Abstract:
OBJECTIVE:Serrated polyps (SPs) are an important cause of postcolonoscopy colorectal cancers (PCCRCs), which is likely the result of suboptimal SP detection during colonoscopy. We assessed the long-term effect of a simple educational intervention focusing on optimising SP detection. DESIGN:An educational intervention, consisting of two 45 min training sessions (held 3 years apart) on serrated polyp detection, was given to endoscopists from 9 Dutch hospitals. Hundred randomly selected and untrained endoscopists from other hospitals were selected as control group. Our primary outcome measure was the proximal SP detection rate (PSPDR) in trained versus untrained endoscopists who participated in our faecal immunochemical test (FIT)-based population screening programme. RESULTS:Seventeen trained and 100 untrained endoscopists were included, who performed 11 305 and 51 039 colonoscopies, respectively. At baseline, PSPDR was equal between the groups (9.3% vs 9.3%). After training, the PSPDR of trained endoscopists gradually increased to 15.6% in 2018. This was significantly higher than the PSPDR of untrained endoscopists, which remained stable around 10% (p=0.018). All below-average (ie, PSPDR ≤6%) endoscopists at baseline improved their PSPDR after training session 1, as did 57% of endoscopists with average PSPDR (6%-12%) at baseline. The second training session further improved the PSPDR in 44% of endoscopists with average PSPDR after the first training. CONCLUSION:A simple educational intervention was associated with substantial long-term improvement of PSPDR in a prospective controlled trial within FIT-based population screening. Widespread implementation of such interventions might be an easy way to improve SP detection, which may ultimately result in fewer PCCRCs. TRIAL REGISTRATION NUMBER:NCT03902899.
journal_name
Gutjournal_title
Gutauthors
Bleijenberg AGC,van Leerdam ME,Bargeman M,Koornstra JJ,van Herwaarden YJ,Spaander MC,Sanduleanu S,Bastiaansen BAJ,Schoon EJ,van Lelyveld N,Dekker E,IJspeert JEGdoi
10.1136/gutjnl-2019-319804subject
Has Abstractpub_date
2020-12-01 00:00:00pages
2150-2158issue
12eissn
0017-5749issn
1468-3288pii
gutjnl-2019-319804journal_volume
69pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND AND AIMS:The effectiveness of surveillance for hepatocellular carcinoma (HCC) in the USA is largely unknown. The objective of this study was to evaluate the effectiveness of HCC surveillance in a national Veterans Administration (VA) practice setting, using the national VA hepatitis C virus (HCV) Clinical Ca...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.230508
更新日期:2011-07-01 00:00:00
abstract::The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28 +/- 3.1 to 85 +/- 12.3 pmol/l (p less than 0.001) and this difference was maintained ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.12.1353
更新日期:1985-12-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive type of GI tumour, and it possesses deregulated cellular energetics. Although recent advances in PDAC biology have led to the discovery of recurrent genetic mutations in Kras, TP53 and SMAD4, which are related to this disease, clinical application...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2018-317163
更新日期:2020-05-01 00:00:00
abstract::The epidemiology of hepatitis C virus (HCV) infection was studied in an English teaching hospital over an 18 month period. A total of 104 HCV antibody positive patients were referred for further investigation. They were divided into those diagnosed through screening (blood donors and intravenous drug abusers) and thos...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.2.269
更新日期:1996-02-01 00:00:00
abstract::During a four hour observation period vasoactive intestinal polypeptide (VIP) is released in increasing amounts from the feline small intestine exposed to cholera toxin. As VIP is known to be located almost exclusively in the intestinal nerves, the present findings strongly suggest that cholera toxin activates the ent...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.22.11.958
更新日期:1981-11-01 00:00:00
abstract::Clinically significant liver involvement in systemic amyloidosis, especially with cholestasis, is rare. We report a case of primary amyloidosis with severe intrahepatic cholestasis leading to terminal liver failure. The present case is the first of its kind reported involving Lambda light chains only as the associated...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.7.903
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVE:Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases. Given the prominence of dysbiosis and colonic dysfunction in patients with Parkinson's disease (PD), we pro...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-316844
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Emerging evidence suggests that highly treatment-resistant tumour-initiating cells (TICs) play a central role in the pathogenesis of pancreatic cancer. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered to be a novel anticancer agent; however, recent studies have shown th...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.149039
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Increased infertility in women has been reported after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis but reported infertility rates vary substantially. AIMS:(1) To perform a systematic review and meta-analysis of the relative risk of infertility post-IPAA compared with medical management; (2) t...
journal_title:Gut
pub_type: 杂志文章,meta分析,评审
doi:10.1136/gut.2005.090316
更新日期:2006-11-01 00:00:00
abstract::It has been reported that intestinal permeability to polyethylene glycol 400 is increased in patients with Crohn's disease and their apparently unaffected first degree relatives. Because of the implications that these findings have for the aetiology of Crohn's disease these studies were repeated. Patients with Crohn's...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.3.320
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVE:HCV is intimately linked with the liver lipid metabolism, devoted to the efflux of triacylglycerols stored in lipid droplets (LDs) in the form of triacylglycerol-rich very-low-density lipoproteins (VLDLs): (i) the most infectious HCV particles are those of lowest density due to association with triacylglycero...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-311508
更新日期:2017-12-01 00:00:00
abstract::The activity of an interferon induced enzyme, (2',5') oligo adenylate synthetase, was determined in peripheral blood mononuclear cells and granulocytes of patients with inflammatory bowel disease and compared with its activity in cells isolated from normal subjects. In spite of the fact that circulating interferon is ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.6.556
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:Several pharmacological agents for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) have been studied. Clinical trials evaluating the protective effect of non-steroidal anti-inflammatory drugs (NSAIDs) have yielded inconclusive results. AIM:To perform a meta-an...
journal_title:Gut
pub_type: 杂志文章,meta分析,评审
doi:10.1136/gut.2007.140756
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces apoptosis in transformed cells and is considered as an agent for cancer therapy. As there is evidence that TRAIL is also essential for apoptosis in animal models of liver injury, we investigated the role of TRAIL in viral hepat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.056929
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Fatigue is a frequent and disabling symptom reported by patients with chronic hepatitis C (CHC). Its mechanism is poorly understood. Recent attention has focused on the role of leptin and energy expenditure in CHC. Our aims were to analyse fatigue in CHC and to determine its relationship with diseas...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.3.434
更新日期:2002-09-01 00:00:00
abstract::To investigate the mechanisms underlying the hepatotoxicity induced by methyl dopa, we have examined sera from nine patients with liver damage following the use of the drug for evidence of sensitisation to drug altered liver cell membrane antigens using both immunofluorescence and antibody dependent cell mediated cyto...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.11.1233
更新日期:1985-11-01 00:00:00
abstract::This paper describes four patients whose chief symptoms were steatorrhoea and loss of weight. Despite the absence of a history of abdominal pain investigations showed that these patients had chronic pancreatitis, which responded to medical treatment. The pathological findings in two of these cases and in six which cam...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.3.3.252
更新日期:1962-09-01 00:00:00
abstract:BACKGROUND:Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation. OBJECTIVE:To d...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2014-307094
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis. AIMS:To define the role of IL-8 in acute pancreatitis by neutralising its effects with a monoclonal anti-IL-8 antibody (WS-4), in a rabbi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.2.232
更新日期:1998-08-01 00:00:00
abstract::Aspirin administration to normal subjects resulted in a reduction in gastric prostaglandin E (PGE) output. Both PGE concentration and gastric juice volume were decreased. Gastric acid output also decreased, although the difference was not statistically significant. An increased sensitivity of the PGE system to inhibit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.1.54
更新日期:1976-01-01 00:00:00
abstract::Fasting and postprandial plasma concentrations of glycine and taurine conjugates of cholic, chenodeoxycholic, and deoxycholic acid were measured by a high pressure liquid chromatography-enzymatic assay in nine healthy subjects. The mean value of each bile acid concentration increased significantly (2.4-4.7 times) in t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.3.249
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Gastrokine 1 (GKN1) is a stomach-specific protein that is normally expressed in gastric mucosa but not in primary tumours and cell lines. Based on this evidence, it was presumed that GKN1 might play a role in gastric cancer development; however, its function and molecular mechanism are not clear. A ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.230623
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Recently, non-invasive techniques such as 3 dimensional ultrasonography (3DUS) have been developed to assess gastric wall characteristics and to investigate their relationship with upper gastrointestinal sensations. To date, no head-to-head comparison has been carried out between the barostat and the 3DUS te...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.062836
更新日期:2006-12-01 00:00:00
abstract::Inflammatory fibroid polyps are uncommon but well documented as solitary polyps occurring typically in the stomach or ileum. A Devon family has previously been reported in which a female in three successive generations has presented with multiple polyps requiring repeated surgery over a number of years. A further two ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.7.1004
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVES:National guidelines for the management of irritable bowel syndrome (IBS) recommend that psychological therapies should be considered, but their relative efficacy is unknown, because there have been few head-to-head trials. We performed a systematic review and network meta-analysis to try to resolve this unce...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321191
更新日期:2020-08-01 00:00:00
abstract::This case report describes the histological and macroscopic changes seen within a few months in the gastric mucosa of a 28 year old woman patient with upper abdominal symptoms. With hindsight these changes were the first signs of Sjögren's syndrome. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.8.1142
更新日期:1993-08-01 00:00:00
abstract:PURPOSE:Despite recent advances in colorectal cancer (CRC) treatment, the prognosis of patients suffering from this malignancy still remains substandard, and metastatic recurrence following curative surgery is the leading cause of mortality. Therefore, it is imperative to identify prognostic markers to predict the clin...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309359
更新日期:2017-01-01 00:00:00
abstract::Intestinal protein loss in chronic inflammatory bowel diseases may be easily determined by measurement of alpha-1-antitrypsin (alpha 1-AT) stool concentration and alpha 1-AT clearance. Both parameters were significantly raised in 36 and 34 patients respectively with chronic inflammatory bowel diseases, compared with e...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.4.386
更新日期:1987-04-01 00:00:00
abstract::The aims of the present study were to determine the relative amplitudes of intragastric motor responses evoked by different vagal branches and to establish whether the effects of acute or chronic vagotomy could be predicted from these data. Intragastric pressure responses to electrical stimulation of the vagus were me...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.10.811
更新日期:1980-10-01 00:00:00
abstract::Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and derma...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.8.929
更新日期:1986-08-01 00:00:00