A search for persistent virus infection in Crohn's disease.

abstract：OBJECTIVE:To establish an appropriate steroid treatment regimen for autoimmune pancreatitis (AIP). METHODS:A retrospective survey of AIP treatment was conducted in 17 centres in Japan. The main outcome measures were rate of remission and relapse. RESULTS:Of 563 patients with AIP, 459 (82%) received steroid treatment....

journal_title：Gut

authors： Kamisawa T,Shimosegawa T,Okazaki K,Nishino T,Watanabe H,Kanno A,Okumura F,Nishikawa T,Kobayashi K,Ichiya T,Takatori H,Yamakita K,Kubota K,Hamano H,Okamura K,Hirano K,Ito T,Ko SB,Omata M

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:There is no information about the frequency of liver dysfunction in patients with inflammatory bowel disease (IBD) treated with immunosuppressants and infected with hepatitis B (HBV) and/or C virus (HCV). AIM:To assess the influence of immunosuppressants on the course of HBV and HCV infection in IBD. METHO...

journal_title：Gut

authors： Loras C,Gisbert JP,Mínguez M,Merino O,Bujanda L,Saro C,Domenech E,Barrio J,Andreu M,Ordás I,Vida L,Bastida G,González-Huix F,Piqueras M,Ginard D,Calvet X,Gutiérrez A,Abad A,Torres M,Panés J,Chaparro M,Pascual I

更新日期：2010-10-01 00:00:00

abstract：:A simple evocative test has been used to study pancreatic function. Serial estimations of amylase and lipase in blood serum are made at intervals up to six hours and again at 24 hours after injecting intravenously standard doses of secretin and pancreozymin. The results of 213 tests on a normal group, in pancreatic di...

journal_title：Gut

authors： BURTON P,HAMMOND EM,HARPER AA,HOWAT HT,SCOTT JE,VARLEY H

更新日期：1960-06-01 00:00:00

abstract：:Iron deficiency anaemia is one of the most common disorders in the world. Also, one third of inflammatory bowel disease (IBD) patients suffer from recurrent anaemia. Anaemia has significant impact on the quality of life of affected patients. Chronic fatigue, a frequent IBD symptom itself, is commonly caused by anaemia...

journal_title：Gut

authors： Gasche C,Lomer MC,Cavill I,Weiss G

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:Gastric cancer (GC) remains difficult to cure due to heterogeneity in a clinical challenge and the molecular mechanisms underlying this disease are complex and not completely understood. Accumulating evidence suggests that microRNAs (miRNAs) play an important role in GC, but the role of specific miRNAs involv...

journal_title：Gut

authors： Han TS,Hur K,Xu G,Choi B,Okugawa Y,Toiyama Y,Oshima H,Oshima M,Lee HJ,Kim VN,Chang AN,Goel A,Yang HK

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Sulfhydryl (SH) compounds are essential in maintaining mucosal integrity in the gastrointestinal tract. A decrease in colonic mucosal SH compounds affects the redox status of the mucosa, resulting in vulnerability to further attacks. Therefore, there is a strong need for in vivo evaluation of SH compounds in...

journal_title：Gut

authors： Togashi H,Oikawa K,Adachi T,Sugahara K,Ito J,Takeda T,Watanabe H,Saito K,Saito T,Fukui T,Takeda H,Ohya H,Kawata S

更新日期：2003-09-01 00:00:00

abstract：:Of 27 patients with liver disease and cryoglobulinaemia 18 proved to have paraproteins. Six of these monoclonal immunoglobulins were shown to have antibody activity, directed to human gamma globulin, alpha(1)-fetoprotein, smooth muscle, and mitochondria.Eight of the patients suffered from acute viral hepatitis, five o...

journal_title：Gut

authors： Roux ME,Florin-Christensen A,Arana RM,Doniach D

更新日期：1974-05-01 00:00:00

abstract：BACKGROUND:Diabetes has been associated with an increased risk of hepatocellular carcinoma (HCC) in studies of referred patients. This is the first population based case control study in the USA to examine this association while adjusting for other major risk factors related to HCC. METHODS:We used the Surveillance Ep...

journal_title：Gut

authors： Davila JA,Morgan RO,Shaib Y,McGlynn KA,El-Serag HB

更新日期：2005-04-01 00:00:00

abstract：:Paracetamol poisoning is the most common cause of fulminant liver failure in the United Kingdom. An accurate assessment of prognosis at the time of referral will allow the appropriate application of liver transplantation in this setting. The outcome of 92 patients consecutively admitted to a specialist liver unit with...

journal_title：Gut

authors： Mutimer DJ,Ayres RC,Neuberger JM,Davies MH,Holguin J,Buckels JA,Mayer AD,McMaster P,Elias E

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Genetic predisposition and gliadin exposure are known to be crucial factors in the development of coeliac disease. Circumstantial evidence suggests that other unidentified environmental factors may also be of pathogenetic importance. AIM:To define the relation between cigarette smoking and the risk of devel...

journal_title：Gut

authors： Snook JA,Dwyer L,Lee-Elliott C,Khan S,Wheeler DW,Nicholas DS

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The efficacy of a levofloxacin-based regimen as the first-line treatment and a clarithromycin-based regimen as the second-line treatment for Helicobacter pylori infection remains unknown. The aim of this study was to assess the eradication rates of these two regimens using different administration sequences....

journal_title：Gut

authors： Liou JM,Lin JT,Chang CY,Chen MJ,Cheng TY,Lee YC,Chen CC,Sheng WH,Wang HP,Wu MS

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Fibrosis associated with chronic pancreatitis is an irreversible lesion that can disrupt pancreatic exocrine and endocrine function. Currently, there are no approved treatments for this disease. We previously showed that siRNA against collagen-specific chaperone protein gp46, encapsulated in vi...

journal_title：Gut

authors： Ishiwatari H,Sato Y,Murase K,Yoneda A,Fujita R,Nishita H,Birukawa NK,Hayashi T,Sato T,Miyanishi K,Takimoto R,Kobune M,Ota S,Kimura Y,Hirata K,Kato J,Niitsu Y

更新日期：2013-09-01 00:00:00

abstract：:The influence of dehydrocholate on bromsulphtalein relative-storage capacity, bilary transport maximum (Tm), and fractional transfer rates between plasma, liver and bile have been studied in unanaesthetized dogs. In six dogs, storage capacity, Tm, and fractional transfer rates from plasma to liver, liver to bile, and ...

journal_title：Gut

authors： Delage Y,Erlinger S,Duval M,Bpenhamou JP

更新日期：1975-02-01 00:00:00

abstract：:We report the occurrence of achalasia and diffuse oesophageal spasm in brother and sister. The familial occurrence of these unusual disorders is consistent with the possibility that they share a common aetiology and indicates the potential importance of genetic predisposition. ...

journal_title：Gut

authors： Kaye MD,Demeules JE

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Cholera toxin produces intestinal secretion by activation of the adenylate cyclase complex. However animal studies have shown 5-hydroxytryptamine may be released after exposure to cholera toxin, and thereby contribute to the secretory state. AIM:To determine whether cholera toxin releases 5-hydroxytryptamin...

journal_title：Gut

authors： Bearcroft CP,Perrett D,Farthing MJ

更新日期：1996-10-01 00:00:00

abstract：:The investigation and treatment of 131 patients with 'obscure' gastrointestinal bleeding has been reviewed. One hundred and six patients were assessed electively for recurrent haemorrhage, 25 presented as emergencies. The major presenting feature was melaena (55 patients), anaemia (35), rectal bleeding (34), haemateme...

journal_title：Gut

authors： Thompson JN,Salem RR,Hemingway AP,Rees HC,Hodgson HJ,Wood CB,Allison DJ,Spencer J

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Intrahepatic cholestasis of pregnancy (ICP) has a complex aetiology with a significant genetic component. ABCB11 encodes the bile salt export pump (BSEP); mutations cause a spectrum of cholestatic disease, and are implicated in the aetiology of ICP. METHODS:ABCB11 variation in ICP was investigated by screen...

journal_title：Gut

authors： Dixon PH,van Mil SW,Chambers J,Strautnieks S,Thompson RJ,Lammert F,Kubitz R,Keitel V,Glantz A,Mattsson LA,Marschall HU,Molokhia M,Moore GE,Linton KJ,Williamson C

更新日期：2009-04-01 00:00:00

abstract：:The effects of luminal instillation of 16,16 dimethyl PGE2 (dmPGE2) on gastric acid secretion and back diffusion of H+ were studied in anaesthetised dogs which were prepared with a segment of the greater curvature of the stomach mounted in a double lumen chamber. This model permitted simultaneous evaluation of two seg...

journal_title：Gut

authors： Cheung LY,Lowry SF,Perry J,Larson K

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:Integrins are transmembrane cell surface receptors that mediate cell-cell and cell-matrix contacts. Integrin-linked kinase (ILK) is the binding partner of beta1 and beta3 integrins, and has been ascribed essential roles in development, angiogenesis and tumourigenesis. However, in vivo evidence for the latter...

journal_title：Gut

authors： Assi K,Mills J,Owen D,Ong C,St Arnaud R,Dedhar S,Salh B

更新日期：2008-07-01 00:00:00

abstract：:Patients with functional gastrointestinal disorders may have visceral sensory dysfunction so that physiological stimuli induce their symptoms. The clinical significance of altered perception-that is, its relation to clinical symptoms-remains unclear. Data indicate that sensory dysfunction is associated with altered re...

journal_title：Gut

authors： Azpiroz F

更新日期：2002-07-01 00:00:00

abstract：:The ability to digest mucus, mucolytic activity of isolated pepsins and samples of human gastric juice has been assayed by measuring the fall in viscosity when incubated with purified pig gastric mucus glycoprotein. Pure human pepsin 1, the peptic ulcer associated pepsin, digested gastric mucus glycoprotein at a faste...

journal_title：Gut

authors： Pearson JP,Ward R,Allen A,Roberts NB,Taylor WH

更新日期：1986-03-01 00:00:00

abstract：:Both carbachol (10(-4)-10(-3) mol/l) and cholecystokinin octapeptide (CCK-8) (10(-8)-10(-6) mol/l) significantly stimulated the release of pepsinogen from rabbit gastric mucosa maintained in organ culture (213-216% and 143-261% of control, respectively, p less than 0.05-0.01). The secretion was not affected by removin...

journal_title：Gut

authors： Miyamoto T,Itoh M,Noguchi Y,Yokochi K

更新日期：1992-01-01 00:00:00

abstract：:HLA antigens and various aspects of atopy were studied in 42 Finnish children and adolescents with coeliac disease, and the results were compared with findings of recent population studies. The HLA associations were as expected: relative risks for coeliac disease in individuals with HLA-B8, DR3, and DR7 were 8 . 0, 18...

journal_title：Gut

authors： Verkasalo M,Tiilikainen A,Kuitunen P,Savilahti E,Backman A

更新日期：1983-04-01 00:00:00

abstract：:The effects on gastric emptying of a solid meal of the specific 5-HT3-receptor antagonist ICS 205-930, 10 mg and 20 mg intravenously were assessed with a scintigraphic technique in 12 normals. The 50% emptying time was less, the lag phase was shorter and the post lag emptying rate was faster after 20 mg ICS 205-930 (p...

journal_title：Gut

authors： Akkermans LM,Vos A,Hoekstra A,Roelofs JM,Horowitz M

更新日期：1988-09-01 00:00:00

abstract：UNLABELLED:Data on the natural history of elderly-onset inflammatory bowel disease (IBD) are scarce. METHODS:In a French population-based cohort we identified 841 IBD patients >60 years of age at diagnosis from 1988 to 2006, including 367 Crohn's disease (CD) and 472 ulcerative colitis (UC). RESULTS:Median age at dia...

journal_title：Gut

authors： Charpentier C,Salleron J,Savoye G,Fumery M,Merle V,Laberenne JE,Vasseur F,Dupas JL,Cortot A,Dauchet L,Peyrin-Biroulet L,Lerebours E,Colombel JF,Gower-Rousseau C

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:Roux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations. DESIGN:We used functional MRI, ea...

journal_title：Gut

authors： Scholtz S,Miras AD,Chhina N,Prechtl CG,Sleeth ML,Daud NM,Ismail NA,Durighel G,Ahmed AR,Olbers T,Vincent RP,Alaghband-Zadeh J,Ghatei MA,Waldman AD,Frost GS,Bell JD,le Roux CW,Goldstone AP

更新日期：2014-06-01 00:00:00

abstract：:Distal duodenal biopsy specimens taken from 30 white, 35 Indian, and 20 Afro-Caribbean residents of West Birmingham during routine endoscopy for dyspepsia, were assessed by dissecting microscopy and morphometry. Finger-shaped villi were significantly less frequent in the Indian and Afro-Caribbean subjects than in the ...

journal_title：Gut

authors： Wood GM,Gearty JC,Cooper BT

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Dietary lectins can alter the proliferation of colonic cells. Differentiation is regulated by adhesion molecules which, being glycosylated, are targets for lectin binding. AIMS:To examine the effects of dietary lectins on differentiation, adhesion, and proliferation of colorectal cancer cells. METHODS:Diff...

journal_title：Gut

authors： Jordinson M,El-Hariry I,Calnan D,Calam J,Pignatelli M

更新日期：1999-05-01 00:00:00

abstract：:This study determined the location and tissue density of cells immunoreactive for tumour necrosis factor alpha (TNF alpha) in intestinal specimens from 24 patients with chronic inflammatory bowel disease (15 with Crohn's disease, nine with ulcerative colitis) and 11 controls. There was significantly increased density ...

journal_title：Gut

authors： Murch SH,Braegger CP,Walker-Smith JA,MacDonald TT

更新日期：1993-12-01 00:00:00

abstract：:Results emerging from endoscopic treatments to ablate Barrett's oesophagus indicate that APC alone or ALA-PDT in combination with APC achieves complete clearance of Barrett's epithelium in approximately two thirds of patients. ...

journal_title：Gut

authors： Van Laethem JL,Devière J

更新日期：2004-06-01 00:00:00