Abstract:
OBJECTIVE:Treatments with sequential therapy (SEQ) or bismuth quadruple (QUAD) therapy have been proposed as empirical firstline regimens for Helicobacter pylori. We compared the efficacy and tolerability of 10 day SEQ with 10 day modified QUAD as both firstline and secondline treatments for H pylori in a randomised crossover study. DESIGN:H pylori positive and treatment naïve patients were randomly assigned to receive either 10 day SEQ (esomeprazole for 10 days, amoxicillin for an initial 5 days, followed by clarithromycin and metronidazole for a subsequent 5 days) or modified QUAD (esomeprazole, bismuth subcitrate, tetracycline and metronidazole). H pylori eradication was confirmed by urea breath test at 8 weeks. Patients who failed the initial assigned treatment were crossed over to receive the alternate regimen. The primary outcome was eradication rates of firstline treatment by intention to treat (ITT) and per protocol (PP) analyses. RESULTS:357 patients were randomised to receive either SEQ or QUAD. The PP eradication rates of the SEQ and QUAD groups were 95.2% and 98.8%, respectively (p=0.10). Based on ITT analysis, the corresponding eradication rates were 89.4% and 92.7%, respectively (p=0.36). Eight (4.8%) patients in the SEQ and two (1.2%) patients in the QUAD who failed the firstline treatment were crossed over to the alternate regimen with 100% retreatment success. The overall incidence of adverse events was higher in the QUAD (16.7%) than in the SEQ (8.1%; p=0.032) group. CONCLUSIONS:Ten day sequential and modified bismuth quadruple therapies are both highly effective as empirical firstline therapies for H pylori in Chinese patients. CLINICALTRIALSGOV:NCT 01760824.
journal_name
Gutjournal_title
Gutauthors
Liu KS,Hung IF,Seto WK,Tong T,Hsu AS,Lam FY,But DY,Wong SY,Leung WKdoi
10.1136/gutjnl-2013-306120subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1410-5issue
9eissn
0017-5749issn
1468-3288pii
gutjnl-2013-306120journal_volume
63pub_type
杂志文章,随机对照试验相关文献
GUT文献大全abstract::Lymphangiomas are rare tumours of lymphatic vessels, most commonly found in children. We present the unusual case of small bowel obstruction caused by benign lymphangioma in a middle aged woman. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.12.1568
更新日期:1991-12-01 00:00:00
abstract::4-Aminosalicylic acid (4-ASA) has been suggested as an effective treatment for both active and quiescent ulcerative colitis. 5-Aminosalicylic acid (5-ASA) is well accepted for the maintenance treatment of inactive ulcerative colitis. Moreover, recent studies suggest that 5-ASA may also be effective in maintaining remi...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.35.8.1081
更新日期:1994-08-01 00:00:00
abstract::Seven patients with hypoalbuminaemia and extensive jejunoileal Crohn's disease were treated with an elemental diet for 28 to 56 days. Over this time there was an increase in total plasma proteins from mean of 49.1 to 59.0 g/l and a mean rise in serum albumin from 20.7 to 30.0 g/l (P less than 0.05). In addition, there...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.22.5.383
更新日期:1981-05-01 00:00:00
abstract::In a search for past or present infection with herpes viruses, serum antibody titres to herpes simplex type 1 virus, cytomegalovirus, and varicella-zoster virus were measured by complement fixation test in 58 patients with achalasia. Serum was also taken from 40 age and sex matched patients without oesophageal symptom...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.3.299
更新日期:1993-03-01 00:00:00
abstract::The effects on gastric emptying of a solid meal of the specific 5-HT3-receptor antagonist ICS 205-930, 10 mg and 20 mg intravenously were assessed with a scintigraphic technique in 12 normals. The 50% emptying time was less, the lag phase was shorter and the post lag emptying rate was faster after 20 mg ICS 205-930 (p...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.29.9.1249
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We have previously shown that hypnosis can be used to study the effect of different emotions on the motility of the gastrointestinal tract. These studies demonstrated that both anger and excitement increased colonic motility while happiness led to a reduction. The purpose of this study was to ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.51.5.701
更新日期:2002-11-01 00:00:00
abstract::These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines which this document supersedes were written in 2...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309262
更新日期:2015-11-01 00:00:00
abstract::Lymphocytic gastritis and primary gastric lymphoma are rare conditions with unknown aetiology. It has recently been suggested that Helicobacter pylori has a role in the pathogenesis of both of them. The occurrence of lymphocytic gastritis and H pylori was studied in a series of patients with primary gastric lymphoma. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.4.471
更新日期:1995-10-01 00:00:00
abstract::Six jaundiced patients with primary sclerosing cholangitis and a dominant biliary stricture were managed by endoscopic placement of endoprostheses. Five showed considerable improvement within weeks of stenting: their serum bilirubin concentration fell from mean (range) 266 mumol/l (63-681) to 65 mumol/l (10-280) after...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.11.1364
更新日期:1991-11-01 00:00:00
abstract::We report massive acute haemolysis associated with hepatitis A in a 36 year old Irish woman. Although mild anaemia is not uncommon during viral hepatitis, haemolysis of the severity observed in this patient has previously been reported only in patients with glucose-6-phosphate dehydrogenase deficiency. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.7.838
更新日期:1990-07-01 00:00:00
abstract::Two patients who developed biochemical and histological evidence of hepatitis while taking the anti-anginal drug perhexiline maleate are described. The pathological changes were those of mild to moderate fatty change together with a hepatitis which resembled alcoholic hepatitis, including in one patient the presence o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.3.186
更新日期:1979-03-01 00:00:00
abstract::A series of experiments has been performed in healthy male volunteers to investigate the disposition of orally administered disodium azodisalicylate, a potentially useful drug for the treatment of ulcerative colitis. The drug was given by mouth in doses of up to 2 g a day for six weeks and there were no adverse effect...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.12.1081
更新日期:1982-12-01 00:00:00
abstract::Sex differences exist in the site specific incidences of colorectal cancer. The increased incidence of colonic cancer in women with breast cancer and the protective effect of increasing parity suggest a role for sex hormones. To explore the molecular basis, the expression of messenger RNA for oestrogen and progesteron...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.5.611
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:Cryptogenic multifocal ulcerating stenosing enteritis (CMUSE) is an extremely rare, but devastating, disease of unknown aetiology. We investigated the genetic basis of this autosomal recessive condition in a pair of affected siblings who have 40-year histories of catastrophic gastrointestinal and extraintesti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-303581
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Shortage of organ donors, a critical challenge for treatment of end-stage organ failure, has motivated the development of alternative strategies to generate organs in vitro. Here, we aim to describe the hepatorganoids, which is a liver tissue model generated by three-dimensional (3D) bioprinting of HepaRG cel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319960
更新日期:2020-05-20 00:00:00
abstract::The effects of corticotrophin and of cortisone, methyl prednisolone, and of aldosterone on the gastric secretion of dogs have been investigated. Juice was collected from dogs with denervated pouches under basal conditions and when stimulated with meat extract and with histamine. For each secretion the volume, viscosit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.1.36
更新日期:1960-03-01 00:00:00
abstract::We investigated the distribution of short chain fatty acids (SCFA) in enema samples taken from subjects before sigmoidoscopy as an indicator of possible microbial community differences between subjects subsequently diagnosed as normal or having colonic disorders. The major SCFA in all groups were acetic, propionic, an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.11.1539
更新日期:1988-11-01 00:00:00
abstract::Caeruloplasmin is an alpha 2 protein produced in the liver that is responsible for transporting copper in the blood. Caeruloplasmin values are usually high in patients with chronic liver diseases, including chronic active hepatitis: low values, however, are characteristic of Wilson's disease. The case of a 17 year old...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.5.549
更新日期:1991-05-01 00:00:00
abstract::Faecal bile acid excretion was examined in 13 patients with adenomatous polyps of the large bowel and compared with a series of matched healthy subjects. Bile acids were analysed in detail with respect to the composition of individual bile acids and their mode of conjugation. The total excretion of bile acids by the p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.8.824
更新日期:1984-08-01 00:00:00
abstract::In a randomised clinical trial, patients with moderately active Crohn's disease received either prednisolone 0.5 mg/kg/day plus a normal diet, or an elemental diet plus oral framycetin, colistin and nystatin. Patients were assessed using the Crohn's disease activity index (CDAI), ESR, and faecal granulocyte excretion ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.26.10.994
更新日期:1985-10-01 00:00:00
abstract::A case is described of non-necrotizing, epithelioid cell granulomatous synovitis of the ankle of a 22-year-old man with Crohn's disease. It appears to be the first published example of granulomatous arthritis in association with Crohn's disease. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.4.257
更新日期:1972-04-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that up to 0.5% of the Caucasian population is homozygous for the HFE gene C282Y mutation. High prevalence values have been reported in Northern Europe. To what extent the presence of this mutation is associated with overt clinical haemochromatosis is unclear. AIM:To determine th...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.47.4.575
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:Invasion of the intestinal mucosa by leucocytes is a characteristic of intestinal inflammation but the role of the epithelium in orchestrating this recruitment has not been examined in vivo. Cultured intestinal epithelial cells secrete a wide variety of chemokines, often in response to agents present in the ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.4.526
更新日期:2001-10-01 00:00:00
abstract::The cognitive model of depression assigns a central role to negatively biased information processing in the pathogenesis of the emotional disorder. The relationship between depression and irritable bowel syndrome (IBS) was explored from a cognitive perspective. A word recognition memory task was constructed: subjects ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.9.1230
更新日期:1993-09-01 00:00:00
abstract::Eighty patients were asked if they would have preferred their ileocolonic resection and anastomosis for Crohn's disease, to have been carried out sooner, later or at the same time as it was done. Seventy of the patients replied (88%). No patient would have preferred their operation to have been later, while 74% though...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.5.656
更新日期:1994-05-01 00:00:00
abstract::The responses to deglutition of the lower oesophageal high pressure zone were studied in 13 healthy subjects. The recording assembly included three perfused pressure recording catheters, whose recording orifices were at the same axial level, and a more distally situated pH electrode. Relaxation and contraction progres...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.5.352
更新日期:1972-05-01 00:00:00
abstract:INTRODUCTION:CD248 (endosialin) is a stromal cell marker expressed on fibroblasts and pericytes. During liver injury, myofibroblasts are the main source of fibrotic matrix. OBJECTIVE:To determine the role of CD248 in the development of liver fibrosis in the rodent and human setting. DESIGN:CD248 expression was studie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308325
更新日期:2016-07-01 00:00:00
abstract::Basal serum gastrin in 40 patients with benign gastric ulcer was 103 +/- 10.7 pg/ml, a level significantly higher than corresponding estimations in normal subjects and patients with duodenal ulcer. Following stimulation by a protein meal, a mean rise of 124 pg/ml was achieved at 75 minutes and prior atropinization ind...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.3.166
更新日期:1972-03-01 00:00:00
abstract::The role of the proximal and distal stomach in the emptying of solids and liquids from the stomach remains unclear. We have used a dual isotope technique to quantify proximal and distal stomach emptying of a solid (100 g of 99mTc labelled liver/ground beef) liquid (either 200 ml of normal saline (eight subjects) or 25...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.6.615
更新日期:1991-06-01 00:00:00
abstract::The spectrum of clinical disease associated with specific defects in jejunal brush border membrane sodium/proton exchange is poorly defined and only two patients have been described so far. Jejunal brush border membrane transport studies were performed in a boy who presented with lethal familial protracted diarrhoea i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.10.1156
更新日期:1990-10-01 00:00:00