Double-blind controlled trial of amylopectin sulphate (Depepsen) in the symptomatic treatment of duodenal ulcer.

abstract：:Hepatitis B and hepatitis C infections are important causes of end-stage liver disease and primary liver cancer. Successful antiviral treatment prior to the development of cirrhosis will prevent most of the morbidity and mortality associated with those infections. This can be achieved for a high proportion of patients...

journal_title：Gut

authors： Mutimer DJ,Lok A

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) and cause gastric ulceration. NSAIDs also impair granulation tissue angiogenesis and healing of established gastric ulcers in humans. The mechanism whereby NSAIDs inhibit granulation tissue angiogenesis is unknown but may involve inh...

journal_title：Gut

authors： Hull MA,Thomson JL,Hawkey CJ

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:Exposure of the oesophageal mucosa to gastric acid and bile acids leads to the accumulation of reactive oxygen species (ROS), a known risk factor for Barrett's oesophagus and progression to oesophageal adenocarcinoma (OAC). This study investigated the functions of glutathione peroxidase 7 (GPX7), frequently s...

journal_title：Gut

authors： Peng D,Belkhiri A,Hu T,Chaturvedi R,Asim M,Wilson KT,Zaika A,El-Rifai W

更新日期：2012-09-01 00:00:00

abstract：:An intensive histological search for Helicobacter pylori in gastric biopsy specimens has led to the detection of other spiral shaped bacteria in the human gastric mucosa. The clinical and morphological findings of 39 cases (0.25% of all gastric biopsies performed in the observation period) are reported for 34 patients...

journal_title：Gut

authors： Heilmann KL,Borchard F

更新日期：1991-02-01 00:00:00

abstract：:This case report describes the histological and macroscopic changes seen within a few months in the gastric mucosa of a 28 year old woman patient with upper abdominal symptoms. With hindsight these changes were the first signs of Sjögren's syndrome. ...

journal_title：Gut

authors： van Leeuwen ML,Tjiong HL,van Blankenstein M,Mulder AH,Bakker CM

更新日期：1993-08-01 00:00:00

abstract：:4-Aminosalicylic acid (4-ASA) has been suggested as an effective treatment for both active and quiescent ulcerative colitis. 5-Aminosalicylic acid (5-ASA) is well accepted for the maintenance treatment of inactive ulcerative colitis. Moreover, recent studies suggest that 5-ASA may also be effective in maintaining remi...

journal_title：Gut

authors： Schreiber S,Howaldt S,Raedler A

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Linkage data have now identified several inflammatory bowel disease (IBD) susceptibility loci but these data have not been consistently replicated in independent studies. One potential explanation for this is the possibility that patients enrolled in such studies may have been erroneously classified with res...

journal_title：Gut

authors： Silverberg MS,Daly MJ,Moskovitz DN,Rioux JD,McLeod RS,Cohen Z,Greenberg GR,Hudson TJ,Siminovitch KA,Steinhart AH

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Patients with liver cirrhosis are at increased risk of serious bacterial infections carrying a high case fatality rate. Case reports have suggested an association between liver cirrhosis and pyogenic liver abscess. AIMS:To estimate the risk and case fatality rate of pyogenic liver abscess in Danish patients...

journal_title：Gut

authors： Mølle I,Thulstrup AM,Vilstrup H,Sørensen HT

更新日期：2001-02-01 00:00:00

abstract：:An improved technique for the detection of alpha-gliadin sensitised mononuclear cells in the peripheral blood of untreated coeliac patients is described. This method is a modification of the direct LMIF assay, and involves exposure of lymphocytes to alpha-gliadin and the assay of the resultant lymphokine produced usin...

journal_title：Gut

authors： O'Farrelly C,Feighery C,Greally JF,Weir DG

更新日期：1982-01-01 00:00:00

abstract：:The effects of the methyl ester analogue of prostaglandin E1, misoprostol, on gastric epithelial cell proliferation were investigated in six dogs given 300 micrograms/kg/day of misoprostol orally for 11 weeks and in six control dogs given placebo for 11 weeks. Misoprostol treatment resulted in a 36% increase in stomac...

journal_title：Gut

authors： Goodlad RA,Madgwick AJ,Moffatt MR,Levin S,Allen JL,Wright NA

更新日期：1989-03-01 00:00:00

abstract：:Cimetidine 200 mg three times daily and 400 mg at night was given to 10 subjects for four weeks. Apparent liver blood flow was measured by indocyanine green clearance and microsomal enzyme activity by antipyrine clearance, before and after cimetidine. There was no reduction in indocyanine green clearance but antipyrin...

journal_title：Gut

authors： Daneshmend TK,Ene MD,Parker G,Roberts CJ

更新日期：1984-02-01 00:00:00

abstract：:Two consecutive trials of out-patient treatment for mild cases of active ulcerative colitis are described. In the first trial oral prednisone gave significantly better results than a placebo. In the second trial "salazopyrin" gave final results approaching those of prednisone, although over a longer time and with a hi...

journal_title：Gut

authors： LENNARD-JONES JE,LONGMORE AJ,NEWELL AC,WILSON CW,JONES FA

更新日期：1960-09-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by perip...

journal_title：Gut

authors： Thoree VC,Golby SJ,Boursier L,Hackett M,Dunn-Walters DK,Sanderson JD,Spencer J

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Lynch syndrome is caused by germline mismatch repair (MMR) gene mutations. The PREMM(1,2,6) model predicts the likelihood of a MMR gene mutation based on personal and family cancer history. OBJECTIVE:To compare strategies using PREMM(1,2,6) and tumour testing (microsatellite instability (MSI) and/or immunoh...

journal_title：Gut

authors： Kastrinos F,Steyerberg EW,Balmaña J,Mercado R,Gallinger S,Haile R,Casey G,Hopper JL,LeMarchand L,Lindor NM,Newcomb PA,Thibodeau SN,Syngal S,Colon Cancer Family Registry.

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:The risk of developing adenocarcinoma in non-dysplastic Barrett's oesophagus is low and difficult to predict. Accurate tools for risk stratification are needed to increase the efficiency of surveillance. We aimed to develop a prediction model for progression using clinical variables and genetic markers. METH...

journal_title：Gut

authors： Timmer MR,Martinez P,Lau CT,Westra WM,Calpe S,Rygiel AM,Rosmolen WD,Meijer SL,Ten Kate FJ,Dijkgraaf MG,Mallant-Hent RC,Naber AH,van Oijen AH,Baak LC,Scholten P,Böhmer CJ,Fockens P,Maley CC,Graham TA,Bergman JJ,Kri

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND AIM:There are few data on the course of Helicobacter pylori infection in asymptomatic subjects. The aim of this study was to assess the effect of eradication therapy on the development of dyspeptic and gastro-oesophageal reflux disease in a cohort of asymptomatic individuals observed over a prolonged per...

journal_title：Gut

authors： Vaira D,Vakil N,Rugge M,Gatta L,Ricci C,Menegatti M,Leandro G,Holton J,Russo VM,Miglioli M

更新日期：2003-11-01 00:00:00

abstract：:Lymphocytic gastritis is a new histopathological entity characterised by a dense lymphocytic infiltration of surface and pit gastric epithelium. Previous retrospective work has suggested that lymphocytic gastritis is related to an endoscopic form of gastropathy comprising enlarged folds, nodules and erosions, commonly...

journal_title：Gut

authors： Haot J,Jouret A,Willette M,Gossuin A,Mainguet P

更新日期：1990-03-01 00:00:00

abstract：:Circulating immune complexes were determined in 59 consecutive patients with Crohn's disease and 100 blood donors by a double method based on the inhibition of the agglutinating activity of CIq and/or rheumatoid factor on the IgG-coated polystyrene particles. In patients, the incidence of positive immune complexes was...

journal_title：Gut

authors： Fiasse R,Lurhuma AZ,Cambiaso CL,Masson PL,Dive C

更新日期：1978-07-01 00:00:00

abstract：:The increase in activities of hepatic thymidylate synthetase (EC 2.1.1.45) and thymidine kinase (EC 2.7.1.21), which catalyse the formation of thymidylate through the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which were given glucocorticoids (hydrocorti...

journal_title：Gut

authors： Tsukamoto I,Kojo S

更新日期：1989-03-01 00:00:00

abstract：:CLINICAL PRESENTATION: A 51-year-old man, who had no previous disease, underwent a screening oesophagogastroduodenoscopy, which revealed multiple yellowish lesions in the middle thoracic oesophagus. All lesions were ≤3 mm in size and slightly elevated. Each lesion showed one or two white protrusions on the surface (fi...

journal_title：Gut

authors： Hamada K,Yamasaki Y,Kubota JI,Okada H

更新日期：2019-01-01 00:00:00

abstract：:All cases of Crohn's disease in the Nottingham area were ascertained and the date and place of domicile and work at the time of onset of symptoms noted. Applying the Knox and Pike and Smith tests for clustering of patients in time and space, no significant results were observed. Further analysis of differences in time...

journal_title：Gut

authors： Miller DS,Keighley A,Smith PG,Hughes AO,Langman MJ

更新日期：1975-06-01 00:00:00

abstract：:Pouchitis may complicate the construction of an ileal pouch after colectomy for ulcerative colitis (UC) but not familial adenomatous polyposis (FAP). To examine whether differences in eicosanoid metabolism might explain why pouchitis is largely confined to UC patients, this study compared arachidonic acid stimulated r...

journal_title：Gut

authors： Gertner DJ,Rampton DS,Madden MV,Talbot IC,Nicholls RJ,Lennard-Jones JE

更新日期：1994-10-01 00:00:00

abstract：:The ability to digest mucus, mucolytic activity of isolated pepsins and samples of human gastric juice has been assayed by measuring the fall in viscosity when incubated with purified pig gastric mucus glycoprotein. Pure human pepsin 1, the peptic ulcer associated pepsin, digested gastric mucus glycoprotein at a faste...

journal_title：Gut

authors： Pearson JP,Ward R,Allen A,Roberts NB,Taylor WH

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Gastric mucosal surface hydrophobicity (GMSH) is an essential component of the mucosal defence system that is decreased by Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs). Gastric ulcers occur predominantly in elderly subjects, and may thus reflect diminished mucosal resistance. AIMS:...

journal_title：Gut

authors： Hackelsberger A,Platzer U,Nilius M,Schultze V,Günther T,Dominguez-Muñoz JE,Malfertheiner P

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or ...

journal_title：Gut

authors： Higuchi S,Ahmad TR,Argueta DA,Perez PA,Zhao C,Schwartz GJ,DiPatrizio NV,Haeusler RA

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have demonstrated that probiotics are effective in maintenance of remission in pouchitis patients. Howe...

journal_title：Gut

authors： Kühbacher T,Ott SJ,Helwig U,Mimura T,Rizzello F,Kleessen B,Gionchetti P,Blaut M,Campieri M,Fölsch UR,Kamm MA,Schreiber S

更新日期：2006-06-01 00:00:00

abstract：:Serum samples from 26 monozygotic twin pairs concordant or discordant with regard to inflammatory bowel disease, and rectal biopsies from 42 twins of the same subject group, were examined for IgG subclasses. They were all compared with normal controls. Almost all affected twins were in clinical remission. Paired immun...

journal_title：Gut

authors： Helgeland L,Tysk C,Järnerot G,Kett K,Lindberg E,Danielsson D,Andersen SN,Brandtzaeg P

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:Nicotinamide phosphoribosyltransferase (NAMPT, also referred to as pre-B cell colony-enhancing factor or visfatin) is critically required for the maintenance of cellular nicotinamide adenine dinucleotide (NAD) supply catalysing the rate-limiting step of the NAD salvage pathway. NAMPT is strongly upregulated i...

journal_title：Gut

authors： Gerner RR,Klepsch V,Macheiner S,Arnhard K,Adolph TE,Grander C,Wieser V,Pfister A,Moser P,Hermann-Kleiter N,Baier G,Oberacher H,Tilg H,Moschen AR

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Endoscopic surveillance for Barrett's oesophagus (BO) is under discussion given the overall low incidence of neoplastic progression and lack of evidence that it prevents advanced oesophageal adenocarcinoma (OAC). The aim of this study was to evaluate the impact of endoscopic BO surveillance on tumour stage an...

journal_title：Gut

authors： Kastelein F,van Olphen SH,Steyerberg EW,Spaander MC,Bruno MJ,ProBar-Study Group.

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND AIMS:We followed a population based cohort of patients with inflammatory bowel disease (IBD) from Olmsted County, Minnesota, in order to analyse long term survival and cause specific mortality. MATERIAL AND METHODS:A total of 692 patients were followed for a median of 14 years. Standardised mortality ra...

journal_title：Gut

authors： Jess T,Loftus EV Jr,Harmsen WS,Zinsmeister AR,Tremaine WJ,Melton LJ 3rd,Munkholm P,Sandborn WJ

更新日期：2006-09-01 00:00:00