Prognosis and risk factors of metastasis in colorectal carcinoids: results of a nationwide registry over 15 years.

abstract：:The informational aspects of nucleic acid synthesis have attracted much more attention than the quantitative significance of DNA, rRNA, tRNA, and nucleotide synthesis. Animal and human studies suggest that in energetic terms, 5-10% of the energy used in synthesising tissue protein is expended in manufacturing an appro...

journal_title：Gut

authors： Grimble GK

更新日期：1994-01-01 00:00:00

abstract：:Introduction of a radioactive gastrointestinal marker (51CrCl3) into a combined study (75SeHCAT + 58CoB12) of ileal function by whole body counting has been undertaken. The technique was assessed in 23 subjects (15 patients with inflammatory bowel disease, six on non-steroidal anti-inflammatory drugs for rheumatoid ar...

journal_title：Gut

authors： Smith T,Bjarnason I

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:TFF1 is a 6.5 kDa secreted protein that is expressed predominantly in normal gastric mucosa. It is coexpressed with mucins and it can form dimers via a free carboxy terminal cysteine residue. AIMS:To investigate the molecular forms of TFF1 that are present in normal human stomach and the association of the ...

journal_title：Gut

authors： Newton JL,Allen A,Westley BR,May FE

更新日期：2000-03-01 00:00:00

abstract：:An elderly woman with chronic ulcerative colitis who developed proximal muscle weakness, increased serum creatine phosphokinase activity, and histological and electromyographic abnormalities characteristic of polymyositis is described. Treatment with corticosteroids and 5-acetylsalicylic acid was followed by a remissi...

journal_title：Gut

authors： Chugh S,Dilawari JB,Sawhney IM,Dang N,Radotra BD,Chawla YK

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:Using genome-wide promoter methylation assay, B cell CLL/lymphoma 6 member B (BCL6B) was found to be preferentially methylated in cancer. A study was undertaken to examine the epigenetic regulation, biological function and clinical significance of BCL6B in gastric cancer (GC). METHODS:BCL6B promoter methylat...

journal_title：Gut

authors： Xu L,Li X,Chu ES,Zhao G,Go MY,Tao Q,Jin H,Zeng Z,Sung JJ,Yu J

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Familial adenomatous polyposis (FAP) is a clinically well defined hereditary disease caused by germline mutations within the adenomatous polyposis coli (APC) gene. Although several techniques are applied in the mutation analysis of FAP kindreds about 20-50% of cases remain unclear, with no APC mutation ident...

journal_title：Gut

authors： Heinimann K,Müllhaupt B,Weber W,Attenhofer M,Scott RJ,Fried M,Martinoli S,Müller H,Dobbie Z

更新日期：1998-11-01 00:00:00

abstract：:The leakiness of the cell membranes of colonic epithelial cells isolated by the collagenase/Dispase technique from normal or diseased colons was assessed in a 4 h 51Cr release assay. Cells from normal, adenoma bearing or cancer bearing colons showed 51Cr release of 8% or less in almost all of 46 cell populations teste...

journal_title：Gut

authors： Gibson PR,van de Pol E,Barratt PJ,Doe WF

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immun...

journal_title：Gut

authors： Zhao Y,Shuen TWH,Toh TB,Chan XY,Liu M,Tan SY,Fan Y,Yang H,Lyer SG,Bonney GK,Loh E,Chang KTE,Tan TC,Zhai W,Chan JKY,Chow EK,Chee CE,Lee GH,Dan YY,Chow PK,Toh HC,Lim SG,Chen Q

更新日期：2018-10-01 00:00:00

abstract：:Patients with chronic active hepatitis or alcoholic cirrhosis have serum antibodies to many more serotypes of Escherichia coli than do patients with primary biliary cirrhosis or cryptogenic cirrhosis, or normal controls. They also have antibodies against more serotypes than cirrhotic patients with a portacaval shunt. ...

journal_title：Gut

authors： Simjee AE,Hamilton-Miller JM,Thomas HC,Brumfitt W,Sherlock S

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is associated with a marked infiltration of the gastric epithelium by neutrophils, macrophages, lymphocytes, and plasma cells. Despite the presence of phagocytes in close vicinty to H pylori microbes a great number of people are unable to eradicate bacteria. AIMS:To investigate...

journal_title：Gut

authors： Chmiela M,Czkwianianc E,Wadstrom T,Rudnicka W

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Major histocompatibility complex class II deficient (Aalpha0/0) mice have decreased CD4+ T cells, making them immunologically similar to patients with acquired immunodeficiency syndrome (AIDS). Both patients with AIDS and Aalpha0/0 mice have hypertrophic gastric folds. To clarify the mechanism of ga...

journal_title：Gut

authors： Fukui T,Nishio A,Okazaki K,Uza N,Ueno S,Kido M,Inoue S,Kitamura H,Kiriya K,Ohashi S,Asada M,Tamaki H,Matsuura M,Kawasaki K,Suzuki K,Uchida K,Fukui H,Nakase H,Watanabe N,Chiba T

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND AIM:Accumulation and infiltration by neutrophil granulocytes is a prominent feature in the local inflammatory process in ulcerative colitis (UC). The present study was performed to evaluate human neutrophil lipocalin (HNL) as a specific neutrophil marker in the inflamed lesions of the colon and rectum in...

journal_title：Gut

authors： Carlson M,Raab Y,Sevéus L,Xu S,Hällgren R,Venge P

更新日期：2002-04-01 00:00:00

abstract：:Recent reports have indicated a possible role for 111Indium leucocyte scintigraphy in the management of patients with acute inflammatory bowel disease. Our experience with this technique in 15 patients (nine with ulcerative colitis, six with Crohn's disease) is described. Perfect agreement was not obtained between sci...

journal_title：Gut

authors： Buxton-Thomas MS,Dickinson RJ,Maltby P,Hunter JO,Wraight EP

更新日期：1984-12-01 00:00:00

abstract：:Endoscopic sphincterotomy has become the first line treatment for patients with common bile duct (CBD) stones. This technique may fail, however, due to difficult anatomy, previous surgery, periampullary diverticula or the presence of a large stone. The importance of stone size to the success of endoscopic sphincteroto...

journal_title：Gut

authors： Lauri A,Horton RC,Davidson BR,Burroughs AK,Dooley JS

更新日期：1993-12-01 00:00:00

abstract：:The effects of low power (1-2 Watts), long exposure (30-400 seconds), interstitial Nd YAG laser therapy on dimethylhydrazine induced rat colonic neoplasms and normal rat colon have been studied. After a single exposure with appropriate laser parameters, dimethylhydrazine induced rat colonic neoplasms underwent coagula...

journal_title：Gut

authors： Matthewson K,Barton T,Lewin MR,O'Sullivan JP,Northfield TC,Bown SG

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:Roux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations. DESIGN:We used functional MRI, ea...

journal_title：Gut

authors： Scholtz S,Miras AD,Chhina N,Prechtl CG,Sleeth ML,Daud NM,Ismail NA,Durighel G,Ahmed AR,Olbers T,Vincent RP,Alaghband-Zadeh J,Ghatei MA,Waldman AD,Frost GS,Bell JD,le Roux CW,Goldstone AP

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:Cryptogenic multifocal ulcerating stenosing enteritis (CMUSE) is an extremely rare, but devastating, disease of unknown aetiology. We investigated the genetic basis of this autosomal recessive condition in a pair of affected siblings who have 40-year histories of catastrophic gastrointestinal and extraintesti...

journal_title：Gut

authors： Brooke MA,Longhurst HJ,Plagnol V,Kirkby NS,Mitchell JA,Rüschendorf F,Warner TD,Kelsell DP,MacDonald TT

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of this study was to unravel the mechanisms responsible for the increased risk of gall stone disease in hypertriglyceridaemia (HTG) and to compare the effects of triglyceride lowering therapy by bezafibrate and fish oil on determinants of cholelithiasis (biliary lipid composition and gall bla...

journal_title：Gut

authors： Jonkers IJ,Smelt AH,Ledeboer M,Hollum ME,Biemond I,Kuipers F,Stellaard F,Boverhof R,Meinders AE,Lamers CH,Masclee AA

更新日期：2003-01-01 00:00:00

abstract：:Electrogenic (Cl-) secretion was measured as the short circuit current (Isc, microA/cm2) across muscle-stripped sheets of jejunum and ileum incubated in vitro after removal from fed rats, rats starved for three days, and chronically undernourished rats (50% of fed control intake for 21 days). Concentration and Isc res...

journal_title：Gut

authors： Nzegwu HC,Levin RJ

更新日期：1994-09-01 00:00:00

abstract：:The distribution of the endoplasmic reticulum in human hepatocytes is defined in quantitative terms using the techniques of morphometry. The subjects of the study are liver biopsies from normal, untreated subjects and patients being treated with various drugs. In contrast to rat hepatocytes, the amount of smooth endop...

journal_title：Gut

authors： Jézéquel AM,Koch M,Orlandi F

更新日期：1974-09-01 00:00:00

abstract：:The prevalence of deoxyribonucleic acid (DNA) aneuploidy in 297 samples from 38 patients with ulcerative colitis of varying duration was investigated by flow cytometry. In 12 patients colitis was complicated by the development of colorectal carcinoma: one had three synchronous carcinomas. Only four of 14 carcinomas we...

journal_title：Gut

authors： Fozard JB,Quirke P,Dixon MF,Giles GR,Bird CC

更新日期：1986-12-01 00:00:00

abstract：OBJECTIVE:Gastric cancer is the third leading cause of cancer death worldwide and infection by Helicobacter pylori is the strongest risk factor. We have reported increased epidermal growth factor receptor (EGFR) phosphorylation in the H. pylori-induced human carcinogenesis cascade, and association with DNA damage. Our ...

journal_title：Gut

authors： Sierra JC,Asim M,Verriere TG,Piazuelo MB,Suarez G,Romero-Gallo J,Delgado AG,Wroblewski LE,Barry DP,Peek RM Jr,Gobert AP,Wilson KT

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Despite intent to cure surgery with negative resection margins, locoregional recurrence is common in pancreatic cancer. AIMS:To determine whether detection of K-ras gene mutation in the histologically negative surgical margins of pancreatic cancer reflects unrecognised disease. PATIENTS:Seventy patients wh...

journal_title：Gut

authors： Kim J,Reber HA,Dry SM,Elashoff D,Chen SL,Umetani N,Kitago M,Hines OJ,Kazanjian KK,Hiramatsu S,Bilchik AJ,Yong S,Shoup M,Hoon DS

更新日期：2006-11-01 00:00:00

abstract：:Lymphangiomas are rare tumours of lymphatic vessels, most commonly found in children. We present the unusual case of small bowel obstruction caused by benign lymphangioma in a middle aged woman. ...

journal_title：Gut

authors： Campbell WJ,Irwin ST,Biggart JD

更新日期：1991-12-01 00:00:00

abstract：OBJECTIVE:Tissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in stem cell activity in rapidly proliferating isthmus stem cells in the stomach corpus. DESIGN:We uncovered the specific expression of Iqgap3 in proliferating isthm...

journal_title：Gut

authors： Matsuo J,Douchi D,Myint K,Mon NN,Yamamura A,Kohu K,Heng DL,Chen S,Mawan NA,Nuttonmanit N,Li Y,Srivastava S,Ho SWT,Lee NYS,Lee HK,Adachi M,Tamura A,Chen J,Yang H,Teh M,So JB,Yong WP,Tan P,Yeoh KG,Chuang LSH

更新日期：2020-12-08 00:00:00

abstract：OBJECTIVES:Endothelial progenitor cells (EPCs) circulate with increased numbers in the peripheral blood of patients with highly-vascularised hepatocellular carcinoma (HCC) and contribute to angiogenesis and neovascularisation. We hypothesised that angiogenic EPCs, that is, colony forming unit-endothelial cells (CFU-ECs...

journal_title：Gut

authors： Shih YT,Wang MC,Zhou J,Peng HH,Lee DY,Chiu JJ

更新日期：2015-07-01 00:00:00

abstract：:Six jaundiced patients with primary sclerosing cholangitis and a dominant biliary stricture were managed by endoscopic placement of endoprostheses. Five showed considerable improvement within weeks of stenting: their serum bilirubin concentration fell from mean (range) 266 mumol/l (63-681) to 65 mumol/l (10-280) after...

journal_title：Gut

authors： Lombard M,Farrant M,Karani J,Westaby D,Williams R

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Watery stools are equated with rapid and hard stools with slow intestinal transit; however, the relation between stool form and transit through specific regions of the gut is not clear cut. In addition, more information is needed on interindividual variability of these measurements. AIM:To examine the relat...

journal_title：Gut

authors： Degen LP,Phillips SF

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin. DESIGN:In this Phase 2b double-blind, placebo-controlled study, treatment-naive adults with HCV genotype 1 (N=365) or 4 (N=30) infection were randomly assig...

journal_title：Gut

authors： Hézode C,Hirschfield GM,Ghesquiere W,Sievert W,Rodriguez-Torres M,Shafran SD,Thuluvath PJ,Tatum HA,Waked I,Esmat G,Lawitz EJ,Rustgi VK,Pol S,Weis N,Pockros PJ,Bourlière M,Serfaty L,Vierling JM,Fried MW,Weiland O,B

更新日期：2015-06-01 00:00:00

abstract：:The response of lymphocytes from peripheral blood and mesenteric lymph nodes to stimulation with phytohaemagglutinin in vitro has been studied in eight patients suffering from active Crohn's disease. Patients with Crohn's disease exhibited reduced responses when compared with similar studies performed in control subje...

journal_title：Gut

authors： Guillou PJ,Brennan TG,Giles GR

更新日期：1973-01-01 00:00:00