Abstract:
:The increase in activities of hepatic thymidylate synthetase (EC 2.1.1.45) and thymidine kinase (EC 2.7.1.21), which catalyse the formation of thymidylate through the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which were given glucocorticoids (hydrocortisone and dexamethasone) or indomethacin. These drugs also prevented the augment of hepatic DNA content in 24 h regenerating liver.
journal_name
Gutjournal_title
Gutauthors
Tsukamoto I,Kojo Sdoi
10.1136/gut.30.3.387subject
Has Abstractpub_date
1989-03-01 00:00:00pages
387-90issue
3eissn
0017-5749issn
1468-3288journal_volume
30pub_type
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