Twenty four hour manometric recording of colonic motor activity in healthy man.

abstract：BACKGROUND:Mouse models of colitis and cancer are indispensable for our understanding of the pathogenesis of these diseases. In the past, mice had to be sacrificed in order to analyse colitis activity and tumour development. We have developed a safe method for high resolution endoscopic monitoring of living mice. METH...

journal_title：Gut

authors： Becker C,Fantini MC,Wirtz S,Nikolaev A,Kiesslich R,Lehr HA,Galle PR,Neurath MF

更新日期：2005-07-01 00:00:00

abstract：:A 24 hour gastric aspiration study was carried out on nine Polya gastrectomy, eight pernicious anaemia, and nine matched control subjects. Intragastric pH, bacteria, nitrite, and N-nitroso compounds were assessed half hourly whilst ambulant and hourly when in bed. Both total and nitrate reducing bacterial counts were ...

journal_title：Gut

authors： Hall CN,Darkin D,Brimblecombe R,Cook AJ,Kirkham JS,Northfield TC

更新日期：1986-05-01 00:00:00

abstract：:The endothelins are a group of three related peptides with two receptor subtypes, ET(A) and ET(B). Following the discovery of endothelin 1 as a potent vasoconstrictor, there has been intense interest in the role of endothelin on vascular function in liver disease. Speculation on the role of endothelin in the pathogene...

journal_title：Gut

authors： Moore K

更新日期：2004-02-01 00:00:00

abstract：:Water and electrolyte balance has been studied in 39 patients with a permanent ileostomy, who had had a proctocolectomy for ulcerative colitis. The findings have been compared with those in 39 healthy subjects who were matched for age and sex. The ileostomists were found to lose excessive quantities of water and sodiu...

journal_title：Gut

authors： Kennedy HJ,Al-Dujaili EA,Edwards CR,Truelove SC

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Insulin resistance is a frequent feature of chronic hepatitis C. Whether insulin resistance could be the cause or consequence of steatosis and fibrosis is unknown. The ability of HCV genotype 3 to promote steatosis by itself provides an unique opportunity to answer this question. AIMS:The aim of the present...

journal_title：Gut

authors： Fartoux L,Poujol-Robert A,Guéchot J,Wendum D,Poupon R,Serfaty L

更新日期：2005-07-01 00:00:00

abstract：:Forty two white patients of British or Irish descent with coeliac disease and 28 with dermatitis herpetiformis were typed for class I HLA-A, B, and C, and class II DR and DQ antigens. In coeliac disease there was a significant increase in the frequencies of A1, B8, DR3, DR7, and DQw2 compared with controls but no incr...

journal_title：Gut

authors： Sachs JA,Awad J,McCloskey D,Navarrete C,Festenstein H,Elliot E,Walker-Smith JA,Griffiths CE,Leonard JN,Fry L

更新日期：1986-05-01 00:00:00

abstract：:We investigated the distribution of the collagen band in 33 patients with collagenous colitis to estimate the likelihood of the disease being diagnosed in biopsy specimens from the left side of the colon, such as those obtained using flexible sigmoidoscopy. To be included in this study patients had a subepithelial col...

journal_title：Gut

authors： Tanaka M,Mazzoleni G,Riddell RH

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Interstitial cells of Cajal (ICC) are pacemakers and mediators of motor neurotransmission in gastrointestinal smooth muscles. ICC require cellular signalling via Kit, a receptor tyrosine kinase, for development and maintenance of phenotype. Much of the evidence demonstrating the functions of ICC com...

journal_title：Gut

authors： Takayama I,Daigo Y,Ward SM,Sanders KM,Walker RL,Horowitz B,Yamanaka T,Fujino MA

更新日期：2002-06-01 00:00:00

abstract：:Eight patients with traumatic transverse lesions of the spinal cord and eight healthy controls were examined with respect to the function of the anal sphincters. Continuous recordings of anal pressure and electromyograms from the striated sphincter muscles were obtained during gradual rectal distension by means of an ...

journal_title：Gut

authors： Frenckner B

更新日期：1975-08-01 00:00:00

abstract：:Studies in the rat jejunum in vivo have shown that 5-hydroxytryptamine (5-HT) causes secretion of fluid and luminal release of prostaglandin (PG) E2. These effects can be blocked by indomethacin and ketanserin, which suggests that PGE2 may be an important intermediate in the transduction mechanism leading to 5-HT indu...

journal_title：Gut

authors： Munck LK,Mertz-Nielsen A,Westh H,Bukhave K,Beubler E,Rask-Madsen J

更新日期：1988-10-01 00:00:00

abstract：:Glycosylation is a key modification of proteins and lipids and is involved in most intermolecular and intercellular interactions. The gastrointestinal mucus gel is continuous and can be divided into two layers: a secreted loosely associated layer and a layer firmly attached to the mucosa. In addition, the membrane-bou...

journal_title：Gut

authors： Moran AP,Gupta A,Joshi L

更新日期：2011-10-01 00:00:00

abstract：:Ultrastructural features of the liver in eight cases of Indian childhood cirrhosis, a fatal and elusive liver disease in India, have been described. Severe parenchymal damage, diffuse creeping fibrosis, and other light microscopic alterations, including the frequent presence of cytoplasmic hyaline, reported earlier ar...

journal_title：Gut

authors： Roy S,Ramalingaswami V,Nayak NC

更新日期：1971-09-01 00:00:00

abstract：OBJECTIVES:Despite being proposed 4 years ago, there has been no independent validation study of the Rome IV criteria for IBS. We assessed their performance for the diagnosis of IBS in secondary care and compared them with the previous iteration, the Rome III criteria. DESIGN:We collected complete symptom data from co...

journal_title：Gut

authors： Black CJ,Craig O,Gracie DJ,Ford AC

更新日期：2020-09-24 00:00:00

abstract：BACKGROUND AND AIMS:Gastric acid secretion is downregulated by Helicobacter pylori infection and upregulated after its eradication, but the mechanisms are still unclear. We examined the effects of H pylori eradication on the number of parietal cells and on expression of molecules functioning in acid secretion in the hu...

journal_title：Gut

authors： Osawa H,Kita H,Ohnishi H,Hoshino H,Mutoh H,Ishino Y,Watanabe E,Satoh K,Sugano K

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:The number of colonoscopies required to reach competency is not well established. The primary aim of this study was to determine the number of colonoscopies trainees need to perform to attain competency, defined by a caecal intubation rate (CIR) ≥90%. As competency depends on completion, we also investigated ...

journal_title：Gut

authors： Ward ST,Mohammed MA,Walt R,Valori R,Ismail T,Dunckley P

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Global DNA hypomethylation has been found in the premalignant stages of some neoplasms and has been implicated as an important factor for tumour progression. AIMS:The aim of this study was to evaluate whether DNA hypomethylation occurs during the process of gastric carcinogenesis. METHODS:Gastric specimens...

journal_title：Gut

authors： Cravo M,Pinto R,Fidalgo P,Chaves P,Glória L,Nobre-Leitão C,Costa Mira F

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:The incidence figures for ulcerative colitis (UC) and Crohn's disease (CD) have been difficult to interpret, and geographical variations may be due to differences in classification criteria and study design. Few studies have based the incidence on prospective systematic follow up to confirm the initial diagn...

journal_title：Gut

authors： Moum B,Ekbom A,Vatn MH,Aadland E,Sauar J,Lygren I,Schulz T,Stray N,Fausa O

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To highlight the contribution of the gut microbiota to the modulation of host metabolism by dietary inulin-type fructans (ITF prebiotics) in obese women. METHODS:A double blind, placebo controlled, intervention study was performed with 30 obese women treated with ITF prebiotics (inulin/oligofructose 50/50 mi...

journal_title：Gut

authors： Dewulf EM,Cani PD,Claus SP,Fuentes S,Puylaert PG,Neyrinck AM,Bindels LB,de Vos WM,Gibson GR,Thissen JP,Delzenne NM

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:Gastric carcinoma development is triggered by Helicobacter pylori. Chronic H. pylori infection leads to reduced acid secretion, which may allow the growth of a different gastric bacterial community. This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy. Our a...

journal_title：Gut

authors： Ferreira RM,Pereira-Marques J,Pinto-Ribeiro I,Costa JL,Carneiro F,Machado JC,Figueiredo C

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity. METHODS:Experimental liver fibrosis in mice induced by bile duct ligation or CCl4 application was used to characterise the mechanisms determining failure of innate imm...

journal_title：Gut

authors： Hackstein CP,Assmus LM,Welz M,Klein S,Schwandt T,Schultze J,Förster I,Gondorf F,Beyer M,Kroy D,Kurts C,Trebicka J,Kastenmüller W,Knolle PA,Abdullah Z

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:To determine the therapeutic equivalence and safety of once daily (OD) versus three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in patients with active ulcerative colitis. DESIGN:A randomised, double-blind, double-dummy, parallel group, multicentre, international, ph...

journal_title：Gut

authors： Kruis W,Kiudelis G,Rácz I,Gorelov IA,Pokrotnieks J,Horynski M,Batovsky M,Kykal J,Boehm S,Greinwald R,Mueller R,International Salofalk OD Study Group.

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Osteoporosis and fractures are frequently encountered in patients with Crohn's disease. In order to prevent fractures, treatment with bone protecting drugs appears warranted early in the course of bone disease when bone loss is not yet prominent. We therefore aimed to demonstrate a beneficial effect on bone d...

journal_title：Gut

authors： van Bodegraven AA,Bravenboer N,Witte BI,Dijkstra G,van der Woude CJ,Stokkers PC,Russel MG,Oldenburg B,Pierik M,Roos JC,van Hogezand RA,Dik VK,Oostlander AE,Netelenbos JC,van de Langerijt L,Hommes DW,Lips P,Dutch Initiat

更新日期：2014-09-01 00:00:00

abstract：:The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28 +/- 3.1 to 85 +/- 12.3 pmol/l (p less than 0.001) and this difference was maintained ...

journal_title：Gut

authors： Savage AP,Gornacz GE,Adrian TE,Ghatei MA,Goodlad RA,Wright NA,Bloom SR

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:In the revised Atlanta classification of acute pancreatitis, the term necrotising pancreatitis also refers to patients with only extrapancreatic fat necrosis without pancreatic parenchymal necrosis (EXPN), as determined on contrast-enhanced CT (CECT). Patients with EXPN are thought to have a better clinical o...

journal_title：Gut

authors： Bakker OJ,van Santvoort H,Besselink MG,Boermeester MA,van Eijck C,Dejong K,van Goor H,Hofker S,Ahmed Ali U,Gooszen HG,Bollen TL,Dutch Pancreatitis Study Group.

更新日期：2013-10-01 00:00:00

abstract：AIM:The aim of this study was to implement an imaging protocol for positron emission tomography/computed tomography (PET/CT) colonography and to combine this protocol with whole body PET/CT tumour staging for a single whole body examination for routine clinical use. SUBJECTS AND METHODS:A whole body PET/CT protocol fo...

journal_title：Gut

authors： Veit P,Kühle C,Beyer T,Kuehl H,Herborn CU,Börsch G,Stergar H,Barkhausen J,Bockisch A,Antoch G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Norovirus infection is the most frequent cause of infectious diarrhoea in the western world. This study aimed to characterise functionally and histomorphologically the diseased duodenum in human biopsies. METHODS:Norovirus infection was diagnosed by the Kaplan criteria and confirmed by PCR of stool samples....

journal_title：Gut

authors： Troeger H,Loddenkemper C,Schneider T,Schreier E,Epple HJ,Zeitz M,Fromm M,Schulzke JD

更新日期：2009-08-01 00:00:00

abstract：:Both experimental cholecystitis and luminal distension inhibit fluid absorption and stimulate motor activity in the gall bladder. These functional alterations are mimicked by exogenous prostaglandins (PGs) and inhibited by potent cyclooxygenase inhibitors, but direct evidence of a primary role of endogenous PGs is not...

journal_title：Gut

authors： Thornell E,Jivegård L,Bukhave K,Rask-Madsen J,Svanvik J

更新日期：1986-04-01 00:00:00

abstract：:Jejunal absorption of sodium and water has been investigated in 10 normal Indians and 11 patients with chronic tropical sprue. Normal saline and solutions containing amino acids and dipeptides were studied. In both groups little absorption of sodium and water from normal saline was seen. Mean water and sodium absorpti...

journal_title：Gut

authors： Hellier MD,Bhat P,Albert J,Baker SJ

更新日期：1977-06-01 00:00:00

abstract：:Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of IgA-bearing plasma cells. Peripheral blood lymphocytes, however, showed normal numbers of IgA-bearing lymphocytes. The t...

journal_title：Gut

authors： Hodgson HJ,Jewell DP

更新日期：1977-08-01 00:00:00

abstract：:Recent evidence suggests that the production of colorectal carcinogens is facilitated when the pH of the colonic contents is alkaline. It follows that the colonic intraluminal pH of patients with colorectal neoplasms should be higher than in normal subjects. Gastrointestinal pH has been measured in 30 patients with co...

journal_title：Gut

authors： Pye G,Evans DF,Ledingham S,Hardcastle JD

更新日期：1990-12-01 00:00:00