Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with ulcerative colitis.

abstract：:The effects of pentagastrin and the putative gastrin antagonist proglumide on interdigestive motility of the upper small bowel were studied in a randomised double blind study in 10 healthy human volunteers. Intraluminal pressures were recorded manometrically in the duodenum and jejunum for five hours. Sixty minutes af...

journal_title：Gut

authors： Erckenbrecht JF,Caspari J,Wienbeck M

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Human growth factors are potential therapeutic agents for various inflammatory disorders affecting the gastrointestinal tract. However, they are unstable when administered orally and systemic administration requires high doses increasing the risk of unwanted side effects. Live microorganism-based delivery sy...

journal_title：Gut

authors： Hamady ZZ,Scott N,Farrar MD,Lodge JP,Holland KT,Whitehead T,Carding SR

更新日期：2010-04-01 00:00:00

abstract：:The cognitive model of depression assigns a central role to negatively biased information processing in the pathogenesis of the emotional disorder. The relationship between depression and irritable bowel syndrome (IBS) was explored from a cognitive perspective. A word recognition memory task was constructed: subjects ...

journal_title：Gut

authors： Gomborone JE,Dewsnap PA,Libby GW,Farthing MJ

更新日期：1993-09-01 00:00:00

abstract：:There is no universally available laboratory test to diagnose bile acid diarrhoea (BAD). OBJECTIVE:To conduct a systematic review and meta-analysis to identify a biomarker for idiopathic BAD in patients with functional bowel disorder (FBD) with diarrhoea. DESIGN:We searched multiple databases through 15 May 2015. Da...

journal_title：Gut

authors： Valentin N,Camilleri M,Altayar O,Vijayvargiya P,Acosta A,Nelson AD,Murad MH

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:IgA class serum autoantibodies against type 2 (tissue) transglutaminase (TG2) bind to both intestinal and extraintestinal normal tissue sections in vitro, eliciting endomysial, reticulin, and jejunal antibody reactions. It is not known whether similar binding also occurs in coeliac patients in vivo, and may ...

journal_title：Gut

authors： Korponay-Szabó IR,Halttunen T,Szalai Z,Laurila K,Király R,Kovács JB,Fésüs L,Mäki M

更新日期：2004-05-01 00:00:00

abstract：:Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral venous blood obtained at autopsy of sudden death victims within fou...

journal_title：Gut

authors： Cummings JH,Pomare EW,Branch WJ,Naylor CP,Macfarlane GT

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...

journal_title：Gut

authors： Verdú EF,Bercik P,Verma-Gandhu M,Huang XX,Blennerhassett P,Jackson W,Mao Y,Wang L,Rochat F,Collins SM

更新日期：2006-02-01 00:00:00

abstract：:Seventeen paediatric patients with immunodeficiency syndromes (10 with selective IgA deficiency, four with panhypogammaglobulinaemia, and three with selective T cell deficiency) were investigated for bacterial overgrowth of the small intestine and gut permeability to macromolecules. Five of 12 patients showed viable b...

journal_title：Gut

authors： Pignata C,Budillon G,Monaco G,Nani E,Cuomo R,Parrilli G,Ciccimarra F

更新日期：1990-08-01 00:00:00

abstract：:Virulent Helicobacter pylori strains which have been clinically associated with severe outcome induce increased gastric mucosal immune responses. Although several bacterial pathogenic factors have been shown to have a considerable role in H pylori infection, variability in host immune responses may also contribute to ...

journal_title：Gut

authors： Shimoyama T,Crabtree JE

更新日期：1998-07-01 00:00:00

abstract：:Previous studies have shown that ileal infusion of partially digested triglyceride inhibits jejunal motility. The partial digest used in those studies contained a mixture of glycerol, free fatty acid, mono-, di-, and triglycerides. In Part I of the present study we have separately infused emulsions containing either g...

journal_title：Gut

authors： Spiller RC,Trotman IF,Adrian TE,Bloom SR,Misiewicz JJ,Silk DB

更新日期：1988-08-01 00:00:00

abstract：:Jejunal absorption of sodium and water has been investigated in 10 normal Indians and 11 patients with chronic tropical sprue. Normal saline and solutions containing amino acids and dipeptides were studied. In both groups little absorption of sodium and water from normal saline was seen. Mean water and sodium absorpti...

journal_title：Gut

authors： Hellier MD,Bhat P,Albert J,Baker SJ

更新日期：1977-06-01 00:00:00

abstract：:Recent evidence suggests that the production of colorectal carcinogens is facilitated when the pH of the colonic contents is alkaline. It follows that the colonic intraluminal pH of patients with colorectal neoplasms should be higher than in normal subjects. Gastrointestinal pH has been measured in 30 patients with co...

journal_title：Gut

authors： Pye G,Evans DF,Ledingham S,Hardcastle JD

更新日期：1990-12-01 00:00:00

abstract：:Pancreatic secretion of lipase and chymotrypsin in response to elemental diets and a crushed food homogenate was studied in normal subjects. The solutions were infused at constant flow rates at the ligament of Treitz with polyethylene glycol as a nonabsorbable marker. A triple lumen tube was used, enabling collection ...

journal_title：Gut

authors： Vison N,Hecketsweiler P,Butel J,Bernier JJ

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The colons of patients with pneumatosis cystoides coli produce excessive H2. Exposure to alkyl halides could explain this. Six consecutive patients who had pneumatosis cystoides coli while taking chloral hydrate (1-5+ g/day) are reported. Patients 2 and 3 were investigated after they had ceased chlo...

journal_title：Gut

authors： Florin TH

更新日期：1997-12-01 00:00:00

abstract：:Lactulose H2 breath tests are widely used for quantifying carbohydrate malabsorption, but the validity of the commonly used technique (interval sampling of H2 concentrations) has not been systematically investigated. In eight healthy adults we studied the reproducibility of the technique and the accuracy with which 5 ...

journal_title：Gut

authors： Rumessen JJ,Hamberg O,Gudmand-Høyer E

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:A previous pilot study showed that early arrival time of a microbubble in a hepatic vein is a sensitive indicator of cirrhosis. AIM:To see if this index can also grade diffuse liver disease. PATIENTS:Thirty nine fasted patients with histologically characterised disease were studied prospectively. Nine pati...

journal_title：Gut

authors： Blomley MJ,Lim AK,Harvey CJ,Patel N,Eckersley RJ,Basilico R,Heckemann R,Urbank A,Cosgrove DO,Taylor-Robinson SD

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Surgery in patients with malignant bile duct obstruction is associated with high postoperative morbidity and mortality. Tumour necrosis factor alpha (TNF-alpha) plays a key role in the pathogenesis of these complications. AIMS:To determine the effect of biliary drainage on plasma concentrations of TNF-alpha...

journal_title：Gut

authors： Ballinger AB,Woolley JA,Ahmed M,Mulcahy H,Alstead EM,Landon J,Clark ML,Farthing MJ

更新日期：1998-04-01 00:00:00

abstract：:The role of Helicobacter pylori infection in the pathogenesis of functional dyspepsia is debated. It is known that a substantial fraction of dyspeptic patients manifest a low discomfort threshold to gastric distension. This study investigated the symptomatic pattern in 27 H pylori positive and 23 H pylori negative pat...

journal_title：Gut

authors： Mearin F,de Ribot X,Balboa A,Salas A,Varas MJ,Cucala M,Bartolomé R,Armengol JR,Malagelada JR

更新日期：1995-07-01 00:00:00

abstract：:Twenty healthy subjects eating normal diets made repeated five-day stool collections, the 10 females making their collections in four to six successive weeks. In most subjects there were striking variations in transit time, measured by Hinton's method. The variability of average faecal wet and dry weight, faecal volum...

journal_title：Gut

authors： Wyman JB,Heaton KW,Manning AP,Wicks AC

更新日期：1978-02-01 00:00:00

abstract：:Results emerging from endoscopic treatments to ablate Barrett's oesophagus indicate that APC alone or ALA-PDT in combination with APC achieves complete clearance of Barrett's epithelium in approximately two thirds of patients. ...

journal_title：Gut

authors： Van Laethem JL,Devière J

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:Chronic pancreatitis is a progressive inflammatory disorder of the pancreas characterised by permanent destruction of acinar cells. Mutations in the chymotrypsinogen C (CTRC) gene have been linked to the development of chronic pancreatitis. The aim of the present study was to explore whether CTRC mutants indu...

journal_title：Gut

authors： Szmola R,Sahin-Tóth M

更新日期：2010-03-01 00:00:00

abstract：:An enema that contained a complex of bismuth citrate and polyacrylate was compared with 5-aminosalicylic acid (5-ASA) enemas for treatment of distal ulcerative colitis. The multicentre trial involving 63 patients was randomised and double blind with enemas given over four weeks; clinical, sigmoidoscopic, and histologi...

journal_title：Gut

authors： Pullan RD,Ganesh S,Mani V,Morris J,Evans BK,Williams GT,Rhodes J

更新日期：1993-05-01 00:00:00

abstract：:Gastric adaptation was impaired immediately after the performance of complete vagotomy in a series of 20 acute experiments in the dog. Preliminary isolation of the intact vagi in 10 of these animals produced alterations in adaptation similar to those seen after vagal division. It is concluded that alterations in gastr...

journal_title：Gut

authors： Carter DC,Whitfield HN,Macleod IB

更新日期：1972-11-01 00:00:00

abstract：OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...

journal_title：Gut

authors： Hochart A,Gower-Rousseau C,Sarter H,Fumery M,Ley D,Spyckerelle C,Peyrin-Biroulet L,Laberenne JE,Vasseur F,Savoye G,Turck D,Epimad Group.

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Multiorgan failure is a severe life threatening state where present therapeutic approaches are suboptimal. Epidermal growth factor (EGF) is a potent stimulant of repair in in vitro and in vivo models. We therefore examined its potential beneficial effect in reducing mortality and injury induced by the noxiou...

journal_title：Gut

authors： Caballero ME,Berlanga J,Ramirez D,Lopez-Saura P,Gozalez R,Floyd DN,Marchbank T,Playford RJ

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Guidelines mandate expert pathology review of Barrett's oesophagus (BO) biopsies that reveal dysplasia, but there are no evidence-based standards to corroborate expert reviewer status. We investigated BO concordance rates and pathologist features predictive of diagnostic discordance. DESIGN:Pathologists (n=5...

journal_title：Gut

authors： van der Wel MJ,Coleman HG,Bergman JJGHM,Jansen M,Meijer SL,BOLERO working group.

更新日期：2020-05-01 00:00:00

abstract：:Vagal and spinal afferents represent the information superhighways that convey sensory information from the gut to the central nervous system. These afferents are sensitive to both mechanical and chemical stimuli. Vagal afferents terminate in the muscle layers and in the mucosa. Muscle afferents are activated at physi...

journal_title：Gut

authors： Grundy D

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity of the microbiome was often observed in association with poorer health outcomes or disease in general. Conversely, factors or manifest ...

journal_title：Gut

authors： Frost F,Kacprowski T,Rühlemann M,Pietzner M,Bang C,Franke A,Nauck M,Völker U,Völzke H,Dörr M,Baumbach J,Sendler M,Schulz C,Mayerle J,Weiss FU,Homuth G,Lerch MM

更新日期：2020-11-09 00:00:00

abstract：OBJECTIVE:The gut-brain axis is considered as a major regulatory checkpoint in the control of glucose homeostasis. The detection of nutrients and/or hormones in the duodenum informs the hypothalamus of the host's nutritional state. This process may occur via hypothalamic neurons modulating central release of nitric oxi...

journal_title：Gut

authors： Fournel A,Drougard A,Duparc T,Marlin A,Brierley SM,Castro J,Le-Gonidec S,Masri B,Colom A,Lucas A,Rousset P,Cenac N,Vergnolle N,Valet P,Cani PD,Knauf C

更新日期：2017-02-01 00:00:00

abstract：:It has been suggested that an intact vagal supply is essential for the normal function of the recptors in the duodenum and proximal small bowel, which influence the rate of gastric emptying. This paper reports the effect of vagal denervation on gastric emptying and also examines the site and mode of action of receptor...

journal_title：Gut

authors： Shahidullah M,Kennedy TL,Parks TG

更新日期：1975-05-01 00:00:00