Microalbuminuria in inflammatory bowel disease.


:Microalbuminuria independently predicts the development of nephropathy and increased cardiovascular morbidity and mortality in diabetic patients, but it may be an indicator of the acute phase response. This study examined microalbuminuria as a marker of the acute phase response in patients with inflammatory bowel disease and correlated it with the disease activity in 95 patients with inflammatory bowel disease (ulcerative colitis (n = 52), Crohn's disease (n = 43)) determined by the simple index of Harvey and Bradshaw. Fifty patients were in complete clinical remission and 45 patients had active disease. Microalbuminuria was detected in all patients with inflammatory bowel disease (147 (17) v 18 (2) microgram/min, inflammatory bowel disease v controls mean (SEM), p < 0.007). Patients with active inflammatory bowel disease had higher concentrations of microalbuminuria compared with patients in remission (206 (19) v 65 (8) microgram/min, mean (SEM), p < 0.0001). Eight patients with active inflammatory bowel disease who were sequentially followed up with measurements of microalbuminuria had significantly lower values, when the disease was inactive (active inflammatory bowel disease 192 (44) v inactive inflammatory bowel disease 64 (14) microgram/min, p < 0.03). There was a significant correlation with the simple index of Harvey and Bradshaw (r = 0.818, p < 0.0001). Microalbuminuria values were significantly lower in inflammatory bowel disease patients in remission, maintained with olsalazine compared with those patients maintained with mesalazine and salazopyrine, but no significant difference was seen in values of microalbuminuria in active inflammatory bowel disease patients receiving different salicylates. This study also measured serum amyloid-A as an indicator of the acute phase response in the same patients. Serum amyloid-A was significantly increased in active disease compared with inactive disease (151 (43) v 33 (7) or controls 11 (2) micrograms/ml, p < 0.05). In conclusion microalbuminuria is present in abnormal amounts in all patients with active inflammatory bowel disease, and values fall when the disease is quiescent. Microalbuminuria is probably a consequence of an acute phase response and provides a simple, rapid, and inexpensive test, which has the potential to monitor inflammatory bowel disease activity and response to treatment.






Mahmud N,Stinson J,O'Connell MA,Mantle TJ,Keeling PW,Feely J,Weir DG,Kelleher D




Has Abstract


1994-11-01 00:00:00














  • Evaluation of colonic myoelectrical activity in health and functional disorders.

    abstract::Electrical activity of the colon was investigated in six healthy volunteers and 22 patients presenting functional colonic disorders associated with pain, constipation, or diarrhoea. Myoelectrical activity during 10 hours, including two daily meals, was recorded from eight groups of nickel-chrome electrodes using a 1.5...


    pub_type: 杂志文章


    authors: Bueno L,Fioramonti J,Ruckebusch Y,Frexinos J,Coulom P

    更新日期:1980-06-01 00:00:00

  • Inflammatory gradient in Barrett's oesophagus: implications for disease complications.

    abstract:INTRODUCTION:Barrett's oesophageal epithelium (BE) is clinically important due to the associated inflammatory and malignant complications which are unevenly distributed throughout the BE segment. As the immunoregulatory environment may influence disease manifestations, we analysed the inflammatory and cytokine response...


    pub_type: 杂志文章


    authors: Fitzgerald RC,Abdalla S,Onwuegbusi BA,Sirieix P,Saeed IT,Burnham WR,Farthing MJ

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    pub_type: 杂志文章


    authors: Rinderknecht H,Renner IG,Carmack C

    更新日期:1979-10-01 00:00:00

  • Cystic dystrophy of the gastric and duodenal wall developing in heterotopic pancreas: an unrecognised entity.

    abstract::Ten patients in whom cystic dystrophy developed in a heterotopic pancreas of the duodenal (nine patients) or gastric (one patient) wall are reported. All were young or middle aged white men, only two of whom were alcoholic. The symptoms were caused by intestinal or biliary stenosis, or both, secondary to the inflammat...


    pub_type: 杂志文章


    authors: Fléjou JF,Potet F,Molas G,Bernades P,Amouyal P,Fékété F

    更新日期:1993-03-01 00:00:00

  • Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource.

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    pub_type: 杂志文章


    authors: Stournaras E,Qian W,Pappas A,Hong YY,Shawky R,UK IBD BioResource Investigators.,Raine T,Parkes M,UK IBD Bioresource Investigators.

    更新日期:2020-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Hudson M,Chitolie A,Hutton RA,Smith MS,Pounder RE,Wakefield AJ

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    pub_type: 杂志文章


    authors: Hayat JO,Gabieta-Somnez S,Yazaki E,Kang JY,Woodcock A,Dettmar P,Mabary J,Knowles CH,Sifrim D

    更新日期:2015-03-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: McNamara D,O'Morain C

    更新日期:1999-07-01 00:00:00

  • Coeliac disease in the father affects the newborn.

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    authors: Ludvigsson JF,Ludvigsson J

    更新日期:2001-08-01 00:00:00

  • Asymptomatic primary biliary cirrhosis.

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    pub_type: 杂志文章


    authors: Fox RA,Scheuer PJ,Sherlock S

    更新日期:1973-06-01 00:00:00

  • Faecal immunochemical tests versus guaiac faecal occult blood tests: what clinicians and colorectal cancer screening programme organisers need to know.

    abstract::Although colorectal cancer (CRC) is a common cause of cancer-related death, it is fortunately amenable to screening with faecal tests for occult blood and endoscopic tests. Despite the evidence for the efficacy of guaiac-based faecal occult blood tests (gFOBT), they have not been popular with primary care providers in...


    pub_type: 杂志文章,评审


    authors: Tinmouth J,Lansdorp-Vogelaar I,Allison JE

    更新日期:2015-08-01 00:00:00

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    pub_type: 评论,杂志文章,评审


    authors: Gionchetti P,Lammers KM,Rizzello F,Campieri M

    更新日期:2005-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Monés J,Carrió I,Roca M,Estorch M,Calabuig R,Sainz S,Martinez-Duncker C,Vilardell F

    更新日期:1991-02-01 00:00:00

  • Metagenomics analysis of gut microbiota in response to diet intervention and gestational diabetes in overweight and obese women: a randomised, double-blind, placebo-controlled clinical trial.

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    pub_type: 杂志文章


    authors: Mokkala K,Paulin N,Houttu N,Koivuniemi E,Pellonperä O,Khan S,Pietilä S,Tertti K,Elo LL,Laitinen K

    更新日期:2021-02-01 00:00:00

  • Multiple and recurrent inflammatory fibroid polyps in a Devon family ('Devon polyposis syndrome'): an update.

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    pub_type: 杂志文章


    authors: Allibone RO,Nanson JK,Anthony PP

    更新日期:1992-07-01 00:00:00

  • The gastric response to a transpyloric duodenal tube.

    abstract::The quantification of gastric, pancreatic, biliary, and small bowel functions in man often requires the use of intestinal tubes. In this study, the presence of a transpyloric tube did not alter gastric emptying, acid secretion, or serum gastrin levels in response to an ordinary solid meal. ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Longstreth GF,Malagelada JR,Go VL

    更新日期:1975-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Rumessen JJ,Hamberg O,Gudmand-Høyer E

    更新日期:1990-01-01 00:00:00

  • Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies.

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    pub_type: 杂志文章


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    authors: Pereira AD,Suspiro A,Chaves P,Saraiva A,Glória L,de Almeida JC,Leitão CN,Soares J,Mira FC

    更新日期:1998-05-01 00:00:00

  • Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis?

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    pub_type: 杂志文章


    authors: Teich N,Mössner J,Keim V

    更新日期:1999-03-01 00:00:00

  • Interferon alfa-2b for decompensated liver disease caused by either chronic hepatitis B or C: preliminary results of a pilot study.

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    pub_type: 杂志文章


    authors: Dimopoulou M,Fafoutis K,Basiliou K,Ketikoglou J,Karvountzis G

    更新日期:1993-01-01 00:00:00

  • Delta 4-3-oxosteroid 5 beta-reductase deficiency: failure of ursodeoxycholic acid treatment and response to chenodeoxycholic acid plus cholic acid.

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    authors: Clayton PT,Mills KA,Johnson AW,Barabino A,Marazzi MG

    更新日期:1996-04-01 00:00:00

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    authors: Triger DR,Charlton CA,Ward AM

    更新日期:1982-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Fish SM,Proujansky R,Reenstra WW

    更新日期:1999-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Gear MW,Dent NA,Colin-Jones DG,Lennard-Jones JH,Colley JR

    更新日期:1990-10-01 00:00:00

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    authors: Miquel JF,Moreno M,Amigo L,Molina H,Mardones P,Wistuba II,Rigotti A

    更新日期:2003-07-01 00:00:00

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    pub_type: 杂志文章,多中心研究


    authors: Ling H,Pickard K,Ivan C,Isella C,Ikuo M,Mitter R,Spizzo R,Bullock M,Braicu C,Pileczki V,Vincent K,Pichler M,Stiegelbauer V,Hoefler G,Almeida MI,Hsiao A,Zhang X,Primrose J,Packham G,Liu K,Bojja K,Gafà R,Xiao L

    更新日期:2016-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Hahn U,Schuppan D,Hahn EG,Merker HJ,Riecken EO

    更新日期:1987-01-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


    authors: McNicholl AG,Marin AC,Molina-Infante J,Castro M,Barrio J,Ducons J,Calvet X,de la Coba C,Montoro M,Bory F,Perez-Aisa A,Forné M,Gisbert JP,Participant Centres.

    更新日期:2014-02-01 00:00:00