Abstract:
:Hepatitis C virus (HCV) is a human pathogen responsible for acute and chronic liver disease, infecting an estimated 130-170 million persons worldwide. An intriguing feature of HCV infection is its peculiar relationship with lipids: (1) HCV virions circulate in serum bound to lipoproteins; (2) lipids have been shown to modulate (and, indeed, are essential to) the HCV life cycle; and (3) an occasionally severe accumulation of triglycerides is found in a distinct subgroup of patients in the form of hepatic steatosis. As a result, lipid metabolism is overall altered, conferring an idiosyncratic profile to HCV infection. The scope of this review is to discuss these aspects, focusing on both their molecular mechanisms and their clinical consequences.
journal_name
Gutjournal_title
Gutauthors
Negro Fdoi
10.1136/gut.2009.192732subject
Has Abstractpub_date
2010-09-01 00:00:00pages
1279-87issue
9eissn
0017-5749issn
1468-3288pii
gut.2009.192732journal_volume
59pub_type
杂志文章,评审相关文献
GUT文献大全abstract:BACKGROUND:Cholera toxin produces intestinal secretion by activation of the adenylate cyclase complex. However animal studies have shown 5-hydroxytryptamine may be released after exposure to cholera toxin, and thereby contribute to the secretory state. AIM:To determine whether cholera toxin releases 5-hydroxytryptamin...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.39.4.528
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. The geographical prevalence varies considerably in different countries and Scotland is regarded as an area of low risk for the disease. AIMS:To assess the association between chronic hepatitis C infection (HCV) and HCC in a popul...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.1.128
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Caroli's disease is a rare congenital disorder characterised by cystic dilatation of the intrahepatic bile ducts and an increased risk of cholangiocellular carcinoma. The cause is unknown, but occasional familial clustering suggests that some cases are inherited, in particular when occurring in association w...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.5.780
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Dyspepsia is a chronic disease with significant impact on the use of health care resources. A management strategy based on Helicobacter pylori testing has been recommended but the long term effect is unknown. AIM:To investigate the long term effect of a test and treat strategy compared with prompt endoscopy...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.2004.043570
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Whole body catabolism as the result of intrahepatic metabolic derangement is common in liver transplant candidates. However, individual nutritional assessment parameters lack sensitivity and specificity in determining energy status of these patients. Recently, serum hepatocyte growth factor (HGF) has been sh...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.6.862
更新日期:1999-06-01 00:00:00
abstract::Infection with the delta agent can only occur in the context of coexistent hepatitis B virus infection. We describe a patient in whom the clinical features of acute delta hepatitis developed when seroconversion from hepatitis B surface antigen to antibody had already occurred and diagnosis of recent acute hepatitis B ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.2.212
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND AND AIMS:We followed a population based cohort of patients with inflammatory bowel disease (IBD) from Olmsted County, Minnesota, in order to analyse long term survival and cause specific mortality. MATERIAL AND METHODS:A total of 692 patients were followed for a median of 14 years. Standardised mortality ra...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.079350
更新日期:2006-09-01 00:00:00
abstract::Recent evidence suggests that the production of colorectal carcinogens is facilitated when the pH of the colonic contents is alkaline. It follows that the colonic intraluminal pH of patients with colorectal neoplasms should be higher than in normal subjects. Gastrointestinal pH has been measured in 30 patients with co...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.12.1355
更新日期:1990-12-01 00:00:00
abstract::An investigation of immunological parameters was conducted in 38 patients with Crohn's disease. The immunological tests employed included skin tests with dinitrochlorobenzene and a battery of common skin test antigens, lymphocyte transformation with phytohaemagglutinin and pokeweed mitogen, serum immunoglobulins, and ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.2.100
更新日期:1976-02-01 00:00:00
abstract::Although colorectal cancer (CRC) is a common cause of cancer-related death, it is fortunately amenable to screening with faecal tests for occult blood and endoscopic tests. Despite the evidence for the efficacy of guaiac-based faecal occult blood tests (gFOBT), they have not been popular with primary care providers in...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2014-308074
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:An increasing number of patients with severe or refractory ulcerative colitis involving only the rectum and sigmoid colon are being offered restorative proctocolectomy with ileal reservoir but very few data are available concerning the outcome for these patients. AIM:This study was designed to compare the o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.4.574
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation and increased epithelial permeability. Both tumour necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) have been implicated in IBD. AIMS:To understand better the effects of these cytokines on epithelial cell ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.2.191
更新日期:1999-08-01 00:00:00
abstract::Forty patients with endoscopically proven persistent duodenal ulcer who had been treated for six weeks with cimetidine (1 g/day) were randomly allocated to receive a further six weeks' treatment with cimetidine (1 g/day) or ranitidine (300 mg/day). Ulcers healed in 12 of 19 patients given cimetidine (63%) and in 13 of...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.25.10.1113
更新日期:1984-10-01 00:00:00
abstract::A group of 80 patients with diseases of the small intestine were given a standardized psychiatric assessment every time they attended the outpatients' department over a period of a year. Forty-six patients with idiopathic steatorrhoea, 23 patients with Crohn's disease, and 11 patients with alactasia were interviewed o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.6.459
更新日期:1970-06-01 00:00:00
abstract::Colonic exfoliated epithelial cells in faecal material provide a source of human DNA which has been analysed for the presence of the tumour marker ras, in order to detect early tumour cells. The stool samples were subjected to a preliminary sample preparation step followed by centrifugation. DNA was extracted from bot...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.1.81
更新日期:1995-01-01 00:00:00
abstract::Clinico-pathological features of 56 patients with primary gastric lymphoma were evaluated retrospectively. All cases were regraded according to a classification of Isaacson et al into high grade and low grade B-cell mucosa associated lymphoid tissue lymphoma. A third group of mixed grade was recognised in 11 patients ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.10.1307
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces apoptosis in transformed cells and is considered as an agent for cancer therapy. As there is evidence that TRAIL is also essential for apoptosis in animal models of liver injury, we investigated the role of TRAIL in viral hepat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.056929
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-311970
更新日期:2017-11-01 00:00:00
abstract::Two consecutive trials of out-patient treatment for mild cases of active ulcerative colitis are described. In the first trial oral prednisone gave significantly better results than a placebo. In the second trial "salazopyrin" gave final results approaching those of prednisone, although over a longer time and with a hi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.3.217
更新日期:1960-09-01 00:00:00
abstract:BACKGROUND/AIMS:To investigate the prognostic values of putative hepatic stem/progenitor cell (HSC/HPC) biomarkers in patients with hepatocellular carcinoma (HCC). METHODS:Fourteen biomarkers related to HSCs/HPCs or tumour angiogenesis were assessed by qRT-PCR and then validated by tissue microarrays (TMAs) in three i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.176271
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:This is a consensus developed by a group of expert endoscopists aiming to standardise the preparation, process and endoscopic procedural steps for diagnosis of early upper gastrointestinal (GI) cancers. METHOD:The Delphi method was used to develop consensus statements through identification of clinical ques...
journal_title:Gut
pub_type: 共识发展会议,杂志文章
doi:10.1136/gutjnl-2018-317111
更新日期:2019-02-01 00:00:00
abstract::There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid for...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.4.531
更新日期:1993-04-01 00:00:00
abstract::Colorectal cancer is the second commonest cause of cancer death in the UK. An effective national screening programme is urgently required to reduce the substantial morbidity and mortality from the disease. The success of any screening programme will depend on the screening test detecting early Dukes's A carcinomas and...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.4.590
更新日期:1995-04-01 00:00:00
abstract::A 45 year old man is described with Whipple's disease who presented with weight loss, lethargy, and ascites. He subsequently developed fever and a mass in the neck, but died despite antibiotic treatment and nutritional support. Necropsy showed extraintestinal lymphoma. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.11.1627
更新日期:1993-11-01 00:00:00
abstract::An enema that contained a complex of bismuth citrate and polyacrylate was compared with 5-aminosalicylic acid (5-ASA) enemas for treatment of distal ulcerative colitis. The multicentre trial involving 63 patients was randomised and double blind with enemas given over four weeks; clinical, sigmoidoscopic, and histologi...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.34.5.676
更新日期:1993-05-01 00:00:00
abstract::Though amoebic liver abscess and liver cirrhosis occur very commonly in hospital practice in the tropics, they have not to the knowledge of the present authors hitherto been reported to occur simultaneously in the same patient. The patient described here, who had clear-cut clinical and histological features of chronic...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.2.161
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:The ground squirrel on a high cholesterol diet exhibits prolonged intestinal transit, a pathogenetic factor in cholesterol gallstone formation. AIMS:To examine the effect of a high cholesterol diet on the characteristics of the migrating myoelectrical complex (MMC) and the potential benefit of erythromycin....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.6.817
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND AND AIMS:The choice of colorectal surgery in patients with familial adenomatous polyposis lies between the morbidity of proctocolectomy and ileum-pouch-anal anastomosis (IPAA) and the mortality from rectal cancer after total colectomy and ileorectal anastomosis (IRA). The aims of the present study were: (1) ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.2.231
更新日期:2001-08-01 00:00:00
abstract::Some patients with the Zollinger-Ellison syndrome appear to have hypergastrinaemia and hyperplasia of the antral G cells but no tumour. This subgroup has been classified as Zollinger-Ellison syndrome type 1. We have treated such a patient by vagotomy and antrectomy, the fasting plasma gastrin and acid secretion subseq...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.1.25
更新日期:1973-01-01 00:00:00
abstract:BACKGROUND:Because hepatic cirrhosis is a major risk factor for hepatocellular carcinoma, recent guidelines by the European Association for the Study of the Liver (EASL) on clinical management of hepatocellular carcinoma recommend periodic ultrasound surveillance of cirrhotic patients with immediate workup for nodules ...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2003.032359
更新日期:2004-09-01 00:00:00