Abstract:
:Removal of the right lobe of the liver which was occupied largely by metastases, together with resection of ileal primary tumours, brought about complete remission of symptoms and signs in a 43-year-old man with a six-year history of the carcinoid syndrome. Investigations should be orientated toward surgery. When practicable, radical surgery of the type described here appears to offer the best hope of alleviating the distressing clinical features of the condition.
journal_name
Gutjournal_title
Gutauthors
Zeegen R,Rothwell-Jackson R,Sandler Mdoi
10.1136/gut.10.8.617subject
Has Abstractpub_date
1969-08-01 00:00:00pages
617-22issue
8eissn
0017-5749issn
1468-3288journal_volume
10pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND:A previous pilot study showed that early arrival time of a microbubble in a hepatic vein is a sensitive indicator of cirrhosis. AIM:To see if this index can also grade diffuse liver disease. PATIENTS:Thirty nine fasted patients with histologically characterised disease were studied prospectively. Nine pati...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.8.1188
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Monocyte chemoattractant protein 1 (MCP-1) is increased transmurally in inflammatory bowel disease (IBD). Although MCP-1 is considered to play an important role in fibrotic disease in other organs, the role of MCP-1 in gut fibrosis is unknown. We investigated the fibrotic potential of MCP-1 in the g...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.068429
更新日期:2006-05-01 00:00:00
abstract::Endoscopic sphincterotomy has become the first line treatment for patients with common bile duct (CBD) stones. This technique may fail, however, due to difficult anatomy, previous surgery, periampullary diverticula or the presence of a large stone. The importance of stone size to the success of endoscopic sphincteroto...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.12.1718
更新日期:1993-12-01 00:00:00
abstract::Forty two white patients of British or Irish descent with coeliac disease and 28 with dermatitis herpetiformis were typed for class I HLA-A, B, and C, and class II DR and DQ antigens. In coeliac disease there was a significant increase in the frequencies of A1, B8, DR3, DR7, and DQw2 compared with controls but no incr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.5.515
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:Metabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remain...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311326
更新日期:2017-06-01 00:00:00
abstract::Previous studies have suggested that profound inhibition of gastric acid secretion may increase exposure to potentially carcinogenic N-nitroso compounds. The aim of this study was to find out if the proton pump inhibitor omeprazole (20 mg daily) is associated with increased concentrations of potentially carcinogenic N...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.4.455
更新日期:1994-04-01 00:00:00
abstract:UNLABELLED:Data on the natural history of elderly-onset inflammatory bowel disease (IBD) are scarce. METHODS:In a French population-based cohort we identified 841 IBD patients >60 years of age at diagnosis from 1988 to 2006, including 367 Crohn's disease (CD) and 472 ulcerative colitis (UC). RESULTS:Median age at dia...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-303864
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:Gastric carcinoma development is triggered by Helicobacter pylori. Chronic H. pylori infection leads to reduced acid secretion, which may allow the growth of a different gastric bacterial community. This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy. Our a...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314205
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Lipids may exacerbate symptoms induced by gut stimuli. AIM:To determine the mechanism whereby fat exerts this effect. SUBJECTS:Twenty four healthy subjects were studied during fasting. METHODS:We measured perception (0-6 scale) in response to jejunal balloon distension and transmucosal electrical nerve st...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.5.690
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Tumour vascularisation is a determinant of the development of metastases. AIMS:To measure blood flow in normal stomach and gastric adenocarcinomas by laser Doppler flowmetry and correlate blood flow with vascularisation after immunohistochemical staining of resected specimens for CD31 and von Willebrand fac...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.45.3.341
更新日期:1999-09-01 00:00:00
abstract::Gastric adaptation was impaired immediately after the performance of complete vagotomy in a series of 20 acute experiments in the dog. Preliminary isolation of the intact vagi in 10 of these animals produced alterations in adaptation similar to those seen after vagal division. It is concluded that alterations in gastr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.11.874
更新日期:1972-11-01 00:00:00
abstract:BACKGROUND:Increased infertility in women has been reported after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis but reported infertility rates vary substantially. AIMS:(1) To perform a systematic review and meta-analysis of the relative risk of infertility post-IPAA compared with medical management; (2) t...
journal_title:Gut
pub_type: 杂志文章,meta分析,评审
doi:10.1136/gut.2005.090316
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Although evidence points to a role for histamine and serotonin in visceral hypersensitivity, activation of calcium channels such as transient receptor potential vanilloid 4 (TRPV4) also causes visceral hypersensitivity. We hypothesised that TRPV4 is important for the generation of hypersensitivity, mediating...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.192567
更新日期:2010-04-01 00:00:00
abstract::A patient with myelofibrosis developed repeated gastrointestinal haemorrhage from the small intestine, which was found to be infiltrated with extramedullary haemopoiesis. Nineteen months later he presented with subacute intestinal obstruction; radiology and laparotomy documented progressive infiltration of the small b...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.7.873
更新日期:1986-07-01 00:00:00
abstract::The cholesteryl-14C-octanoate breath test was used to monitor the intraluminal enzymatic activity of pancreatin preparations in six patients with severe pancreatic insufficiency. Conventional enzyme replacement, with cimetidine as an adjunct, was compared to supplementation with enteric coated microspheres. In healthy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.11.1324
更新日期:1990-11-01 00:00:00
abstract:INTRODUCTION:Survival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC). METHODS:The ICBP SURVMARK-2 project...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321089
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Although Helicobacter pylori has been implicated in the pathogenesis of gastric mucosa associated lymphoid tissue (MALT) and MALT lymphoma, it is not known how it may trigger these lesions and whether there is an identifiable pre-neoplastic stage. AIMS:To investigate the relation between MALT, H pylori infe...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.6.837
更新日期:1996-06-01 00:00:00
abstract::An intensive histological search for Helicobacter pylori in gastric biopsy specimens has led to the detection of other spiral shaped bacteria in the human gastric mucosa. The clinical and morphological findings of 39 cases (0.25% of all gastric biopsies performed in the observation period) are reported for 34 patients...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.2.137
更新日期:1991-02-01 00:00:00
abstract::In a prospective study we compared the diagnostic accuracy of endoscopic fine needle aspiration cytology with that of brush cytology and forceps biopsy in relation to gross tumour pattern and site in 265 confirmed consecutive cases of malignancy of the oesophagus, stomach, colon, and rectum. Aspiration cytology gave t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.7.745
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:The reported cumulative risk of developing pouchitis in ulcerative colitis (UC) patients undergoing ileal pouch-anal anastomosis (IPAA) approaches 50% after 10 years. To date, no preoperative serological predictor of pouchitis has been found. AIMS:To assess whether preoperative perinuclear antineutrophil cy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.5.671
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE AND DESIGN:The goal of the study was to determine whether the mutational profile of early colorectal polyps correlated with growth behaviour. The growth of small polyps (6-9 mm) that were first identified during routine screening of patients was monitored over time by interval imaging with CT colonography. Mu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-312232
更新日期:2017-12-01 00:00:00
abstract::Cholecystokinin (CCK) release and gall bladder emptying in response to a fatty meal are completely abolished in coeliac disease. To determine the effect of lipid digestion on CCK release and gall bladder motility, six patients with untreated coeliac disease and a flat jejunal mucosa were studied on two separate days. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.1.17
更新日期:1995-01-01 00:00:00
abstract::Six cases of faecal stasis in active proctocolitis are reported. In each case the left colon was severely diseased but the right colon was unaffected. X-ray studies showed retention of barium in the right colon for as long as five weeks. In two patients subacute intestinal obstruction developed and in three patients c...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.3.4.301
更新日期:1962-12-01 00:00:00
abstract::The distribution of mucosal PGE2-like activity was determined by bioassay technique in the body and antrum of the stomach and in the duodenum of healthy subjects and duodenal ulcer patients before and after administration of aspirin, paracetamol, or histamine. In healthy subjects, the oxyntic, antral and duodenal muco...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.22.4.283
更新日期:1981-04-01 00:00:00
abstract:BACKGROUND AND AIMS:The diagnostic yield of capsule endoscopy (CE) compared with magnetic resonance imaging (MRI) in small bowel Crohn's disease is not well established. We prospectively investigated CE, MRI, and double contrast fluoroscopy in patients with suspected small bowel Crohn's disease. METHODS:Fifty two cons...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.069427
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Helicobacter pylori infection and gastric atrophy are both risk factors for gastric cancer. We aimed to elucidate the natural history of gastric cancer development according to H pylori infection and gastric atrophy status. SUBJECTS AND METHODS:A total of 9293 participants in a mass health appraisa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.055400
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Thrombosis may be an important effector mechanism in the pathogenesis of Crohn's disease. METHODS:This study therefore investigated the prevalence of independent thrombotic risk factors (factor VII coagulant activity, lipoprotein (a), fibrinogen, plasma triglycerides, and smoking) in patients with Crohn's d...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.5.733
更新日期:1996-05-01 00:00:00
abstract::To evaluate whether the general trophic effect of gastrin on the oxyntic mucosa is an indirect effect mediated by histamine H2 receptors, sustained 24 hour hypergastrinaemia was induced in Sprague-Dawley rats by treatment with the long acting and potent histamine H2 antagonist loxtidine for five months. The trophic ef...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.11.1547
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. OBJECTIVE:To explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease. DESIGN:The regulated miRNAs in human livers infected with hepatitis C virus were identified...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300717
更新日期:2012-11-01 00:00:00
abstract::The effects of intravenous N-acetylcysteine on hepatic and systemic haemodynamics were investigated in 11 patients with stable cirrhosis (eight alcohol; two primary biliary cirrhosis; one cryptogenic). N-acetylcysteine administration had no effect on the mean heart rate or mean arterial blood pressure despite a signif...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.9.1290
更新日期:1994-09-01 00:00:00