Helicobacter pylori infection in patients with early gastric cancer by the endoscopic phenol red test.

Abstract:

BACKGROUND:An endoscopic procedure that uses a pH indicator called phenol red to assess Helicobacter pylori infected gastric mucosa has recently been developed. This test makes it possible to take biopsy specimens from H pylori infected areas. AIM:This test was applied to patients with early gastric cancers to clarify the role of H pylori in gastric carcinogenesis. SUBJECTS:Sixty five patients with early gastric cancer (50 with differentiated adenocarcinoma and 15 with undifferentiated adenocarcinoma). METHODS:Patients with early gastric cancer underwent the endoscopic phenol red test before their operation. In this test, areas infected with H pylori can be observed as "coloured" areas where phenol red was turned from yellow to red. RESULTS:H pylori infection was significantly (p < 0.001) more frequent in patients with differentiated adenocarcinomas than in those with undifferentiated adenocarcinomas. Differentiated adenocarcinomas were usually located in areas of mucosa infected with H pylori, but undifferentiated adenocarcinomas were frequently located in non-infected areas. CONCLUSION:H pylori may be a strong risk factor for differentiated early gastric cancer.

journal_name

Gut

journal_title

Gut

authors

Iseki K,Tatsuta M,Iishi H,Baba M,Ishiguro S

doi

10.1136/gut.42.1.20

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

20-3

issue

1

eissn

0017-5749

issn

1468-3288

journal_volume

42

pub_type

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