Clonal chromosomal abnormalities in congenital bile duct dilatation (Caroli's disease).

abstract：OBJECTIVE:Polycystic liver diseases (PCLDs) are genetic disorders characterised by progressive bile duct dilatation and/or cyst development. Their pathogenesis is a consequence of hyperproliferation, hypersecretion and microRNA alterations in cholangiocytes. Here we evaluate the role of matrix metalloproteases (MMPs) i...

journal_title：Gut

authors： Urribarri AD,Munoz-Garrido P,Perugorria MJ,Erice O,Merino-Azpitarte M,Arbelaiz A,Lozano E,Hijona E,Jiménez-Agüero R,Fernandez-Barrena MG,Jimeno JP,Marzioni M,Marin JJ,Masyuk TV,LaRusso NF,Prieto J,Bujanda L,Banales JM

更新日期：2014-10-01 00:00:00

abstract：:A single oral dose of 4-46 mmol calcium gluconate at pH 5-6 was administered intragastrically to 15 male volunteers without gastrointestinal disease. There was a significant rise in acid output from 30-90 minutes after the calcium was given compared with the basal hourly collection. The serum gastrin level 30 minutes ...

journal_title：Gut

authors： Brodie MJ,Ganguli PC,Fine A,Thomson TJ

更新日期：1977-02-01 00:00:00

abstract：:A histological study of peroral jejunal biopsies and resection specimens from patients with malignant histiocytosis of the intestine (MHI) has revealed characteristic lesions consisting of intramucosal histiocytic aggregations which invade surface and crypt epithelium. These lesions are found in 'uninvolved' jejunal m...

journal_title：Gut

authors： Isaacson P

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:Increased expression of proinflammatory cytokines, including tumour necrosis factor alpha, interleukin 6, and interferon gamma, as well as activation of proinflammatory signalling molecules such as nuclear factor kappa B, is characteristic of inflammatory bowel disease (IBD). AIMS:To investigate expression ...

journal_title：Gut

authors： Schreiber S,Rosenstiel P,Hampe J,Nikolaus S,Groessner B,Schottelius A,Kühbacher T,Hämling J,Fölsch UR,Seegert D

更新日期：2002-09-01 00:00:00

abstract：:The rate of gastric emptying of two antacids, magaldrate and Maalox, was investigated using scintigraphy. Successful labelling of the antacids was carried out with 99mTc. The stability of the 99mTc-labelled antacids was satisfactory and there was no difference in antacid capacity between the labelled and unlabelled an...

journal_title：Gut

authors： Monés J,Carrió I,Roca M,Estorch M,Calabuig R,Sainz S,Martinez-Duncker C,Vilardell F

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Independent component analysis (ICA) of the electroencephalogram (EEG) overcomes many of the classical problems in EEG analysis. We used ICA to determine the brain responses to painful stimulation of the oesophagus. METHODS:Twelve subjects with a median age of 41 years were included. With a nasal e...

journal_title：Gut

authors： Drewes AM,Sami SA,Dimcevski G,Nielsen KD,Funch-Jensen P,Valeriani M,Arendt-Nielsen L

更新日期：2006-05-01 00:00:00

abstract：:The purpose of this single blind controlled multicentre trial was to compare the relative effectiveness of pirenzepine and cimetidine in healing endoscopically proven duodenal ulcers. One hundred and twenty six patients with duodenal ulcer were treated with a daily dose of 100 mg pirenzepine (50 mg each before breakfa...

journal_title：Gut

authors： Brunner H,Dittrich H,Kratochvil P,Brandstätter G,Hentschel E,Schütze K,Tragl KH,Kern H,Löffelmann K,Zeiler H

更新日期：1984-02-01 00:00:00

abstract：:An enema that contained a complex of bismuth citrate and polyacrylate was compared with 5-aminosalicylic acid (5-ASA) enemas for treatment of distal ulcerative colitis. The multicentre trial involving 63 patients was randomised and double blind with enemas given over four weeks; clinical, sigmoidoscopic, and histologi...

journal_title：Gut

authors： Pullan RD,Ganesh S,Mani V,Morris J,Evans BK,Williams GT,Rhodes J

更新日期：1993-05-01 00:00:00

abstract：:To investigate the mechanisms underlying the hepatotoxicity induced by methyl dopa, we have examined sera from nine patients with liver damage following the use of the drug for evidence of sensitisation to drug altered liver cell membrane antigens using both immunofluorescence and antibody dependent cell mediated cyto...

journal_title：Gut

authors： Neuberger J,Kenna JG,Nouri Aria K,Williams R

更新日期：1985-11-01 00:00:00

abstract：:The effects of different bile salts on the absorption of fluid, electrolytes, and monosaccharides have been investigated in the rat small intestine in vivo. In the jejunum, deoxycholate (1 mM) impaired absorption of water and potassium, but not of sodium or glucose; at higher concentrations (2.5 and 5 mM) secretion of...

journal_title：Gut

authors： Harries JT,Sladen GE

更新日期：1972-08-01 00:00:00

abstract：BACKGROUND:Hirschsprung's disease (HSCR) is a congenital disorder characterised by an absence of ganglion cells in the nerve plexuses of the lower digestive tract. Manifestation of the disease has been linked to mutations in genes that encode the crucial signals for the development of the enteric nervous system-the RET...

journal_title：Gut

authors： Garcia-Barceló M,Sham MH,Lui VC,Chen BL,Ott J,Tam PK

更新日期：2003-04-01 00:00:00

abstract：:The cognitive model of depression assigns a central role to negatively biased information processing in the pathogenesis of the emotional disorder. The relationship between depression and irritable bowel syndrome (IBS) was explored from a cognitive perspective. A word recognition memory task was constructed: subjects ...

journal_title：Gut

authors： Gomborone JE,Dewsnap PA,Libby GW,Farthing MJ

更新日期：1993-09-01 00:00:00

abstract：:Small bowel enteropathies that are associated with an autoimmune process are often resistant to treatment. Two children with autoimmune enteropathy were treated with cyclosporin A for eight months. Both improved, as assessed by growth, small intestinal mucosal morphology, and carbohydrate absorption. Cyclosporin A is ...

journal_title：Gut

authors： Sanderson IR,Phillips AD,Spencer J,Walker-Smith JA

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Patients with Crohn's disease suffer from intestinal bile acid malabsorption. Intestinal bile acid absorption is mediated by the apical sodium dependent bile acid transporter ASBT/IBAT (SLC10A2). In rats, ASBT is induced by glucocorticoids. AIMS:To study whether human ASBT is activated by glucocorticoids an...

journal_title：Gut

authors： Jung D,Fantin AC,Scheurer U,Fried M,Kullak-Ublick GA

更新日期：2004-01-01 00:00:00

abstract：:Plasma- and erythrocyte-selenium concentrations were determined in five consecutive patients with Crohn's disease given preoperative total parenteral nutrition - nil per os - for a mean period of 34 days per patient. No blood components were administered during the total parenteral nutrition. Before the total parenter...

journal_title：Gut

authors： Jacobson S,Plantin LO

更新日期：1985-01-01 00:00:00

abstract：:Serumfolate folate levels and the bacteriology of the small intestine were studied in 13 patients with jejunal diverticulosis, 29 patients with partial gastrectomy, and five patients with ileal disease. The mean serum folate level in the patients with partial gastrectomy (7.2 mmug/ml) was similar to that of control su...

journal_title：Gut

authors： Hoffbrand AV,Tabaqchali S,Booth CC,Mollin DL

更新日期：1971-01-01 00:00:00

abstract：OBJECTIVE:This phase II, randomised, double-blind, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PF-00547659, a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion molecule (MAdCAM) to selectively reduce lymphocyte homing to the intestinal tract, i...

journal_title：Gut

authors： Sandborn WJ,Lee SD,Tarabar D,Louis E,Klopocka M,Klaus J,Reinisch W,Hébuterne X,Park DI,Schreiber S,Nayak S,Ahmad A,Banerjee A,Brown LS,Cataldi F,Gorelick KJ,Cheng JB,Hassan-Zahraee M,Clare R,D'Haens GR

更新日期：2018-10-01 00:00:00

abstract：:The effect of octreotide, a synthetic analogue of somatostatin, on the modulation of the acetic acid model of experimental colitis was examined. Colitis was induced by intracolonic administration of 2 ml of 5% acetic acid. The inflammatory response elicited by the acetic acid resulted in increased colonic synthesis of...

journal_title：Gut

authors： Eliakim R,Karmeli F,Okon E,Rachmilewitz D

更新日期：1993-02-01 00:00:00

abstract：:The nervous system in the intestine controls motility, secretion, sensory perception, and immune function. Peptidergic neurones with neurotransmitters such as substance P and nerve growth factors have been the main focus of neuroimmunomodulation research in the gut. This review summarises the present knowledge concern...

journal_title：Gut

authors： Straub RH,Wiest R,Strauch UG,Härle P,Schölmerich J

更新日期：2006-11-01 00:00:00

abstract：:The effects on gastric emptying of a solid meal of the specific 5-HT3-receptor antagonist ICS 205-930, 10 mg and 20 mg intravenously were assessed with a scintigraphic technique in 12 normals. The 50% emptying time was less, the lag phase was shorter and the post lag emptying rate was faster after 20 mg ICS 205-930 (p...

journal_title：Gut

authors： Akkermans LM,Vos A,Hoekstra A,Roelofs JM,Horowitz M

更新日期：1988-09-01 00:00:00

abstract：:Extracellular electrical and contractile activities were recorded in vitro from strips of human colonic smooth muscle obtained at the time of surgery. Serosal electrical activity of longitudinally oriented strips from the taenia and intertaenial region was characterised by continuous oscillation at a frequency of 28 +...

journal_title：Gut

authors： Gill RC,Cote KR,Bowes KL,Kingma YJ

更新日期：1986-03-01 00:00:00

abstract：:Faecal chymotrypsin was measured in patients with chronic pancreatitis and in healthy black urban and rural control subjects. In the patients, significantly lower values of faecal chymotrypsin were obtained (mean (SD) 2.4 1.79 U/g stool) whereas in urban control subjects, values were within the normal range (mean (SD)...

journal_title：Gut

authors： Riedel L,Walker AR,Segal I,Mohamed AE,Smyth AE,Daya B,Naik I

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is associated with cardiovascular risk. The aim of this study was to determine the role of fatty liver in predicting coronary artery disease and clinical outcomes in patients undergoing coronary angiogram. METHOD...

journal_title：Gut

authors： Wong VW,Wong GL,Yip GW,Lo AO,Limquiaco J,Chu WC,Chim AM,Yu CM,Yu J,Chan FK,Sung JJ,Chan HL

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Integrins are transmembrane cell surface receptors that mediate cell-cell and cell-matrix contacts. Integrin-linked kinase (ILK) is the binding partner of beta1 and beta3 integrins, and has been ascribed essential roles in development, angiogenesis and tumourigenesis. However, in vivo evidence for the latter...

journal_title：Gut

authors： Assi K,Mills J,Owen D,Ong C,St Arnaud R,Dedhar S,Salh B

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Assessment of disease extension and activity is crucial to guide treatment in Crohn's disease. The objective of the current cross-sectional study was to determine the accuracy of MR for this assessment. DESIGN:50 patients with clinically active (n = 35) or inactive (n = 15) Crohn's disease underwent ileocolo...

journal_title：Gut

authors： Rimola J,Rodriguez S,García-Bosch O,Ordás I,Ayala E,Aceituno M,Pellisé M,Ayuso C,Ricart E,Donoso L,Panés J

更新日期：2009-08-01 00:00:00

abstract：:The role of the proximal and distal stomach in the emptying of solids and liquids from the stomach remains unclear. We have used a dual isotope technique to quantify proximal and distal stomach emptying of a solid (100 g of 99mTc labelled liver/ground beef) liquid (either 200 ml of normal saline (eight subjects) or 25...

journal_title：Gut

authors： Collins PJ,Houghton LA,Read NW,Horowitz M,Chatterton BE,Heddle R,Dent J

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Chemokines are small polypeptides, a major function of which is lymphocyte recruitment and trafficking. The aim of this study was to assess the involvement of inherited variations in CCR2, CCR5, and the ligand RANTES in determining disease outcome in hepatitis C virus (HCV) infected individuals. ME...

journal_title：Gut

authors： Goulding C,McManus R,Murphy A,MacDonald G,Barrett S,Crowe J,Hegarty J,McKiernan S,Kelleher D

更新日期：2005-08-01 00:00:00

abstract：:Rosetting techniques were used to estimate T and B cell subpopulations in the peripheral blood in patients with treated and untreated adult coeliac disease and in control subjects. In patients with untreated coeliac disease, T cell numbers were significantly lower than in controls or treated patients, although there w...

journal_title：Gut

authors： Bullen AW,Losowsky MS

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:There is no information about the frequency of liver dysfunction in patients with inflammatory bowel disease (IBD) treated with immunosuppressants and infected with hepatitis B (HBV) and/or C virus (HCV). AIM:To assess the influence of immunosuppressants on the course of HBV and HCV infection in IBD. METHO...

journal_title：Gut

authors： Loras C,Gisbert JP,Mínguez M,Merino O,Bujanda L,Saro C,Domenech E,Barrio J,Andreu M,Ordás I,Vida L,Bastida G,González-Huix F,Piqueras M,Ginard D,Calvet X,Gutiérrez A,Abad A,Torres M,Panés J,Chaparro M,Pascual I

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Diabetes has been associated with an increased risk of hepatocellular carcinoma (HCC) in studies of referred patients. This is the first population based case control study in the USA to examine this association while adjusting for other major risk factors related to HCC. METHODS:We used the Surveillance Ep...

journal_title：Gut

authors： Davila JA,Morgan RO,Shaib Y,McGlynn KA,El-Serag HB

更新日期：2005-04-01 00:00:00