Abstract:
OBJECTIVE:Population-based studies demonstrating the clinical impact of interferon-free direct-acting antiviral (DAA) therapies are lacking. We examined the impact of the introduction of DAAs on HCV-related decompensated cirrhosis (DC) through analysis of population-based data from Scotland. DESIGN:Through analysis of national surveillance data (involving linkage of HCV diagnosis and clinical databases to hospital and deaths registers), we determined i) the scale-up in the number of patients treated and achieving a sustained viral response (SVR), and ii) the change in the trend of new presentations with HCV-related DC, with the introduction of DAAs. RESULTS:Approximately 11 000 patients had been treated in Scotland over the 8-year period 2010/11 to 2017/18. The scale-up in the number of patients achieving SVR between the pre-DAA and DAA eras was 2.3-fold overall and 5.9-fold among those with compensated cirrhosis (the group at immediate risk of developing DC). In the pre-DAA era, the annual number of HCV-related DC presentations increased 4.6-fold between 2000 (30) and 2014 (142). In the DAA era, presentations decreased by 51% to 69 in 2018 (and by 67% among those with chronic infection at presentation), representing a significant change in trend (rate ratio 0.88, 95% CI 0.85 to 0.90). With the introduction of DAAs, an estimated 330 DC cases had been averted during 2015-18. CONCLUSIONS:National scale-up in interferon-free DAA treatment is associated with the rapid downturn in presentations of HCV-related DC at the population-level. Major progress in averting HCV-related DC in the short-term is feasible, and thus other countries should strive to achieve the same.
journal_name
Gutjournal_title
Gutauthors
Hutchinson SJ,Valerio H,McDonald SA,Yeung A,Pollock K,Smith S,Barclay S,Dillon JF,Fox R,Bramley P,Fraser A,Kennedy N,Gunson RN,Templeton K,Innes H,McLeod A,Weir A,Hayes PC,Goldberg Ddoi
10.1136/gutjnl-2019-320007subject
Has Abstractpub_date
2020-12-01 00:00:00pages
2223-2231issue
12eissn
0017-5749issn
1468-3288pii
gutjnl-2019-320007journal_volume
69pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND AND AIMS:Juvenile polyps occur in several Mendelian disorders, whether in association with gastrointestinal cancer alone (juvenile polyposis syndrome, JPS) or as part of known syndromes (Cowden, Gorlin, and Bannayan-Zonana) in association with developmental abnormalities, dysmorphic features, or extraintesti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.3.406
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Genetic predisposition and gliadin exposure are known to be crucial factors in the development of coeliac disease. Circumstantial evidence suggests that other unidentified environmental factors may also be of pathogenetic importance. AIM:To define the relation between cigarette smoking and the risk of devel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.39.1.60
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. The geographical prevalence varies considerably in different countries and Scotland is regarded as an area of low risk for the disease. AIMS:To assess the association between chronic hepatitis C infection (HCV) and HCC in a popul...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.1.128
更新日期:1997-01-01 00:00:00
abstract::Three cases of apparent primary villous atrophy of the terminal ileum in women with chronic diarrhoea are reported. Eight cases have previously been reported in the literature. Clinical characteristics are the presence of severe chronic secretory diarrhoea with episodes of hypokalaemia combined with signs of ileal mal...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.41.4.561
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Simple and inexpensive non-invasive fibrosis tests are highly needed but have been poorly studied in sub-Saharan Africa. METHODS:Using liver histology as a gold standard, we developed a novel index using routine laboratory tests to predict significant fibrosis in patients with chronic HBV infection in The G...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309260
更新日期:2016-08-01 00:00:00
abstract::ABO and Rhesus blood group data have been examined for 1,680 patients treated for gastric cancer in four London hospitals. The risk of developing gastric cancer was estimated to be 16% higher for group A subjects than for group O subjects, in close agreement with many previous reports throughout the world. More detail...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.7.570
更新日期:1971-07-01 00:00:00
abstract:OBJECTIVE:As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immun...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-315201
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.066100
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:Tissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in stem cell activity in rapidly proliferating isthmus stem cells in the stomach corpus. DESIGN:We uncovered the specific expression of Iqgap3 in proliferating isthm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-322779
更新日期:2020-12-08 00:00:00
abstract::Pathogenic E coli have adhesive properties which are mirrored by an increase in their surface hydrophobicity. E coli isolated from patients with ulcerative colitis possess a mannose resistant adhesin similar to that found in pathogenic E coli. In this study 42 E coli isolates from patients with colitis have been compa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.1.41
更新日期:1988-01-01 00:00:00
abstract::A manometric method was developed to study the motor activity in the unprepared human colon, and the results in eight healthy subjects were compared with those obtained in the same subjects after bowel cleansing with a non-absorbable solution containing polyethylene glycol 4000 (PEG). A tube assembly (4.5 m long, 12 l...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.5.649
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVES:Gastric cancer is strongly associated with Helicobacter pylori (H. pylori). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-320839
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Lamina propria (LPLs) and intraepithelial (IELs) lymphocytes are markedly increased in coeliac mucosa, and are thought to play a crucial role in the generation of villous atrophy in coeliac disease (CD). However, the mechanisms by which they mediate the killing of enterocytes in this condition are still poor...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.3.380
更新日期:2001-09-01 00:00:00
abstract::The free primary amines present in the faeces of 44 infants (1-18 months) with gastroenteritis have been examined by field desorption mass spectrometry of the lactone form of their fluorescamine derivatives without their prior separation. p-Tyramine, 2-phenylethylamine, the diamines, putrescine and cadaverine and seve...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.10.1173
更新日期:1986-10-01 00:00:00
abstract::An indicator fractionation technique using radioactive rubidium has been used to measure pancreatic blood flow after infusions of secretin, pancreozymin, urecholine, and pentagastrin. Secretin resulted in the production of a large volume of low viscous pancreatic juice and was associated with an increase in the cardia...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.1.62
更新日期:1970-01-01 00:00:00
abstract::There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid for...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.4.531
更新日期:1993-04-01 00:00:00
abstract::Eluates were prepared by high salt extraction from normal colonic mucosa and adenocarcinomatous tissue from 28 patients, eight more from unmatched colonic tissue and five from patients with other gastrointestinal disease. Immunoglobulins were detected by ELISA: IgG was present in 24% eluates from normal colon and 21% ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.10.1053
更新日期:1985-10-01 00:00:00
abstract::Though amoebic liver abscess and liver cirrhosis occur very commonly in hospital practice in the tropics, they have not to the knowledge of the present authors hitherto been reported to occur simultaneously in the same patient. The patient described here, who had clear-cut clinical and histological features of chronic...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.2.161
更新日期:1980-02-01 00:00:00
abstract::The cause of a biliary tract stricture may be difficult to determine radiologically. Exfoliative biliary cytology was evaluated in 62 patients (median age 65 years, range 30-94) with biliary tract strictures presenting to the Hepatobiliary Unit between January 1984 and December 1989. Bile samples were taken during end...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.10.1408
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined. OBJECTIVE:To compare the performance of CE to VC for the detecti...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2016-313213
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Norovirus infection is the most frequent cause of infectious diarrhoea in the western world. This study aimed to characterise functionally and histomorphologically the diseased duodenum in human biopsies. METHODS:Norovirus infection was diagnosed by the Kaplan criteria and confirmed by PCR of stool samples....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.160150
更新日期:2009-08-01 00:00:00
abstract::The motor activity of the transverse, descending, and sigmoid colon was recorded for 24 hours in 14 healthy volunteers with a colonoscope positioned catheter. During the study the patients ate two 1000 kcal mixed meals and one continental breakfast. Colonic motor activity was low before meals and minimal during sleep;...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.1.17
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have a considerable risk of recurrent ulcer complications. We hypothesised that a proton pump inhibitor (lansoprazole) is superior to a histamine 2 receptor antagonist (famotidine) for the prevention of recurrent ulcer bleeding...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2019-318715
更新日期:2020-04-01 00:00:00
abstract::Proximal diversion has commonly been used for severe perianal Crohn's disease in an attempt to relieve local symptoms, whether the primary intestinal disease is in the colon or small bowel. Two patients are presented in whom diversion led to severe symptomatic disease in the previously normal defunctioned bowel. In ea...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.8.1139
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:Silibinin is a flavonolignan that is well established for its robust antiviral activity against HCV infection and has undergone several clinical trials for the management of hepatitis C. Despite its potency, silibinin suffers from poor solubility and bioavailability, restricting its clinical use. To overcome ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-312019
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND AND AIMS:The gastrointestinal microflora exerts a barrier effect against enteropathogens. The aim of this study was to examine if bifidobacteria, a major species of the human colonic microflora, participates in the barrier effect by developing antimicrobial activity against enterovirulent bacteria. METHODS:...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.47.5.646
更新日期:2000-11-01 00:00:00
abstract::An estimated 7.5 million individuals in England and Wales are actively infected with Helicobacter pylori and hence knowledge of local resistance rates is of growing importance. Also, information on strain resistance following treatment failure is crucial in selecting an appropriate regimen as the development of bacter...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.50.3.285
更新日期:2002-03-01 00:00:00
abstract::The effect of peritoneal lavage with the addition of camostate to the lavage fluid on the outcome of taurocholate pancreatitis in rats was studied. Camostate is a low molecular weight protease inhibitor which has been developed recently. Peritoneal lavage was performed for 12 hours and camostate was added to the lavag...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.8.934
更新日期:1990-08-01 00:00:00
abstract:OBJECTIVE:Many patients with irritable bowel syndrome IBS not only have abdominal pain but also may suffer from visceral hypersensitivity and heighted visceral nociception. Moreover, IBS has few effective therapeutic agents and mechanisms of disease are unclear. Our goals were to (i) identify microRNA (miRNA) expressio...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306464
更新日期:2016-05-01 00:00:00
abstract::The activity of an interferon induced enzyme, (2',5') oligo adenylate synthetase, was determined in peripheral blood mononuclear cells and granulocytes of patients with inflammatory bowel disease and compared with its activity in cells isolated from normal subjects. In spite of the fact that circulating interferon is ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.6.556
更新日期:1985-06-01 00:00:00