Antibodies to Escherichia coli in chronic liver diseases.

abstract：:The injection of rabbits' ileum with homogenates of both normal and Crohn's affected human bowel tissue gave Crohn's-like changes in 11 of 27 animals after six months, but 12 months after injection the rabbit bowel had reverted to normal. The addition of ampicillin to the homogenates prevented the appearance of these ...

journal_title：Gut

authors： Donnelly BJ,Delaney PV,Healy TM

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Studies on intestinal T cell clones from the mucosa of patients with coeliac disease have led to the identification of immunogenic gliadin epitopes. One is HLA-DQ8 restricted, its recognition by T cells being increased by introduction of negatively charged residues operated by tissue transglutaminase. AIM:T...

journal_title：Gut

authors： Mazzarella G,Maglio M,Paparo F,Nardone G,Stefanile R,Greco L,van de Wal Y,Kooy Y,Koning F,Auricchio S,Troncone R

更新日期：2003-01-01 00:00:00

abstract：:Peptide histidine isoleucine, a 27 amino acid peptide with close amino acid sequence homology to vasoactive intestinal peptide and secretin, is distributed throughout the mammalian intestinal tract, where it has been localised to intramural neurones. An intestinal perfusion technique has been used to study the effect ...

journal_title：Gut

authors： Moriarty KJ,Hegarty JE,Tatemoto K,Mutt V,Christofides ND,Bloom SR,Wood JR

更新日期：1984-06-01 00:00:00

abstract：:Big differences in the prevalence of peptic ulcer are known to exist in different parts of India. This paper reports a high incidence in Assam and records certain differences with peptic ulcers found in south India. ...

journal_title：Gut

authors： MALHOTRA SL,MAJUMDAR CT,BARDOLOI PC

更新日期：1964-08-01 00:00:00

abstract：:The present study was undertaken to investigate the possibility that central nervous system monoaminergic pathways may play a role in the control of gastric acid and gastrin secretion in man. Submaximal pentagastrin stimulated (0.25 micrograms/kg/h) gastric acid secretion, as well as basal gastrin concentrations were ...

journal_title：Gut

authors： Caldara R,Barbieri C,Piepoli V,Borzio M,Masci E

更新日期：1985-10-01 00:00:00

abstract：:The present study was undertaken to investigate the effect of alpha- and beta-adrenergic agonists on secretion of epidermal growth factor (EGF) from the rat submandibular glands and to test the possibility of intestinal absorption of EGF. Alpha-adrenergic agonists increased the concentration of salivary EGF by approxi...

journal_title：Gut

authors： Olsen PS,Kirkegaard P,Poulsen SS,Nexø E

更新日期：1984-11-01 00:00:00

abstract：:Faecal fat excretion was measured on a metabolic ward in 16 patients with duodenal ulcer before operation, and in patients who were in good health more than one year after truncal vagotomy and pyloroplasty (n = 11), bilateral selective vagotomy and pyloroplasty (n = 9), or highly selective vagotomy without a drainage ...

journal_title：Gut

authors： Edwards JP,Lyndon PJ,Smith RB,Johnston D

更新日期：1974-07-01 00:00:00

abstract：:A dodecapeptide of A-gliadin, which shares amino acid homologies with the E1b protein of adenovirus 12, was used to produce murine monoclonal antibodies. Five monoclonal antibodies were produced and were screened by enzyme linked immunosorbant assay, immunodot assay, and immunoblotting. The antibodies were tested agai...

journal_title：Gut

authors： Ellis HJ,Doyle AP,Sturgess RP,Ciclitira PJ

更新日期：1992-11-01 00:00:00

abstract：:In a double-blind controlled trial amylopectin sulphate (Depepsen) had no significant advantage over placebo in the symptomatic treatment of duodenal ulcer. ...

journal_title：Gut

authors： Baron JH,Gribble RJ,Holdstock DJ,Misiewicz JJ

更新日期：1977-09-01 00:00:00

abstract：:Management strategies for reflux disease are very different from those for dyspepsia and so differentiating between patients with "true" dyspepsia and those whose primary symptom is heartburn is a key step in their management. This separation has become more clear during the last decade as insights into reflux disease...

journal_title：Gut

authors： Dent J

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Surgery in patients with malignant bile duct obstruction is associated with high postoperative morbidity and mortality. Tumour necrosis factor alpha (TNF-alpha) plays a key role in the pathogenesis of these complications. AIMS:To determine the effect of biliary drainage on plasma concentrations of TNF-alpha...

journal_title：Gut

authors： Ballinger AB,Woolley JA,Ahmed M,Mulcahy H,Alstead EM,Landon J,Clark ML,Farthing MJ

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. AIMS:To study the effect of glyceryl trinitrate, a nitr...

journal_title：Gut

authors： Greaves R,Miller J,O'Donnell L,McLean A,Farthing MJ

更新日期：1998-03-01 00:00:00

abstract：:Increasing suppression of gastric secretion by anticholinergic drugs is accompanied by a rising mucus concentration; the actual output of mucus shows little change despite a marked reduction in the secretory volume. The problems involved in the estimation of mucus secretion and the importance of the above findings in ...

journal_title：Gut

authors： PIPER DW,STIEL MC,FENTON B

更新日期：1962-06-01 00:00:00

abstract：:Central reading, that is, independent, off-site, blinded review or reading of imaging endpoints, has been identified as a crucial component in the conduct and analysis of inflammatory bowel disease clinical trials. Central reading is the final step in a workflow that has many parts, all of which can be improved. Furth...

journal_title：Gut

authors： Gottlieb K,Daperno M,Usiskin K,Sands BE,Ahmad H,Howden CW,Karnes W,Oh YS,Modesto I,Marano C,Stidham RW,Reinisch W

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVES:Roux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations. DESIGN:We used functional MRI, ea...

journal_title：Gut

authors： Scholtz S,Miras AD,Chhina N,Prechtl CG,Sleeth ML,Daud NM,Ismail NA,Durighel G,Ahmed AR,Olbers T,Vincent RP,Alaghband-Zadeh J,Ghatei MA,Waldman AD,Frost GS,Bell JD,le Roux CW,Goldstone AP

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:Young-onset colorectal cancer (YCRC) incidence is rising. Scant data exist on YCRC risk after presentation with concerning symptoms such as iron-deficiency anaemia (IDA) or haematochezia. We examined the association between IDA and YCRC, and haematochezia and YCRC. DESIGN:Cohort study of US Veterans aged 18-...

journal_title：Gut

authors： Demb J,Liu L,Murphy CC,Doubeni CA,Martínez ME,Gupta S

更新日期：2020-12-18 00:00:00

abstract：:Imaging of biliary strictures may suggest malignancy but cytology can provide a tissue diagnosis. The aim of this study is to compare the diagnostic value of brush cytology and bile cytology. Thirty two patients (20 males, 12 females, median age 66 years, range 31-84) with biliary strictures at endoscopic retrograde c...

journal_title：Gut

authors： Kurzawinski T,Deery A,Dooley J,Dick R,Hobbs K,Davidson B

更新日期：1992-12-01 00:00:00

abstract：:An elderly woman with chronic ulcerative colitis who developed proximal muscle weakness, increased serum creatine phosphokinase activity, and histological and electromyographic abnormalities characteristic of polymyositis is described. Treatment with corticosteroids and 5-acetylsalicylic acid was followed by a remissi...

journal_title：Gut

authors： Chugh S,Dilawari JB,Sawhney IM,Dang N,Radotra BD,Chawla YK

更新日期：1993-04-01 00:00:00

abstract：:This report presents a patient with proximal small bowel cystic pneumatosis associated with poorly controlled coeliac disease and pseudo-obstruction. Cystic pneumatosis is rare in the proximal small bowel and we can find no report of its occurrence in association with coeliac disease. ...

journal_title：Gut

authors： Sackier JM,Smith EJ,Wood CB

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate the prognostic values of putative hepatic stem/progenitor cell (HSC/HPC) biomarkers in patients with hepatocellular carcinoma (HCC). METHODS:Fourteen biomarkers related to HSCs/HPCs or tumour angiogenesis were assessed by qRT-PCR and then validated by tissue microarrays (TMAs) in three i...

journal_title：Gut

authors： Yang XR,Xu Y,Yu B,Zhou J,Qiu SJ,Shi GM,Zhang BH,Wu WZ,Shi YH,Wu B,Yang GH,Ji Y,Fan J

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Hirschsprung's disease (HSCR) is a congenital disorder characterised by an absence of ganglion cells in the nerve plexuses of the lower digestive tract. Manifestation of the disease has been linked to mutations in genes that encode the crucial signals for the development of the enteric nervous system-the RET...

journal_title：Gut

authors： Garcia-Barceló M,Sham MH,Lui VC,Chen BL,Ott J,Tam PK

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:Lesogaberan (AZD3355) is a novel γ-aminobutyric acid B-type receptor agonist designed to treat gastro-oesophageal reflux disease (GERD) by inhibiting transient lower oesophageal sphincter relaxations. A randomised, double-blind, placebo-controlled, multi-centre phase IIb study was performed to assess the effi...

journal_title：Gut

authors： Shaheen NJ,Denison H,Björck K,Karlsson M,Silberg DG

更新日期：2013-09-01 00:00:00

abstract：:Microalbuminuria independently predicts the development of nephropathy and increased cardiovascular morbidity and mortality in diabetic patients, but it may be an indicator of the acute phase response. This study examined microalbuminuria as a marker of the acute phase response in patients with inflammatory bowel dise...

journal_title：Gut

authors： Mahmud N,Stinson J,O'Connell MA,Mantle TJ,Keeling PW,Feely J,Weir DG,Kelleher D

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND AND AIMS:The gastrointestinal microflora exerts a barrier effect against enteropathogens. The aim of this study was to examine if bifidobacteria, a major species of the human colonic microflora, participates in the barrier effect by developing antimicrobial activity against enterovirulent bacteria. METHODS:...

journal_title：Gut

authors： Liévin V,Peiffer I,Hudault S,Rochat F,Brassart D,Neeser JR,Servin AL

更新日期：2000-11-01 00:00:00

abstract：:In order to investigate further the reported beneficial effect of deglycyrrhizinated liquorice in gastric ulcer, a trial with a double-blind, cross-over design was performed. The patients were treated during two consecutive periods of four weeks each with either liquorice extract during the first period and placebo du...

journal_title：Gut

authors： Engqvist A,von Feilitzen F,Pyk E,Reichard H

更新日期：1973-09-01 00:00:00

abstract：BACKGROUND:Caroli's disease is a rare congenital disorder characterised by cystic dilatation of the intrahepatic bile ducts and an increased risk of cholangiocellular carcinoma. The cause is unknown, but occasional familial clustering suggests that some cases are inherited, in particular when occurring in association w...

journal_title：Gut

authors： Parada LA,Hallén M,Hägerstrand I,Tranberg KG,Johansson B

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Hydrogen sulphide (H(2)S) is a potent toxin normally present in the colonic lumen which may play a role in ulcerative colitis (UC). Two enzymes, thiol methyltransferase (TMT) and rhodanese (RHOD), are thought to be responsible for sulphide removal but supportive evidence is lacking. AIMS:To determine the di...

journal_title：Gut

authors： Picton R,Eggo MC,Merrill GA,Langman MJ,Singh S

更新日期：2002-02-01 00:00:00

abstract：:mu-, delta- and kappa-opioid receptors are widely expressed in the central nervous system where they mediate the strong analgesic and mood-altering actions of opioids, and modulate numerous endogenous functions. To investigate the contribution of the kappa-opioid receptor (KOR) to opioid function in vivo, we have gene...

journal_title：Gut

authors： Black D,Trevethick M

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND AIM:Accumulation and infiltration by neutrophil granulocytes is a prominent feature in the local inflammatory process in ulcerative colitis (UC). The present study was performed to evaluate human neutrophil lipocalin (HNL) as a specific neutrophil marker in the inflamed lesions of the colon and rectum in...

journal_title：Gut

authors： Carlson M,Raab Y,Sevéus L,Xu S,Hällgren R,Venge P

更新日期：2002-04-01 00:00:00

abstract：:Many of the symptoms characteristic of the functional gastrointestinal disorders (FGID) are consistent with dysfunction of the motor and/or sensory apparatus of the digestive tract. Those aspects of sensorimotor dysfunction most relevant to the FGID include alterations in: gut contractile activity; myoelectrical activ...

journal_title：Gut

authors： Kellow JE,Delvaux M,Azpiroz F,Camilleri M,Quigley EM,Thompson DG

更新日期：1999-09-01 00:00:00