Abstract:
:Training to contract the abdominal muscles effectively and to relax the pelvic floor during defecation straining helps some patients with severe constipation. Hitherto all such training has used a visible or audible signal of sphincter muscle activity as a biofeedback method to assist in relaxation. A randomised controlled trial comparing the outcome of muscular training without any biofeedback device with the same training supplemented by an electromyographic (EMG) record visible to the patient is reported. Significant symptomatic improvement was noted and electromyographic measurements confirmed a decrease in pelvic floor muscle activity during defecation straining after treatment in both groups. The outcome was similar in the two treatment groups. Muscular coordination training using personal instruction and encouragement without a visual display is thus a potentially successful treatment suitable for outpatient use by paramedical personnel.
journal_name
Gutjournal_title
Gutauthors
Koutsomanis D,Lennard-Jones JE,Roy AJ,Kamm MAdoi
10.1136/gut.37.1.95subject
Has Abstractpub_date
1995-07-01 00:00:00pages
95-9issue
1eissn
0017-5749issn
1468-3288journal_volume
37pub_type
临床试验,杂志文章,随机对照试验相关文献
GUT文献大全abstract:BACKGROUND:Simple and inexpensive non-invasive fibrosis tests are highly needed but have been poorly studied in sub-Saharan Africa. METHODS:Using liver histology as a gold standard, we developed a novel index using routine laboratory tests to predict significant fibrosis in patients with chronic HBV infection in The G...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309260
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVES:Recent studies using the lactulose hydrogen breath test (LHBT) suggest most patients with irritable bowel syndrome (IBS) have small intestinal bacterial overgrowth (SIBO). However, the validity of the LHBT has been questioned, particularly as this test could reflect changes in oro-caecal transit. Therefore, ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.205476
更新日期:2011-03-01 00:00:00
abstract::Video endoscopic images were used to investigate whether gastroenterologists could agree on the definition of lesions within the stomach seen at endoscopy, with particular reference to those seen in patients taking non-steroidal anti-inflammatory drugs. Seven experienced endoscopists, unaware of the patients' clinical...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.8.1030
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Integrins mediate cell matrix adhesion and regulate cell growth and survival. In colonic epithelial cells, alpha(2)beta(1) integrin controls glandular differentiation and proliferation. Butyrate stimulates differentiation and induces apoptosis in vitro. AIMS:We investigated whether butyrate induction of apo...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.5.729
更新日期:2003-05-01 00:00:00
abstract::The finding in primary IgA nephropathy of increased levels of IgA to food antigens and particularly to gliadin prompted the hypothesis that a subgroup of these patients may have latent coeliac disease. The observation that gliadin may experimentally induce IgA mesangial deposits supported this hypothesis. We evaluated...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.4.476
更新日期:1992-04-01 00:00:00
abstract::The disposition of antipyrine following oral administration of 1200 mg has been investigated in 10 patients with histologically confirmed hepatosplenic schistosomiasis and 11 normal subjects living in Sudan. Drug metabolising activity as assessed by antipyrine clearance was similar in patients when compared with norma...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.9.808
更新日期:1978-09-01 00:00:00
abstract:AIMS:To determine the harm that ensues from faecal occult blood (FOB) screening for colorectal cancer. METHODS:150 251 people were randomly allocated either to receive biennial Haemoccult FOB tests (n =75 253) or not to be contacted (n=74 998). Study group patients returning positive tests were offered colonic investi...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.45.4.588
更新日期:1999-10-01 00:00:00
abstract::The possible relationship between enteroglucagon and cellular proliferation in a rat model of intestinal adaptation after suppression and stimulation of enteroglucagon by somatostatin and bombesin has been investigated. Forty eight rats were divided into three groups of 16 animals, each group being further sub-divided...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.1.89
更新日期:1985-01-01 00:00:00
abstract::In 1964 Samman and White described 13 patients with lymphoedema of the lower extremities associated with an unusual dystrophy of the finger and toe nails: this they termed the 'yellow-nail' syndrome. Affected nails were thickened, excessively curved along both axes, very slow growing and of yellowish-grey hue; cuticle...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.11.1266
更新日期:1985-11-01 00:00:00
abstract::Spirits from areas of high and low incidence of cancer of the oesophagus were examined for volatile nitrosamines using a chemiluminescent detector. No nitrosamines were found, the detection limit being 0.001 microng/ml. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.4.301
更新日期:1977-04-01 00:00:00
abstract:PURPOSE:Despite recent advances in colorectal cancer (CRC) treatment, the prognosis of patients suffering from this malignancy still remains substandard, and metastatic recurrence following curative surgery is the leading cause of mortality. Therefore, it is imperative to identify prognostic markers to predict the clin...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309359
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Firm recommendations about the way thiopurine drugs are introduced and the use of thiopurine methyltransferase (TPMT) and metabolite measurements during treatment in inflammatory bowel disease (IBD) are lacking. AIM:To evaluate pharmacokinetics and tolerance after initiation of thiopurine treatment with a f...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2005.074930
更新日期:2006-10-01 00:00:00
abstract::Thirty eight patients with Crohn's disease and 30 patients with ulcerative colitis have been assessed using the technique of faecal excretion of 111Indium granulocytes to quantify precisely acute inflammatory activity. At the time of each faecal granulocyte measurement the serum concentration of the acute phase protei...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.7.809
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVE:Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-318281
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:Many patients with irritable bowel syndrome IBS not only have abdominal pain but also may suffer from visceral hypersensitivity and heighted visceral nociception. Moreover, IBS has few effective therapeutic agents and mechanisms of disease are unclear. Our goals were to (i) identify microRNA (miRNA) expressio...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306464
更新日期:2016-05-01 00:00:00
abstract::In a prospective survey positive antimitochondrial antibodies have been detected in 69/4200 (1.64%) of all sera submitted to a routine immunology laboratory. Of the 69, only nine patients had uniquivocal primary biliary cirrhosis, six others had chronic active hepatitis, 10 had abnormal liver function tests without ev...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.10.814
更新日期:1982-10-01 00:00:00
abstract:BACKGROUND:There is a widespread notion that obesity leads to gastro-oesophageal reflux but scientific evidence of an association is limited and inconsistent. AIMS:To estimate the strength of the association between body mass and reflux symptoms, we performed a population based cross sectional interview study. SUBJEC...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.47.1.26
更新日期:2000-07-01 00:00:00
abstract::A perfused rat stomach technique which can detect synthetic human gastrin I in amounts greater than 10 ng and measure by block assay amounts greater than 50 ng was used to study circulating gastrin-like activity in normal subjects, patients with peptic ulcer, and patients with the Zollinger-Ellison syndrome. No detect...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.2.88
更新日期:1972-02-01 00:00:00
abstract::Intragastric total bile acid concentrations were measured before and after a corn oil test meal in 16 patients with erosive oesophagitis and symptoms of gastro-oesophageal reflux. Sixteen age and sex matched control subjects were also studied. No significant difference was detected between fasting or postprandial gast...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.5.495
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND AND AIM:The treatment of ulcerative colitis (UC) with 5-aminosalicylic acid (5-ASA) does not have the same therapeutic effect in all patients. We tested the hypothesis that the effectiveness of the drug is related to its mucosal concentration. PATIENTS:Twenty one UC patients receiving oral 5-ASA (2.4-3.2 g/...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.47.3.410
更新日期:2000-09-01 00:00:00
abstract::Management strategies for reflux disease are very different from those for dyspepsia and so differentiating between patients with "true" dyspepsia and those whose primary symptom is heartburn is a key step in their management. This separation has become more clear during the last decade as insights into reflux disease...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.50.suppl_4.iv17
更新日期:2002-05-01 00:00:00
abstract::Bowel function was assessed in 51 subjects: 10 women and seven men who habitually consumed an omnivorous, vegetarian, or vegan diet. The subjects on these diets had a mean intake of fibre of 23 g, 37 g, and 47 g respectively. Mean transit times were variable and not significantly different between the groups. Vegans, ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.2.164
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Whole body catabolism as the result of intrahepatic metabolic derangement is common in liver transplant candidates. However, individual nutritional assessment parameters lack sensitivity and specificity in determining energy status of these patients. Recently, serum hepatocyte growth factor (HGF) has been sh...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.6.862
更新日期:1999-06-01 00:00:00
abstract::Nutritional status and immune function were correlated with clinical features in 56 patients with Crohn's disease. These were divided arbitrarily into either undernourished or well nourished groups according to whether their midarm circumference was below or above 90% of ideal standard. Results were also compared with...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.5.465
更新日期:1984-05-01 00:00:00
abstract::The synchronous change in the antral release of gastrin and somatostatin into a vein draining the stomach was studied during acidic and alkaline intragastric pH in six anaesthetised duodenal ulcer patients and six controls after atropinisation. No differences in the basal secretion of gastrin and somatostatin were obs...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.2.206
更新日期:1987-02-01 00:00:00
abstract:OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly and thus there is a strong need to better define its natural history in these patients. DESIGN:Liver biopsies were systematically performed in 798 consecutive patients with severe obesity u...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2016-312238
更新日期:2017-09-01 00:00:00
abstract::A histological study of peroral jejunal biopsies and resection specimens from patients with malignant histiocytosis of the intestine (MHI) has revealed characteristic lesions consisting of intramucosal histiocytic aggregations which invade surface and crypt epithelium. These lesions are found in 'uninvolved' jejunal m...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.5.381
更新日期:1980-05-01 00:00:00
abstract::An investigation of immunological parameters was conducted in 38 patients with Crohn's disease. The immunological tests employed included skin tests with dinitrochlorobenzene and a battery of common skin test antigens, lymphocyte transformation with phytohaemagglutinin and pokeweed mitogen, serum immunoglobulins, and ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.2.100
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:The prevalence of duodenal carcinoma is much higher in familial adenomatous polyposis (FAP) than in the background population, and duodenal adenomatosis is found in most polyposis patients. AIMS:To describe the long term natural history of duodenal adenomatosis in FAP and evaluate if cancer prophylactic sur...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2003.027771
更新日期:2004-03-01 00:00:00
abstract::Three cases are presented of lymphocytic colitis with chronic diarrhoea concurrent with longterm use of Cyclo 3 Fort, a phlebotonic drug used in France. The histological and immunopathological features of lymphocytic colitis are described. We show that lymphocytic colitis is drug induced, particularly in one patient w...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.3.426
更新日期:1994-03-01 00:00:00