Modulation of human upper intestinal nutrient transit by a beta adrenoreceptor mediated pathway.

abstract：BACKGROUND:Hereditary forms of chronic idiopathic intestinal pseudo-obstruction (CIIP) are well described but the aetiology of most cases of sporadic CIIP is unknown. AIM:To determines whether herpes viruses can persist in the gastrointestinal tract, thereby implicating them in the pathogenesis of CIIP. METHODS:Twent...

journal_title：Gut

authors： Debinski HS,Kamm MA,Talbot IC,Khan G,Kangro HO,Jeffries DJ

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, may play a critical role in many chronic pain conditions. The possible involvement of BDNF in the altered gut sensation in patients with irritable bowel syndrome (IBS) was investigated in the present study. METHODS:Rectosigmoid bi...

journal_title：Gut

authors： Yu YB,Zuo XL,Zhao QJ,Chen FX,Yang J,Dong YY,Wang P,Li YQ

更新日期：2012-05-01 00:00:00

abstract：:The effect of 28 days' continuous administration of oral indomethacin on gastroduodenal morphology, gastric mucosal blood flow, and gastric mucosal prostaglandin E2 (PGE2) metabolism in man was studied to define further the mechanisms of mucosal injury induced by indomethacin. Indomethacin caused acute gastroduodenal ...

journal_title：Gut

authors： Shorrock CJ,Rees WD

更新日期：1992-02-01 00:00:00

abstract：:In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within ...

journal_title：Gut

authors： Gebbers JO,Ferguson DJ,Mason C,Kelly P,Jewell DP

更新日期：1987-05-01 00:00:00

abstract：:A 60 year old man developed steatorrhoea, weight loss, mild diabetes mellitus, labile hypertension and limb cramps. Raised plasma concentrations of catecholamines, particularly noradrenaline and a computed tomography-scan showing an adrenal tumour strongly suggested a pheochromocytoma. Adrenoreceptor blockade reversed...

journal_title：Gut

authors： Thesleff P,Benoni C,Mårtensson H,Nilsson A,Sundler F,Akesson B

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:The natural course of chronic hepatitis C varies widely. To improve the profiling of patients at risk of developing advanced liver disease, we assessed the relative contribution of factors for liver fibrosis progression in hepatitis C. DESIGN:We analysed 1461 patients with chronic hepatitis C with an estimat...

journal_title：Gut

authors： Rüeger S,Bochud PY,Dufour JF,Müllhaupt B,Semela D,Heim MH,Moradpour D,Cerny A,Malinverni R,Booth DR,Suppiah V,George J,Argiro L,Halfon P,Bourlière M,Talal AH,Jacobson IM,Patin E,Nalpas B,Poynard T,Pol S,Abel L,

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The choice of colorectal surgery in patients with familial adenomatous polyposis lies between the morbidity of proctocolectomy and ileum-pouch-anal anastomosis (IPAA) and the mortality from rectal cancer after total colectomy and ileorectal anastomosis (IRA). The aims of the present study were: (1) ...

journal_title：Gut

authors： Vasen HF,van Duijvendijk P,Buskens E,Bülow C,Björk J,Järvinen HJ,Bülow S

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Motor disturbances are sometimes associated with diarrhoea by unknown mechanisms. AIM:To determine if there is a quantitative link between intestinal motility and epithelial secretion. SUBJECTS:Experiments were performed in 21 healthy volunteers and three patients with villus atrophy. METHODS:Duodenal and...

journal_title：Gut

authors： Mellander A,Järbur K,Sjövall H

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND/AIMS:By contrast with animal models, in most cases it is not possible to examine the systemic response in patients in the first hours after onset of acute pancreatitis. The aim was to determine whether endoscopic retrograde cholangiopancreaticography (ERP)-induced pancreatitis can be used as a human model fo...

journal_title：Gut

authors： Messmann H,Vogt W,Holstege A,Lock G,Heinisch A,von Fürstenberg A,Leser HG,Zirngibl H,Schölmerich J

更新日期：1997-01-01 00:00:00

abstract：:This paper describes the construction and use of "radio pills" which transmit changes in intraluminar pressure. ...

journal_title：Gut

authors： CONNELL AM,ROWLANDS EN

更新日期：1960-09-01 00:00:00

abstract：OBJECTIVE:Tissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in stem cell activity in rapidly proliferating isthmus stem cells in the stomach corpus. DESIGN:We uncovered the specific expression of Iqgap3 in proliferating isthm...

journal_title：Gut

authors： Matsuo J,Douchi D,Myint K,Mon NN,Yamamura A,Kohu K,Heng DL,Chen S,Mawan NA,Nuttonmanit N,Li Y,Srivastava S,Ho SWT,Lee NYS,Lee HK,Adachi M,Tamura A,Chen J,Yang H,Teh M,So JB,Yong WP,Tan P,Yeoh KG,Chuang LSH

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:Concordance rates in siblings and twins provide strong evidence that genetic susceptibility is important in the pathogenesis of inflammatory bowel disease. The number and identity of susceptibility genes is largely uncertain. Cytokine genes are attractive candidate loci. AIMS:To study allelic frequencies of...

journal_title：Gut

authors： Louis E,Satsangi J,Roussomoustakaki M,Parkes M,Fanning G,Welsh K,Jewell D

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Ethanol undergoes a first pass metabolism (FPM) in the stomach and liver. Gastric FPM of ethanol primarily depends on the activity of gastric alcohol dehydrogenase (ADH). In addition, the speed of gastric emptying (GE) may modulate both gastric and hepatic FPM of ethanol. AIMS:To study the effect of modulat...

journal_title：Gut

authors： Oneta CM,Simanowski UA,Martinez M,Allali-Hassani A,Parés X,Homann N,Conradt C,Waldherr R,Fiehn W,Coutelle C,Seitz HK

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:Guidelines mandate expert pathology review of Barrett's oesophagus (BO) biopsies that reveal dysplasia, but there are no evidence-based standards to corroborate expert reviewer status. We investigated BO concordance rates and pathologist features predictive of diagnostic discordance. DESIGN:Pathologists (n=5...

journal_title：Gut

authors： van der Wel MJ,Coleman HG,Bergman JJGHM,Jansen M,Meijer SL,BOLERO working group.

更新日期：2020-05-01 00:00:00

abstract：:Calcium palmitate occurred in 20% of the gallstones studied in this laboratory by x-ray diffraction and was the most important crystalline constituent after the different forms of cholesterol and calcium carbonate. Only one calculus contained alpha-palmitic acid. The gallstones came from America, England, Australia, S...

journal_title：Gut

authors： Sutor DJ

更新日期：1970-07-01 00:00:00

abstract：:Extracorporeal shock wave lithotripsy of pancreatic duct stones (largest stone 12 (SD) 6 mm) was performed in 24 patients with abdominal pain and a dilated duct system (main pancreatic duct 10 (3) mm). The procedure was well tolerated in all but two patients, who had a mild pancreatitic attack immediately after lithot...

journal_title：Gut

authors： Sauerbruch T,Holl J,Sackmann M,Paumgartner G

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:To investigate the potential tumour suppressor functions of glutathione peroxidase 7 (GPX7) and examine the interplay between epigenetic and genetic events in regulating its expression in oesophageal adenocarcinomas (OAC). DESIGN:In vitro and in vivo cell models were developed to investigate the biological a...

journal_title：Gut

authors： Peng D,Hu T,Soutto M,Belkhiri A,Zaika A,El-Rifai W

更新日期：2014-04-01 00:00:00

abstract：:An intensive histological search for Helicobacter pylori in gastric biopsy specimens has led to the detection of other spiral shaped bacteria in the human gastric mucosa. The clinical and morphological findings of 39 cases (0.25% of all gastric biopsies performed in the observation period) are reported for 34 patients...

journal_title：Gut

authors： Heilmann KL,Borchard F

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVE:To develop an affordable and robust pipeline for selection of patient-specific somatic structural variants (SSVs) being informative about radicality of the primary resection, response to adjuvant therapy, incipient recurrence and response to treatment performed in relation to diagnosis of recurrence. DESIGN:...

journal_title：Gut

authors： Reinert T,Schøler LV,Thomsen R,Tobiasen H,Vang S,Nordentoft I,Lamy P,Kannerup AS,Mortensen FV,Stribolt K,Hamilton-Dutoit S,Nielsen HJ,Laurberg S,Pallisgaard N,Pedersen JS,Ørntoft TF,Andersen CL

更新日期：2016-04-01 00:00:00

abstract：:Clinical data and histology from the oesophagus, gastric antrum, and duodenum were collected from 36 patients undergoing surgery for duodenal ulcer. Gastritis was present in 94% of the patients (25% of atrophic type), oesophagitis in 72% and duodenitis in 39%. Abnormal biopsies were present from all three sites in 33%...

journal_title：Gut

authors： Earlam RJ,Amerigo J,Kakavoulis T,Pollock DJ

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Colorectal carcinoids are often described as low-grade malignant. However, no study has compared the survival between patients with colorectal carcinoids and those with carcinomas, in a large series. In addition, no global consensus has been established on the crucial determinants of metastasis in colorectal...

journal_title：Gut

authors： Konishi T,Watanabe T,Kishimoto J,Kotake K,Muto T,Nagawa H,Japanese Society for Cancer of the Colon and Rectum.

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is k...

journal_title：Gut

authors： Berrebi D,Maudinas R,Hugot JP,Chamaillard M,Chareyre F,De Lagausie P,Yang C,Desreumaux P,Giovannini M,Cézard JP,Zouali H,Emilie D,Peuchmaur M

更新日期：2003-06-01 00:00:00

abstract：:Much research in the pathophysiology of gall stones has been devoted to various molecular species of bile salts. Recent findings have shown the importance of phospholipids in biliary pathophysiology. In the present study the addition of increasing doses of egg lecithin to human and model biles progressively prolonged ...

journal_title：Gut

authors： Halpern Z,Moshkowitz M,Laufer H,Peled Y,Gilat T

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVES:Many patients with Crohn's disease (CD) have low bone mineral density (BMD) that may not be solely attributable to glucocorticoid use. We hypothesised that low BMD in patients with CD is associated with elevated circulating levels of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D). We fu...

journal_title：Gut

authors： Abreu MT,Kantorovich V,Vasiliauskas EA,Gruntmanis U,Matuk R,Daigle K,Chen S,Zehnder D,Lin YC,Yang H,Hewison M,Adams JS

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Although evidence points to a role for histamine and serotonin in visceral hypersensitivity, activation of calcium channels such as transient receptor potential vanilloid 4 (TRPV4) also causes visceral hypersensitivity. We hypothesised that TRPV4 is important for the generation of hypersensitivity, mediating...

journal_title：Gut

authors： Cenac N,Altier C,Motta JP,d'Aldebert E,Galeano S,Zamponi GW,Vergnolle N

更新日期：2010-04-01 00:00:00

abstract：:The eosinophil population is increased in the jejunal mucosa of patients with coeliac disease. Eosinophils may participate in the mucosal damage by releasing their granule components that have cytotoxic properties such as eosinophil cationic protein (ECP) and major basic protein (MBP). This study aimed to assess the p...

journal_title：Gut

authors： Colombel JF,Torpier G,Janin A,Klein O,Cortot A,Capron M

更新日期：1992-09-01 00:00:00

abstract：:We report two patients with periampullary cysts associated with recurrent attacks of acute pancreatitis. In both patients the diagnosis was made preoperatively by upper gastrointestinal endoscopy and ERCP, which was also useful in determining the relationship of the cysts to the biliary and pancreatic ductal systems. ...

journal_title：Gut

authors： Kalvaria I,Bornman PC,Girdwood AH,Marks IN

更新日期：1987-03-01 00:00:00

abstract：:Oral treatment with chenodeoxycholic acid causes dissolution of cholesterol gallstones in man. In order to determine the mechanism of this effect, we have measured 24-hour biliary lipid output, lipid composition of fasting gallbladder bile, and bile acid pool sizes before and during such treatment in six patients with...

journal_title：Gut

authors： Northfield TC,LaRusso NF,Hofmann AF,Thistle JL

更新日期：1975-01-01 00:00:00

abstract：:Although the development of endoscopic methods of treatment for biliary obstruction has proceeded rapidly in recent years, endoscopic retrograde cholangiopancreatographic (ERCP) services are patchily distributed. A recent survey by the British Society of Gastroenterology has shown that almost half the district general...

journal_title：Gut

authors： Gear MW,Dent NA,Colin-Jones DG,Lennard-Jones JH,Colley JR

更新日期：1990-10-01 00:00:00

abstract：:A 69 year old woman developed chronic diarrhoea while being treated with ranitidine. Sigmoidoscopy was performed after six weeks and showed typical histological features of lymphocytic colitis. Ranitidine was withdrawn and the diarrhoea resolved. Eight months later, a 72 hour oral rechallenge period of ranitidine, was...

journal_title：Gut

authors： Beaugerie L,Patey N,Brousse N

更新日期：1995-11-01 00:00:00