Role of Helicobacter pylori surface structures in bacterial interaction with macrophages.

Abstract:

BACKGROUND:Helicobacter pylori infection is associated with a marked infiltration of the gastric epithelium by neutrophils, macrophages, lymphocytes, and plasma cells. Despite the presence of phagocytes in close vicinty to H pylori microbes a great number of people are unable to eradicate bacteria. AIMS:To investigate the involvement of multiple bacterial 'adhesins' and some phagocytic receptors in the process of the ingestion of H pylori by macrophages. BACTERIA: H pylori strains differing in the expression of sialic acid dependent (sHA) or sialic acid independent (HA) haemagglutinin and heparan sulphate binding were selected for the study. METHODS:The uptake of fluorescein labelled H pylori bacteria by a homogenous macrophage cell line J 774A.1 was estimated in a quantitative fluorometric assay. RESULTS:The ingestion of H pylori 17874 and 25 strains expressing sHA was inhibited by the pretreatment of the bacteria with anti-sHA antibodies or fetuin as well as by treatment of the macrophages with neuraminidase. In contrast the uptake of H pylori 17875 strain expressing HA remained unchanged. The phagocytosis of all investigated bacteria was inhibited after the treatment with heparin, hyaluronic acid or vitronectin with fresh but not heat inactivated serum. CONCLUSIONS:The results suggest that H pylori surface compounds binding host proteins such as fetuin, heparin/haparan sulphate, hyaluronic acid, and vitronectin in the presence of complement, could allow the bacteria to avoid phagocytosis.

journal_name

Gut

journal_title

Gut

authors

Chmiela M,Czkwianianc E,Wadstrom T,Rudnicka W

doi

10.1136/gut.40.1.20

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

20-4

issue

1

eissn

0017-5749

issn

1468-3288

journal_volume

40

pub_type

杂志文章

相关文献

GUT文献大全
  • Oestrus and gasric secretion in the dog.

    abstract::Marked decreases in 24-hour Heidenhain pouch secretion, lasting from nine to 18 days, were observed in five mongrel bitches during periods of naturally occurring oestrus. Neither oophorectomy nor control celiotomy caused significant change in Heidenhain pouch secretion in bitches who were not experiencing oestrus. The...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.11.10.855

    authors: Landor JH,Wild RA

    更新日期:1970-10-01 00:00:00

  • Twenty four hour manometric recording of colonic motor activity in healthy man.

    abstract::The motor activity of the transverse, descending, and sigmoid colon was recorded for 24 hours in 14 healthy volunteers with a colonoscope positioned catheter. During the study the patients ate two 1000 kcal mixed meals and one continental breakfast. Colonic motor activity was low before meals and minimal during sleep;...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.28.1.17

    authors: Narducci F,Bassotti G,Gaburri M,Morelli A

    更新日期:1987-01-01 00:00:00

  • Incidence and management of malignant digestive endocrine tumours in a well defined French population.

    abstract:BACKGROUND AND AIMS:Little is known about the epidemiology of malignant digestive endocrine tumours. The aim of this study was to report on their incidence and management in a well defined population. METHODS:Data were obtained from the population based Digestive Cancer Registry of Burgundy (France) over a 24 year per...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2003.026401

    authors: Lepage C,Bouvier AM,Phelip JM,Hatem C,Vernet C,Faivre J

    更新日期:2004-04-01 00:00:00

  • B-cell clonality and infection with Helicobacter pylori: implications for development of gastric lymphoma.

    abstract:BACKGROUND:Although Helicobacter pylori has been implicated in the pathogenesis of gastric mucosa associated lymphoid tissue (MALT) and MALT lymphoma, it is not known how it may trigger these lesions and whether there is an identifiable pre-neoplastic stage. AIMS:To investigate the relation between MALT, H pylori infe...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.38.6.837

    authors: Sorrentino D,Ferraccioli GF,DeVita S,Avellini C,Beltrami CA,Labombarda A,Bernardis V,De Biase F,Trevisi A,Pivetta B,Boiocchi M,Bartoli E

    更新日期:1996-06-01 00:00:00

  • Alcohol consumption in patients with colorectal adenomatous polyps.

    abstract::The risk of developing colorectal adenomatous polyps is probably increased by a variety of dietary and environmental factors. We found an association with current alcohol and cigarette consumption. The risk of polyps was increased three times in drinkers who did not smoke and two times in smokers who did not drink, wi...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.32.1.70

    authors: Cope GF,Wyatt JI,Pinder IF,Lee PN,Heatley RV,Kelleher J

    更新日期:1991-01-01 00:00:00

  • Biliary lipid output during three meals and an overnight fast. II. Effect of chenodeoxycholic acid treatment in gallstone subjects.

    abstract::Oral treatment with chenodeoxycholic acid causes dissolution of cholesterol gallstones in man. In order to determine the mechanism of this effect, we have measured 24-hour biliary lipid output, lipid composition of fasting gallbladder bile, and bile acid pool sizes before and during such treatment in six patients with...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.16.1.12

    authors: Northfield TC,LaRusso NF,Hofmann AF,Thistle JL

    更新日期:1975-01-01 00:00:00

  • Serum amylase and serum lipase levels in man after administration of secretin and pancreozymin.

    abstract::A simple evocative test has been used to study pancreatic function. Serial estimations of amylase and lipase in blood serum are made at intervals up to six hours and again at 24 hours after injecting intravenously standard doses of secretin and pancreozymin. The results of 213 tests on a normal group, in pancreatic di...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.1.2.125

    authors: BURTON P,HAMMOND EM,HARPER AA,HOWAT HT,SCOTT JE,VARLEY H

    更新日期:1960-06-01 00:00:00

  • Varicella-zoster virus DNA in the oesophageal myenteric plexus in achalasia.

    abstract::In a search for past or present infection with herpes viruses, serum antibody titres to herpes simplex type 1 virus, cytomegalovirus, and varicella-zoster virus were measured by complement fixation test in 58 patients with achalasia. Serum was also taken from 40 age and sex matched patients without oesophageal symptom...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.34.3.299

    authors: Robertson CS,Martin BA,Atkinson M

    更新日期:1993-03-01 00:00:00

  • Healing of protein losing hypertrophic gastropathy by eradication of Helicobacter pylori--is Helicobacter pylori a pathogenic factor in Ménétrier's disease?

    abstract::Hypertrophic gastropathy--that is, Ménétrier's disease--was found, in a retrospective analysis, to be associated with Helicobacter pylori in more than 90% of patients. It is proposed that hypertrophic gastropathy represents a special form of H pylori gastritis in these patients. A case is described of a 28 year old wo...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.35.5.701

    authors: Bayerdörffer E,Ritter MM,Hatz R,Brooks W,Ruckdeschel G,Stolte M

    更新日期:1994-05-01 00:00:00

  • Mucosal protection against sulphide: importance of the enzyme rhodanese.

    abstract:BACKGROUND:Hydrogen sulphide (H(2)S) is a potent toxin normally present in the colonic lumen which may play a role in ulcerative colitis (UC). Two enzymes, thiol methyltransferase (TMT) and rhodanese (RHOD), are thought to be responsible for sulphide removal but supportive evidence is lacking. AIMS:To determine the di...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.50.2.201

    authors: Picton R,Eggo MC,Merrill GA,Langman MJ,Singh S

    更新日期:2002-02-01 00:00:00

  • Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.

    abstract:PURPOSE:Despite recent advances in colorectal cancer (CRC) treatment, the prognosis of patients suffering from this malignancy still remains substandard, and metastatic recurrence following curative surgery is the leading cause of mortality. Therefore, it is imperative to identify prognostic markers to predict the clin...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-309359

    authors: Okugawa Y,Toiyama Y,Toden S,Mitoma H,Nagasaka T,Tanaka K,Inoue Y,Kusunoki M,Boland CR,Goel A

    更新日期:2017-01-01 00:00:00

  • Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study.

    abstract:BACKGROUND:Wilson's disease is a rare inborn disease related to copper storage, leading to liver cirrhosis and neuropsychological deterioration. Clinical data on larger cohorts are limited owing to low disease frequency. OBJECTIVE AND METHODS:We performed a retrospective analysis of 163 patients with Wilson's disease,...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2005.087262

    authors: Merle U,Schaefer M,Ferenci P,Stremmel W

    更新日期:2007-01-01 00:00:00

  • The histamine H3 receptor agonist N alpha-methylhistamine produced by Helicobacter pylori does not alter somatostatin release from cultured rabbit fundic D-cells.

    abstract:BACKGROUND:The mechanisms underlying the suppression of somatostatin dependent reflexes in Helicobacter pylori infection are not fully determined. The H pylori product N alpha-methylhistamine and inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha) may be responsible for the alterations in somatostat...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.43.2.176

    authors: Beales IL,Calam J

    更新日期:1998-08-01 00:00:00

  • A prospective controlled study comparing brush and bile exfoliative cytology for diagnosing bile duct strictures.

    abstract::Imaging of biliary strictures may suggest malignancy but cytology can provide a tissue diagnosis. The aim of this study is to compare the diagnostic value of brush cytology and bile cytology. Thirty two patients (20 males, 12 females, median age 66 years, range 31-84) with biliary strictures at endoscopic retrograde c...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.33.12.1675

    authors: Kurzawinski T,Deery A,Dooley J,Dick R,Hobbs K,Davidson B

    更新日期:1992-12-01 00:00:00

  • Increased risk and case fatality rate of pyogenic liver abscess in patients with liver cirrhosis: a nationwide study in Denmark.

    abstract:BACKGROUND:Patients with liver cirrhosis are at increased risk of serious bacterial infections carrying a high case fatality rate. Case reports have suggested an association between liver cirrhosis and pyogenic liver abscess. AIMS:To estimate the risk and case fatality rate of pyogenic liver abscess in Danish patients...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.48.2.260

    authors: Mølle I,Thulstrup AM,Vilstrup H,Sørensen HT

    更新日期:2001-02-01 00:00:00

  • Microalbuminuria in inflammatory bowel disease.

    abstract::Microalbuminuria independently predicts the development of nephropathy and increased cardiovascular morbidity and mortality in diabetic patients, but it may be an indicator of the acute phase response. This study examined microalbuminuria as a marker of the acute phase response in patients with inflammatory bowel dise...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.35.11.1599

    authors: Mahmud N,Stinson J,O'Connell MA,Mantle TJ,Keeling PW,Feely J,Weir DG,Kelleher D

    更新日期:1994-11-01 00:00:00

  • Prebiotic inulin-type fructans induce specific changes in the human gut microbiota.

    abstract:OBJECTIVE:Contrary to the long-standing prerequisite of inducing selective (ie, bifidogenic) effects, recent findings suggest that prebiotic interventions lead to ecosystem-wide microbiota shifts. Yet, a comprehensive characterisation of this process is still lacking. Here, we apply 16S rDNA microbiota profiling and ma...

    journal_title:Gut

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/gutjnl-2016-313271

    authors: Vandeputte D,Falony G,Vieira-Silva S,Wang J,Sailer M,Theis S,Verbeke K,Raes J

    更新日期:2017-11-01 00:00:00

  • Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial.

    abstract:OBJECTIVE:Conventional colonoscopy (CC) is considered the reference standard for detection of colorectal neoplasia, but it can still miss a substantial number of adenomas. The use of a transparent plastic cap may improve colonic visualisation. Cap-assisted colonoscopy (CAC) was compared with CC for adenoma detection. S...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/gutjnl-2011-301327

    authors: de Wijkerslooth TR,Stoop EM,Bossuyt PM,Mathus-Vliegen EM,Dees J,Tytgat KM,van Leerdam ME,Fockens P,Kuipers EJ,Dekker E

    更新日期:2012-10-01 00:00:00

  • Studies on breath methane: the effect of ethnic origins and lactulose.

    abstract::The prevalence of methane production in an adult population of 256 subjects was 41%, but it was significantly higher in females (49%), than males (33%). When the population was subdivided into ethnic groups. Caucasians (48%) and Black (45%) had significantly more methane producers than Orientals (24%) and Indians (32%...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.11.951

    authors: Pitt P,de Bruijn KM,Beeching MF,Goldberg E,Blendis LM

    更新日期:1980-11-01 00:00:00

  • Statistical analysis of the lactulose/breath hydrogen test in the measurement of orocaecal transit: its variability and predictive value in assessing drug action.

    abstract::The variability in the orocaecal transit time as measured by the lactulose/breath hydrogen method has been studied for three conditions: lactulose given with a meal, subjects sitting; lactulose given with a meal, subjects semirecumbent; lactulose given in aqueous solution, subjects semirecumbent. Thirty three healthy ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.30.2.171

    authors: Staniforth DH,Rose D

    更新日期:1989-02-01 00:00:00

  • Metagenomics analysis of gut microbiota in response to diet intervention and gestational diabetes in overweight and obese women: a randomised, double-blind, placebo-controlled clinical trial.

    abstract:OBJECTIVE:Gut microbiota and diet are known to contribute to human metabolism. We investigated whether the metagenomic gut microbiota composition and function changes over pregnancy are related to gestational diabetes mellitus (GDM) and can be modified by dietary supplements, fish oil and/or probiotics. DESIGN:The gut...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321643

    authors: Mokkala K,Paulin N,Houttu N,Koivuniemi E,Pellonperä O,Khan S,Pietilä S,Tertti K,Elo LL,Laitinen K

    更新日期:2021-02-01 00:00:00

  • Peptic ulcer bleeding: accessory risk factors and interactions with non-steroidal anti-inflammatory drugs.

    abstract:AIMS:To determine risk factors for peptic ulcer bleeding other than non-steroidal anti-inflammatory drugs (NSAIDs). Methods-Data on possible antecedent risk factors obtained in a large case control study of 1121 patients admitted to hospitals in Glasgow, Newcastle, Nottingham, Oxford, and Portsmouth with bleeding pepti...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究

    doi:10.1136/gut.46.1.27

    authors: Weil J,Langman MJ,Wainwright P,Lawson DH,Rawlins M,Logan RF,Brown TP,Vessey MP,Murphy M,Colin-Jones DG

    更新日期:2000-01-01 00:00:00

  • Can Crohn's disease be diagnosed at laparotomy?

    abstract::The typical macroscopic features of Crohn's disease have been well described and are widely regarded as sufficient to diagnose the disease at laparotomy. We report six patients undergoing laparotomy for symptomatic Crohn's disease, shown radiologically, who were found to have macroscopically normal small bowel despite...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.33.1.140

    authors: Butterworth RJ,Williams GT,Hughes LE

    更新日期:1992-01-01 00:00:00

  • Proliferation cell nuclear antigen (clone 19A2) correlates with 5-bromo-2-deoxyuridine labelling in human colonic epithelium.

    abstract::Measurements of cell proliferation can be used as biomarkers of preneoplastic change. In this study, two immunocytochemical methods that measure different components of the cell cycle were compared to assess cell proliferation on biopsy samples from human colonic mucosa. These methods are based on a monoclonal antibod...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.34.11.1587

    authors: Weisgerber UM,Boeing H,Nemitz R,Raedsch R,Waldherr R

    更新日期:1993-11-01 00:00:00

  • Camostate (FOY-305) improves the therapeutic effect of peritoneal lavage on taurocholate induced pancreatitis.

    abstract::The effect of peritoneal lavage with the addition of camostate to the lavage fluid on the outcome of taurocholate pancreatitis in rats was studied. Camostate is a low molecular weight protease inhibitor which has been developed recently. Peritoneal lavage was performed for 12 hours and camostate was added to the lavag...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.8.934

    authors: Leonhardt U,Seidensticker F,Fussek M,Stöckmann F,Creutzfeldt W

    更新日期:1990-08-01 00:00:00

  • Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon.

    abstract:BACKGROUND:Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is k...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.52.6.840

    authors: Berrebi D,Maudinas R,Hugot JP,Chamaillard M,Chareyre F,De Lagausie P,Yang C,Desreumaux P,Giovannini M,Cézard JP,Zouali H,Emilie D,Peuchmaur M

    更新日期:2003-06-01 00:00:00

  • Gastrin studies in gastric ulcer.

    abstract::Basal serum gastrin in 40 patients with benign gastric ulcer was 103 +/- 10.7 pg/ml, a level significantly higher than corresponding estimations in normal subjects and patients with duodenal ulcer. Following stimulation by a protein meal, a mean rise of 124 pg/ml was achieved at 75 minutes and prior atropinization ind...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.13.3.166

    authors: Korman MG,Soveny C,Hansky J

    更新日期:1972-03-01 00:00:00

  • The relation of sensation in the anal canal to the functional anal sphincter: a possible factor in anal continence.

    abstract::In normal subjects the length of the functional anal sphincter has been compared with the extent of sensation to light touch in the anal canal. At rest, the sphincteric zone was the longer. On distension of the rectum, a decrease in pressure in the anal canal so shortened the functional sphincter that intrarectal pres...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.4.2.179

    authors: Duthie HL,Bennett RC

    更新日期:1963-06-01 00:00:00

  • The effects of corticotrophin and corticoids on secretion from denervated gastric pouches in dogs.

    abstract::The effects of corticotrophin and of cortisone, methyl prednisolone, and of aldosterone on the gastric secretion of dogs have been investigated. Juice was collected from dogs with denervated pouches under basal conditions and when stimulated with meat extract and with histamine. For each secretion the volume, viscosit...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.1.1.36

    authors: CLARKE SD,NEILL DW,WELBOURN RB

    更新日期:1960-03-01 00:00:00

  • Phlegmonous gastritis: an unusual presenting symptom of Sjögren's syndrome.

    abstract::This case report describes the histological and macroscopic changes seen within a few months in the gastric mucosa of a 28 year old woman patient with upper abdominal symptoms. With hindsight these changes were the first signs of Sjögren's syndrome. ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.34.8.1142

    authors: van Leeuwen ML,Tjiong HL,van Blankenstein M,Mulder AH,Bakker CM

    更新日期:1993-08-01 00:00:00