Abstract:
:For the first time the endoscopist has more than one option for the management of gastro-oesophageal varices. It is now feasible to select the appropriate therapy on the basis of the clinical setting. Acute injection sclerotherapy remains a quick and simple technique for the control of active bleeding from oesophageal varices, and could be followed two or three days later by banding ligation. Earlier obliteration of varices with this technique may offer the prospect of only two or three sessions of therapy. The availability of the tissue adhesives and thrombin as injectates for fundal gastric varices provide the option of an initial attempt at endoscopic therapy in this high risk group.
journal_name
Gutjournal_title
Gutauthors
Williams SG,Westaby Ddoi
10.1136/gut.36.5.647subject
Has Abstractpub_date
1995-05-01 00:00:00pages
647-8issue
5eissn
0017-5749issn
1468-3288journal_volume
36pub_type
杂志文章相关文献
GUT文献大全abstract:OBJECTIVE:To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin. DESIGN:In this Phase 2b double-blind, placebo-controlled study, treatment-naive adults with HCV genotype 1 (N=365) or 4 (N=30) infection were randomly assig...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2014-307498
更新日期:2015-06-01 00:00:00
abstract::Thirty male patients (27 homosexual) with biopsy proven chronic active hepatitis B were randomised to receive lymphoblastoid interferon (Wellferon) or no treatment. All patients were HBeAg positive and had continuing viral replication. Patients receiving treatment were given a single daily intramuscular injection of i...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.28.5.619
更新日期:1987-05-01 00:00:00
abstract::An enema that contained a complex of bismuth citrate and polyacrylate was compared with 5-aminosalicylic acid (5-ASA) enemas for treatment of distal ulcerative colitis. The multicentre trial involving 63 patients was randomised and double blind with enemas given over four weeks; clinical, sigmoidoscopic, and histologi...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.34.5.676
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND AND AIMS:A subset of functional dyspepsia (FD) patients report meal-related symptoms, possibly representing a pathophysiologically homogeneous subgroup. The aim of the present study was to establish the time-course of symptoms in relation to meal ingestion, and to assess the relationship between self-reporte...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.137125
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals of 1-2 years. However, yearly surveillance likely leads to overtreatment for many. We prospectively assessed a surveillance protocol aiming to ...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1136/gutjnl-2018-318134
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6. DESIGN:We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expres...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314983
更新日期:2019-01-01 00:00:00
abstract::The peroxisome proliferator activated receptor gamma(PPARgamma) is a nuclear receptor highly expressed in the colon and playing a key role in bacterial induced inflammation. Regulation of colon inflammation by this receptor has been well demonstrated in many experimental models of colitis but also in patients with ulc...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.2006.093484
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Lamina propria (LPLs) and intraepithelial (IELs) lymphocytes are markedly increased in coeliac mucosa, and are thought to play a crucial role in the generation of villous atrophy in coeliac disease (CD). However, the mechanisms by which they mediate the killing of enterocytes in this condition are still poor...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.3.380
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Chronic pancreatitis is a known risk factor for pancreatic adenocarcinoma. Recent work has pointed to a role for bone marrow-derived progenitor cells (BMDCs) in chronic inflammation-based carcinogenesis. Consequently, the role of BMDCs in chronic pancreatitis was investigated. METHODS:The fate of BMDCs was ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.143271
更新日期:2008-08-01 00:00:00
abstract::Distal duodenal biopsy specimens taken from 30 white, 35 Indian, and 20 Afro-Caribbean residents of West Birmingham during routine endoscopy for dyspepsia, were assessed by dissecting microscopy and morphometry. Finger-shaped villi were significantly less frequent in the Indian and Afro-Caribbean subjects than in the ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.3.256
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Lipids may exacerbate symptoms induced by gut stimuli. AIM:To determine the mechanism whereby fat exerts this effect. SUBJECTS:Twenty four healthy subjects were studied during fasting. METHODS:We measured perception (0-6 scale) in response to jejunal balloon distension and transmucosal electrical nerve st...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.5.690
更新日期:2001-05-01 00:00:00
abstract::Based on short recordings, the rectum has been shown to have contractions with a frequency of five to 10 cycles per minute and slow contractions at three cycles per minute. To define anorectal motility over a prolonged period of time, we have studied 12 healthy volunteers using a fine pressure sensitive anorectal prob...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.7.1007
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immun...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-315201
更新日期:2018-10-01 00:00:00
abstract::Patients with chronic active hepatitis or alcoholic cirrhosis have serum antibodies to many more serotypes of Escherichia coli than do patients with primary biliary cirrhosis or cryptogenic cirrhosis, or normal controls. They also have antibodies against more serotypes than cirrhotic patients with a portacaval shunt. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.16.11.871
更新日期:1975-11-01 00:00:00
abstract:METHODS:Four patients with clinicopathological features suggesting a new distinct entity defining extensive small intestinal CD4 T cell infiltration were observed. RESULTS:All four patients presented with chronic diarrhoea, malabsorption, and weight loss. Biopsy specimens of the small intestine disclosed extensive and...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.5.662
更新日期:1999-11-01 00:00:00
abstract::Gastric secretion from 24 subjects was collected by continuous nasogastric aspiration during the plateau of secretion evoked by intravenous histamine diphosphate, 0.01 mg/kg/hr. Simultaneously, phenol red was instilled at a constant rate into the proximal part of the stomach. Concentrations of phenol red in 15-minute ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.10.10.787
更新日期:1969-10-01 00:00:00
abstract:BACKGROUND AND AIMS:The authors' goal was to measure pH at the gastric surface (pH₀) to understand how acid secretion affects the repair of microscopic injury to the gastric epithelium. METHODS:Microscopic gastric damage was induced by laser light, during confocal/two-photon imaging of pH-sensitive dyes (Cl-NERF, BCEC...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300420
更新日期:2012-06-01 00:00:00
abstract::To investigate further the cause of the pancreatic enlargment induced by orally ingested soybean trypsin inhibitor (STI), antibodies raised against STI and purified by affinity chromatography were used to localise dietary STI in the rat gut by fluorescent immunocytochemical methods. This technique permitted the clear ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.4.260
更新日期:1978-04-01 00:00:00
abstract:OBJECTIVES:Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct cancers in terms of a number of clinical and epidemiological characteristics, complicating the design of clinical trials and biomarker developments. We analysed 1048 oesophageal tumour-germline pairs from both subtypes, to chara...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314607
更新日期:2018-10-01 00:00:00
abstract::Circulating immune complexes were determined in 59 consecutive patients with Crohn's disease and 100 blood donors by a double method based on the inhibition of the agglutinating activity of CIq and/or rheumatoid factor on the IgG-coated polystyrene particles. In patients, the incidence of positive immune complexes was...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.7.611
更新日期:1978-07-01 00:00:00
abstract::Family histories were obtained from 50 patients with adenocarcinoma of the colon or rectum in north-east Scotland. A comparable control group was similarly interviewed and in each group the case notes of the first degree relatives were studied where possible. Eight (16%) of the patients with cancer of the colon or rec...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.2.169
更新日期:1982-02-01 00:00:00
abstract:BACKGROUND:Oligodeoxynucleotides (ODNs) containing unmethylated cytosine-guanosine (CpG) sequence motifs constitute the immunostimulatory components of bacterial DNA which potently activate innate immunity. Administration of CpG-ODNs before the onset of experimental colitis prevents intestinal inflammation by induction...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.193177
更新日期:2010-10-01 00:00:00
abstract::Intravenous cholangiograms were performed on 100 unselected nonicteric patients using methylglucamine ioglycamide (Biligram). Fifty patients received 10.5 g of contrast medium and 50 received 5.25 g of medium. The contrast medium was injected evenly over five minutes. Side effects were recorded in only 13% of patients...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.4.268
更新日期:1974-04-01 00:00:00
abstract::A group of 80 patients with diseases of the small intestine were given a standardized psychiatric assessment every time they attended the outpatients' department over a period of a year. Forty-six patients with idiopathic steatorrhoea, 23 patients with Crohn's disease, and 11 patients with alactasia were interviewed o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.6.459
更新日期:1970-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Chronic idiopathic intestinal pseudo-obstruction (CIIP) is characterised by severe impairment of intestinal propulsive motility that mimics bowel obstruction. JC virus (JCV) is a polyomavirus that can infect brain glial cells causing a fatal disease, but may also be found throughout the normal gastr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.152512
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Assessment of disease extension and activity is crucial to guide treatment in Crohn's disease. The objective of the current cross-sectional study was to determine the accuracy of MR for this assessment. DESIGN:50 patients with clinically active (n = 35) or inactive (n = 15) Crohn's disease underwent ileocolo...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.167957
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:Serrated polyps (SPs) are an important cause of postcolonoscopy colorectal cancers (PCCRCs), which is likely the result of suboptimal SP detection during colonoscopy. We assessed the long-term effect of a simple educational intervention focusing on optimising SP detection. DESIGN:An educational intervention,...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319804
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity. METHODS:Experimental liver fibrosis in mice induced by bile duct ligation or CCl4 application was used to characterise the mechanisms determining failure of innate imm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311224
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To elucidate the association between antiviral therapy and extrahepatic outcomes in individuals infected with HCV. METHODS:This nationwide cohort study screened 293,480 Taiwanese residents with HCV infection and excluded those with substantial comorbidity. A total of 12,384 eligible patients who had received...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308163
更新日期:2015-03-01 00:00:00
abstract::The effects of the methyl ester analogue of prostaglandin E1, misoprostol, on gastric epithelial cell proliferation were investigated in six dogs given 300 micrograms/kg/day of misoprostol orally for 11 weeks and in six control dogs given placebo for 11 weeks. Misoprostol treatment resulted in a 36% increase in stomac...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.3.316
更新日期:1989-03-01 00:00:00