The detection and measurement of circulating gastrin-like activity by bioassay.

abstract：:ABO and Rhesus blood group data have been examined for 1,680 patients treated for gastric cancer in four London hospitals. The risk of developing gastric cancer was estimated to be 16% higher for group A subjects than for group O subjects, in close agreement with many previous reports throughout the world. More detail...

journal_title：Gut

authors： Glober GA,Cantrell EG,Doll R,Peto R

更新日期：1971-07-01 00:00:00

abstract：:The cholesteryl-14C-octanoate breath test was used to monitor the intraluminal enzymatic activity of pancreatin preparations in six patients with severe pancreatic insufficiency. Conventional enzyme replacement, with cimetidine as an adjunct, was compared to supplementation with enteric coated microspheres. In healthy...

journal_title：Gut

authors： Mundlos S,Kühnelt P,Adler G

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Portal systemic encephalopathy (PSE) is a complex neuropsychiatric syndrome associated with hepatic failure. Small scale studies have shown the benzodiazepine receptor antagonist flumazenil to be effective in ameliorating PSE. AIMS:To determine the efficacy of flumazenil in patients with non-comatous mild t...

journal_title：Gut

authors： Gyr K,Meier R,Häussler J,Boulétreau P,Fleig WE,Gatta A,Holstege A,Pomier-Layrargues G,Schalm SW,Groeneweg M,Scollo-Lavizzari G,Ventura E,Zeneroli ML,Williams R,Yoo Y,Amrein R

更新日期：1996-08-01 00:00:00

abstract：:Peptide histidine isoleucine, a 27 amino acid peptide with close amino acid sequence homology to vasoactive intestinal peptide and secretin, is distributed throughout the mammalian intestinal tract, where it has been localised to intramural neurones. An intestinal perfusion technique has been used to study the effect ...

journal_title：Gut

authors： Moriarty KJ,Hegarty JE,Tatemoto K,Mutt V,Christofides ND,Bloom SR,Wood JR

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Colonoscopic surveillance for cancer in longstanding extensive ulcerative colitis relies heavily on non-targeted mucosal biopsies. Chromoendoscopy can aid detection of subtle mucosal abnormalities. We hypothesised that routine pancolonic indigo carmine dye spraying would improve the macroscopic dete...

journal_title：Gut

authors： Rutter MD,Saunders BP,Schofield G,Forbes A,Price AB,Talbot IC

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals of 1-2 years. However, yearly surveillance likely leads to overtreatment for many. We prospectively assessed a surveillance protocol aiming to ...

journal_title：Gut

authors： Bleijenberg AG,IJspeert JE,van Herwaarden YJ,Carballal S,Pellisé M,Jung G,Bisseling TM,Nagtegaal ID,van Leerdam ME,van Lelyveld N,Bessa X,Rodríguez-Moranta F,Bastiaansen B,de Klaver W,Rivero L,Spaander MC,Koornstra JJ,B

更新日期：2020-01-01 00:00:00

abstract：:One hundred patients who had undergone operation for duodenal ulcer (68 vagotomy and gastroenterostomy; seven vagotomy and pyloroplasty; 22 gastrectomy and three gastroenterostomy) 10 or more years previously each underwent endoscopy. Biopsies were taken and gastric juice aspirated for measurement of pH and nitrite co...

journal_title：Gut

authors： Watt PC,Sloan JM,Donaldson JD,Patterson CC,Kennedy TL

更新日期：1984-03-01 00:00:00

abstract：:The role of biliary deoxycholate as an endogenous colon carcinogen and the possible association between cholelithiasis and/or cholecystectomy and the subsequent development of large bowel cancer is unclear. This paper describes biliary bile acids analysis performed on 13 patients undergoing cholecystectomy for gall st...

journal_title：Gut

authors： Castleden WM,Detchon P,Misso NL

更新日期：1989-06-01 00:00:00

abstract：:mu-, delta- and kappa-opioid receptors are widely expressed in the central nervous system where they mediate the strong analgesic and mood-altering actions of opioids, and modulate numerous endogenous functions. To investigate the contribution of the kappa-opioid receptor (KOR) to opioid function in vivo, we have gene...

journal_title：Gut

authors： Black D,Trevethick M

更新日期：1998-09-01 00:00:00

abstract：:Cell cultures derived from Crohn's disease and control tissues were subjected to a series of tests designed to detect persistent, non-cytocidal virus infection. No evidence for any such infection was found, and it is concluded that persistent viral infection of gut tissues is unlikely to play a significant role in the...

journal_title：Gut

authors： Phillpotts RJ,Hermon-Taylor J,Teich NM,Brooke BN

更新日期：1980-03-01 00:00:00

abstract：BACKGROUND:5-Lipoxygenase products play a part in inflammatory response. AIMS:The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis. METHODS:Ninety rats with trinitrobenzenesulphonic acid induced colitis...

journal_title：Gut

authors： Bertrán X,Mañé J,Fernández-Bañares F,Castellá E,Bartolí R,Ojanguren I,Esteve M,Gassull MA

更新日期：1996-06-01 00:00:00

abstract：:In this study a perfusion technique has been used to investigate jejunal secretion in response to the dibasic amino acid L-arginine. L-arginine at 5, 15, and 40 mmol/l in isotonic saline solutions induced net intestinal secretion of water and Na+. The structurally similar dibasic amino acid L-lysine caused net absorpt...

journal_title：Gut

authors： Hegarty JE,Fairclough PD,Clark ML,Dawson AM

更新日期：1981-02-01 00:00:00

abstract：OBJECTIVE:Current diagnostic methods for gastro-oesophageal reflux disease (GORD) have moderate sensitivity/specificity and can be invasive and expensive. Pepsin detection in saliva has been proposed as an 'office-based' method for GORD diagnosis. The aims of this study were to establish normal values of salivary pepsi...

journal_title：Gut

authors： Hayat JO,Gabieta-Somnez S,Yazaki E,Kang JY,Woodcock A,Dettmar P,Mabary J,Knowles CH,Sifrim D

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Lamina propria (LPLs) and intraepithelial (IELs) lymphocytes are markedly increased in coeliac mucosa, and are thought to play a crucial role in the generation of villous atrophy in coeliac disease (CD). However, the mechanisms by which they mediate the killing of enterocytes in this condition are still poor...

journal_title：Gut

authors： Di Sabatino A,Ciccocioppo R,D'Alò S,Parroni R,Millimaggi D,Cifone MG,Corazza GR

更新日期：2001-09-01 00:00:00

abstract：AIMS:To determine risk factors for peptic ulcer bleeding other than non-steroidal anti-inflammatory drugs (NSAIDs). Methods-Data on possible antecedent risk factors obtained in a large case control study of 1121 patients admitted to hospitals in Glasgow, Newcastle, Nottingham, Oxford, and Portsmouth with bleeding pepti...

journal_title：Gut

authors： Weil J,Langman MJ,Wainwright P,Lawson DH,Rawlins M,Logan RF,Brown TP,Vessey MP,Murphy M,Colin-Jones DG

更新日期：2000-01-01 00:00:00

abstract：:Upper gastrointestinal function in response to a mixed nutrient meal was evaluated in hyperthyroid patients, both before and after therapy, and in healthy controls. Gastric secretion, gastric emptying, and pancreatic secretion were all normal and normally integrated postprandially in the hyperthyroid patients. Bile ac...

journal_title：Gut

authors： Miller LJ,Owyang C,Malagelada JR,Gorman CA,Go VL

更新日期：1980-08-01 00:00:00

abstract：:The effects of intravenous N-acetylcysteine on hepatic and systemic haemodynamics were investigated in 11 patients with stable cirrhosis (eight alcohol; two primary biliary cirrhosis; one cryptogenic). N-acetylcysteine administration had no effect on the mean heart rate or mean arterial blood pressure despite a signif...

journal_title：Gut

authors： Jones AL,Bangash IH,Bouchier IA,Hayes PC

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVES:National guidelines for the management of irritable bowel syndrome (IBS) recommend that psychological therapies should be considered, but their relative efficacy is unknown, because there have been few head-to-head trials. We performed a systematic review and network meta-analysis to try to resolve this unce...

journal_title：Gut

authors： Black CJ,Thakur ER,Houghton LA,Quigley EMM,Moayyedi P,Ford AC

更新日期：2020-08-01 00:00:00

abstract：:Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination. Its use may be complicated by the development of peripheral neuropathy and liver damage. The majority of patients with perhexiline neuropathy have an impaired ability to effect metabolic drug oxidation which is genetica...

journal_title：Gut

authors： Morgan MY,Reshef R,Shah RR,Oates NS,Smith RL,Sherlock S

更新日期：1984-10-01 00:00:00

abstract：:Synchronous cancers of the oesophagus and stomach diagnosed in a patient showing pronounced leucocytosis were examined for production of granulocyte colony stimulating factor (G-CSF) and expression of G-CSF receptor. Whereas enzyme immunoassay of tissue extracts showed that the oesophageal carcinoma produced G-CSF, th...

journal_title：Gut

authors： Ichiishi E,Yoshikawa T,Kogawa T,Yoshida N,Kondo M

更新日期：2000-03-01 00:00:00

abstract：:Some patients with the Zollinger-Ellison syndrome appear to have hypergastrinaemia and hyperplasia of the antral G cells but no tumour. This subgroup has been classified as Zollinger-Ellison syndrome type 1. We have treated such a patient by vagotomy and antrectomy, the fasting plasma gastrin and acid secretion subseq...

journal_title：Gut

authors： Cowley DJ,Dymock IW,Boyes BE,Wilson RY,Stagg BH,Lewin MR,Polak JM,Pearse AG

更新日期：1973-01-01 00:00:00

abstract：:Hypertrophic gastropathy--that is, Ménétrier's disease--was found, in a retrospective analysis, to be associated with Helicobacter pylori in more than 90% of patients. It is proposed that hypertrophic gastropathy represents a special form of H pylori gastritis in these patients. A case is described of a 28 year old wo...

journal_title：Gut

authors： Bayerdörffer E,Ritter MM,Hatz R,Brooks W,Ruckdeschel G,Stolte M

更新日期：1994-05-01 00:00:00

abstract：:Four young Chinese women took daily doses of an unidentified 'Indian' herbal tea as treatment for psoriasis. Three (one of whom died), developed ascites, hepatomegaly and biochemical abnormalities within 19-45 days. The fourth patient discontinued herbal tea after 21 days when she developed a skin rash. Two patients h...

journal_title：Gut

authors： Kumana CR,Ng M,Lin HJ,Ko W,Wu PC,Todd D

更新日期：1985-01-01 00:00:00

abstract：:Since pancreatobiliary diversion probably stimulates pancreatic growth by increasing cholecystokinin secretion, the effect of the cholecystokinin antagonist CR-1409 on this adaptive response was tested. Male Wistar rats (n = 108) weighing 220-250g were randomised to receive either pancreatobiliary diversion (n = 60) o...

journal_title：Gut

authors： Watanapa P,Efa EF,Beardshall K,Calam J,Sarraf CE,Alison MR,Williamson RC

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn's ...

journal_title：Gut

authors： Stournaras E,Qian W,Pappas A,Hong YY,Shawky R,UK IBD BioResource Investigators.,Raine T,Parkes M,UK IBD Bioresource Investigators.

更新日期：2020-10-01 00:00:00

abstract：:Helicobacter pylori causes chronic (type B) gastritis. The 'intestinal' form of gastric cancer arises against a background of chronic gastritis, and prospective epidemiological studies have shown that H pylori is a major risk factor for this. An increase in mucosal cell proliferation increases the likelihood of a neop...

journal_title：Gut

authors： Lynch DA,Mapstone NP,Clarke AM,Sobala GM,Jackson P,Morrison L,Dixon MF,Quirke P,Axon AT

更新日期：1995-03-01 00:00:00

abstract：:There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid for...

journal_title：Gut

authors： Lampe JW,Fredstrom SB,Slavin JL,Potter JD

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Experimental, clinical, and epidemiological studies have implicated mitogenic metabolites of arachidonic acid such as prostaglandin E(2) (PGE(2)) in colorectal carcinogenesis. Recently, cyclooxygenase 2 (COX-2) which catalyses the conversion of arachidonic acid to PGE(2), has displayed increased levels in hu...

journal_title：Gut

authors： Dimberg J,Samuelsson A,Hugander A,Söderkvist P

更新日期：1999-11-01 00:00:00

abstract：:Three-day faecal collections were obtained from 87 patients with a variety of gastroenterological diagnoses and 12 control subjects while consuming normal diets. Faecal weight, total fatty acids, and the proportion of hydroxystearic (OHSA) acid were measured. All patients had some easily detectable hydroxystearic acid...

journal_title：Gut

authors： Wiggins HS,Pearson JR,Walker JG,Russell RI,Kellock TD

更新日期：1974-08-01 00:00:00

abstract：BACKGROUND:Recent profile studies of microRNA (miRNA) expression have documented a deregulation of miRNA (miR-124) in hepatocellular carcinoma (HCC). OBJECTIVE:To determine the status of miR-124 expression and its underlying mechanisms in the pathogenesis of HCC. METHODS:The expression levels of miR-124 were first ex...

journal_title：Gut

authors： Zheng F,Liao YJ,Cai MY,Liu YH,Liu TH,Chen SP,Bian XW,Guan XY,Lin MC,Zeng YX,Kung HF,Xie D

更新日期：2012-02-01 00:00:00