Population impact of direct-acting antiviral treatment on new presentations of hepatitis C-related decompensated cirrhosis: a national record-linkage study.

Abstract:

OBJECTIVE:Population-based studies demonstrating the clinical impact of interferon-free direct-acting antiviral (DAA) therapies are lacking. We examined the impact of the introduction of DAAs on HCV-related decompensated cirrhosis (DC) through analysis of population-based data from Scotland. DESIGN:Through analysis of national surveillance data (involving linkage of HCV diagnosis and clinical databases to hospital and deaths registers), we determined i) the scale-up in the number of patients treated and achieving a sustained viral response (SVR), and ii) the change in the trend of new presentations with HCV-related DC, with the introduction of DAAs. RESULTS:Approximately 11 000 patients had been treated in Scotland over the 8-year period 2010/11 to 2017/18. The scale-up in the number of patients achieving SVR between the pre-DAA and DAA eras was 2.3-fold overall and 5.9-fold among those with compensated cirrhosis (the group at immediate risk of developing DC). In the pre-DAA era, the annual number of HCV-related DC presentations increased 4.6-fold between 2000 (30) and 2014 (142). In the DAA era, presentations decreased by 51% to 69 in 2018 (and by 67% among those with chronic infection at presentation), representing a significant change in trend (rate ratio 0.88, 95% CI 0.85 to 0.90). With the introduction of DAAs, an estimated 330 DC cases had been averted during 2015-18. CONCLUSIONS:National scale-up in interferon-free DAA treatment is associated with the rapid downturn in presentations of HCV-related DC at the population-level. Major progress in averting HCV-related DC in the short-term is feasible, and thus other countries should strive to achieve the same.

journal_name

Gut

journal_title

Gut

authors

Hutchinson SJ,Valerio H,McDonald SA,Yeung A,Pollock K,Smith S,Barclay S,Dillon JF,Fox R,Bramley P,Fraser A,Kennedy N,Gunson RN,Templeton K,Innes H,McLeod A,Weir A,Hayes PC,Goldberg D

doi

10.1136/gutjnl-2019-320007

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

2223-2231

issue

12

eissn

0017-5749

issn

1468-3288

pii

gutjnl-2019-320007

journal_volume

69

pub_type

杂志文章

相关文献

GUT文献大全
  • Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome.

    abstract:BACKGROUND AND AIMS:Juvenile polyps occur in several Mendelian disorders, whether in association with gastrointestinal cancer alone (juvenile polyposis syndrome, JPS) or as part of known syndromes (Cowden, Gorlin, and Bannayan-Zonana) in association with developmental abnormalities, dysmorphic features, or extraintesti...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.45.3.406

    authors: Bevan S,Woodford-Richens K,Rozen P,Eng C,Young J,Dunlop M,Neale K,Phillips R,Markie D,Rodriguez-Bigas M,Leggett B,Sheridan E,Hodgson S,Iwama T,Eccles D,Bodmer W,Houlston R,Tomlinson I

    更新日期:1999-09-01 00:00:00

  • Adult coeliac disease and cigarette smoking.

    abstract:BACKGROUND:Genetic predisposition and gliadin exposure are known to be crucial factors in the development of coeliac disease. Circumstantial evidence suggests that other unidentified environmental factors may also be of pathogenetic importance. AIM:To define the relation between cigarette smoking and the risk of devel...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.39.1.60

    authors: Snook JA,Dwyer L,Lee-Elliott C,Khan S,Wheeler DW,Nicholas DS

    更新日期:1996-07-01 00:00:00

  • Association between chronic hepatitis C infection and hepatocellular carcinoma in a Scottish population.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. The geographical prevalence varies considerably in different countries and Scotland is regarded as an area of low risk for the disease. AIMS:To assess the association between chronic hepatitis C infection (HCV) and HCC in a popul...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.40.1.128

    authors: Haydon GH,Jarvis LM,Simmonds P,Harrison DJ,Garden OJ,Hayes PC

    更新日期:1997-01-01 00:00:00

  • Primary ileal villous atrophy is often associated with microscopic colitis.

    abstract::Three cases of apparent primary villous atrophy of the terminal ileum in women with chronic diarrhoea are reported. Eight cases have previously been reported in the literature. Clinical characteristics are the presence of severe chronic secretory diarrhoea with episodes of hypokalaemia combined with signs of ileal mal...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.41.4.561

    authors: Marteau P,Lavergne-Slove A,Lemann M,Bouhnik Y,Bertheau P,Becheur H,Galian A,Rambaud JC

    更新日期:1997-10-01 00:00:00

  • The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa.

    abstract:BACKGROUND:Simple and inexpensive non-invasive fibrosis tests are highly needed but have been poorly studied in sub-Saharan Africa. METHODS:Using liver histology as a gold standard, we developed a novel index using routine laboratory tests to predict significant fibrosis in patients with chronic HBV infection in The G...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-309260

    authors: Lemoine M,Shimakawa Y,Nayagam S,Khalil M,Suso P,Lloyd J,Goldin R,Njai HF,Ndow G,Taal M,Cooke G,D'Alessandro U,Vray M,Mbaye PS,Njie R,Mallet V,Thursz M

    更新日期:2016-08-01 00:00:00

  • Interaction between ABO and rhesus blood groups, the site of origin of gastric cancers, and the age and sex of the patient.

    abstract::ABO and Rhesus blood group data have been examined for 1,680 patients treated for gastric cancer in four London hospitals. The risk of developing gastric cancer was estimated to be 16% higher for group A subjects than for group O subjects, in close agreement with many previous reports throughout the world. More detail...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.12.7.570

    authors: Glober GA,Cantrell EG,Doll R,Peto R

    更新日期:1971-07-01 00:00:00

  • Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy.

    abstract:OBJECTIVE:As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immun...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2017-315201

    authors: Zhao Y,Shuen TWH,Toh TB,Chan XY,Liu M,Tan SY,Fan Y,Yang H,Lyer SG,Bonney GK,Loh E,Chang KTE,Tan TC,Zhai W,Chan JKY,Chow EK,Chee CE,Lee GH,Dan YY,Chow PK,Toh HC,Lim SG,Chen Q

    更新日期:2018-10-01 00:00:00

  • Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice.

    abstract:BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2005.066100

    authors: Verdú EF,Bercik P,Verma-Gandhu M,Huang XX,Blennerhassett P,Jackson W,Mao Y,Wang L,Rochat F,Collins SM

    更新日期:2006-02-01 00:00:00

  • Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair.

    abstract:OBJECTIVE:Tissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in stem cell activity in rapidly proliferating isthmus stem cells in the stomach corpus. DESIGN:We uncovered the specific expression of Iqgap3 in proliferating isthm...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-322779

    authors: Matsuo J,Douchi D,Myint K,Mon NN,Yamamura A,Kohu K,Heng DL,Chen S,Mawan NA,Nuttonmanit N,Li Y,Srivastava S,Ho SWT,Lee NYS,Lee HK,Adachi M,Tamura A,Chen J,Yang H,Teh M,So JB,Yong WP,Tan P,Yeoh KG,Chuang LSH

    更新日期:2020-12-08 00:00:00

  • Hydrophobic adhesin of E coli in ulcerative colitis.

    abstract::Pathogenic E coli have adhesive properties which are mirrored by an increase in their surface hydrophobicity. E coli isolated from patients with ulcerative colitis possess a mannose resistant adhesin similar to that found in pathogenic E coli. In this study 42 E coli isolates from patients with colitis have been compa...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.29.1.41

    authors: Burke DA,Axon AT

    更新日期:1988-01-01 00:00:00

  • Motor activity recorded in the unprepared colon of healthy humans.

    abstract::A manometric method was developed to study the motor activity in the unprepared human colon, and the results in eight healthy subjects were compared with those obtained in the same subjects after bowel cleansing with a non-absorbable solution containing polyethylene glycol 4000 (PEG). A tube assembly (4.5 m long, 12 l...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.37.5.649

    authors: Lémann M,Flourié B,Picon L,Coffin B,Jian R,Rambaud JC

    更新日期:1995-11-01 00:00:00

  • Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis.

    abstract:OBJECTIVES:Gastric cancer is strongly associated with Helicobacter pylori (H. pylori). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality....

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-320839

    authors: Ford AC,Yuan Y,Moayyedi P

    更新日期:2020-12-01 00:00:00

  • Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in Fas based cytotoxicity in coeliac disease.

    abstract:BACKGROUND:Lamina propria (LPLs) and intraepithelial (IELs) lymphocytes are markedly increased in coeliac mucosa, and are thought to play a crucial role in the generation of villous atrophy in coeliac disease (CD). However, the mechanisms by which they mediate the killing of enterocytes in this condition are still poor...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.49.3.380

    authors: Di Sabatino A,Ciccocioppo R,D'Alò S,Parroni R,Millimaggi D,Cifone MG,Corazza GR

    更新日期:2001-09-01 00:00:00

  • Studies of the free faecal amines of infants with gastroenteritis and of healthy infants.

    abstract::The free primary amines present in the faeces of 44 infants (1-18 months) with gastroenteritis have been examined by field desorption mass spectrometry of the lactone form of their fluorescamine derivatives without their prior separation. p-Tyramine, 2-phenylethylamine, the diamines, putrescine and cadaverine and seve...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.27.10.1173

    authors: Murray KE,Adams RF,Earl JW,Shaw KJ

    更新日期:1986-10-01 00:00:00

  • Relationship between pancreatic secretion and pancreatic blood flow.

    abstract::An indicator fractionation technique using radioactive rubidium has been used to measure pancreatic blood flow after infusions of secretin, pancreozymin, urecholine, and pentagastrin. Secretin resulted in the production of a large volume of low viscous pancreatic juice and was associated with an increase in the cardia...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.11.1.62

    authors: Goodhead B,Himal HS,Zanbilowicz J

    更新日期:1970-01-01 00:00:00

  • Sex differences in colonic function: a randomised trial.

    abstract::There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid for...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.34.4.531

    authors: Lampe JW,Fredstrom SB,Slavin JL,Potter JD

    更新日期:1993-04-01 00:00:00

  • Elution of cytomegalovirus antibodies from adenocarcinoma of the colon.

    abstract::Eluates were prepared by high salt extraction from normal colonic mucosa and adenocarcinomatous tissue from 28 patients, eight more from unmatched colonic tissue and five from patients with other gastrointestinal disease. Immunoglobulins were detected by ELISA: IgG was present in 24% eluates from normal colon and 21% ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.26.10.1053

    authors: Grail A,Norval M

    更新日期:1985-10-01 00:00:00

  • Amoebic abscess in the cirrhotic liver.

    abstract::Though amoebic liver abscess and liver cirrhosis occur very commonly in hospital practice in the tropics, they have not to the knowledge of the present authors hitherto been reported to occur simultaneously in the same patient. The patient described here, who had clear-cut clinical and histological features of chronic...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.2.161

    authors: Falaiye JM,Okeke GC,Fregene AO

    更新日期:1980-02-01 00:00:00

  • Value of exfoliative cytology for investigating bile duct strictures.

    abstract::The cause of a biliary tract stricture may be difficult to determine radiologically. Exfoliative biliary cytology was evaluated in 62 patients (median age 65 years, range 30-94) with biliary tract strictures presenting to the Hepatobiliary Unit between January 1984 and December 1989. Bile samples were taken during end...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.33.10.1408

    authors: Davidson B,Varsamidakis N,Dooley J,Deery A,Dick R,Kurzawinski T,Hobbs K

    更新日期:1992-10-01 00:00:00

  • Chromoendoscopy versus narrow band imaging in UC: a prospective randomised controlled trial.

    abstract:BACKGROUND:Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined. OBJECTIVE:To compare the performance of CE to VC for the detecti...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/gutjnl-2016-313213

    authors: Bisschops R,Bessissow T,Joseph JA,Baert F,Ferrante M,Ballet V,Willekens H,Demedts I,Geboes K,De Hertogh G,Vermeire S,Rutgeerts P,Van Assche G

    更新日期:2018-06-01 00:00:00

  • Structural and functional changes of the duodenum in human norovirus infection.

    abstract:BACKGROUND:Norovirus infection is the most frequent cause of infectious diarrhoea in the western world. This study aimed to characterise functionally and histomorphologically the diseased duodenum in human biopsies. METHODS:Norovirus infection was diagnosed by the Kaplan criteria and confirmed by PCR of stool samples....

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2008.160150

    authors: Troeger H,Loddenkemper C,Schneider T,Schreier E,Epple HJ,Zeitz M,Fromm M,Schulzke JD

    更新日期:2009-08-01 00:00:00

  • Twenty four hour manometric recording of colonic motor activity in healthy man.

    abstract::The motor activity of the transverse, descending, and sigmoid colon was recorded for 24 hours in 14 healthy volunteers with a colonoscope positioned catheter. During the study the patients ate two 1000 kcal mixed meals and one continental breakfast. Colonic motor activity was low before meals and minimal during sleep;...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.28.1.17

    authors: Narducci F,Bassotti G,Gaburri M,Morelli A

    更新日期:1987-01-01 00:00:00

  • Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind, randomised trial.

    abstract:OBJECTIVE:Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have a considerable risk of recurrent ulcer complications. We hypothesised that a proton pump inhibitor (lansoprazole) is superior to a histamine 2 receptor antagonist (famotidine) for the prevention of recurrent ulcer bleeding...

    journal_title:Gut

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/gutjnl-2019-318715

    authors: Wong GLH,Lau LHS,Ching JYL,Tse YK,Ling RHY,Wong VWS,Chiu PWY,Lau JYW,Chan FKL

    更新日期:2020-04-01 00:00:00

  • Bowel diversion should be used with caution in stenosing anal Crohn's disease.

    abstract::Proximal diversion has commonly been used for severe perianal Crohn's disease in an attempt to relieve local symptoms, whether the primary intestinal disease is in the colon or small bowel. Two patients are presented in whom diversion led to severe symptomatic disease in the previously normal defunctioned bowel. In ea...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.35.8.1139

    authors: Williamson ME,Hughes LE

    更新日期:1994-08-01 00:00:00

  • Highly bioavailable silibinin nanoparticles inhibit HCV infection.

    abstract:OBJECTIVE:Silibinin is a flavonolignan that is well established for its robust antiviral activity against HCV infection and has undergone several clinical trials for the management of hepatitis C. Despite its potency, silibinin suffers from poor solubility and bioavailability, restricting its clinical use. To overcome ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2016-312019

    authors: Liu CH,Lin CC,Hsu WC,Chung CY,Lin CC,Jassey A,Chang SP,Tai CJ,Tai CJ,Shields J,Richardson CD,Yen MH,Tyrrell DLJ,Lin LT

    更新日期:2017-10-01 00:00:00

  • Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity.

    abstract:BACKGROUND AND AIMS:The gastrointestinal microflora exerts a barrier effect against enteropathogens. The aim of this study was to examine if bifidobacteria, a major species of the human colonic microflora, participates in the barrier effect by developing antimicrobial activity against enterovirulent bacteria. METHODS:...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.47.5.646

    authors: Liévin V,Peiffer I,Hudault S,Rochat F,Brassart D,Neeser JR,Servin AL

    更新日期:2000-11-01 00:00:00

  • Molecular testing for antibiotic resistance in Helicobacter pylori.

    abstract::An estimated 7.5 million individuals in England and Wales are actively infected with Helicobacter pylori and hence knowledge of local resistance rates is of growing importance. Also, information on strain resistance following treatment failure is crucial in selecting an appropriate regimen as the development of bacter...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.50.3.285

    authors: Owen RJ

    更新日期:2002-03-01 00:00:00

  • Camostate (FOY-305) improves the therapeutic effect of peritoneal lavage on taurocholate induced pancreatitis.

    abstract::The effect of peritoneal lavage with the addition of camostate to the lavage fluid on the outcome of taurocholate pancreatitis in rats was studied. Camostate is a low molecular weight protease inhibitor which has been developed recently. Peritoneal lavage was performed for 12 hours and camostate was added to the lavag...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.8.934

    authors: Leonhardt U,Seidensticker F,Fussek M,Stöckmann F,Creutzfeldt W

    更新日期:1990-08-01 00:00:00

  • Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1.

    abstract:OBJECTIVE:Many patients with irritable bowel syndrome IBS not only have abdominal pain but also may suffer from visceral hypersensitivity and heighted visceral nociception. Moreover, IBS has few effective therapeutic agents and mechanisms of disease are unclear. Our goals were to (i) identify microRNA (miRNA) expressio...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2013-306464

    authors: Zhou Q,Yang L,Larson S,Basra S,Merwat S,Tan A,Croce C,Verne GN

    更新日期:2016-05-01 00:00:00

  • (2'-5') oligo adenylate synthetase activity in leucocytes of patients with inflammatory bowel disease.

    abstract::The activity of an interferon induced enzyme, (2',5') oligo adenylate synthetase, was determined in peripheral blood mononuclear cells and granulocytes of patients with inflammatory bowel disease and compared with its activity in cells isolated from normal subjects. In spite of the fact that circulating interferon is ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.26.6.556

    authors: Stalnikowicz R,Goder K,Karmeli F,Fiocchi C,Rachmilewitz D

    更新日期:1985-06-01 00:00:00