesions of the gall bladder are frequently observed in asymptomatic subjects, the natural history of these lesions has never been studied using ultrasonography. AIM:The natural history of polypoid lesions of the gall bladder was investigated using ultrasonography. SUBJECTS:Among 4343 pati...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.39.6.860
更新日期:1996-12-01 00:00:00
abstract::Fourteen apparently healthy patients with ileostomies were found to be depleted of total exchangeable sodium and potassium, but had normal serum electrolyte concentrations and normal extracellular fluid and total body water volumes. The low exchangeable sodium and potassiums were thus primarily due to depletion of the...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.6.563
更新日期:1978-06-01 00:00:00
abstract::It has been suggested, on the basis of impaired granulocyte migration to skin windows, that there is a fundamental granulocyte defect in Crohn's disease. In vitro tests of granulocyte function have, however, failed to confirm this. We have studied granulocyte migration to inflamed bowel in Crohn's disease using a new ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.4.378
更新日期:1985-04-01 00:00:00
abstract::Severe watery diarrhoea in a patient with medullary thryoid carcinoma and high calcitonin levels was associated with increased distal ileal flow. Plasma from the patient inhibited small intestinal fluid absorption in dogs without affecting mucosal cyclic AMP levels. When calcitonin was removed from the plasma, the eff...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.7.629
更新日期:1979-07-01 00:00:00
abstract::In dogs with either vagally innervated or denervated pouches, the acid responses to a standard meal, a meal which bypassed the greater part of the small bowel, and a meal introduced directly into the small intestine were measured before and after exclusion of 75% of the small bowel.After intestinal exclusion an increa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.7.539
更新日期:1972-07-01 00:00:00
abstract::Motilin is a hormonal peptide found in the duodenum and jejunum which potently influences gastrointestinal tract motility. Its role in human physiology is not yet established. After a standard hospital lunch the plasma concentration of motilin showed a small, transient, but significant rise in 28 healthy subjects. Ind...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.2.102
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.066100
更新日期:2006-02-01 00:00:00
abstract::An antibody precipitating urease was found in 171 out of 180 human sera. Data obtained on limited material (50 cases) suggest that the anti-urease titre is appreciably higher in the serum of patients suffering from gastric ulcer. This is a pointer towards a possible antigen-antibody mechanism in the genesis of chronic...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.4.4.339
更新日期:1963-12-01 00:00:00
abstract::The frequency of gastric Crohn's disease has been considered low. This study was undertaken to determine the prevalence of chronic gastritis and Helicobacter pylori infection in patients with Crohn's disease. Oesophagogastroduodenoscopy was performed on 62 consecutive patients suffering from ileocolonic Crohn's diseas...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.3.379
更新日期:1996-03-01 00:00:00
abstract::In order to examine the relationship of various haemodynamic parameters in two different liver diseases, 10 patients with cirrhosis of liver and 14 patients with non-cirrhotic portal fibrosis were studied. In cirrhotics, mean (+/- SD) wedged hepatic (25.8 +/- 6.4 mmHg), intrahepatic (24.5 +/- 6.2 mmHg) and intraspleni...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.3.260
更新日期:1987-03-01 00:00:00
abstract::Faecal bile acid excretion was examined in 13 patients with adenomatous polyps of the large bowel and compared with a series of matched healthy subjects. Bile acids were analysed in detail with respect to the composition of individual bile acids and their mode of conjugation. The total excretion of bile acids by the p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.8.824
更新日期:1984-08-01 00:00:00
abstract::A prospective, randomised, comparative study was performed to assess the need for a pure alcohol injection after an epinephrine injection in the arrest of active peptic ulcer bleeding. Sixty four patients with active ulcer bleeding were enrolled in the study. The two groups (epinephrine and epinephrine plus pure alcoh...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.9.1182
更新日期:1993-09-01 00:00:00
abstract::All patients presenting with acute upper gastrointestinal bleeding between November 1986 and April 1988 were admitted to a centralised joint medical/surgical unit, with a policy of early clinical and endoscopic assessment and rapid surgical intervention in those at high risk. Of the 430 patients admitted 69.5% were ov...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.5.504
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:Cirrhotic patients with hepatocellular carcinoma (HCC) frequently have impaired glucose metabolism. AIMS:To investigate whether impaired glucose metabolism affects the growth rate of the tumour. PATIENTS AND METHODS:Tumour doubling time (DT), assessed by ultrasound imaging analysis, was measured in 60 pati...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.1.100
更新日期:2002-07-01 00:00:00