Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis.

abstract：:Traditional Chinese herbal remedies are widely available in the United Kingdom for the treatment of chronic skin disorders. Their benefits are considerable, but their use is completely unregulated. Two patients are described here who suffered an acute hepatitic illness related to taking traditional Chinese herbs. Both...

journal_title：Gut

authors： Kane JA,Kane SP,Jain S

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:The aetiology of Crohn's disease (CD) has been related to nucleotide-binding oligomerisation domain containing 2 (NOD2) and ATG16L1 gene variants. The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients with NOD2/ATG16L1-variant...

journal_title：Gut

authors： Gutiérrez A,Scharl M,Sempere L,Holler E,Zapater P,Almenta I,González-Navajas JM,Such J,Wiest R,Rogler G,Francés R

更新日期：2014-02-01 00:00:00

abstract：:This prospective study was undertaken to evaluate the correlation between densitometric values of gall stones assessed by computed tomography and the success rate of litholytic therapy in 28 patients eligible for oral treatment. A densitometric study of the stones was performed in all patients before treatment. A cut ...

journal_title：Gut

authors： Caroli A,Del Favero G,Di Mario F,Spigariol F,Scalon P,Meggiato T,Zambelli C,Naccarato R

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:There is considerable evidence indicating that the severity of hepatic damage in individuals with cholestatic liver disease is causally associated with the extent of intrahepatic oxidative stress. Increased levels or accelerated generation of reactive oxygen species and toxic degradative products of lipid pe...

journal_title：Gut

authors： Ljubuncic P,Tanne Z,Bomzon A

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:In liver regeneration after portal branch ligation we previously showed that early cellular changes are observed in both the proliferating and atrophying liver lobes. They are therefore not indicative of future proliferative response. In this study we attempted to define precisely, in the same model, the tim...

journal_title：Gut

authors： Stärkel P,Lambotte L,Sempoux C,De Saeger C,Saliez A,Maiter D,Horsmans Y

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:To characterise gut microbiome in patients with hepatocellular carcinoma (HCC) and evaluate the potential of microbiome as non-invasive biomarkers for HCC. DESIGN:We collected 486 faecal samples from East China, Central China and Northwest China prospectively and finally 419 samples completed Miseq sequencin...

journal_title：Gut

authors： Ren Z,Li A,Jiang J,Zhou L,Yu Z,Lu H,Xie H,Chen X,Shao L,Zhang R,Xu S,Zhang H,Cui G,Chen X,Sun R,Wen H,Lerut JP,Kan Q,Li L,Zheng S

更新日期：2019-06-01 00:00:00

abstract：:The carrier rate of hepatitis B virus (HBV) in black Africans averages 10.4% throughout the continent. Even within each country, however, there may be wide variations. HBV carriage in black Africans is largely established in early childhood, mostly through horizontal transmission. Perinatal transmission also occurs bu...

journal_title：Gut

authors： Kew MC

更新日期：1996-01-01 00:00:00

abstract：:Two patients who developed biochemical and histological evidence of hepatitis while taking the anti-anginal drug perhexiline maleate are described. The pathological changes were those of mild to moderate fatty change together with a hepatitis which resembled alcoholic hepatitis, including in one patient the presence o...

journal_title：Gut

authors： Lewis D,Wainwright HC,Kew MC,Zwi S,Isaacson C

更新日期：1979-03-01 00:00:00

abstract：BACKGROUND:Previous studies of anticipation in familial pancreatic cancer have been small and subject to ascertainment bias. Our aim was to determine evidence for anticipation in a large number of European families. PATIENTS AND METHODS:A total of 1223 individuals at risk from 106 families (264 affected individuals) w...

journal_title：Gut

authors： McFaul CD,Greenhalf W,Earl J,Howes N,Neoptolemos JP,Kress R,Sina-Frey M,Rieder H,Hahn S,Bartsch DK,European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC).,German National Case Collection for Familial

更新日期：2006-02-01 00:00:00

abstract：:Evidence is presented which indicates a possible reduction in recognition capacity for tumour cell antigens (EB(2) Burkitt lymphoma cell line) by lymphocytes from some patients with longstanding but inactive Crohn's disease. Three out of seven patients tested also showed diminished or absent lymphocytotoxicity when th...

journal_title：Gut

authors： Maclaurin BP,Cooke WT,Ling NR

更新日期：1972-08-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The goal of the study was to determine whether the mutational profile of early colorectal polyps correlated with growth behaviour. The growth of small polyps (6-9 mm) that were first identified during routine screening of patients was monitored over time by interval imaging with CT colonography. Mu...

journal_title：Gut

authors： Sievers CK,Zou LS,Pickhardt PJ,Matkowskyj KA,Albrecht DM,Clipson L,Bacher JW,Pooler BD,Moawad FJ,Cash BD,Reichelderfer M,Vo TN,Newton MA,Larget BR,Halberg RB

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Watery stools are equated with rapid and hard stools with slow intestinal transit; however, the relation between stool form and transit through specific regions of the gut is not clear cut. In addition, more information is needed on interindividual variability of these measurements. AIM:To examine the relat...

journal_title：Gut

authors： Degen LP,Phillips SF

更新日期：1996-07-01 00:00:00

abstract：:The cause of a biliary tract stricture may be difficult to determine radiologically. Exfoliative biliary cytology was evaluated in 62 patients (median age 65 years, range 30-94) with biliary tract strictures presenting to the Hepatobiliary Unit between January 1984 and December 1989. Bile samples were taken during end...

journal_title：Gut

authors： Davidson B,Varsamidakis N,Dooley J,Deery A,Dick R,Kurzawinski T,Hobbs K

更新日期：1992-10-01 00:00:00

abstract：:A family is described in which there occurred two cases of the lupoid type of active chronic hepatitis with cirrhosis, one of chronic persistent hepatitis, and one of myasthenia gravis. The two cases of lupoid hepatitis were in the proposita, a schoolgirl aged 16 years, and her great-aunt aged 69 years whom she had ne...

journal_title：Gut

authors： Whittingham S,Mackay IR,Kiss ZS

更新日期：1970-10-01 00:00:00

abstract：INTRODUCTION:The use of patient reported outcome measures to support routine inflammatory bowel disease (IBD) care is not widespread and suggests that existing questionnaires lack relevance to day-to-day decisions or are too cumbersome to administer. We developed a simple, generic tool for capturing disease control fro...

journal_title：Gut

authors： Bodger K,Ormerod C,Shackcloth D,Harrison M,IBD Control Collaborative.

更新日期：2014-07-01 00:00:00

abstract：:Intestinal involvement in Schistosoma mansoni infection is usually confined to the ileum and colon. Duodenal infestation was diagnosed in a patient with recurrent schistosomiasis despite treatment who presented with a postoperative small bowel fistula. Duodenal schistosomiasis can be suspected on endoscopy, but must a...

journal_title：Gut

authors： Contractor QQ,Benson L,Schulz TB,Contractor TQ,Kasturi N

更新日期：1988-07-01 00:00:00

abstract：:Cell cultures derived from Crohn's disease and control tissues were subjected to a series of tests designed to detect persistent, non-cytocidal virus infection. No evidence for any such infection was found, and it is concluded that persistent viral infection of gut tissues is unlikely to play a significant role in the...

journal_title：Gut

authors： Phillpotts RJ,Hermon-Taylor J,Teich NM,Brooke BN

更新日期：1980-03-01 00:00:00

abstract：:Lymphocytes obtained after enzymatic digestion of intestinal biopsies from patients with coeliac disease were examined for the presence of gliadin specific antibody secreting cells by means of the ELISPOT technique. This technique permits enumeration of gliadin antibody secreting immunocytes, differentiated with regar...

journal_title：Gut

authors： Lycke N,Kilander A,Nilsson LA,Tarkowski A,Werner N

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND/AIM:The reliability of a quantitative method for the non-invasive assessment of intestinal disaccharide hydrolysis was assessed. METHODS:Differential excretion of intact disaccharide, expressed as ratios of lactulose to appropriate hydrolysable disaccharides in urine collected following combined ingestion, ...

journal_title：Gut

authors： Bjarnason I,Batt R,Catt S,Macpherson A,Maxton D,Menzies IS

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn's ...

journal_title：Gut

authors： Stournaras E,Qian W,Pappas A,Hong YY,Shawky R,UK IBD BioResource Investigators.,Raine T,Parkes M,UK IBD Bioresource Investigators.

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The phenotypic spectrum of familial adenomatous polyposis (FAP) varies from the classic appearance of hundreds of adenomatous colonic polyps in the young adult and early onset colorectal cancer, to the occurrence of sparse adenomas in the older adult, "attenuated" FAP, due to mutations at the 5' or 3' ends o...

journal_title：Gut

authors： Rozen P,Samuel Z,Shomrat R,Legum C

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Gastric carcinogenesis is a multifactorial, multistep process, in which chronic inflammation plays a major role. AIMS:In order to ascertain whether free radical mediated oxidative DNA damage is involved in such a process, concentrations of 8-hydroxydeoxyguanosine (8OHdG), a mutagenic/carcinogenic adduct, an...

journal_title：Gut

authors： Farinati F,Cardin R,Degan P,Rugge M,Mario FD,Bonvicini P,Naccarato R

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND AND AIM:There are few data on the course of Helicobacter pylori infection in asymptomatic subjects. The aim of this study was to assess the effect of eradication therapy on the development of dyspeptic and gastro-oesophageal reflux disease in a cohort of asymptomatic individuals observed over a prolonged per...

journal_title：Gut

authors： Vaira D,Vakil N,Rugge M,Gatta L,Ricci C,Menegatti M,Leandro G,Holton J,Russo VM,Miglioli M

更新日期：2003-11-01 00:00:00

abstract：:To determine the optimum bile acid regimen for rapid gall stone dissolution, 48 gall stone patients were divided into four groups of 12 according to stone diameter and were randomly allocated to receive one of four treatment regimens: bedtime or mealtime chenodeoxycholic acid (CDCA, 12 mg/kg/day) and bedtime or mealti...

journal_title：Gut

authors： Jazrawi RP,Pigozzi MG,Galatola G,Lanzini A,Northfield TC

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:The incidence figures for ulcerative colitis (UC) and Crohn's disease (CD) have been difficult to interpret, and geographical variations may be due to differences in classification criteria and study design. Few studies have based the incidence on prospective systematic follow up to confirm the initial diagn...

journal_title：Gut

authors： Moum B,Ekbom A,Vatn MH,Aadland E,Sauar J,Lygren I,Schulz T,Stray N,Fausa O

更新日期：1997-03-01 00:00:00

abstract：:Three cases of apparent primary villous atrophy of the terminal ileum in women with chronic diarrhoea are reported. Eight cases have previously been reported in the literature. Clinical characteristics are the presence of severe chronic secretory diarrhoea with episodes of hypokalaemia combined with signs of ileal mal...

journal_title：Gut

authors： Marteau P,Lavergne-Slove A,Lemann M,Bouhnik Y,Bertheau P,Becheur H,Galian A,Rambaud JC

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:The potential of endoscopic mucosal resection (EMR) for treating flat dysplastic lesions in chronic ulcerative colitis (CUC) has not been addressed so far. Historically, such lesions were referred for colectomy. Furthermore, there are only limited data to support endoscopic resection of exophytic adenoma-lik...

journal_title：Gut

authors： Hurlstone DP,Sanders DS,Atkinson R,Hunter MD,McAlindon ME,Lobo AJ,Cross SS,Thomson M

更新日期：2007-06-01 00:00:00

abstract：:A dodecapeptide of A-gliadin, which shares amino acid homologies with the E1b protein of adenovirus 12, was used to produce murine monoclonal antibodies. Five monoclonal antibodies were produced and were screened by enzyme linked immunosorbant assay, immunodot assay, and immunoblotting. The antibodies were tested agai...

journal_title：Gut

authors： Ellis HJ,Doyle AP,Sturgess RP,Ciclitira PJ

更新日期：1992-11-01 00:00:00

abstract：:Ileal permeability to different sized polyethyleneglycols (590-942 dalton PEG) was investigated peroperatively in 11 patients with Crohn's disease and seven with colonic carcinoma. A 15 cm ileal segment was converted into a tied loop, in which the PEG's were deposited. Absorption from the ileal segment was then measur...

journal_title：Gut

authors： Olaison G,Leandersson P,Sjödahl R,Tagesson C

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of this study was to unravel the mechanisms responsible for the increased risk of gall stone disease in hypertriglyceridaemia (HTG) and to compare the effects of triglyceride lowering therapy by bezafibrate and fish oil on determinants of cholelithiasis (biliary lipid composition and gall bla...

journal_title：Gut

authors： Jonkers IJ,Smelt AH,Ledeboer M,Hollum ME,Biemond I,Kuipers F,Stellaard F,Boverhof R,Meinders AE,Lamers CH,Masclee AA

更新日期：2003-01-01 00:00:00