Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy.

abstract：:In man, the main pancreatic duct is normally derived from ventral and dorsal embryological buds of the pancreas. In a minority of people, failure of fusion of the two buds results in separate drainage of the dorsal and ventral pancreas, so that the accessory duct provides the main drainage for the gland. Patients with...

journal_title：Gut

authors： Mitchell CJ,Lintott DJ,Ruddell WS,Losowsky MS,Axon AT

更新日期：1979-12-01 00:00:00

abstract：:The role of biliary deoxycholate as an endogenous colon carcinogen and the possible association between cholelithiasis and/or cholecystectomy and the subsequent development of large bowel cancer is unclear. This paper describes biliary bile acids analysis performed on 13 patients undergoing cholecystectomy for gall st...

journal_title：Gut

authors： Castleden WM,Detchon P,Misso NL

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Chronic pancreatitis is a known risk factor for pancreatic adenocarcinoma. Recent work has pointed to a role for bone marrow-derived progenitor cells (BMDCs) in chronic inflammation-based carcinogenesis. Consequently, the role of BMDCs in chronic pancreatitis was investigated. METHODS:The fate of BMDCs was ...

journal_title：Gut

authors： Marrache F,Pendyala S,Bhagat G,Betz KS,Song Z,Wang TC

更新日期：2008-08-01 00:00:00

abstract：:Gastric cancer is a major health burden worldwide and prevention is the most promising strategy to control the disease. The available scientific evidence indicates that curing Helicobacter pylori infection results in a modest retardation of the precancerous process but does not prevent all cancers. Individuals at the ...

journal_title：Gut

authors： Correa P

更新日期：2004-09-01 00:00:00

abstract：:Chronic alcohol consumption induces cytochrome P450IIE1, enabling habitual abusers to consume far greater quantities of alcohol than normal subjects. This pathway of metabolism leads to the production of free radical species, which cause tissue damage through peroxidation of cell membranes. Groups of Wistar rats of eq...

journal_title：Gut

authors： Teare JP,Greenfield SM,Watson D,Punchard NA,Miller N,Rice-Evans CA,Thompson RP

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND AND AIMS:CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single source, a strong association between viral clearance and the human lecucocyte (HLA)-A*03 allele has be...

journal_title：Gut

authors： Fitzmaurice K,Petrovic D,Ramamurthy N,Simmons R,Merani S,Gaudieri S,Sims S,Dempsey E,Freitas E,Lea S,McKiernan S,Norris S,Long A,Kelleher D,Klenerman P

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND/AIM:5-Hydroxytryptamine (5-HT) released from enterochromaffin cells influences intestinal homeostasis by altering gut physiology and is implicated in the pathophysiology of various gut disorders. The mechanisms regulating 5-HT production in the gut remain unclear. This study investigated the T helper (Th) 1/...

journal_title：Gut

authors： Motomura Y,Ghia JE,Wang H,Akiho H,El-Sharkawy RT,Collins M,Wan Y,McLaughlin JT,Khan WI

更新日期：2008-04-01 00:00:00

abstract：:The case of a 44-year-old woman is reported. The diagnosis after the appropriate tests and laparotomy was ACTH-secreting 'apudoma' of the gallbladder. This is a rare tumour and this case is believed to be the first reported of an ectopic hormone producing tumour from this side. ...

journal_title：Gut

authors： Spence RW,Burns-Cox CJ

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Although peroxisome proliferator activated receptor gamma (PPARgamma) agonists have been implicated in differentiation and growth inhibition of cancer cells, the potential therapeutic and chemopreventive effects on gastric cancer are poorly defined. We examined the in vitro and in vivo effects of PP...

journal_title：Gut

authors： Leung WK,Bai AH,Chan VY,Yu J,Chan MW,To KF,Wu JR,Chan KK,Fu YG,Chan FK,Sung JJ

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Gastric acid secretion is downregulated by Helicobacter pylori infection and upregulated after its eradication, but the mechanisms are still unclear. We examined the effects of H pylori eradication on the number of parietal cells and on expression of molecules functioning in acid secretion in the hu...

journal_title：Gut

authors： Osawa H,Kita H,Ohnishi H,Hoshino H,Mutoh H,Ishino Y,Watanabe E,Satoh K,Sugano K

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Global DNA hypomethylation has been found in the premalignant stages of some neoplasms and has been implicated as an important factor for tumour progression. AIMS:The aim of this study was to evaluate whether DNA hypomethylation occurs during the process of gastric carcinogenesis. METHODS:Gastric specimens...

journal_title：Gut

authors： Cravo M,Pinto R,Fidalgo P,Chaves P,Glória L,Nobre-Leitão C,Costa Mira F

更新日期：1996-09-01 00:00:00

abstract：:A histological study of peroral jejunal biopsies and resection specimens from patients with malignant histiocytosis of the intestine (MHI) has revealed characteristic lesions consisting of intramucosal histiocytic aggregations which invade surface and crypt epithelium. These lesions are found in 'uninvolved' jejunal m...

journal_title：Gut

authors： Isaacson P

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:A decrease in arterial isoleucine values after intragastric blood administration in pigs has been observed. This contrasted with increased values of most other amino acids, ammonia, and urea. After an isonitrogenous control meal in these pigs all amino acids including isoleucine increased, and urea increased...

journal_title：Gut

authors： Dejong CH,Meijerink WJ,van Berlo CL,Deutz NE,Soeters PB

更新日期：1996-07-01 00:00:00

abstract：:Central reading, that is, independent, off-site, blinded review or reading of imaging endpoints, has been identified as a crucial component in the conduct and analysis of inflammatory bowel disease clinical trials. Central reading is the final step in a workflow that has many parts, all of which can be improved. Furth...

journal_title：Gut

authors： Gottlieb K,Daperno M,Usiskin K,Sands BE,Ahmad H,Howden CW,Karnes W,Oh YS,Modesto I,Marano C,Stidham RW,Reinisch W

更新日期：2021-02-01 00:00:00

abstract：:The purpose of this single blind controlled multicentre trial was to compare the relative effectiveness of pirenzepine and cimetidine in healing endoscopically proven duodenal ulcers. One hundred and twenty six patients with duodenal ulcer were treated with a daily dose of 100 mg pirenzepine (50 mg each before breakfa...

journal_title：Gut

authors： Brunner H,Dittrich H,Kratochvil P,Brandstätter G,Hentschel E,Schütze K,Tragl KH,Kern H,Löffelmann K,Zeiler H

更新日期：1984-02-01 00:00:00

abstract：OBJECTIVE:To investigate the potential tumour suppressor functions of glutathione peroxidase 7 (GPX7) and examine the interplay between epigenetic and genetic events in regulating its expression in oesophageal adenocarcinomas (OAC). DESIGN:In vitro and in vivo cell models were developed to investigate the biological a...

journal_title：Gut

authors： Peng D,Hu T,Soutto M,Belkhiri A,Zaika A,El-Rifai W

更新日期：2014-04-01 00:00:00

abstract：:The epidemiology of hepatitis C virus (HCV) infection was studied in an English teaching hospital over an 18 month period. A total of 104 HCV antibody positive patients were referred for further investigation. They were divided into those diagnosed through screening (blood donors and intravenous drug abusers) and thos...

journal_title：Gut

authors： Watson JP,Brind AM,Chapman CE,Bates CL,Gould FK,Johnson SJ,Burt AD,Ferguson J,Simmonds P,Bassendine MF

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:Whether peginterferon α and ribavirin combination therapy reduces risk of hepatocellular carcinoma (HCC) or improves survival in patients dual-infected with hepatitis C virus (HCV) and hepatitis B virus (HBV) is unknown. Since it is ethically impossible to conduct a randomised trial to learn the long-term eff...

journal_title：Gut

authors： Liu CJ,Chu YT,Shau WY,Kuo RN,Chen PJ,Lai MS

更新日期：2014-03-01 00:00:00

abstract：:A study of the function of the lower end of the oesophagus in the cat confirms that it behaves as a true physiological sphincter, even though histological evidence for such a structure is absent. Sphincteric action is a function of the circular muscle fibres in the lowest 2 cm. of the oesophagus. Reflex changes in ton...

journal_title：Gut

authors： CLARK CG,VANE JR

更新日期：1961-09-01 00:00:00

abstract：:To explore the role played by beta adrenoreceptor mediated pathways on human upper gut function a series of studies were conducted into the effects of beta adrenoreceptor agonists and antagonists on orocaecal and duodenocaecal transit and on antral and duodenal motor activity. Under control conditions orocaecal transi...

journal_title：Gut

authors： McIntyre AS,Thompson DG,Day S,Burnham WR,Walker ER

更新日期：1992-08-01 00:00:00

abstract：:Paracetamol poisoning is the most common cause of fulminant liver failure in the United Kingdom. An accurate assessment of prognosis at the time of referral will allow the appropriate application of liver transplantation in this setting. The outcome of 92 patients consecutively admitted to a specialist liver unit with...

journal_title：Gut

authors： Mutimer DJ,Ayres RC,Neuberger JM,Davies MH,Holguin J,Buckels JA,Mayer AD,McMaster P,Elias E

更新日期：1994-06-01 00:00:00

abstract：:Results emerging from endoscopic treatments to ablate Barrett's oesophagus indicate that APC alone or ALA-PDT in combination with APC achieves complete clearance of Barrett's epithelium in approximately two thirds of patients. ...

journal_title：Gut

authors： Van Laethem JL,Devière J

更新日期：2004-06-01 00:00:00

abstract：:A 24 hour gastric aspiration study was carried out on nine Polya gastrectomy, eight pernicious anaemia, and nine matched control subjects. Intragastric pH, bacteria, nitrite, and N-nitroso compounds were assessed half hourly whilst ambulant and hourly when in bed. Both total and nitrate reducing bacterial counts were ...

journal_title：Gut

authors： Hall CN,Darkin D,Brimblecombe R,Cook AJ,Kirkham JS,Northfield TC

更新日期：1986-05-01 00:00:00

abstract：OBJECTIVE:Population-based studies demonstrating the clinical impact of interferon-free direct-acting antiviral (DAA) therapies are lacking. We examined the impact of the introduction of DAAs on HCV-related decompensated cirrhosis (DC) through analysis of population-based data from Scotland. DESIGN:Through analysis of...

journal_title：Gut

authors： Hutchinson SJ,Valerio H,McDonald SA,Yeung A,Pollock K,Smith S,Barclay S,Dillon JF,Fox R,Bramley P,Fraser A,Kennedy N,Gunson RN,Templeton K,Innes H,McLeod A,Weir A,Hayes PC,Goldberg D

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Crohn's disease (CD) and ulcerative colitis (UC) are chronic multifactorial inflammatory bowel diseases (IBDs) with unknown aetiology, but a deregulated mucosal immune response to gut-derived bacterial antigens is thought to be involved. Toll-like receptor ligands, especially lipopolysaccharide (LPS...

journal_title：Gut

authors： Tuin A,Poelstra K,de Jager-Krikken A,Bok L,Raaben W,Velders MP,Dijkstra G

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Little is known about the epidemiology of malignant digestive endocrine tumours. The aim of this study was to report on their incidence and management in a well defined population. METHODS:Data were obtained from the population based Digestive Cancer Registry of Burgundy (France) over a 24 year per...

journal_title：Gut

authors： Lepage C,Bouvier AM,Phelip JM,Hatem C,Vernet C,Faivre J

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The risk of colorectal cancer is increased in ulcerative colitis (UC). Patients with UC have diverse colonoscopic appearances. Determining colonoscopic markers for cancer risk could allow patient risk stratification. PATIENTS AND METHODS:Following on from an earlier study which demonstrated a corre...

journal_title：Gut

authors： Rutter MD,Saunders BP,Wilkinson KH,Rumbles S,Schofield G,Kamm MA,Williams CB,Price AB,Talbot IC,Forbes A

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:The transcriptional profile of gastric epithelial cell lines cocultured with Helicobacter pylori and the global gene expression of whole gastric mucosa has been described previously. We aimed to overcome limitations of previous studies by determining the effects of H pylori eradication on the transcriptome of...

journal_title：Gut

authors： Resnick MB,Sabo E,Meitner PA,Kim SS,Cho Y,Kim HK,Tavares R,Moss SF

更新日期：2006-12-01 00:00:00

abstract：:Histochemical enzymatic studies were performed on 30 freshly resected large bowel carcinomas, 30 samples of normal colonic epithelium, and six samples of the histologically normal epithelium (so-called transitional epithelium) immediately adjacent to a carcinoma. Five enzymes were studied: nicotine adenine dinucleotid...

journal_title：Gut

authors： Marsden JR,Dawson IM

更新日期：1974-10-01 00:00:00

abstract：BACKGROUND:In some infants with liver disease, 3-oxo-delta 4 bile acids are the major bile acids in urine, a phenomenon attributed to reduced activity of the delta 4-3-oxosteroid 5 beta-reductase required for synthesis of chenodeoxycholic acid and cholic acid. These patients form a heterogeneous group. Many have a know...

journal_title：Gut

authors： Clayton PT,Mills KA,Johnson AW,Barabino A,Marazzi MG

更新日期：1996-04-01 00:00:00