Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract.

abstract：BACKGROUND:IgA class serum autoantibodies against type 2 (tissue) transglutaminase (TG2) bind to both intestinal and extraintestinal normal tissue sections in vitro, eliciting endomysial, reticulin, and jejunal antibody reactions. It is not known whether similar binding also occurs in coeliac patients in vivo, and may ...

journal_title：Gut

authors： Korponay-Szabó IR,Halttunen T,Szalai Z,Laurila K,Király R,Kovács JB,Fésüs L,Mäki M

更新日期：2004-05-01 00:00:00

abstract：:Colorectal cancer is the second commonest cause of cancer death in the UK. An effective national screening programme is urgently required to reduce the substantial morbidity and mortality from the disease. The success of any screening programme will depend on the screening test detecting early Dukes's A carcinomas and...

journal_title：Gut

authors： Hart AR,Wicks AC,Mayberry JF

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation. OBJECTIVE:To d...

journal_title：Gut

authors： Asada K,Nakajima T,Shimazu T,Yamamichi N,Maekita T,Yokoi C,Oda I,Ando T,Yoshida T,Nanjo S,Fujishiro M,Gotoda T,Ichinose M,Ushijima T

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND AND AIMS:A subset of functional dyspepsia (FD) patients report meal-related symptoms, possibly representing a pathophysiologically homogeneous subgroup. The aim of the present study was to establish the time-course of symptoms in relation to meal ingestion, and to assess the relationship between self-reporte...

journal_title：Gut

authors： Bisschops R,Karamanolis G,Arts J,Caenepeel P,Verbeke K,Janssens J,Tack J

更新日期：2008-11-01 00:00:00

abstract：:Eighty patients were asked if they would have preferred their ileocolonic resection and anastomosis for Crohn's disease, to have been carried out sooner, later or at the same time as it was done. Seventy of the patients replied (88%). No patient would have preferred their operation to have been later, while 74% though...

journal_title：Gut

authors： Scott NA,Hughes LE

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:An endoscopic procedure that uses a pH indicator called phenol red to assess Helicobacter pylori infected gastric mucosa has recently been developed. This test makes it possible to take biopsy specimens from H pylori infected areas. AIM:This test was applied to patients with early gastric cancers to clarify...

journal_title：Gut

authors： Iseki K,Tatsuta M,Iishi H,Baba M,Ishiguro S

更新日期：1998-01-01 00:00:00

abstract：:In a randomised clinical trial, patients with moderately active Crohn's disease received either prednisolone 0.5 mg/kg/day plus a normal diet, or an elemental diet plus oral framycetin, colistin and nystatin. Patients were assessed using the Crohn's disease activity index (CDAI), ESR, and faecal granulocyte excretion ...

journal_title：Gut

authors： Saverymuttu S,Hodgson HJ,Chadwick VS

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVE:Corticosteroid has been established as the standard therapy for autoimmune pancreatitis (AIP), but the requirement for maintenance corticosteroid therapy is controversial. We conducted a randomised controlled trial to clarify the efficacy of maintenance corticosteroid therapy in patients with AIP. DESIGN:We ...

journal_title：Gut

authors： Masamune A,Nishimori I,Kikuta K,Tsuji I,Mizuno N,Iiyama T,Kanno A,Tachibana Y,Ito T,Kamisawa T,Uchida K,Hamano H,Yasuda H,Sakagami J,Mitoro A,Taguchi M,Kihara Y,Sugimoto H,Hirooka Y,Yamamoto S,Inui K,Inatomi O,

更新日期：2017-03-01 00:00:00

abstract：:Faecal stream diversion may induce inflammatory changes in the defunctioned segment of the large intestine. These changes are predominantly mucosal, although confusing histological features including granulomas may be present. The pathology of 15 defunctioned rectal stumps has been studied. All patients had previously...

journal_title：Gut

authors： Warren BF,Shepherd NA,Bartolo DC,Bradfield JW

更新日期：1993-04-01 00:00:00

abstract：:The risk of developing colorectal adenomatous polyps is probably increased by a variety of dietary and environmental factors. We found an association with current alcohol and cigarette consumption. The risk of polyps was increased three times in drinkers who did not smoke and two times in smokers who did not drink, wi...

journal_title：Gut

authors： Cope GF,Wyatt JI,Pinder IF,Lee PN,Heatley RV,Kelleher J

更新日期：1991-01-01 00:00:00

abstract：:The aim of this study is to assess the value of jejunal manometry in the diagnosis of subacute mechanical obstruction distal to the proximal small bowel. In a retrospective review of 850 manometric tracings carried out in patients with unexplained nausea, vomiting, abdominal pain or altered bowel movements, 16 tracing...

journal_title：Gut

authors： Camilleri M

更新日期：1989-04-01 00:00:00

abstract：:In a prospective study we compared the diagnostic accuracy of endoscopic fine needle aspiration cytology with that of brush cytology and forceps biopsy in relation to gross tumour pattern and site in 265 confirmed consecutive cases of malignancy of the oesophagus, stomach, colon, and rectum. Aspiration cytology gave t...

journal_title：Gut

authors： Zargar SA,Khuroo MS,Mahajan R,Jan GM,Dewani K,Koul V

更新日期：1991-07-01 00:00:00

abstract：OBJECTIVE:Gut microbiota and diet are known to contribute to human metabolism. We investigated whether the metagenomic gut microbiota composition and function changes over pregnancy are related to gestational diabetes mellitus (GDM) and can be modified by dietary supplements, fish oil and/or probiotics. DESIGN:The gut...

journal_title：Gut

authors： Mokkala K,Paulin N,Houttu N,Koivuniemi E,Pellonperä O,Khan S,Pietilä S,Tertti K,Elo LL,Laitinen K

更新日期：2021-02-01 00:00:00

abstract：:Fifty two patients with abnormal acid gastro-oesophageal reflux were studied by simultaneous oesophageal pH monitoring and continuous aspiration for 16 hours. Aspirates (from discrete two hour periods) were analysed for volume, pH, bile acids (conjugated and unconjugated), trypsin, and pepsin. The results were compare...

journal_title：Gut

authors： Gotley DC,Morgan AP,Ball D,Owen RW,Cooper MJ

更新日期：1991-10-01 00:00:00

abstract：:Evidence is presented which indicates a possible reduction in recognition capacity for tumour cell antigens (EB(2) Burkitt lymphoma cell line) by lymphocytes from some patients with longstanding but inactive Crohn's disease. Three out of seven patients tested also showed diminished or absent lymphocytotoxicity when th...

journal_title：Gut

authors： Maclaurin BP,Cooke WT,Ling NR

更新日期：1972-08-01 00:00:00

abstract：BACKGROUND:The prevalence of portopulmonary hypertension (PPHTN) in patients with cirrhosis and refractory ascites is unknown. Its presence may preclude patients from receiving a transjugular intrahepatic portosystemic shunt or liver transplantation as a definitive treatment for their end stage cirrhosis. PURPOSE:To d...

journal_title：Gut

authors： Benjaminov FS,Prentice M,Sniderman KW,Siu S,Liu P,Wong F

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The prevalence of duodenal carcinoma is much higher in familial adenomatous polyposis (FAP) than in the background population, and duodenal adenomatosis is found in most polyposis patients. AIMS:To describe the long term natural history of duodenal adenomatosis in FAP and evaluate if cancer prophylactic sur...

journal_title：Gut

authors： Bülow S,Björk J,Christensen IJ,Fausa O,Järvinen H,Moesgaard F,Vasen HF,DAF Study Group.

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma cells express high levels of the antiapoptotic proteins Bcl-X(L) and Mcl-1 and are markedly chemo- and radioresistant. Mitochondria have emerged as central players in apoptosis. Antiapoptotic members of the Bcl-2 protein family localise to the outer mitochondrial membrane and regulate mito...

journal_title：Gut

authors： Okaro AC,Fennell DA,Corbo M,Davidson BR,Cotter FE

更新日期：2002-10-01 00:00:00

abstract：:This study was done to determine the severity and extent of abnormalities of duodenal mucosal architecture in non-specific (non-ulcerative) and ulcer-associated duodenitis. The effect of successful treatment with cimetidine on these changes has also been assessed. A method of microdissection and measurement of villus ...

journal_title：Gut

authors： Hasan M,Sircus W,Ferguson A

更新日期：1981-08-01 00:00:00

abstract：:To test the hypothesis that Helicobacter pylori infection is associated with a decreased intragastric acidity during omeprazole therapy, ambulatory 24 hour dual point gastric pH recordings were performed in 18 H pylori positive and 14 H pylori negative subjects. There was a four to six week washout period between the ...

journal_title：Gut

authors： Verdú EF,Armstrong D,Fraser R,Viani F,Idström JP,Cederberg C,Blum AL

更新日期：1995-04-01 00:00:00

abstract：:Epithelial cells shed from the intestinal villus in starved rats were trapped in mucus which the goblet cells were stimulated to secrete; the number of trapped cells per villus was counted in whole mounts of fixed Feulgen-stained specimens from three sites in the small intestine. Increase in the interval between stimu...

journal_title：Gut

authors： Clarke RM

更新日期：1970-12-01 00:00:00

abstract：:The effects of different bile salts on the absorption of fluid, electrolytes, and monosaccharides have been investigated in the rat small intestine in vivo. In the jejunum, deoxycholate (1 mM) impaired absorption of water and potassium, but not of sodium or glucose; at higher concentrations (2.5 and 5 mM) secretion of...

journal_title：Gut

authors： Harries JT,Sladen GE

更新日期：1972-08-01 00:00:00

abstract：INTRODUCTION:CD248 (endosialin) is a stromal cell marker expressed on fibroblasts and pericytes. During liver injury, myofibroblasts are the main source of fibrotic matrix. OBJECTIVE:To determine the role of CD248 in the development of liver fibrosis in the rodent and human setting. DESIGN:CD248 expression was studie...

journal_title：Gut

authors： Wilhelm A,Aldridge V,Haldar D,Naylor AJ,Weston CJ,Hedegaard D,Garg A,Fear J,Reynolds GM,Croft AP,Henderson NC,Buckley CD,Newsome PN

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn's ...

journal_title：Gut

authors： Stournaras E,Qian W,Pappas A,Hong YY,Shawky R,UK IBD BioResource Investigators.,Raine T,Parkes M,UK IBD Bioresource Investigators.

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In th...

journal_title：Gut

authors： van der Post S,Jabbar KS,Birchenough G,Arike L,Akhtar N,Sjovall H,Johansson MEV,Hansson GC

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Melanoma inhibitory activity 2 (MIA2) is a novel gene of the MIA gene family. The selective expression of MIA2 in hepatocytes is controlled by hepatocyte nuclear factor (HNF) 1 binding sites in the MIA2 promotor. In contrast, in most hepatocellular carcinomas (HCC) MIA2 expression is down-regulated or lost. ...

journal_title：Gut

authors： Hellerbrand C,Amann T,Schlegel J,Wild P,Bataille F,Spruss T,Hartmann A,Bosserhoff AK

更新日期：2008-02-01 00:00:00

abstract：:Faecal bile acid excretion was examined in 13 patients with adenomatous polyps of the large bowel and compared with a series of matched healthy subjects. Bile acids were analysed in detail with respect to the composition of individual bile acids and their mode of conjugation. The total excretion of bile acids by the p...

journal_title：Gut

authors： Tanida N,Hikasa Y,Shimoyama T,Setchell KD

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Wilson's disease is a rare inborn disease related to copper storage, leading to liver cirrhosis and neuropsychological deterioration. Clinical data on larger cohorts are limited owing to low disease frequency. OBJECTIVE AND METHODS:We performed a retrospective analysis of 163 patients with Wilson's disease,...

journal_title：Gut

authors： Merle U,Schaefer M,Ferenci P,Stremmel W

更新日期：2007-01-01 00:00:00

abstract：:Gastric secretion from 24 subjects was collected by continuous nasogastric aspiration during the plateau of secretion evoked by intravenous histamine diphosphate, 0.01 mg/kg/hr. Simultaneously, phenol red was instilled at a constant rate into the proximal part of the stomach. Concentrations of phenol red in 15-minute ...

journal_title：Gut

authors： Hobsley M,Silen W

更新日期：1969-10-01 00:00:00

abstract：OBJECTIVE:Polycystic liver diseases (PCLDs) are genetic disorders characterised by progressive bile duct dilatation and/or cyst development. Their pathogenesis is a consequence of hyperproliferation, hypersecretion and microRNA alterations in cholangiocytes. Here we evaluate the role of matrix metalloproteases (MMPs) i...

journal_title：Gut

authors： Urribarri AD,Munoz-Garrido P,Perugorria MJ,Erice O,Merino-Azpitarte M,Arbelaiz A,Lozano E,Hijona E,Jiménez-Agüero R,Fernandez-Barrena MG,Jimeno JP,Marzioni M,Marin JJ,Masyuk TV,LaRusso NF,Prieto J,Bujanda L,Banales JM

更新日期：2014-10-01 00:00:00