Effect of ICS 205-930 (a specific 5-HT3 receptor antagonist) on gastric emptying of a solid meal in normal subjects.

abstract：OBJECTIVE:As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immun...

journal_title：Gut

authors： Zhao Y,Shuen TWH,Toh TB,Chan XY,Liu M,Tan SY,Fan Y,Yang H,Lyer SG,Bonney GK,Loh E,Chang KTE,Tan TC,Zhai W,Chan JKY,Chow EK,Chee CE,Lee GH,Dan YY,Chow PK,Toh HC,Lim SG,Chen Q

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Overexpression of tissue plasminogen activator (t-PA) in pancreatic cancer cells promotes invasion and proliferation in vitro and tumour growth and angiogenesis in vivo. AIMS:To understand the mechanisms by which t-PA favours cancer progression, we analysed the surface membrane proteins responsible for bind...

journal_title：Gut

authors： Díaz VM,Hurtado M,Thomson TM,Reventós J,Paciucci R

更新日期：2004-07-01 00:00:00

abstract：:Four young Chinese women took daily doses of an unidentified 'Indian' herbal tea as treatment for psoriasis. Three (one of whom died), developed ascites, hepatomegaly and biochemical abnormalities within 19-45 days. The fourth patient discontinued herbal tea after 21 days when she developed a skin rash. Two patients h...

journal_title：Gut

authors： Kumana CR,Ng M,Lin HJ,Ko W,Wu PC,Todd D

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in bone marrow (BM)-derived macrophages but its function in liver injury is unknown. Here we hypothesised that the anti-infl...

journal_title：Gut

authors： Perugorria MJ,Esparza-Baquer A,Oakley F,Labiano I,Korosec A,Jais A,Mann J,Tiniakos D,Santos-Laso A,Arbelaiz A,Gawish R,Sampedro A,Fontanellas A,Hijona E,Jimenez-Agüero R,Esterbauer H,Stoiber D,Bujanda L,Banales JM,K

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Suicide gene therapy consists of the transfer into tumour cells of a "suicide" gene that can convert a non-toxic compound into a lethal drug. Expression of the cytosine deaminase gene leads to the conversion of the non-toxic compound 5-fluorocytosine to 5-fluorouracil. We have recently shown that "suicide ce...

journal_title：Gut

authors： Pierrefite-Carle V,Baqué P,Gavelli A,Brossette N,Benchimol D,Bourgeon A,Saint Paul MC,Staccini P,Rossi B

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Cirrhotic patients with hepatocellular carcinoma (HCC) frequently have impaired glucose metabolism. AIMS:To investigate whether impaired glucose metabolism affects the growth rate of the tumour. PATIENTS AND METHODS:Tumour doubling time (DT), assessed by ultrasound imaging analysis, was measured in 60 pati...

journal_title：Gut

authors： Saito K,Inoue S,Saito T,Kiso S,Ito N,Tamura S,Watanabe H,Takeda H,Misawa H,Togashi H,Matsuzawa Y,Kawata S

更新日期：2002-07-01 00:00:00

abstract：:A prospective, randomised, comparative study was performed to assess the need for a pure alcohol injection after an epinephrine injection in the arrest of active peptic ulcer bleeding. Sixty four patients with active ulcer bleeding were enrolled in the study. The two groups (epinephrine and epinephrine plus pure alcoh...

journal_title：Gut

authors： Lin HJ,Perng CL,Lee SD

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated c...

journal_title：Gut

authors： Parang B,Kaz AM,Barrett CW,Short SP,Ning W,Keating CE,Mittal MK,Naik RD,Washington MK,Revetta FL,Smith JJ,Chen X,Wilson KT,Brand T,Bader DM,Tansey WP,Chen R,Brentnall TA,Grady WM,Williams CS

更新日期：2017-05-01 00:00:00

abstract：:These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines which this document supersedes were written in 2...

journal_title：Gut

authors： Tripathi D,Stanley AJ,Hayes PC,Patch D,Millson C,Mehrzad H,Austin A,Ferguson JW,Olliff SP,Hudson M,Christie JM,Clinical Services and Standards Committee of the British Society of Gastroenterology.

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND/AIMS/METHODS:During hepatic vein catheterisation, in addition to measurement of hepatic venous pressure gradient (HVPG), iodine wedged retrograde portography can be easily obtained. However, it rarely allows correct visualisation of the portal vein. Recently, CO(2) has been suggested to allow better angiogra...

journal_title：Gut

authors： Debernardi-Venon W,Bandi JC,García-Pagán JC,Moitinho E,Andreu V,Real M,Escorsell A,Montanyá X,Bosch J

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori strains possessing the cagA gene are thought to induce interleukin 8 (IL-8) in gastric mucosa. However, it is still unclear whether a relation exists between the cagA gene and the expression patterns of cytokines other than IL-8. AIMS:To investigate the relation between the cagA gene and...

journal_title：Gut

authors： Yamaoka Y,Kita M,Kodama T,Sawai N,Kashima K,Imanishi J

更新日期：1997-10-01 00:00:00

abstract：:Patients with chronic active hepatitis or alcoholic cirrhosis have serum antibodies to many more serotypes of Escherichia coli than do patients with primary biliary cirrhosis or cryptogenic cirrhosis, or normal controls. They also have antibodies against more serotypes than cirrhotic patients with a portacaval shunt. ...

journal_title：Gut

authors： Simjee AE,Hamilton-Miller JM,Thomas HC,Brumfitt W,Sherlock S

更新日期：1975-11-01 00:00:00

abstract：:The induction of adenocarcinomas in the glandular stomach of the adult male Wistar rat by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was used as a model to study the expression of the growth promoting peptide, transforming growth factor alpha (TGF alpha), during experimental gastric carcinogenesis. TGF alpha was iden...

journal_title：Gut

authors： Livingstone JI,Filipe MI,Wastell C

更新日期：1994-05-01 00:00:00

abstract：:Several methods for the preparation of cell suspensions from human gastrointestinal mucosa were investigated. Satisfactory suspensions were obtained by incubating tissue fragments in a solution of collagenase and hyaluronidase overnight at 4 degrees C followed by 30 minutes at 37 degrees C. The resulting suspension co...

journal_title：Gut

authors： Crofton RW,Cochrane C,McClelland DB

更新日期：1978-10-01 00:00:00

abstract：:This paper compares the mortality of 525 men admitted to U.S. Army hospitals in 1944 with ulcerative colitis compared with 518 controls matched for age, race, and rank. The excess mortality in the ulcerative colitis group as compared with the control group was due to approximately equal proportions of deaths from ulce...

journal_title：Gut

authors： NEFZGER MD,ACHESON ED

更新日期：1963-06-01 00:00:00

abstract：:The risk of developing colorectal adenomatous polyps is probably increased by a variety of dietary and environmental factors. We found an association with current alcohol and cigarette consumption. The risk of polyps was increased three times in drinkers who did not smoke and two times in smokers who did not drink, wi...

journal_title：Gut

authors： Cope GF,Wyatt JI,Pinder IF,Lee PN,Heatley RV,Kelleher J

更新日期：1991-01-01 00:00:00

abstract：:Extracorporeal shock wave lithotripsy of pancreatic duct stones (largest stone 12 (SD) 6 mm) was performed in 24 patients with abdominal pain and a dilated duct system (main pancreatic duct 10 (3) mm). The procedure was well tolerated in all but two patients, who had a mild pancreatitic attack immediately after lithot...

journal_title：Gut

authors： Sauerbruch T,Holl J,Sackmann M,Paumgartner G

更新日期：1992-07-01 00:00:00

abstract：:Removal of the right lobe of the liver which was occupied largely by metastases, together with resection of ileal primary tumours, brought about complete remission of symptoms and signs in a 43-year-old man with a six-year history of the carcinoid syndrome. Investigations should be orientated toward surgery. When prac...

journal_title：Gut

authors： Zeegen R,Rothwell-Jackson R,Sandler M

更新日期：1969-08-01 00:00:00

abstract：:To investigate the effects of supplemental oxygen on cardiac rhythm during gastroscopy, 103 patients aged over 60 were randomised to receive either supplemental oxygen or air at 2 litres/minute during the procedure. Pulse rate, blood pressure, oxygen saturation, and a Holter cardiac trace were monitored before, during...

journal_title：Gut

authors： Bowling TE,Hadjiminas CL,Polson RJ,Baron JH,Foale RA

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:Chronic pancreatitis (CP) is an inflammatory disease with progressive fibrosis leading to exocrine and endocrine dysfunction. Currently, there are no approved effective therapies for CP. Stimulator of interferon genes (STING) signalling is a key innate immune sensor of DNA. In this study, we evaluated the rol...

journal_title：Gut

authors： Zhao Q,Manohar M,Wei Y,Pandol SJ,Habtezion A

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or ...

journal_title：Gut

authors： Higuchi S,Ahmad TR,Argueta DA,Perez PA,Zhao C,Schwartz GJ,DiPatrizio NV,Haeusler RA

更新日期：2020-09-01 00:00:00

abstract：:This paper describes opacification and identification of two surgically constructed pancreatico-jujunal shunts. A fibreoptic panendoscope was used with retrograde injection via the ampulla of Vater (ERCP). This procedure makes possible more accurate anatomical evaluation and so more precise clinical appraisal of both...

journal_title：Gut

authors： Miller EW,Goldberg HI,Goldberg SB,Shapiro H

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:In human acute pancreatitis two different types of secretory phospholipase A2 (PLA2) have been found. AIM:To analyse the specific pattern of distribution of these PLA2 activities and their pathophysiological role in experimental acute pancreatitis. SUBJECTS AND METHODS:Catalytic activities of secretory typ...

journal_title：Gut

authors： Uhl W,Schrag HJ,Schmitter N,Nevalainen TJ,Aufenanger J,Wheatley AM,Büchler MW

更新日期：1997-03-01 00:00:00

abstract：:Histocompatibility (HLA) antigen phenotypes have been studied in 100 patients with ulcerative colitis, 100 with Crohn's disease, and 283 normal controls. In addition the incidence of ankylosing spondylitis, sacroiliitis, and "enteropathic" peripheral arthropathy was determined in the patients with inflammatory bowel d...

journal_title：Gut

authors： Mallas EG,Mackintosh P,Asquith P,Cooke WT

更新日期：1976-11-01 00:00:00

abstract：OBJECTIVES:Roux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations. DESIGN:We used functional MRI, ea...

journal_title：Gut

authors： Scholtz S,Miras AD,Chhina N,Prechtl CG,Sleeth ML,Daud NM,Ismail NA,Durighel G,Ahmed AR,Olbers T,Vincent RP,Alaghband-Zadeh J,Ghatei MA,Waldman AD,Frost GS,Bell JD,le Roux CW,Goldstone AP

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:An increasing number of patients with severe or refractory ulcerative colitis involving only the rectum and sigmoid colon are being offered restorative proctocolectomy with ileal reservoir but very few data are available concerning the outcome for these patients. AIM:This study was designed to compare the o...

journal_title：Gut

authors： Samarasekera DN,Stebbing JF,Kettlewell MG,Jewell DP,Mortensen NJ

更新日期：1996-04-01 00:00:00

abstract：:Cirrhosis is associated with the development of a hyperdynamic circulation, which is secondary to the presence of systemic vasodilatation. Several mechanisms have been postulated to be involved in the development of systemic vasodilatation, including increased synthesis of nitric oxide, hyperglucagonaemia, increased c...

journal_title：Gut

authors： Ebrahimkhani MR,Mani AR,Moore K

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:Shortage of organ donors, a critical challenge for treatment of end-stage organ failure, has motivated the development of alternative strategies to generate organs in vitro. Here, we aim to describe the hepatorganoids, which is a liver tissue model generated by three-dimensional (3D) bioprinting of HepaRG cel...

journal_title：Gut

authors： Yang H,Sun L,Pang Y,Hu D,Xu H,Mao S,Peng W,Wang Y,Xu Y,Zheng YC,Du S,Zhao H,Chi T,Lu X,Sang X,Zhong S,Wang X,Zhang H,Huang P,Sun W,Mao Y

更新日期：2020-05-20 00:00:00

abstract：BACKGROUND:Lamina propria (LPLs) and intraepithelial (IELs) lymphocytes are markedly increased in coeliac mucosa, and are thought to play a crucial role in the generation of villous atrophy in coeliac disease (CD). However, the mechanisms by which they mediate the killing of enterocytes in this condition are still poor...

journal_title：Gut

authors： Di Sabatino A,Ciccocioppo R,D'Alò S,Parroni R,Millimaggi D,Cifone MG,Corazza GR

更新日期：2001-09-01 00:00:00

abstract：:Two patients with specific pancreatic amylase deficiency are described. The greatly reduced pancreatic amylase activity was not due to an enzymatically inactive amylase molecule but to an almost complete absence of the molecule itself. The findings are of diagnostic importance as they show that low pancreatic amylase ...

journal_title：Gut

authors： Sjölund K,Häggmark A,Ihse I,Skude G,Kärnström U,Wikander M

更新日期：1991-05-01 00:00:00