Estimation of carcinoembryonic antigen in ulcerative colitis with special reference to malignant change.

abstract：OBJECTIVE:Colorectal cancer is the second most common cause of cancer death in Europe and North America. Alarm features are used to prioritize access to urgent investigation, but there is little information concerning their utility in the diagnosis of colorectal cancer. METHODS:A systematic review and meta-analysis of...

journal_title：Gut

authors： Ford AC,Veldhuyzen van Zanten SJ,Rodgers CC,Talley NJ,Vakil NB,Moayyedi P

更新日期：2008-11-01 00:00:00

abstract：:A family is described in which there occurred two cases of the lupoid type of active chronic hepatitis with cirrhosis, one of chronic persistent hepatitis, and one of myasthenia gravis. The two cases of lupoid hepatitis were in the proposita, a schoolgirl aged 16 years, and her great-aunt aged 69 years whom she had ne...

journal_title：Gut

authors： Whittingham S,Mackay IR,Kiss ZS

更新日期：1970-10-01 00:00:00

abstract：:Gastric adaptation was impaired immediately after the performance of complete vagotomy in a series of 20 acute experiments in the dog. Preliminary isolation of the intact vagi in 10 of these animals produced alterations in adaptation similar to those seen after vagal division. It is concluded that alterations in gastr...

journal_title：Gut

authors： Carter DC,Whitfield HN,Macleod IB

更新日期：1972-11-01 00:00:00

abstract：:When there is villus atrophy in a jejunal biopsy, intraepithelial lymphocyte (IEL) mitosis correlates with a diagnosis of coeliac disease. We have examined the significance of IEL mitosis in jejunal biopsies with normal villi. Counts of IEL per 100 villus enterocytes, and IEL mitosis per 1000 IEL, were carried out in ...

journal_title：Gut

authors： Ferguson A,Ziegler K

更新日期：1986-06-01 00:00:00

abstract：:In normal subjects the length of the functional anal sphincter has been compared with the extent of sensation to light touch in the anal canal. At rest, the sphincteric zone was the longer. On distension of the rectum, a decrease in pressure in the anal canal so shortened the functional sphincter that intrarectal pres...

journal_title：Gut

authors： Duthie HL,Bennett RC

更新日期：1963-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a human pathogen responsible for acute and chronic liver disease, infecting an estimated 130-170 million persons worldwide. An intriguing feature of HCV infection is its peculiar relationship with lipids: (1) HCV virions circulate in serum bound to lipoproteins; (2) lipids have been shown to...

journal_title：Gut

authors： Negro F

更新日期：2010-09-01 00:00:00

abstract：:Traditional Chinese herbal remedies are widely available in the United Kingdom for the treatment of chronic skin disorders. Their benefits are considerable, but their use is completely unregulated. Two patients are described here who suffered an acute hepatitic illness related to taking traditional Chinese herbs. Both...

journal_title：Gut

authors： Kane JA,Kane SP,Jain S

更新日期：1995-01-01 00:00:00

abstract：:Evidence is presented of a higher than normal incidence both of clinical coeliac disease and of small-intestinal mucosal abnormalities in relatives of children with coeliac disease. In such relatives the incidence of mucosal abnormality may differ from the incidence of clinical coeliac disease. The data show an absenc...

journal_title：Gut

authors： Robinson DC,Watson AJ,Wyatt EH,Marks JM,Roberts DF

更新日期：1971-10-01 00:00:00

abstract：:The investigation and treatment of 131 patients with 'obscure' gastrointestinal bleeding has been reviewed. One hundred and six patients were assessed electively for recurrent haemorrhage, 25 presented as emergencies. The major presenting feature was melaena (55 patients), anaemia (35), rectal bleeding (34), haemateme...

journal_title：Gut

authors： Thompson JN,Salem RR,Hemingway AP,Rees HC,Hodgson HJ,Wood CB,Allison DJ,Spencer J

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Although polypoid lesions of the gall bladder are frequently observed in asymptomatic subjects, the natural history of these lesions has never been studied using ultrasonography. AIM:The natural history of polypoid lesions of the gall bladder was investigated using ultrasonography. SUBJECTS:Among 4343 pati...

journal_title：Gut

authors： Moriguchi H,Tazawa J,Hayashi Y,Takenawa H,Nakayama E,Marumo F,Sato C

更新日期：1996-12-01 00:00:00

abstract：:Inflammatory fibroid polyps are uncommon but well documented as solitary polyps occurring typically in the stomach or ileum. A Devon family has previously been reported in which a female in three successive generations has presented with multiple polyps requiring repeated surgery over a number of years. A further two ...

journal_title：Gut

authors： Allibone RO,Nanson JK,Anthony PP

更新日期：1992-07-01 00:00:00

abstract：:Increased antibody production and hypergammaglobulinaemia in cirrhosis are probably to a large extent due to decreased hepatic extraction of antigens. The deceased extraction is presumably related to changed microcirculation caused by damaged anatomical structure of the liver. It is therefore to be expected that immun...

journal_title：Gut

authors： Prytz H,Bjorneboe M,Christoffersen P,Poulsen H,Orskov F

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Progression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis. In the majority of cases, this is associated with gain of a substantial part of chromosome 20q, indicating that multiple genes on the 20q ampli...

journal_title：Gut

authors： Sillars-Hardebol AH,Carvalho B,Tijssen M,Beliën JA,de Wit M,Delis-van Diemen PM,Pontén F,van de Wiel MA,Fijneman RJ,Meijer GA

更新日期：2012-11-01 00:00:00

abstract：:Previous reports have shown that both Crohn's disease and ulcerative colitis affect people in white collar occupations associated with higher income and higher social class more frequently than other groups in the population. This study sought to carry these analyses one step further and investigate the distribution o...

journal_title：Gut

authors： Sonnenberg A

更新日期：1990-09-01 00:00:00

abstract：:Levels of clotting factors II, V, and VII were measured on admission and then daily in 12 patients with grade IV hepatic coma due to fulminant hepatic failure. Factor VII levels obtained within 36 hours of the development of grade IV coma were not of value in predicting which patients would subsequently recover consci...

journal_title：Gut

authors： Gazzard BG,Henderson JM,Williams R

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:Mouse models of colitis and cancer are indispensable for our understanding of the pathogenesis of these diseases. In the past, mice had to be sacrificed in order to analyse colitis activity and tumour development. We have developed a safe method for high resolution endoscopic monitoring of living mice. METH...

journal_title：Gut

authors： Becker C,Fantini MC,Wirtz S,Nikolaev A,Kiesslich R,Lehr HA,Galle PR,Neurath MF

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Flares are a well known phenomenon during antiviral treatment for chronic hepatitis B. Little is known about the effect of flares on response. We investigated the timing and characteristics of flares, in relation to treatment response (hepatitis B e antigen loss). PATIENTS:A total of 266 patients, ...

journal_title：Gut

authors： Flink HJ,Sprengers D,Hansen BE,van Zonneveld M,de Man RA,Schalm SW,Janssen HL,HBV 99-01 Study Group.

更新日期：2005-11-01 00:00:00

abstract：:In a Danish multicentre trial we compared the relapse preventing effects of olsalazine and sulphasalazine in patients with ulcerative colitis over a 12 month treatment period. Two hundred and twenty seven patients (118 men) with at least two previous attacks of ulcerative colitis were randomly allocated according to a...

journal_title：Gut

authors： Kiilerich S,Ladefoged K,Rannem T,Ranløv PJ

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:Liver fibrosis and cirrhosis resulting from chronic liver injury represent a major healthcare burden worldwide. Growth differentiation factor (GDF) 11 has been recently investigated for its role in rejuvenation of ageing organs, but its role in chronic liver diseases has remained unknown. Here, we investigate...

journal_title：Gut

authors： Dai Z,Song G,Balakrishnan A,Yang T,Yuan Q,Möbus S,Weiss AC,Bentler M,Zhu J,Jiang X,Shen X,Bantel H,Jaeckel E,Kispert A,Vogel A,Saborowski A,Büning H,Manns M,Cantz T,Ott M,Sharma AD

更新日期：2020-06-01 00:00:00

abstract：:An association between duodenal ulceration and a low fibre intake and a high refined carbohydrate diet has been reported. We therefore compared the current diet, smoking habits, social class, and possible other risk factors of 78 patients with duodenal ulcer and a community control group matched for age and sex. Logis...

journal_title：Gut

authors： Katschinski BD,Logan RF,Edmond M,Langman MJ

更新日期：1990-09-01 00:00:00

abstract：:A 24 hour gastric aspiration study was carried out on nine Polya gastrectomy, eight pernicious anaemia, and nine matched control subjects. Intragastric pH, bacteria, nitrite, and N-nitroso compounds were assessed half hourly whilst ambulant and hourly when in bed. Both total and nitrate reducing bacterial counts were ...

journal_title：Gut

authors： Hall CN,Darkin D,Brimblecombe R,Cook AJ,Kirkham JS,Northfield TC

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND AND AIM:To clarify the roles of Helicobacter pylori cytotoxin in gastric atrophy, the cytotoxin positive rate and cytotoxin activity in Fukui and Okinawa, where the prevalence of atrophic gastritis and gastric cancer risk are quite different, were studied. MATERIALS:Seventy three strains from Fukui and 51 f...

journal_title：Gut

authors： Ito S,Azuma T,Murakita H,Hirai M,Miyaji H,Ito Y,Ohtaki Y,Yamazaki Y,Kuriyama M,Keida Y,Kohli Y

更新日期：1996-12-01 00:00:00

abstract：:Tumour cell membrane fatty acid composition was investigated using an animal model of colorectal carcinogenesis. Eighty six male Wistar rats were fed experimental diets containing either 5% saturated fat or 20% saturated fat. Colorectal tumours were induced by intraperitoneal injection of azoxymethane, and control rat...

journal_title：Gut

authors： Nicholson ML,Neoptolemos JP,Clayton HA,Talbot IC,Bell PR

更新日期：1991-04-01 00:00:00

abstract：:Bowel function was assessed in 51 subjects: 10 women and seven men who habitually consumed an omnivorous, vegetarian, or vegan diet. The subjects on these diets had a mean intake of fibre of 23 g, 37 g, and 47 g respectively. Mean transit times were variable and not significantly different between the groups. Vegans, ...

journal_title：Gut

authors： Davies GJ,Crowder M,Reid B,Dickerson JW

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. AIMS:To evaluate wh...

journal_title：Gut

authors： Korponay-Szabó IR,Laurila K,Szondy Z,Halttunen T,Szalai Z,Dahlbom I,Rantala I,Kovács JB,Fésüs L,Mäki M

更新日期：2003-02-01 00:00:00

abstract：:The gastric secretory response to insulin changes in many patients between ;immediate' tests, within two weeks of vagotomy, and ;delayed' tests, done at least six months later. Patients who develop recurrent duodenal ulceration after vagotomy and pyloroplasty show highly significant increases in peak and rise in conce...

journal_title：Gut

authors： Watkin DF,Duthie HL

更新日期：1971-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Monocyte chemoattractant protein 1 (MCP-1) is increased transmurally in inflammatory bowel disease (IBD). Although MCP-1 is considered to play an important role in fibrotic disease in other organs, the role of MCP-1 in gut fibrosis is unknown. We investigated the fibrotic potential of MCP-1 in the g...

journal_title：Gut

authors： Motomura Y,Khan WI,El-Sharkawy RT,Verma-Gandhu M,Verdu EF,Gauldie J,Collins SM

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:MicroRNA (miRNA) expression profile can be used as prognostic marker for human cancers. We aim to explore the significance of miRNAs in colorectal cancer (CRC) metastasis. DESIGN:We performed miRNA microarrays using primary CRC tissues from patients with and without metastasis, and validated selected candida...

journal_title：Gut

authors： Ling H,Pickard K,Ivan C,Isella C,Ikuo M,Mitter R,Spizzo R,Bullock M,Braicu C,Pileczki V,Vincent K,Pichler M,Stiegelbauer V,Hoefler G,Almeida MI,Hsiao A,Zhang X,Primrose J,Packham G,Liu K,Bojja K,Gafà R,Xiao L

更新日期：2016-06-01 00:00:00

abstract：:Typical 'pouchitis' is a well recognised complication of ileal pouches in ulcerative colitis. Infrequently, a refractory pouchitis (RP) presents with certain clinical, endoscopic, and pathological features resembling Crohn's disease and is often ascribed to misdiagnosis of the initial colitis. To test that hypothesis ...

journal_title：Gut

authors： Subramani K,Harpaz N,Bilotta J,Bodian C,Rubin PH,Janowitz HD,Gelernt IM,Sachar DB

更新日期：1993-11-01 00:00:00

abstract：:We have previously shown that rats fed raw soya flour (RSF) for more than four months develop hyperplastic foci of pancreatic acinar cells, which undergo malignant change if feeding RSF is continued throughout the life of the animals. The tendency to undergo malignant change is augmented by the additional use of a gen...

journal_title：Gut

authors： McGuinness EE,Morgan RG,Wormsley KG

更新日期：1987-01-01 00:00:00