Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat.

Abstract:

:The increase in activities of hepatic thymidylate synthetase (EC 2.1.1.45) and thymidine kinase (EC 2.7.1.21), which catalyse the formation of thymidylate through the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which were given glucocorticoids (hydrocortisone and dexamethasone) or indomethacin. These drugs also prevented the augment of hepatic DNA content in 24 h regenerating liver.

journal_name

Gut

journal_title

Gut

authors

Tsukamoto I,Kojo S

doi

10.1136/gut.30.3.387

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

387-90

issue

3

eissn

0017-5749

issn

1468-3288

journal_volume

30

pub_type

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