Abstract:
BACKGROUND:An endoscopic procedure that uses a pH indicator called phenol red to assess Helicobacter pylori infected gastric mucosa has recently been developed. This test makes it possible to take biopsy specimens from H pylori infected areas. AIM:This test was applied to patients with early gastric cancers to clarify the role of H pylori in gastric carcinogenesis. SUBJECTS:Sixty five patients with early gastric cancer (50 with differentiated adenocarcinoma and 15 with undifferentiated adenocarcinoma). METHODS:Patients with early gastric cancer underwent the endoscopic phenol red test before their operation. In this test, areas infected with H pylori can be observed as "coloured" areas where phenol red was turned from yellow to red. RESULTS:H pylori infection was significantly (p < 0.001) more frequent in patients with differentiated adenocarcinomas than in those with undifferentiated adenocarcinomas. Differentiated adenocarcinomas were usually located in areas of mucosa infected with H pylori, but undifferentiated adenocarcinomas were frequently located in non-infected areas. CONCLUSION:H pylori may be a strong risk factor for differentiated early gastric cancer.
journal_name
Gutjournal_title
Gutauthors
Iseki K,Tatsuta M,Iishi H,Baba M,Ishiguro Sdoi
10.1136/gut.42.1.20subject
Has Abstractpub_date
1998-01-01 00:00:00pages
20-3issue
1eissn
0017-5749issn
1468-3288journal_volume
42pub_type
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