Cyclic AMP and cyclic GMP levels in human colonic mucosa before and during chenodeoxycholic acid therapy.

abstract：:Cell cultures derived from Crohn's disease and control tissues were subjected to a series of tests designed to detect persistent, non-cytocidal virus infection. No evidence for any such infection was found, and it is concluded that persistent viral infection of gut tissues is unlikely to play a significant role in the...

journal_title：Gut

authors： Phillpotts RJ,Hermon-Taylor J,Teich NM,Brooke BN

更新日期：1980-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Little is known about the epidemiology of malignant digestive endocrine tumours. The aim of this study was to report on their incidence and management in a well defined population. METHODS:Data were obtained from the population based Digestive Cancer Registry of Burgundy (France) over a 24 year per...

journal_title：Gut

authors： Lepage C,Bouvier AM,Phelip JM,Hatem C,Vernet C,Faivre J

更新日期：2004-04-01 00:00:00

abstract：:Thirty of 81 consecutive HIV antibody positive patients referred with non-cryptosporidial diarrhoea had no potential infectious cause; most had AIDS related complex rather than the full blown syndrome. Opportunistic infections with cytomegalovirus (CMV), mycobacterium avium-intracellulare (MAI), and herpes simplex vir...

journal_title：Gut

authors： Connolly GM,Shanson D,Hawkins DA,Webster JN,Gazzard BG

更新日期：1989-02-01 00:00:00

abstract：:Colorectal cancer is the second commonest cause of cancer death in the UK. An effective national screening programme is urgently required to reduce the substantial morbidity and mortality from the disease. The success of any screening programme will depend on the screening test detecting early Dukes's A carcinomas and...

journal_title：Gut

authors： Hart AR,Wicks AC,Mayberry JF

更新日期：1995-04-01 00:00:00

abstract：:The amylase/creatinine clearance ratio (Cam/Ccr ratio) was determined in 239 subjects. In 87 hospitalised patients without pancreatic disease (controls) the Cam/Ccr ratio was 3.02 +/- 0.69 (mean +/- ISD). The ratio was above the normal range in all patients with acute pancreatitis but was normal in those with chronic ...

journal_title：Gut

authors： Marten A,Beales D,Elias E

更新日期：1977-09-01 00:00:00

abstract：OBJECTIVE:Lesogaberan (AZD3355) is a novel γ-aminobutyric acid B-type receptor agonist designed to treat gastro-oesophageal reflux disease (GERD) by inhibiting transient lower oesophageal sphincter relaxations. A randomised, double-blind, placebo-controlled, multi-centre phase IIb study was performed to assess the effi...

journal_title：Gut

authors： Shaheen NJ,Denison H,Björck K,Karlsson M,Silberg DG

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Somatostatin has been used to prevent pancreatitis after endoscopic retrograde cholangiopancreatography but its effect on acute non-biliary pancreatitis is still unclear. AIM:The purpose of this study was to evaluate the function of the sphincter of Oddi (SO) and the effect of somatostatin on patients with ...

journal_title：Gut

authors： Lai KH,Lo GH,Cheng JS,Fu MT,Wang EM,Chan HH,Wang YY,Hsu PI,Lin CK

更新日期：2001-12-01 00:00:00

abstract：:Completeness of vagotomy has been assessed by use of the electrical stimulation test and the insulin test in 50 patients suffering from chronic duodenal ulceration. A positive result from either was taken as evidence of incomplete vagotomy. The electrical stimulation test provided such evidence more often than the ins...

journal_title：Gut

authors： Hollanders D

更新日期：1971-08-01 00:00:00

abstract：OBJECTIVE:Persistent colonisation by Helicobacter pylori, and especially by cagA-positive strains, has been related to several health outcomes with effects in opposite directions. Thus, it is important to evaluate its influence on total and category-specific mortality. DESIGN:We conducted prospective cohort analyses i...

journal_title：Gut

authors： Chen Y,Segers S,Blaser MJ

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:To establish an appropriate steroid treatment regimen for autoimmune pancreatitis (AIP). METHODS:A retrospective survey of AIP treatment was conducted in 17 centres in Japan. The main outcome measures were rate of remission and relapse. RESULTS:Of 563 patients with AIP, 459 (82%) received steroid treatment....

journal_title：Gut

authors： Kamisawa T,Shimosegawa T,Okazaki K,Nishino T,Watanabe H,Kanno A,Okumura F,Nishikawa T,Kobayashi K,Ichiya T,Takatori H,Yamakita K,Kubota K,Hamano H,Okamura K,Hirano K,Ito T,Ko SB,Omata M

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Genetic predisposition and gliadin exposure are known to be crucial factors in the development of coeliac disease. Circumstantial evidence suggests that other unidentified environmental factors may also be of pathogenetic importance. AIM:To define the relation between cigarette smoking and the risk of devel...

journal_title：Gut

authors： Snook JA,Dwyer L,Lee-Elliott C,Khan S,Wheeler DW,Nicholas DS

更新日期：1996-07-01 00:00:00

abstract：:Dysphagia in a 79 year old lady was caused by a giant polypoid tumour in mid-oesophagus. Surgery was not appropriate. Shrinkage of the tumour and its eventual detachment were achieved by stopping its blood supply by YAG laser photocoagulation of the tumour stalk. Good, temporary palliation of the dysphagia was achieve...

journal_title：Gut

authors： Richardson D,Wyatt JI,Miloszewski KJ

更新日期：1992-08-01 00:00:00

abstract：INTRODUCTION:Recent data have suggested that specific haplotypic variants of the DLG5 gene on chromosome 10q23 may be associated with susceptibility to inflammatory bowel disease (IBD) in Germany. Haplotype D, notably characterised by the presence of a G-->A substitution at nucleotide 113, was associated with susceptib...

journal_title：Gut

authors： Noble CL,Nimmo ER,Drummond H,Smith L,Arnott ID,Satsangi J

更新日期：2005-10-01 00:00:00

abstract：:The HGT-1 gastric cancer cell line was used to determine the actions of protein kinase C on the stimulation of adenylate cyclase by the human histamine H2 receptor, and the receptors for gastric inhibitory polypeptide and truncated glucagon like peptide 1 (TGLP-1). Suspensions of HGT-1 cells were preincubated with the...

journal_title：Gut

authors： McKenna P,Williams JM,Gespach CP,Hanson PJ

更新日期：1993-07-01 00:00:00

abstract：:This third section of the European Crohn's and Colitis Organisation (ECCO) Consensus on the management of Crohn's disease concerns postoperative recurrence, fistulating disease, paediatrics, pregnancy, psychosomatics, extraintestinal manifestations, and alternative therapy. The first section on definitions and diagnos...

journal_title：Gut

authors： Caprilli R,Gassull MA,Escher JC,Moser G,Munkholm P,Forbes A,Hommes DW,Lochs H,Angelucci E,Cocco A,Vucelic B,Hildebrand H,Kolacek S,Riis L,Lukas M,de Franchis R,Hamilton M,Jantschek G,Michetti P,O'Morain C,Anwar MM

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:The molecular mechanisms mediating the antiproliferative effects of interferon alpha on human pancreatic carcinoma cells are poorly understood. AIM:To characterise the effects of interferon alpha on protein kinase C isoenzyme expression in interferon alpha sensitive and resistant human pancreatic tumour cel...

journal_title：Gut

authors： Rosewicz S,Weder M,Kaiser A,Riecken EO

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...

journal_title：Gut

authors： Hochart A,Gower-Rousseau C,Sarter H,Fumery M,Ley D,Spyckerelle C,Peyrin-Biroulet L,Laberenne JE,Vasseur F,Savoye G,Turck D,Epimad Group.

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:A rapid, reliable, and accurate test for the diagnosis of infection with Helicobacter pylori is needed for screening dyspeptic patients before referral for endoscopy. AIM:To compare a new rapid whole blood test (Helisal rapid blood, Cortecs), two serum enzyme linked immunosorbent assays (ELISAs; Helico-G, S...

journal_title：Gut

authors： Reilly TG,Poxon V,Sanders DS,Elliott TS,Walt RP

更新日期：1997-04-01 00:00:00

abstract：:Infusion of fat into the ileum slows small bowel transit and increases absorption of a carbohydrate meal. Paired studies were undertaken to investigate the effect of adding fat to the diet on gastrointestinal transit and absorption in eight people with terminal ileostomies. Each subject ate a daily diet that contained...

journal_title：Gut

authors： Higham SE,Read NW

更新日期：1990-04-01 00:00:00

abstract：:Ileal disease or resection causes bile salt malabsorption and a reduction in the bile salt content of bile. Since cholesterol solubility requires adequate bile salt concentrations, depletion of the bile salt content of bile might, therefore, jeopardize cholesterol solubility and predispose to cholesterol gallstone for...

journal_title：Gut

authors： Dowling RH,Bell GD,White J

更新日期：1972-06-01 00:00:00

abstract：:We have found increased small intestinal permeability to 51Cr-ethylenediaminetetra acetate in patients with ankylosing spondylitis compared with controls. There is no significant difference between patients with ankylosing spondylitis and patients with rheumatoid arthritis taking non-steroidal anti-inflammatory drugs ...

journal_title：Gut

authors： Morris AJ,Howden CW,Robertson C,Duncan A,Torley H,Sturrock RD,Russell RI

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Watery stools are equated with rapid and hard stools with slow intestinal transit; however, the relation between stool form and transit through specific regions of the gut is not clear cut. In addition, more information is needed on interindividual variability of these measurements. AIM:To examine the relat...

journal_title：Gut

authors： Degen LP,Phillips SF

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVES:Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in hu...

journal_title：Gut

authors： Kiesslich R,Duckworth CA,Moussata D,Gloeckner A,Lim LG,Goetz M,Pritchard DM,Galle PR,Neurath MF,Watson AJ

更新日期：2012-08-01 00:00:00

abstract：:The effect of sodium taurocholate instillation on the stimulated stomachs of patients with duodenal ulceration has been investigated. Instillation into the stomach of sodium taurocholate significantly reduced pentagastrin stimulated volume and outputs of both acid and sodium, with no change in the calculated volume of...

journal_title：Gut

authors： Lewin MR,Pifano E,Daniel RD,Boulos PB,Clark CG

更新日期：1983-01-01 00:00:00

abstract：:The most reliable method of making a specific aetiological diagnosis of chronic viral hepatitis would be to identify virus specific cytotoxic T lymphocytes responsible for the killing of virus infected hepatocytes in each patient's liver. Unfortunately, this can not be proposed for routine diagnosis and surrogate test...

journal_title：Gut

authors： Bonino F,Colloredo Mels G,Bellati G,Ideo G,Oliveri F,Colombatto P,Brunetto MR

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is associated with cardiovascular risk. The aim of this study was to determine the role of fatty liver in predicting coronary artery disease and clinical outcomes in patients undergoing coronary angiogram. METHOD...

journal_title：Gut

authors： Wong VW,Wong GL,Yip GW,Lo AO,Limquiaco J,Chu WC,Chim AM,Yu CM,Yu J,Chan FK,Sung JJ,Chan HL

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Endoscopic diagnosis of short segments of Barrett's epithelium (SSBE)' is difficult and its meaning in terms of the presence of specialised columnar epithelium (SCE) has not been prospectively evaluated. AIMS:To evaluate the prevalence of SCE in patients with an endoscopic diagnosis of SSBE and in individua...

journal_title：Gut

authors： Pereira AD,Suspiro A,Chaves P,Saraiva A,Glória L,de Almeida JC,Leitão CN,Soares J,Mira FC

更新日期：1998-05-01 00:00:00

abstract：:Five cases of volvulus of varying lengths of the small intestine are described. The incidence and the aetiology of the condition are briefly discussed. Shock as a feature of extensive volvulus is stressed, and its cause in these cases is related to the previous animal experimental work of others. The other clinical fe...

journal_title：Gut

authors： TALBOT CH

更新日期：1960-03-01 00:00:00

abstract：:All cases of Crohn's disease in the Nottingham area were ascertained and the date and place of domicile and work at the time of onset of symptoms noted. Applying the Knox and Pike and Smith tests for clustering of patients in time and space, no significant results were observed. Further analysis of differences in time...

journal_title：Gut

authors： Miller DS,Keighley A,Smith PG,Hughes AO,Langman MJ

更新日期：1975-06-01 00:00:00

abstract：:Carriers of beta amino acids and imino acids in the small intestine of rabbits and guinea pigs are chloride dependent, and a cotransport of chloride, sodium, and 2-methyl-aminoisobutyric acid has been shown. This study examines the chloride dependence of amino acid transport in the human small intestine. The steady st...

journal_title：Gut

authors： Munck LK

更新日期：1995-02-01 00:00:00