Abstract:
:The amylase/creatinine clearance ratio (Cam/Ccr ratio) was determined in 239 subjects. In 87 hospitalised patients without pancreatic disease (controls) the Cam/Ccr ratio was 3.02 +/- 0.69 (mean +/- ISD). The ratio was above the normal range in all patients with acute pancreatitis but was normal in those with chronic pancreatitis and carcinoma of the pancreas. In 18 patients with choledocholithiasis a raised ratio distinguished those with pancreatitis as assessed independently by the surgeon at laparotomy from those with a macroscopically normal pancreas. Raised Cam/Ccr ratios were also found in diabetics with ketoacidosis and in three patients with fulminant alcoholic liver disease. Though a positive correlation was found between the Cam/Ccr ratio and serum creatinine concentration, abnormally high ratios did not occur in 30 patients with chronic renal failure. A significant increase in Cam/Ccr ratios was produced in six healthy volunteers by intravenous injection of glucagon. However, it is unlikely that hyperglucagonaemia alone accounts for the increased Cam/Ccr ratio seen in acute pancreatitis, as no correlation was found between the clearance ratio and the plasma glucagon concentration in a series of patients. In two other patients in whom excess circulating pancreatic polypeptide was detected the Cam/Ccr ratio was normal. It is concluded that, in view of the sensitivity and relative specificity of finding an increased Cam/Ccr ratio in acute pancreatitis, its determination should be valuable clinically, especially in those cases of hyperamylasaemia where the cause is in doubt. The mechanism whereby the ratio is increased is unknown, and it is unlikely that either glucagon or pancreatic polypeptide is a major factor in its production.
journal_name
Gutjournal_title
Gutauthors
Marten A,Beales D,Elias Edoi
10.1136/gut.18.9.703subject
Has Abstractpub_date
1977-09-01 00:00:00pages
703-8issue
9eissn
0017-5749issn
1468-3288journal_volume
18pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND:Pyoderma gangrenosum (PG) is a chronic ulcerating skin condition that often occurs in association with inflammatory bowel disease. There have been a number of reports of PG responding to infliximab, a monoclonal antibody against tumour necrosis factor alpha. AIM:In the first randomised placebo controlled tr...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.2005.074815
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Increased serum antibodies against carbonic anhydrase II (CA-II Ab) or IgG4 levels have been reported in cases of autoimmune chronic pancreatitis (ACP). AIM:To assess the relevance of serum CA-II Ab and IgG4 levels for the diagnosis of ACP in idiopathic CP (ICP) versus alcoholic CP and Sjogren's syndrome (S...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2004.047142
更新日期:2005-05-01 00:00:00
abstract::There has been a vast increase in GI literature focused on the use of machine learning in endoscopy. The relative novelty of this field poses a challenge for reviewers and readers of GI journals. To appreciate scientific quality and novelty of machine learning studies, understanding of the technical basis and commonly...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2019-320466
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic approach for PDAC u...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-320608
更新日期:2020-10-21 00:00:00
abstract:BACKGROUND AND AIMS:Perturbation of differentiation of the crypt-villus axis of the human small intestine is associated with several intestinal disorders of clinical importance. At present, differentiation of small intestinal enterocytes in the crypt-villus axis is not well characterised. SUBJECTS AND METHODS:Expressi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.073262
更新日期:2006-08-01 00:00:00
abstract::This study reports on a group of 20 patients with an initial diagnosis of primary biliary cirrhosis (PBC) whose serum tested negative for antimitochondrial antibodies by immunofluorescence. All had a clinical history compatible with primary biliary cirrhosis, and results of biochemical, histological, and radiological ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.2.260
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:There is a widespread notion that obesity leads to gastro-oesophageal reflux but scientific evidence of an association is limited and inconsistent. AIMS:To estimate the strength of the association between body mass and reflux symptoms, we performed a population based cross sectional interview study. SUBJEC...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.47.1.26
更新日期:2000-07-01 00:00:00
abstract::The sample population in this initial case control study of the adenosine diphosphate ribosyl transferase (ADPRT) response of inflammatory bowel disease patients included: 23 patients with ulcerative colitis (UC)-active and inactive, 13 patients with Crohn's disease (CD)-active and inactive, 14 first degree relatives ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.12.1680
更新日期:1988-12-01 00:00:00
abstract::The effects of luminal instillation of 16,16 dimethyl PGE2 (dmPGE2) on gastric acid secretion and back diffusion of H+ were studied in anaesthetised dogs which were prepared with a segment of the greater curvature of the stomach mounted in a double lumen chamber. This model permitted simultaneous evaluation of two seg...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.9.775
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:The prevalence of duodenal carcinoma is much higher in familial adenomatous polyposis (FAP) than in the background population, and duodenal adenomatosis is found in most polyposis patients. AIMS:To describe the long term natural history of duodenal adenomatosis in FAP and evaluate if cancer prophylactic sur...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2003.027771
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Hereditary forms of chronic idiopathic intestinal pseudo-obstruction (CIIP) are well described but the aetiology of most cases of sporadic CIIP is unknown. AIM:To determines whether herpes viruses can persist in the gastrointestinal tract, thereby implicating them in the pathogenesis of CIIP. METHODS:Twent...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.1.100
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is k...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.6.840
更新日期:2003-06-01 00:00:00
abstract::The most reliable method of making a specific aetiological diagnosis of chronic viral hepatitis would be to identify virus specific cytotoxic T lymphocytes responsible for the killing of virus infected hepatocytes in each patient's liver. Unfortunately, this can not be proposed for routine diagnosis and surrogate test...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.2_suppl.s36
更新日期:1993-01-01 00:00:00
abstract::Prostaglandins (PGs) are synthesised by gastric mucosa, and have been shown to inhibit gastric acid secretion and ulcer formation in man and experimental animals. Recently exogenous PGs, mainly of the E group, have been used for the treatment of peptic ulcer disease. We therefore searched for a drug that would stimula...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.10.882
更新日期:1979-10-01 00:00:00
abstract:OBJECTIVE:Tissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in stem cell activity in rapidly proliferating isthmus stem cells in the stomach corpus. DESIGN:We uncovered the specific expression of Iqgap3 in proliferating isthm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-322779
更新日期:2020-12-08 00:00:00
abstract:BACKGROUND:Lynch syndrome is caused by germline mismatch repair (MMR) gene mutations. The PREMM(1,2,6) model predicts the likelihood of a MMR gene mutation based on personal and family cancer history. OBJECTIVE:To compare strategies using PREMM(1,2,6) and tumour testing (microsatellite instability (MSI) and/or immunoh...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2011-301265
更新日期:2013-02-01 00:00:00
abstract::Both hog gastrin and synthetic gastrin stimulate the cardiac sphincter to increase tone and augment the resistance to reflux. Endogenous gastrin has a similar effect, and gastrin also stimulates the secretion of acid which has also been found to increase the resistance of the sphincter, but the effect of gastrin appea...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.10.9.730
更新日期:1969-09-01 00:00:00
abstract::A case of adenocarcinoma of the ileum, occurring in an area concomitantly the site of Crohn's disease, is described. Examination of the literature suggests that there are certain characteristics of the small bowel carcinoma which arises in Crohn's disease. These include invisibility of the tumour on macroscopic inspec...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.16.7.533
更新日期:1975-07-01 00:00:00
abstract:BACKGROUND:Integrins are transmembrane cell surface receptors that mediate cell-cell and cell-matrix contacts. Integrin-linked kinase (ILK) is the binding partner of beta1 and beta3 integrins, and has been ascribed essential roles in development, angiogenesis and tumourigenesis. However, in vivo evidence for the latter...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.142778
更新日期:2008-07-01 00:00:00
abstract::The effects of pentagastrin and the putative gastrin antagonist proglumide on interdigestive motility of the upper small bowel were studied in a randomised double blind study in 10 healthy human volunteers. Intraluminal pressures were recorded manometrically in the duodenum and jejunum for five hours. Sixty minutes af...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.25.9.953
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed medications, but they are associated with a number of serious adverse effects, including hypertension, cardiovascular disease, kidney injury and GI complications. OBJECTIVE:To develop a set of multidisciplinary recommenda...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2019-319300
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:Contrary to the long-standing prerequisite of inducing selective (ie, bifidogenic) effects, recent findings suggest that prebiotic interventions lead to ecosystem-wide microbiota shifts. Yet, a comprehensive characterisation of this process is still lacking. Here, we apply 16S rDNA microbiota profiling and ma...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2016-313271
更新日期:2017-11-01 00:00:00
abstract::An enema that contained a complex of bismuth citrate and polyacrylate was compared with 5-aminosalicylic acid (5-ASA) enemas for treatment of distal ulcerative colitis. The multicentre trial involving 63 patients was randomised and double blind with enemas given over four weeks; clinical, sigmoidoscopic, and histologi...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.34.5.676
更新日期:1993-05-01 00:00:00
abstract::The role of biliary deoxycholate as an endogenous colon carcinogen and the possible association between cholelithiasis and/or cholecystectomy and the subsequent development of large bowel cancer is unclear. This paper describes biliary bile acids analysis performed on 13 patients undergoing cholecystectomy for gall st...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.6.860
更新日期:1989-06-01 00:00:00
abstract::To investigate the effects of supplemental oxygen on cardiac rhythm during gastroscopy, 103 patients aged over 60 were randomised to receive either supplemental oxygen or air at 2 litres/minute during the procedure. Pulse rate, blood pressure, oxygen saturation, and a Holter cardiac trace were monitored before, during...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.11.1492
更新日期:1993-11-01 00:00:00
abstract::Seventeen paediatric patients with immunodeficiency syndromes (10 with selective IgA deficiency, four with panhypogammaglobulinaemia, and three with selective T cell deficiency) were investigated for bacterial overgrowth of the small intestine and gut permeability to macromolecules. Five of 12 patients showed viable b...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.8.879
更新日期:1990-08-01 00:00:00
abstract::40749 RP is a pyridil-2-tetrahydrothiophene derivative, belonging to a new class of gastric antisecretory drugs. We compared its effects on gastric secretion with cimetidine. Intragastric acidity, nocturnal acid output, gastrin and pepsinogen-I profiles were measured in patients with duodenal ulcer in clinical remissi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.4.423
更新日期:1986-04-01 00:00:00
abstract::Serumfolate folate levels and the bacteriology of the small intestine were studied in 13 patients with jejunal diverticulosis, 29 patients with partial gastrectomy, and five patients with ileal disease. The mean serum folate level in the patients with partial gastrectomy (7.2 mmug/ml) was similar to that of control su...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.1.27
更新日期:1971-01-01 00:00:00
abstract::Increased arachidonic acid concentrations in experimental rodent colonic cancer have been described recently. In humans, a reduced erythrocyte stearic acid to oleic acid ratio has been reported in patients with colorectal cancer and it has been proposed that similar changes exist in the cancer tissue. The long chain f...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.3.278
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVE:Caffeine reduces toxic Ca2+ signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP3R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental acute pancreatitis (AP). We have determined effects of caffeine an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309363
更新日期:2017-02-01 00:00:00