Arachidonic acid and docosahexaenoic acid are increased in human colorectal cancer.

abstract：:Stimulation of the rectal mucosa with a bipolar electrode leads to relaxation of the internal anal sphincter. Intraoperative studies in two subjects showed that transmission of the impulse was independent of extrinsic nerves and was interrupted by circular myotomy. Characteristics of the reflex were studied in 11 heal...

journal_title：Gut

authors： Kamm MA,Lennard-Jones JE,Nicholls RJ

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:A non-invasive test for assessment of fat digestion has been developed based on the intraluminal hydrolysis of cholesteryl-[1-13C]octanoate by pancreatic esterase. AIMS:To determine the diagnostic performance of this breath test in the assessment of exocrine pancreatic function. METHODS:The test was perfor...

journal_title：Gut

authors： Ventrucci M,Cipolla A,Ubalducci GM,Roda A,Roda E

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Gastric cancer remains a major cause of cancer mortality globally but no good prognostic tumour marker is available. Soluble fragment of E-cadherin protein has been reported to increase in the sera of patients with cancer and recently was found to be elevated in 67% of patients with gastric cancer. AIMS:To ...

journal_title：Gut

authors： Chan AO,Lam SK,Chu KM,Lam CM,Kwok E,Leung SY,Yuen ST,Law SY,Hui WM,Lai KC,Wong CY,Hu HC,Lai CL,Wong J

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase 2 (COX-2) and matrix metalloproteinases (MMPs) have been implicated in tissue injury and fibrogenesis in animal models but little is known regarding their role in hepatitis C virus (HCV) related liver disease in humans. AIMS:To characterise the intrahepatic expression pattern of COX-2 and MMP...

journal_title：Gut

authors： Núñez O,Fernández-Martínez A,Majano PL,Apolinario A,Gómez-Gonzalo M,Benedicto I,López-Cabrera M,Boscá L,Clemente G,García-Monzón C,Martín-Sanz P

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Impaired iron handling in riboflavin deficiency is thought to be partially a result of significant morphological and cytokinetic changes within the small intestine. AIMS:The aim of the study was to find out if the responses of the rat small intestine to riboflavin deficiency induced at weaning could be reve...

journal_title：Gut

authors： Williams EA,Rumsey RD,Powers HJ

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...

journal_title：Gut

authors： Hochart A,Gower-Rousseau C,Sarter H,Fumery M,Ley D,Spyckerelle C,Peyrin-Biroulet L,Laberenne JE,Vasseur F,Savoye G,Turck D,Epimad Group.

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying. AIMS:To assess the effects of endogenous GLP-1 on endocrine pancreatic secretion and antro-pyloro-duodenal motility by utilising the GLP-...

journal_title：Gut

authors： Schirra J,Nicolaus M,Roggel R,Katschinski M,Storr M,Woerle HJ,Göke B

更新日期：2006-02-01 00:00:00

abstract：:A family is described in which eight members in three successive generations had a sliding type of oesophageal hiatus hernia (or partial thoracic stomach) as a sole anomaly. The trait in this family behaved as a strict dominant, manifesting the segregation of a single abnormal autosomal gene. Other possible aetiologie...

journal_title：Gut

authors： Carré IJ,Froggatt P

更新日期：1970-01-01 00:00:00

abstract：:Both hog gastrin and synthetic gastrin stimulate the cardiac sphincter to increase tone and augment the resistance to reflux. Endogenous gastrin has a similar effect, and gastrin also stimulates the secretion of acid which has also been found to increase the resistance of the sphincter, but the effect of gastrin appea...

journal_title：Gut

authors： Giles GR,Mason MC,Humphries C,Clark CG

更新日期：1969-09-01 00:00:00

abstract：BACKGROUND:TFF1 is a 6.5 kDa secreted protein that is expressed predominantly in normal gastric mucosa. It is coexpressed with mucins and it can form dimers via a free carboxy terminal cysteine residue. AIMS:To investigate the molecular forms of TFF1 that are present in normal human stomach and the association of the ...

journal_title：Gut

authors： Newton JL,Allen A,Westley BR,May FE

更新日期：2000-03-01 00:00:00

abstract：:The role of lamina propria cells in regulating human colonic ion transport was investigated in vitro. Normal human colonic mucosae were mounted in Ussing chambers, and short circuit current changes (delta SCC) were monitored in response to immune cell activation. Anti-human immunoglobulin E (anti-IgE) and formyl-Methi...

journal_title：Gut

authors： Stack WA,Keely SJ,O'Donoghue DP,Baird AW

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Coeliac disease (CD) is triggered by an abnormal reaction to gluten. Peptides resulting from partially digested gluten of wheat, barley or rye cause inflammation of the small intestinal mucosa. Previous contradictory studies suggest that oats may trigger the abnormal immunological response in patien...

journal_title：Gut

authors： Comino I,Real A,de Lorenzo L,Cornell H,López-Casado MÁ,Barro F,Lorite P,Torres MI,Cebolla A,Sousa C

更新日期：2011-07-01 00:00:00

abstract：:The medication history of patients presenting with benign oesophageal stricture is compared with an age and sex matched control population selected from the community. Fifty five out of 151 consecutive admissions to a dysphagia clinic were found to have benign oesophageal stricture. Twenty six out of 53 (49%) had been...

journal_title：Gut

authors： Wilkins WE,Ridley MG,Pozniak AL

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Patients with liver cirrhosis are at increased risk of serious bacterial infections carrying a high case fatality rate. Case reports have suggested an association between liver cirrhosis and pyogenic liver abscess. AIMS:To estimate the risk and case fatality rate of pyogenic liver abscess in Danish patients...

journal_title：Gut

authors： Mølle I,Thulstrup AM,Vilstrup H,Sørensen HT

更新日期：2001-02-01 00:00:00

abstract：:Octreotide has been proposed for the treatment of variceal bleeding. The effects on portal pressure, however, have been variable in published studies. As bleeding is more directly related to pressure in the varices, this study investigated the effect on variceal pressure of octreotide and terlipressin, a vasoactive dr...

journal_title：Gut

authors： Nevens F,Van Steenbergen W,Yap SH,Fevery J

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Opioids are increasingly prescribed in the West and have deleterious GI consequences. Pharmacological therapies to treat opioid-induced constipation (OIC) are available, but their relative efficacy is unclear. We performed a systematic review and network meta-analysis to address this deficit in current knowle...

journal_title：Gut

authors： Luthra P,Burr NE,Brenner DM,Ford AC

更新日期：2019-03-01 00:00:00

abstract：:Chronic idiopathic constipation may be the result of an autonomic neuropathy. This hypothesis was tested in 23 constipated patients and 17 age matched controls, using the acetylcholine sweat spot test devised to test autonomic integrity in diabetes. Acetylcholine (0.01%) was injected in the dorsum of the foot painted ...

journal_title：Gut

authors： Altomare D,Pilot MA,Scott M,Williams N,Rubino M,Ilincic L,Waldron D

更新日期：1992-11-01 00:00:00

abstract：:Using 24 hour pH monitoring as a reference standard, the usefulness of the acid perfusion (AP) test in predicting gastro-oesophageal reflux disease (GORD) was assessed in 71 non-cardiac chest pain (NCCP) patients and 23 endoscopic oesophagitis patients. Of the 71 NCCP patients, 35 had a positive AP test (of whom 20 ha...

journal_title：Gut

authors： Hewson EG,Sinclair JW,Dalton CB,Wu WC,Castell DO,Richter JE

更新日期：1989-03-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to compare azathioprine versus mesalazine tablets for the prevention of clinical recurrence in patients with postoperative Crohn's disease (CD) with moderate or severe endoscopic recurrence. METHODS:This was a 1 year, double-blind, double-dummy, randomised study which took place in 2...

journal_title：Gut

authors： Reinisch W,Angelberger S,Petritsch W,Shonova O,Lukas M,Bar-Meir S,Teml A,Schaeffeler E,Schwab M,Dilger K,Greinwald R,Mueller R,Stange EF,Herrlinger KR,International AZT-2 Study Group.

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Lipids may exacerbate symptoms induced by gut stimuli. AIM:To determine the mechanism whereby fat exerts this effect. SUBJECTS:Twenty four healthy subjects were studied during fasting. METHODS:We measured perception (0-6 scale) in response to jejunal balloon distension and transmucosal electrical nerve st...

journal_title：Gut

authors： Accarino AM,Azpiroz F,Malagelada JR

更新日期：2001-05-01 00:00:00

abstract：:The association between Cryptosporidium, chronic diarrhoea and a proximal small intestinal mucosal enteropathy was reviewed over a six and a half year period. One hundred and twenty three children with cryptosporidiosis and no clinical evidence of immune deficiency were identified. 50% of children excreting only Crypt...

journal_title：Gut

authors： Phillips AD,Thomas AG,Walker-Smith JA

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVE:A high body mass index (BMI) is associated with an increased risk for severe liver disease. It is unclear if this risk differs across BMI categories, and if the association is partially attributed to development of type 2 diabetes mellitus (T2DM). DESIGN:We used register data from more than 1.2 million Swedi...

journal_title：Gut

authors： Hagström H,Tynelius P,Rasmussen F

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Serrated polyps (SPs) are an important cause of postcolonoscopy colorectal cancers (PCCRCs), which is likely the result of suboptimal SP detection during colonoscopy. We assessed the long-term effect of a simple educational intervention focusing on optimising SP detection. DESIGN:An educational intervention,...

journal_title：Gut

authors： Bleijenberg AGC,van Leerdam ME,Bargeman M,Koornstra JJ,van Herwaarden YJ,Spaander MC,Sanduleanu S,Bastiaansen BAJ,Schoon EJ,van Lelyveld N,Dekker E,IJspeert JEG

更新日期：2020-12-01 00:00:00

abstract：:The effects of sulphasalazine, 5-aminosalicylic acid (5-ASA), and sulphapyridine on peroxidation of red cell membrane lipids, measured as malondialdehyde production, were assessed. Sulphasalazine and 5-ASA, at concentrations of 10(-5)-10(-3) M significantly inhibit lipid peroxidation, suggesting an antioxidant action ...

journal_title：Gut

authors： Greenfield SM,Punchard NA,Thompson RP

更新日期：1991-10-01 00:00:00

abstract：:This experimental study was undertaken to follow the influence of phenobarbital on bile chemistry and gallstone formation. Phenobarbital (400 mg/kg/day) was administered to golden hamsters receiving a diet known to induce cholesterol gallstones. After a 28-day period none of the control animals had gallstones whereas ...

journal_title：Gut

authors： Lagarriga J,Bouchier IA

更新日期：1973-12-01 00:00:00

abstract：:Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrati...

journal_title：Gut

authors： Osborne DH,Lennon J,Henderson M,Lidgard G,Creel R,Carter DC

更新日期：1977-02-01 00:00:00

abstract：:Serum samples from 26 monozygotic twin pairs concordant or discordant with regard to inflammatory bowel disease, and rectal biopsies from 42 twins of the same subject group, were examined for IgG subclasses. They were all compared with normal controls. Almost all affected twins were in clinical remission. Paired immun...

journal_title：Gut

authors： Helgeland L,Tysk C,Järnerot G,Kett K,Lindberg E,Danielsson D,Andersen SN,Brandtzaeg P

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:HCV is intimately linked with the liver lipid metabolism, devoted to the efflux of triacylglycerols stored in lipid droplets (LDs) in the form of triacylglycerol-rich very-low-density lipoproteins (VLDLs): (i) the most infectious HCV particles are those of lowest density due to association with triacylglycero...

journal_title：Gut

authors： Beilstein F,Lemasson M,Pène V,Rainteau D,Demignot S,Rosenberg AR

更新日期：2017-12-01 00:00:00

abstract：:We investigated the distribution of the collagen band in 33 patients with collagenous colitis to estimate the likelihood of the disease being diagnosed in biopsy specimens from the left side of the colon, such as those obtained using flexible sigmoidoscopy. To be included in this study patients had a subepithelial col...

journal_title：Gut

authors： Tanaka M,Mazzoleni G,Riddell RH

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Eosinophilic oesophagitis (EoO) is a clinicopathological condition defined by proton pump inhibitor-refractory oesophageal symptoms combined with oesophageal eosinophilia. The pharmacodynamic effect of mepolizumab (a humanised anti-interleukin-5 monoclonal antibody) in EoO was evaluated. METHODS:Eleven adult...

journal_title：Gut

authors： Straumann A,Conus S,Grzonka P,Kita H,Kephart G,Bussmann C,Beglinger C,Smith DA,Patel J,Byrne M,Simon HU

更新日期：2010-01-01 00:00:00