Transit through the gut measured by analysis of a single stool.


:A method is described for measuring transit time through the gut which requires the collection of only one stool. A dose of 20 radio-opaque markers is given to the subject on each of three consecutive days with breakfast, each dose of marker being of a different type. The first stool passed after rising on the fourth day is collected and its marker content analysed. The method has been validated in 15 subjects by comparing it on 36 occasions with mean transit time measured by a continuous marker technique (MTT-C). In 35 of these studies transit measured from a single stool (SST) and MTT-C were significantly correlated R = 0.78 P less than 0.001. In one study the designated stool contained none of the SST markers. An alternative way of validating the SST method is described by comparing it with the average of the three mean transit times from three separate doses of marker (MTT-S). The average MTT-S agreed very closely with MTT-C in 36 studies R = 0.94 P less than 0.001 and proved a satisfactory alternative method for validating transit techniques. In a total of 66 studies in 22 subjects average MTT-S correlated significantly with SST, R = 0.85 P less than 0.001.






Cummings JH,Wiggins HS





Has Abstract


1976-03-01 00:00:00














  • Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium.

    abstract:BACKGROUND:Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. AIMS:To establish a new colitis associated neoplasia model in p53 deficie...


    pub_type: 杂志文章


    authors: Fujii S,Fujimori T,Kawamata H,Takeda J,Kitajima K,Omotehara F,Kaihara T,Kusaka T,Ichikawa K,Ohkura Y,Ono Y,Imura J,Yamaoka S,Sakamoto C,Ueda Y,Chiba T

    更新日期:2004-05-01 00:00:00

  • HFE gene mutation (C282Y) and phenotypic expression among a hospitalised population in a high prevalence area of haemochromatosis.

    abstract:BACKGROUND:Previous studies have shown that up to 0.5% of the Caucasian population is homozygous for the HFE gene C282Y mutation. High prevalence values have been reported in Northern Europe. To what extent the presence of this mutation is associated with overt clinical haemochromatosis is unclear. AIM:To determine th...


    pub_type: 杂志文章


    authors: Distante S,Berg JP,Lande K,Haug E,Bell H

    更新日期:2000-10-01 00:00:00

  • Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial.

    abstract:OBJECTIVE:The aim of the study was to compare azathioprine versus mesalazine tablets for the prevention of clinical recurrence in patients with postoperative Crohn's disease (CD) with moderate or severe endoscopic recurrence. METHODS:This was a 1 year, double-blind, double-dummy, randomised study which took place in 2...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Reinisch W,Angelberger S,Petritsch W,Shonova O,Lukas M,Bar-Meir S,Teml A,Schaeffeler E,Schwab M,Dilger K,Greinwald R,Mueller R,Stange EF,Herrlinger KR,International AZT-2 Study Group.

    更新日期:2010-06-01 00:00:00

  • Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony stimulating factor produced by squamous cell carcinoma of the oesophagus.

    abstract::Synchronous cancers of the oesophagus and stomach diagnosed in a patient showing pronounced leucocytosis were examined for production of granulocyte colony stimulating factor (G-CSF) and expression of G-CSF receptor. Whereas enzyme immunoassay of tissue extracts showed that the oesophageal carcinoma produced G-CSF, th...


    pub_type: 杂志文章


    authors: Ichiishi E,Yoshikawa T,Kogawa T,Yoshida N,Kondo M

    更新日期:2000-03-01 00:00:00

  • Randomised controlled trial of long term portographic follow up versus variceal band ligation following transjugular intrahepatic portosystemic stent shunt for preventing oesophageal variceal rebleeding.

    abstract:BACKGROUND/AIMS:Transjugular intrahepatic portosystemic stent shunt (TIPSS) is effective in the prevention of variceal rebleeding but requires invasive portographic follow up. This randomised controlled trial aims to test the hypothesis that combining variceal band ligation (VBL) with TIPSS can obviate the need for lon...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tripathi D,Lui HF,Helmy A,Dabos K,Forrest E,Stanley AJ,Jalan R,Redhead DN,Hayes PC

    更新日期:2004-03-01 00:00:00

  • Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice.

    abstract:BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...


    pub_type: 杂志文章


    authors: Verdú EF,Bercik P,Verma-Gandhu M,Huang XX,Blennerhassett P,Jackson W,Mao Y,Wang L,Rochat F,Collins SM

    更新日期:2006-02-01 00:00:00

  • Decision analysis in the surgical treatment of patients with familial adenomatous polyposis: a Dutch-Scandinavian collaborative study including 659 patients.

    abstract:BACKGROUND AND AIMS:The choice of colorectal surgery in patients with familial adenomatous polyposis lies between the morbidity of proctocolectomy and ileum-pouch-anal anastomosis (IPAA) and the mortality from rectal cancer after total colectomy and ileorectal anastomosis (IRA). The aims of the present study were: (1) ...


    pub_type: 杂志文章


    authors: Vasen HF,van Duijvendijk P,Buskens E,Bülow C,Björk J,Järvinen HJ,Bülow S

    更新日期:2001-08-01 00:00:00

  • HLA antigens and atopy in children with coeliac disease.

    abstract::HLA antigens and various aspects of atopy were studied in 42 Finnish children and adolescents with coeliac disease, and the results were compared with findings of recent population studies. The HLA associations were as expected: relative risks for coeliac disease in individuals with HLA-B8, DR3, and DR7 were 8 . 0, 18...


    pub_type: 杂志文章


    authors: Verkasalo M,Tiilikainen A,Kuitunen P,Savilahti E,Backman A

    更新日期:1983-04-01 00:00:00

  • Acute lower GI bleeding in the UK: patient characteristics, interventions and outcomes in the first nationwide audit.

    abstract:OBJECTIVE:Lower GI bleeding (LGIB) is a common reason for emergency hospital admission, although there is paucity of data on presentations, interventions and outcomes. In this nationwide UK audit, we describe patient characteristics, interventions including endoscopy, radiology and surgery as well as clinical outcomes....


    pub_type: 杂志文章,多中心研究


    authors: Oakland K,Guy R,Uberoi R,Hogg R,Mortensen N,Murphy MF,Jairath V,UK Lower GI Bleeding Collaborative.

    更新日期:2018-04-01 00:00:00

  • Modulation of human upper intestinal nutrient transit by a beta adrenoreceptor mediated pathway.

    abstract::To explore the role played by beta adrenoreceptor mediated pathways on human upper gut function a series of studies were conducted into the effects of beta adrenoreceptor agonists and antagonists on orocaecal and duodenocaecal transit and on antral and duodenal motor activity. Under control conditions orocaecal transi...


    pub_type: 临床试验,杂志文章


    authors: McIntyre AS,Thompson DG,Day S,Burnham WR,Walker ER

    更新日期:1992-08-01 00:00:00

  • Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin release.

    abstract::Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin secretion were studied by using the isolated perfused rat stomach. [Asu1,7]-eel calcitonin (10(-9)--10(-7)M) caused a simultaneous dose-dependent increase of gastric somatostatin release and decrease of gastrin secretion, with a significant correla...


    pub_type: 杂志文章


    authors: Chiba T,Taminato T,Kadowaki S,Goto Y,Mori K,Seino Y,Abe H,Chihara K,Matsukura S,Fujita T,Kondo T

    更新日期:1980-02-01 00:00:00

  • Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis.

    abstract:BACKGROUND:Activated hepatic stellate cells (HSCs) are an attractive target for antifibrotic therapy based on their key role in extracellular matrix accumulation during liver injury. AIM:: To develop a system for regulable and cell-specific gene expression in HSCs to enable targeted delivery of therapeutic genes. MET...


    pub_type: 杂志文章


    authors: Kinoshita K,Iimuro Y,Fujimoto J,Inagaki Y,Namikawa K,Kiyama H,Nakajima Y,Otogawa K,Kawada N,Friedman SL,Ikeda K

    更新日期:2007-03-01 00:00:00

  • Effects of olsalazine and sulphasalazine on jejunal and ileal water and electrolyte absorption in normal human subjects.

    abstract::The effect of sulphasalazine and olsalazine on jejunal and ileal water and electrolyte absorption was investigated in normal subjects by a steady state intestinal perfusion of a physiological glucose bicarbonate electrolyte solution in the absence and presence of increasing concentrations of each drug. (Olsalazine 0.2...


    pub_type: 杂志文章


    authors: Raimundo AH,Patil DH,Frost PG,Silk DB

    更新日期:1991-03-01 00:00:00

  • Metagenomics analysis of gut microbiota in response to diet intervention and gestational diabetes in overweight and obese women: a randomised, double-blind, placebo-controlled clinical trial.

    abstract:OBJECTIVE:Gut microbiota and diet are known to contribute to human metabolism. We investigated whether the metagenomic gut microbiota composition and function changes over pregnancy are related to gestational diabetes mellitus (GDM) and can be modified by dietary supplements, fish oil and/or probiotics. DESIGN:The gut...


    pub_type: 杂志文章


    authors: Mokkala K,Paulin N,Houttu N,Koivuniemi E,Pellonperä O,Khan S,Pietilä S,Tertti K,Elo LL,Laitinen K

    更新日期:2021-02-01 00:00:00

  • Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome.

    abstract:BACKGROUND:Meal ingestion is often associated with exacerbation of gastrointestinal symptoms in subjects with irritable bowel syndrome (IBS). Furthermore, recent preliminary data suggest that 5-hydroxytryptamine (5-HT) concentration in platelet poor plasma is elevated following meal ingestion in some subjects with diar...


    pub_type: 杂志文章


    authors: Houghton LA,Atkinson W,Whitaker RP,Whorwell PJ,Rimmer MJ

    更新日期:2003-05-01 00:00:00

  • Increased nitric oxide production in lymphatic endothelial cells causes impairment of lymphatic drainage in cirrhotic rats.

    abstract:BACKGROUND AND AIM:The lymphatic network plays a major role in maintaining tissue fluid homoeostasis. Therefore several pathological conditions associated with oedema formation result in deficient lymphatic function. However, the role of the lymphatic system in the pathogenesis of ascites and oedema formation in cirrho...


    pub_type: 杂志文章


    authors: Ribera J,Pauta M,Melgar-Lesmes P,Tugues S,Fernández-Varo G,Held KF,Soria G,Tudela R,Planas AM,Fernández-Hernando C,Arroyo V,Jiménez W,Morales-Ruiz M

    更新日期:2013-01-01 00:00:00

  • Clq metabolism in ulcerative colitis and Crohn's disease.

    abstract::The metabolism of pure radioiodine labelled Clq has been observed in five patients with ulcerative colitis, five patients with Crohn's disease, and in five control subjects. Both the fractional catabolic rate and the synthesis rate of Clq were increased in the five patients with Crohn's disease and in four of the five...


    pub_type: 杂志文章


    authors: Potter BJ,Hodgson HJ,Mee AS,Jewell DP

    更新日期:1979-11-01 00:00:00

  • Does Helicobacter pylori infection increase gastric sensitivity in functional dyspepsia?

    abstract::The role of Helicobacter pylori infection in the pathogenesis of functional dyspepsia is debated. It is known that a substantial fraction of dyspeptic patients manifest a low discomfort threshold to gastric distension. This study investigated the symptomatic pattern in 27 H pylori positive and 23 H pylori negative pat...


    pub_type: 杂志文章


    authors: Mearin F,de Ribot X,Balboa A,Salas A,Varas MJ,Cucala M,Bartolomé R,Armengol JR,Malagelada JR

    更新日期:1995-07-01 00:00:00

  • CO(2) wedged hepatic venography in the evaluation of portal hypertension.

    abstract:BACKGROUND/AIMS/METHODS:During hepatic vein catheterisation, in addition to measurement of hepatic venous pressure gradient (HVPG), iodine wedged retrograde portography can be easily obtained. However, it rarely allows correct visualisation of the portal vein. Recently, CO(2) has been suggested to allow better angiogra...


    pub_type: 杂志文章


    authors: Debernardi-Venon W,Bandi JC,García-Pagán JC,Moitinho E,Andreu V,Real M,Escorsell A,Montanyá X,Bosch J

    更新日期:2000-06-01 00:00:00

  • Predictive value of oesophageal pH variables in children with gastro-oesophageal reflux.

    abstract::Sixty three 24 hour oesophageal pH studies were performed in children with known or suspected gastro-oesophageal reflux and their progress was followed for at least a year. Forty two studies were of children who were well at follow up who were not receiving medical treatment for gastro-oesophageal reflux, and had not ...


    pub_type: 杂志文章


    authors: Colson DJ,Campbell CA,Wright VA,Watson BW

    更新日期:1990-04-01 00:00:00

  • Paraproteins with antibody activity in acute viral hepatitis and chronic autoimmune liver diseases.

    abstract::Of 27 patients with liver disease and cryoglobulinaemia 18 proved to have paraproteins. Six of these monoclonal immunoglobulins were shown to have antibody activity, directed to human gamma globulin, alpha(1)-fetoprotein, smooth muscle, and mitochondria.Eight of the patients suffered from acute viral hepatitis, five o...


    pub_type: 杂志文章


    authors: Roux ME,Florin-Christensen A,Arana RM,Doniach D

    更新日期:1974-05-01 00:00:00

  • Gastrocytoprotection by colloidal bismuth subcitrate (De-Nol) and sucralfate. Role of endogenous prostaglandins.

    abstract::This study compares the gastroprotective effects of colloidal bismuth subcitrate (De-Nol) with those of sucralfate and a methylated analogue of prostaglandin E2 (PGE2) against acute gastric lesions induced by acidified aspirin and absolute ethanol in rats. Both De-Nol and sucralfate given orally prevented dose depende...


    pub_type: 杂志文章


    authors: Konturek SJ,Radecki T,Piastucki I,Brzozowski T,Drozdowicz D

    更新日期:1987-02-01 00:00:00

  • Evaluation of differential disaccharide excretion in urine for non-invasive investigation of altered intestinal disaccharidase activity caused by alpha-glucosidase inhibition, primary hypolactasia, and coeliac disease.

    abstract:BACKGROUND/AIM:The reliability of a quantitative method for the non-invasive assessment of intestinal disaccharide hydrolysis was assessed. METHODS:Differential excretion of intact disaccharide, expressed as ratios of lactulose to appropriate hydrolysable disaccharides in urine collected following combined ingestion, ...


    pub_type: 杂志文章


    authors: Bjarnason I,Batt R,Catt S,Macpherson A,Maxton D,Menzies IS

    更新日期:1996-09-01 00:00:00

  • Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection.

    abstract:BACKGROUND AND AIMS:CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single source, a strong association between viral clearance and the human lecucocyte (HLA)-A*03 allele has be...


    pub_type: 杂志文章


    authors: Fitzmaurice K,Petrovic D,Ramamurthy N,Simmons R,Merani S,Gaudieri S,Sims S,Dempsey E,Freitas E,Lea S,McKiernan S,Norris S,Long A,Kelleher D,Klenerman P

    更新日期:2011-11-01 00:00:00

  • Acid and gastrin responses during intragastric titration in normal subjects and duodenal ulcer patients with G-cell hyperfunction.

    abstract::Amino acid induced acid and gastrin responses during intragastric titration at pH 2.5 and 5.5 were compared in normal subjects and duodenal ulcer patients with G-cell hyperfunction. The latter were identified on the basis of raised basal or maximal acid outputs and increased gastrin responses to feeding. In normal sub...


    pub_type: 杂志文章


    authors: Cooper RG,Dockray GJ,Calam J,Walker R

    更新日期:1985-03-01 00:00:00

  • Class II major histocompatibility complex antigen expression on peripheral blood monocytes in patients with inflammatory bowel disease.

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    pub_type: 杂志文章


    authors: Gardiner KR,Crockard AD,Halliday MI,Rowlands BJ

    更新日期:1994-04-01 00:00:00

  • Small bowel haemorrhage due to cytomegalovirus vasculitis.

    abstract::A case is described of a life threatening vasculitis of the small bowel leading to massive gastrointestinal haemorrhage which was apparently due to cytomegalovirus inclusion disease. Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine. This ...


    pub_type: 杂志文章


    authors: Sackier JM,Kelly SB,Clarke D,Rees AJ,Wood CB

    更新日期:1991-11-01 00:00:00

  • Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation.

    abstract:BACKGROUND:Early events in the progression of 90% of sporadic colorectal cancers depend on constitutive activation of Wnt signalling. Recent data also indicate a close association between the Hedgehog (Hh) and Wnt pathways in colonic epithelial cell differentiation. AIMS:To investigate whether expression of Gli1, a tr...


    pub_type: 杂志文章


    authors: Akiyoshi T,Nakamura M,Koga K,Nakashima H,Yao T,Tsuneyoshi M,Tanaka M,Katano M

    更新日期:2006-07-01 00:00:00

  • Nerve activity recordings in routine human intestinal biopsies.

    abstract:BACKGROUND:Most direct understanding of enteric nerve (patho)physiology has been obtained by electrode and imaging techniques in animal models and human surgical samples. Until now, neuronal activity recordings from a more accessible human tissue source have remained a true challenge. OBJECTIVES:To record nerve activi...


    pub_type: 杂志文章


    authors: Cirillo C,Tack J,Vanden Berghe P

    更新日期:2013-02-01 00:00:00

  • Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression.

    abstract:BACKGROUND:Sodium butyrate, a product of colonic bacterial fermentation, is able to inhibit cell proliferation and to stimulate cell differentiation of colonic epithelial cell lines. It has been proposed that these cellular effects could be linked to its ability to cause hyperacetylation of histone through the inhibiti...


    pub_type: 杂志文章


    authors: Siavoshian S,Segain JP,Kornprobst M,Bonnet C,Cherbut C,Galmiche JP,Blottière HM

    更新日期:2000-04-01 00:00:00