Abstract:
:The peroxisome proliferator activated receptor gamma(PPARgamma) is a nuclear receptor highly expressed in the colon and playing a key role in bacterial induced inflammation. Regulation of colon inflammation by this receptor has been well demonstrated in many experimental models of colitis but also in patients with ulcerative colitis, characterised by impaired expression of PPARgamma confined to their colon epithelial cells. Recent data showing that PPARgamma was the major functional receptor mediating the common aminosalicylate activities in inflammatory bowel diseases (IBD) have also reinforced the roles of this receptor in the control of intestinal inflammation. The aims of this review are to discuss the potential roles of PPARgamma in the physiopathology of IBD, as well as the emerging therapeutic strategies targeting this receptor.
journal_name
Gutjournal_title
Gutauthors
Dubuquoy L,Rousseaux C,Thuru X,Peyrin-Biroulet L,Romano O,Chavatte P,Chamaillard M,Desreumaux Pdoi
10.1136/gut.2006.093484subject
Has Abstractpub_date
2006-09-01 00:00:00pages
1341-9issue
9eissn
0017-5749issn
1468-3288pii
55/9/1341journal_volume
55pub_type
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