Abstract:
:We investigated the distribution of short chain fatty acids (SCFA) in enema samples taken from subjects before sigmoidoscopy as an indicator of possible microbial community differences between subjects subsequently diagnosed as normal or having colonic disorders. The major SCFA in all groups were acetic, propionic, and butyric acids. A significantly higher ratio of acetate to total SCFA and lower ratio of butyrate to total SCFA was found for polyp-colon cancer subjects than for normal subjects. There were no significant differences in the ratios of acetate, propionate, or butyrate between the diverticulosis or inflammatory bowel groups and the normal group. There were no significant sex differences nor were there correlations with the ratios of acetate, propionate or butyrate and age, subject weight, or dry weights of samples. Significant differences in concentrations of individual acids were found between normal and certain diagnostic groups. The difference in proportions of individual SCFA between groups suggest differences in fermentation patterns of the colonic microflora.
journal_name
Gutjournal_title
Gutauthors
Weaver GA,Krause JA,Miller TL,Wolin MJdoi
10.1136/gut.29.11.1539subject
Has Abstractpub_date
1988-11-01 00:00:00pages
1539-43issue
11eissn
0017-5749issn
1468-3288journal_volume
29pub_type
杂志文章相关文献
GUT文献大全abstract:OBJECTIVE:Reports on the effects of bone marrow-derived cells on hepatic fibrosis are contradictory. Impaired fibrosis but increased inflammation has recently been demonstrated 10 weeks after bone marrow transplantation (BM-Tx) in Abcb4-/- mice. It is hypothesised that BM-Tx might have long-term therapeutic potential b...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300608
更新日期:2012-06-01 00:00:00
abstract:AIMS:To determine the sources of founding for UK gastroenterology research papers and the relative impact of papers funded by different groups and of unfunded ones. METHODS:UK gastroenterology papers from 1988-94 were selectively retrieved from the Science Citation Index by means of a specially constructed filter base...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.2.288
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Crohn's disease (CD) and ulcerative colitis (UC) are chronic multifactorial inflammatory bowel diseases (IBDs) with unknown aetiology, but a deregulated mucosal immune response to gut-derived bacterial antigens is thought to be involved. Toll-like receptor ligands, especially lipopolysaccharide (LPS...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.128868
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Dyspepsia and irritable bowel syndrome are suitable conditions for assessment of quality of life. Their similarities justify the elaboration of a single specific questionnaire for the two conditions. AIMS:To examine the process leading to the validation of the psychometric properties of the functional diges...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.44.4.527
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. DESIGN:International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structu...
journal_title:Gut
pub_type: 共识发展会议,杂志文章
doi:10.1136/gutjnl-2019-318556
更新日期:2019-09-01 00:00:00
abstract::Gastric mucosal blood flow in the rat was determined by the indicator fractionation technique of Sapirstein using Rb86Cl. Antral and corpus flow rates were determined in response to increasing doses of pentagastrin and histamine and the effect of vagotomy was determined. With progressive stimulation the antral:corpus ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.1.14
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined. OBJECTIVE:To compare the performance of CE to VC for the detecti...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2016-313213
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:Many patients with irritable bowel syndrome IBS not only have abdominal pain but also may suffer from visceral hypersensitivity and heighted visceral nociception. Moreover, IBS has few effective therapeutic agents and mechanisms of disease are unclear. Our goals were to (i) identify microRNA (miRNA) expressio...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306464
更新日期:2016-05-01 00:00:00
abstract::The aim of this study is to assess the value of jejunal manometry in the diagnosis of subacute mechanical obstruction distal to the proximal small bowel. In a retrospective review of 850 manometric tracings carried out in patients with unexplained nausea, vomiting, abdominal pain or altered bowel movements, 16 tracing...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.4.468
更新日期:1989-04-01 00:00:00
abstract::Previous studies have suggested that profound inhibition of gastric acid secretion may increase exposure to potentially carcinogenic N-nitroso compounds. The aim of this study was to find out if the proton pump inhibitor omeprazole (20 mg daily) is associated with increased concentrations of potentially carcinogenic N...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.4.455
更新日期:1994-04-01 00:00:00
abstract::During the clinical investigation of patients with gastrointestinal disease by exhaled breath hydrogen measurement, the occurrence of inexplicable variations in recorded hydrogen values led to a search for extra intestinal factors which were capable of adversely influencing breath hydrogen concentration and impairing ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.12.1349
更新日期:1985-12-01 00:00:00
abstract::Lactulose H2 breath tests are widely used for quantifying carbohydrate malabsorption, but the validity of the commonly used technique (interval sampling of H2 concentrations) has not been systematically investigated. In eight healthy adults we studied the reproducibility of the technique and the accuracy with which 5 ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.1.37
更新日期:1990-01-01 00:00:00
abstract::Inflammatory mediators from intestinal mast cells may serve as initiators of acute and delayed inflammation. Mast cell histamine release was measured in 19 patients with inflammatory bowel diseases using gut mast cells from enzymatically dispersed endoscopic forceps biopsy specimens of macroscopically inflamed and nor...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.7.791
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVES:Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in hu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300695
更新日期:2012-08-01 00:00:00
abstract::A previous cohort study suggested that there might be an association between use of cimetidine and motor neurone disease. The Oxford Record Linkage Study was used to explore this hypothesis. In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.12.1660
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:Gluten-free diet (GFD) is the only management for coeliac disease (CD). Available methods to assess GFD compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause gut mucosal damage. We aimed to develop a method to determine gluten intake and monitor GFD compliance in p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-310148
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Most direct understanding of enteric nerve (patho)physiology has been obtained by electrode and imaging techniques in animal models and human surgical samples. Until now, neuronal activity recordings from a more accessible human tissue source have remained a true challenge. OBJECTIVES:To record nerve activi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301777
更新日期:2013-02-01 00:00:00
abstract:AIM:To compare acceptability and diagnostic accuracy of a recently available faecal immunochemical test (FIT) system (HM-JACKarc) with the FIT routinely used in an established screening programme (OC-Sensor). DESIGN:Randomised controlled trial (ISRCTN20086618) within a population-based colorectal cancer (CRC) screenin...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2016-312716
更新日期:2018-03-01 00:00:00
abstract::4-Aminosalicylic acid (4-ASA) has been suggested as an effective treatment for both active and quiescent ulcerative colitis. 5-Aminosalicylic acid (5-ASA) is well accepted for the maintenance treatment of inactive ulcerative colitis. Moreover, recent studies suggest that 5-ASA may also be effective in maintaining remi...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.35.8.1081
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic approach for PDAC u...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-320608
更新日期:2020-10-21 00:00:00
abstract:OBJECTIVE:To develop gene expression profiles that characterise KRAS-, BRAF- or PIK3CA-activated- tumours, and to explore whether these profiles might be helpful in predicting the response to the epidermal growth factor receptor (EGFR) pathway inhibitors better than mutation status alone. DESIGN:Fresh frozen tumour sa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-302423
更新日期:2013-04-01 00:00:00
abstract::Family histories were obtained from 50 patients with adenocarcinoma of the colon or rectum in north-east Scotland. A comparable control group was similarly interviewed and in each group the case notes of the first degree relatives were studied where possible. Eight (16%) of the patients with cancer of the colon or rec...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.2.169
更新日期:1982-02-01 00:00:00
abstract::Sera from patients with Crohn's disease have been reported to show positive immunofluorescence with lymph nodes of nude mice primed with a filtrate of intestinal tissue affected with Crohn's disease. An indirect immunofluorescence assay was used to test sera of 63 unrelated patients with Crohn's disease, 21 with ulcer...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.12.1426
更新日期:1986-12-01 00:00:00
abstract::The important issue of whether Heliobacter pylori eradication leads to increased reflux has been the subject of many apparently contradictory publications, but when we asked two leading authorities to give us their views, there turned out to be considerable consensus, as you can read below. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.019844
更新日期:2004-02-01 00:00:00
abstract::This pilot study was designed to assess the tolerance and effectiveness of interferon alfa-2b in patients with decompensated liver disease caused by chronic hepatitis B (n = 7) or C (n = 5). Preliminary results suggest that patients may benefit from small doses of interferon (improvement in liver function tests and re...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.2_suppl.s104
更新日期:1993-01-01 00:00:00
abstract::A method is described for measuring transit time through the gut which requires the collection of only one stool. A dose of 20 radio-opaque markers is given to the subject on each of three consecutive days with breakfast, each dose of marker being of a different type. The first stool passed after rising on the fourth ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.3.219
更新日期:1976-03-01 00:00:00
abstract::Thirty male patients (27 homosexual) with biopsy proven chronic active hepatitis B were randomised to receive lymphoblastoid interferon (Wellferon) or no treatment. All patients were HBeAg positive and had continuing viral replication. Patients receiving treatment were given a single daily intramuscular injection of i...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.28.5.619
更新日期:1987-05-01 00:00:00
abstract::The motor activity of the transverse, descending, and sigmoid colon was recorded for 24 hours in 14 healthy volunteers with a colonoscope positioned catheter. During the study the patients ate two 1000 kcal mixed meals and one continental breakfast. Colonic motor activity was low before meals and minimal during sleep;...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.1.17
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:Endoscopic surveillance for Barrett's oesophagus (BO) is under discussion given the overall low incidence of neoplastic progression and lack of evidence that it prevents advanced oesophageal adenocarcinoma (OAC). The aim of this study was to evaluate the impact of endoscopic BO surveillance on tumour stage an...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2014-308802
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:MicroRNA (miRNA) expression profile can be used as prognostic marker for human cancers. We aim to explore the significance of miRNAs in colorectal cancer (CRC) metastasis. DESIGN:We performed miRNA microarrays using primary CRC tissues from patients with and without metastasis, and validated selected candida...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2015-309372
更新日期:2016-06-01 00:00:00