Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing.

abstract：:This study investigated the mechanisms by which TAGH solution (a mixture of triiodothyronine, amino acids, glucagon, and heparin) induces DNA synthesis in hepatocytes in the liver of intact rats, with particular reference to events at the epidermal growth factor (EGF) receptor. Both partial hepatectomy and infusion of...

journal_title：Gut

authors： Vesey DA,Selden AC,Hodgson HJ

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Teduglutide, a GLP-2 analogue, may restore intestinal structural and functional integrity by promoting repair and growth of the mucosa and reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS). This 24-week placebo-contr...

journal_title：Gut

authors： Jeppesen PB,Gilroy R,Pertkiewicz M,Allard JP,Messing B,O'Keefe SJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Multiorgan failure is a severe life threatening state where present therapeutic approaches are suboptimal. Epidermal growth factor (EGF) is a potent stimulant of repair in in vitro and in vivo models. We therefore examined its potential beneficial effect in reducing mortality and injury induced by the noxiou...

journal_title：Gut

authors： Caballero ME,Berlanga J,Ramirez D,Lopez-Saura P,Gozalez R,Floyd DN,Marchbank T,Playford RJ

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:The epithelial layer of the GI tract is equipped with innate immune receptors to sense invading pathogens. Dysregulation in innate immune signalling pathways is associated with severe inflammatory diseases, but the responsiveness of GI epithelial cells to bacterial stimulation remains unclear. DESIGN:We gene...

journal_title：Gut

authors： Kayisoglu O,Weiss F,Niklas C,Pierotti I,Pompaiah M,Wallaschek N,Germer CT,Wiegering A,Bartfeld S

更新日期：2020-06-22 00:00:00

abstract：:The relationship between physical activity and risk of symptomatic diverticular disease has not been investigated directly. This association was examined in a prospective cohort of 47,678 American men, 40 to 75 years of age, and free of diagnosed diverticular disease, colon or rectal polyp, ulcerative colitis, and can...

journal_title：Gut

authors： Aldoori WH,Giovannucci EL,Rimm EB,Ascherio A,Stampfer MJ,Colditz GA,Wing AL,Trichopoulos DV,Willett WC

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:Persistent colonisation by Helicobacter pylori, and especially by cagA-positive strains, has been related to several health outcomes with effects in opposite directions. Thus, it is important to evaluate its influence on total and category-specific mortality. DESIGN:We conducted prospective cohort analyses i...

journal_title：Gut

authors： Chen Y,Segers S,Blaser MJ

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In th...

journal_title：Gut

authors： van der Post S,Jabbar KS,Birchenough G,Arike L,Akhtar N,Sjovall H,Johansson MEV,Hansson GC

更新日期：2019-12-01 00:00:00

abstract：:Heartburn is a common symptom affecting 21-44% of the adult population on a monthly basis. Oesophagitis is less common, affecting 2% of individuals. Epidemiological studies have shown that patients with gastro-oesophageal reflux disease (GORD) have similar incidence rates of Helicobacter pylori infection as do control...

journal_title：Gut

authors： McNamara D,O'Morain C

更新日期：1999-07-01 00:00:00

abstract：:Plasminogen activator activity was studied in bile and perfusate during extracorporeal pig liver perfusion. Plasminogen activator activity in bile was up to 58 times greater than in perfusate. A high level of plasminogen activator activity in bile was also found after the addition of urokinase to the perfusate. These ...

journal_title：Gut

authors： Jedrychowski A,Parbhoo SP,Hillenbrand P

更新日期：1972-01-01 00:00:00

abstract：:Fasting insulin, lipids and lipoproteins were measured in 22 middle aged female non-insulin dependent diabetics with gall stone disease (cases) and in 22 non-insulin dependent diabetics without gall stone disease (controls). The groups were matched for sex, age, obesity, and fasting glucose concentrations. No differen...

journal_title：Gut

authors： Laakso M,Suhonen M,Julkunen R,Pyörälä K

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:Adherent-invasive Escherichia coli (AIEC) are a leading candidate bacterial trigger for Crohn's disease (CD). The AIEC pathovar is defined by in vitro cell-line assays examining specific bacteria/cell interactions. No molecular marker exists for their identification. Our aim was to identify a molecular proper...

journal_title：Gut

authors： O'Brien CL,Bringer MA,Holt KE,Gordon DM,Dubois AL,Barnich N,Darfeuille-Michaud A,Pavli P

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma cells express high levels of the antiapoptotic proteins Bcl-X(L) and Mcl-1 and are markedly chemo- and radioresistant. Mitochondria have emerged as central players in apoptosis. Antiapoptotic members of the Bcl-2 protein family localise to the outer mitochondrial membrane and regulate mito...

journal_title：Gut

authors： Okaro AC,Fennell DA,Corbo M,Davidson BR,Cotter FE

更新日期：2002-10-01 00:00:00

abstract：:We have studied B-lymphocyte function in 39 patients with Crohn's disease and 35 normal individuals using a reverse haemolytic plaque assay as the effector system. Ten patients had active Crohn's disease, the others being in an inactive state of the disease. Compared with normal individuals, the Crohn's disease patien...

journal_title：Gut

authors： Sieber G,Herrmann F,Zeitz M,Teichmann H,Rühl H

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:Small bowel transplantation remains a difficult therapeutic option endangered by a high rate of rejection and infectious complications. To improve these clinical results, it is mandatory to set up animal models to test alternative immunosuppressive regimens which may lead to immunotolerance. AIMS:To determi...

journal_title：Gut

authors： Sarnacki S,Auber F,Crétolle C,Camby C,Cavazzana-Calvo M,Müller W,Wagner N,Brousse N,Révillon Y,Fischer A,Cerf-Bensussan N

更新日期：2000-07-01 00:00:00

abstract：:The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28 +/- 3.1 to 85 +/- 12.3 pmol/l (p less than 0.001) and this difference was maintained ...

journal_title：Gut

authors： Savage AP,Gornacz GE,Adrian TE,Ghatei MA,Goodlad RA,Wright NA,Bloom SR

更新日期：1985-12-01 00:00:00

abstract：:There is no universally available laboratory test to diagnose bile acid diarrhoea (BAD). OBJECTIVE:To conduct a systematic review and meta-analysis to identify a biomarker for idiopathic BAD in patients with functional bowel disorder (FBD) with diarrhoea. DESIGN:We searched multiple databases through 15 May 2015. Da...

journal_title：Gut

authors： Valentin N,Camilleri M,Altayar O,Vijayvargiya P,Acosta A,Nelson AD,Murad MH

更新日期：2016-12-01 00:00:00

abstract：:To evaluate the effects of cisapride on gastric emptying of extracellular fat and hunger and fullness 10 volunteers consumed a meal consisting of 60 ml technectium-99m (99mTc)-V-thiocyanate labelled olive oil and 290 ml indium-113m (113mIn) labelled soup after taking cisapride (10 mg four times daily orally) and place...

journal_title：Gut

authors： Jones KL,Horowitz M,Carney BI,Sun WM,Chatterton BE

更新日期：1996-03-01 00:00:00

abstract：:The cholesteryl-14C-octanoate breath test was used to monitor the intraluminal enzymatic activity of pancreatin preparations in six patients with severe pancreatic insufficiency. Conventional enzyme replacement, with cimetidine as an adjunct, was compared to supplementation with enteric coated microspheres. In healthy...

journal_title：Gut

authors： Mundlos S,Kühnelt P,Adler G

更新日期：1990-11-01 00:00:00

abstract：:Coeliac disease is triggered by ingestion of wheat gliadin and is probably immune mediated. There is evidence by light microscopy that expression of class II major histocompatibility complex (MHC) molecules is increased in the small intestinal epithelium of patients with untreated coeliac disease and that gliadin can ...

journal_title：Gut

authors： Zimmer KP,Poremba C,Weber P,Ciclitira PJ,Harms E

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:Hepatocellular adenomas (HCAs) classically develop in women who are taking oral contraceptives and have a risk of malignant transformation into hepatocellular carcinoma (HCC). HCA with malignant transformation is, however, an ill-defined entity thought to be an anecdotic pathway to HCC. The objective of this ...

journal_title：Gut

authors： Farges O,Ferreira N,Dokmak S,Belghiti J,Bedossa P,Paradis V

更新日期：2011-01-01 00:00:00

abstract：:This paper reviews the experience gained over the past few years in two techniques of liver support, charcoal haemoperfusion and polyacrylonitrile membrane haemodialysis. Problems with charcoal haemoperfusion have centred around platelet aggregation and hypertension, and new carbon preparations with a variety of diffe...

journal_title：Gut

authors： Williams R

更新日期：1978-06-01 00:00:00

abstract：:The effects on gastric emptying of a solid meal of the specific 5-HT3-receptor antagonist ICS 205-930, 10 mg and 20 mg intravenously were assessed with a scintigraphic technique in 12 normals. The 50% emptying time was less, the lag phase was shorter and the post lag emptying rate was faster after 20 mg ICS 205-930 (p...

journal_title：Gut

authors： Akkermans LM,Vos A,Hoekstra A,Roelofs JM,Horowitz M

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Some cirrhotic patients with tense ascites who undergo paracentesis develop a circulatory dysfunction syndrome, manifested by an increase in plasma renin activity. Recently, a significant inverse correlation between postparacentesis changes in plasma renin activity and systemic vascular resistance has been d...

journal_title：Gut

authors： Cabrera J,Falcón L,Gorriz E,Pardo MD,Granados R,Quinones A,Maynar M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The liver represents one of the major sites of human glucuronidation. Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to the formation of usually inactive glucuronides. Hepatic glucuronidation undergoes significant changes during fetal and neonatal development re...

journal_title：Gut

authors： Strassburg CP,Strassburg A,Kneip S,Barut A,Tukey RH,Rodeck B,Manns MP

更新日期：2002-02-01 00:00:00

abstract：:The effects of specific nutrients on intestinal maturation and repair after injury are practically unknown. The purpose of this work was to study the effects of dietary nucleotides on the repair of the intestinal mucosa after chronic diarrhoea induced by a lactose enriched diet in the weanling rat. One group of weanli...

journal_title：Gut

authors： Bueno J,Torres M,Almendros A,Carmona R,Nuñez MC,Rios A,Gil A

更新日期：1994-07-01 00:00:00

abstract：:The value of lactulose treatment in hepatic encephalopathy is widely recognised but its mode of action remains controversial. Much evidence supports a role for gamma-aminobutyric acid in hepatic encephalopathy, and lactulose could alter its bacterial production in the gut. Using the rat synaptic membrane assay and gas...

journal_title：Gut

authors： al Mardini H,al Jumaili B,Record CO,Burke D

更新日期：1991-09-01 00:00:00

abstract：:The absorption of short chain fatty acids by the human rectum in the absence of chloride has been studied using a dialysis bag technique. Absorption rates of sodium, water, and short chain fatty acids were unchanged on replacing chloride with sulphate. Final concentrations of bicarbonate were 35.4 +/- 3.4 mmol/l in th...

journal_title：Gut

authors： McNeil NI,Cummings JH,James WP

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND:Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. AIMS:To study the effect of glyceryl trinitrate, a nitr...

journal_title：Gut

authors： Greaves R,Miller J,O'Donnell L,McLean A,Farthing MJ

更新日期：1998-03-01 00:00:00

abstract：:The benzimidazole anthelmintics mebendazole and fenbendazole have been shown to be much less effective against Nippostrongylus brasiliensis infections in the rat on a combined iron and protein deficient diet. In the present experiments it was shown that the anthelmintic efficacy of mebendazole was significantly impair...

journal_title：Gut

authors： Duncombe VM,Bolin TD,Davis AE,Fagan MR,Kelly JD

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:It is presently not well understood to what extent peptic ulcer and gastric cancer represent related diseases. AIMS:The objective of this study was to assess past occurrence of gastric and duodenal ulcers in patients with cancer of the gastric cardia or other parts of the stomach. METHODS:The association b...

journal_title：Gut

authors： Molloy RM,Sonnenberg A

更新日期：1997-02-01 00:00:00