Abstract:
:This experimental study was undertaken to follow the influence of phenobarbital on bile chemistry and gallstone formation. Phenobarbital (400 mg/kg/day) was administered to golden hamsters receiving a diet known to induce cholesterol gallstones. After a 28-day period none of the control animals had gallstones whereas five of 12 animals with added phenobarbital developed stones. Ten of 19 animals on the lithogenic diet formed gallstones but when phenobarbital was added gallstones occurred in 16 of 19 hamsters. The administration of phenobarbital resulted in the production of bile which was relatively more saturated with cholesterol, the bile salt + phospholipid: cholesterol of 24.8 +/- 12.7 in control animals altering to 9.1 +/- 6.2 in animals receiving phenobarbital. Hepatic bilirubin uridine diphosphate-glucuronyl transferase activity was not increased in animals on phenobarbital. It was concluded that, in the hamster at least, there is no indication that large doses of phenobarbital will reduce the potential for gallstone formation.
journal_name
Gutjournal_title
Gutauthors
Lagarriga J,Bouchier IAdoi
10.1136/gut.14.12.956subject
Has Abstractpub_date
1973-12-01 00:00:00pages
956-61issue
12eissn
0017-5749issn
1468-3288journal_volume
14pub_type
杂志文章相关文献
GUT文献大全abstract:OBJECTIVE:Most colorectal cancer (CRC) screening programmes are nowadays based on faecal immunochemical testing (FIT). Eligible subjects often use oral anticoagulants (OACs) or non-steroidal anti-inflammatory drugs (NSAIDs), which could possibly stimulate bleeding from both benign and premalignant lesions in the colon....
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316344
更新日期:2019-05-01 00:00:00
abstract::The effect of the unconjugated bile acids, cholic, deoxycholic, chenodeoxycholic, and ursodeoxycholic acids, and of the conjugated bile acid taurocholic acid on the mucosal-to-serosal transport and tissue uptake of the naturally occurring folate derivative, 5-methyltetrahydrofolate (5-CH3H4PteGlu) was examined in ever...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.12.1376
更新日期:1984-12-01 00:00:00
abstract::A technique has been developed which allows the position of the upper gastrointestinal tract, as determined radiographically, to be superimposed on the pancreatic photoscan, performed after an injection of (75)Se-selenomethionine. Results of the technique applied to 27 ;abnormal' and 23 ;normal' subjects are described...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.10.8.665
更新日期:1969-08-01 00:00:00
abstract:BACKGROUND:Recent profile studies of microRNA (miRNA) expression have documented a deregulation of miRNA (miR-124) in hepatocellular carcinoma (HCC). OBJECTIVE:To determine the status of miR-124 expression and its underlying mechanisms in the pathogenesis of HCC. METHODS:The expression levels of miR-124 were first ex...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2011.239145
更新日期:2012-02-01 00:00:00
abstract::The treatment is described of 17 patients with presumed viral hepatitis who developed hepatic coma unresponsive to standard conservative measures. Five patients were considered for treatment by exchange transfusion. Four were treated, with transient improvement in two, but all died. Nine patients were considered for t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.10.11.898
更新日期:1969-11-01 00:00:00
abstract::To investigate the mechanisms underlying the hepatotoxicity induced by methyl dopa, we have examined sera from nine patients with liver damage following the use of the drug for evidence of sensitisation to drug altered liver cell membrane antigens using both immunofluorescence and antibody dependent cell mediated cyto...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.11.1233
更新日期:1985-11-01 00:00:00
abstract::For the first time the endoscopist has more than one option for the management of gastro-oesophageal varices. It is now feasible to select the appropriate therapy on the basis of the clinical setting. Acute injection sclerotherapy remains a quick and simple technique for the control of active bleeding from oesophageal...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.5.647
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. OBJECTIVE:To explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease. DESIGN:The regulated miRNAs in human livers infected with hepatitis C virus were identified...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300717
更新日期:2012-11-01 00:00:00
abstract::In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.5.588
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:Vedolizumab is a gut-selective antibody to α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). We report an integrated summary of the safety of vedolizumab. DESIGN:Safety data (May 2009-June 2013) from six trials of vedolizumab were integrated. Adverse events were evaluated i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311079
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:Non-coeliac gluten sensitivity (NCGS) is characterised by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing foods, in the absence of coeliac disease (CD) and wheat allergy. No biomarkers are available to diagnose NCGS and the gold standard double-blind placebo-controlled gl...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319281
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Multiple cancers may occur in an individual because of a genetic predisposition, environmental exposure, cancer therapy, or immunological deficiency. Colorectal cancer is one of the most commonly diagnosed cancers, and inherited factors play an important role in its aetiology. AIMS:To characterise the occur...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.5.647
更新日期:2002-05-01 00:00:00
abstract::By prolonged immunization of an inbred rat strain with isologous liver homogenate in Freund's complete adjuvant a low grade autoimmune ;cholangitis' with periductular fibrosis has been demonstrated. The lesion could be transferred to isogeneic animals by serial spleen cell injections and was associated with mild but v...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.6.458
更新日期:1971-06-01 00:00:00
abstract::Both hog gastrin and synthetic gastrin stimulate the cardiac sphincter to increase tone and augment the resistance to reflux. Endogenous gastrin has a similar effect, and gastrin also stimulates the secretion of acid which has also been found to increase the resistance of the sphincter, but the effect of gastrin appea...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.10.9.730
更新日期:1969-09-01 00:00:00
abstract::Evidence is presented of a higher than normal incidence both of clinical coeliac disease and of small-intestinal mucosal abnormalities in relatives of children with coeliac disease. In such relatives the incidence of mucosal abnormality may differ from the incidence of clinical coeliac disease. The data show an absenc...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.10.789
更新日期:1971-10-01 00:00:00
abstract::Electrogenic (Cl-) secretion was measured as the short circuit current (Isc, microA/cm2) across muscle-stripped sheets of jejunum and ileum incubated in vitro after removal from fed rats, rats starved for three days, and chronically undernourished rats (50% of fed control intake for 21 days). Concentration and Isc res...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.9.1237
更新日期:1994-09-01 00:00:00
abstract::In duodenal ulceration the Alcian blue staining acid mucosubstances in goblet cells are reduced and the goblet cells themselves disappear. At the same time periodic acid-Schiff (PAS) staining neutral mucosubstances appear in the cells of the surface epithelium. These changes have been measured quantitatively with the ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.10.909
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND:Whole body catabolism as the result of intrahepatic metabolic derangement is common in liver transplant candidates. However, individual nutritional assessment parameters lack sensitivity and specificity in determining energy status of these patients. Recently, serum hepatocyte growth factor (HGF) has been sh...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.6.862
更新日期:1999-06-01 00:00:00
abstract::A case is described of primary biliary cirrhosis in a 59 year old woman who initially presented with a rash over her lower legs 18 months before diagnosis. Skin biopsy examination showed non-caseating granulomas of the sarcoid type. It is believed that this is the first reported case of primary biliary cirrhosis prese...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.4.564
更新日期:1994-04-01 00:00:00
abstract::Small intestinal mucosa obtained from six fasting patients with cholera by a peroral biopsy technique was studied with the electron microscope. The cultures of their rectal swabs were all positive for Vibrio cholerae. In the absorptive cells, large pseudopod-like cytoplasmic processes with deformed microvilli or witho...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.7.531
更新日期:1974-07-01 00:00:00
abstract:BACKGROUND:A non-invasive test for assessment of fat digestion has been developed based on the intraluminal hydrolysis of cholesteryl-[1-13C]octanoate by pancreatic esterase. AIMS:To determine the diagnostic performance of this breath test in the assessment of exocrine pancreatic function. METHODS:The test was perfor...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.1.81
更新日期:1998-01-01 00:00:00
abstract::As relatively little is known of human colonic motor activity either in health, or in pathological conditions, we investigated mass movements in 14 chronically constipated patients and 18 healthy volunteers. Mass movements were recorded from proximal and distal colon during 24 h (12 noon-12 noon) by a colonoscopically...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.9.1173
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Coeliac disease (CD) is triggered by an abnormal reaction to gluten. Peptides resulting from partially digested gluten of wheat, barley or rye cause inflammation of the small intestinal mucosa. Previous contradictory studies suggest that oats may trigger the abnormal immunological response in patien...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.225268
更新日期:2011-07-01 00:00:00
abstract::Using 24 hour pH monitoring as a reference standard, the usefulness of the acid perfusion (AP) test in predicting gastro-oesophageal reflux disease (GORD) was assessed in 71 non-cardiac chest pain (NCCP) patients and 23 endoscopic oesophagitis patients. Of the 71 NCCP patients, 35 had a positive AP test (of whom 20 ha...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.3.305
更新日期:1989-03-01 00:00:00
abstract::Much research in the pathophysiology of gall stones has been devoted to various molecular species of bile salts. Recent findings have shown the importance of phospholipids in biliary pathophysiology. In the present study the addition of increasing doses of egg lecithin to human and model biles progressively prolonged ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.1.110
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Independent component analysis (ICA) of the electroencephalogram (EEG) overcomes many of the classical problems in EEG analysis. We used ICA to determine the brain responses to painful stimulation of the oesophagus. METHODS:Twelve subjects with a median age of 41 years were included. With a nasal e...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.2005.068460
更新日期:2006-05-01 00:00:00
abstract::A patient with myelofibrosis developed repeated gastrointestinal haemorrhage from the small intestine, which was found to be infiltrated with extramedullary haemopoiesis. Nineteen months later he presented with subacute intestinal obstruction; radiology and laparotomy documented progressive infiltration of the small b...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.7.873
更新日期:1986-07-01 00:00:00
abstract::To investigate further the cause of the pancreatic enlargment induced by orally ingested soybean trypsin inhibitor (STI), antibodies raised against STI and purified by affinity chromatography were used to localise dietary STI in the rat gut by fluorescent immunocytochemical methods. This technique permitted the clear ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.4.260
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:The use of corticosteroids in active Crohn's disease often becomes limited by side effects. Budesonide is a potent corticosteroid with low systemic bioavailability due to an extensive first pass liver metabolism. AIMS:To compare the efficacy and safety of two dosage regimens of budesonide and prednisolone i...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.41.2.209
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVES:Gastric cancer is strongly associated with Helicobacter pylori (H. pylori). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-320839
更新日期:2020-12-01 00:00:00