Liver damage associated with perhexiline maleate.

abstract：BACKGROUND AND AIMS:Fer kinase is activated by a number of growth factors and cytokines, and phosphorylates cortactin during cell shape change induced cortical actin reorganisation. In addition, Fer participates in cytoskeletal interactions mediated by cadherins, platelet endothelial cell adhesion molecule 1 (PECAM-1),...

journal_title：Gut

authors： Qi W,Ebbert KV,Craig AW,Greer PA,McCafferty DM

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:As pathogen sensors, Toll-like receptors (TLR) play a role in the first defence line during HCV infection. However, the impact of the DNA sensor TLR9 on the natural course of HCV infection is unknown. To address this, TLR9 promoter polymorphisms (single nucleotide polymorphisms (SNPs)) rs187084 and rs5743836 ...

journal_title：Gut

authors： Fischer J,Weber ANR,Böhm S,Dickhöfer S,El Maadidi S,Deichsel D,Knop V,Klinker H,Möller B,Rasenack J,Wang L,Sharma M,Hinrichsen H,Spengler U,Buggisch P,Sarrazin C,Pawlita M,Waterboer T,Wiese M,Probst-Müller E,Malin

更新日期：2017-10-01 00:00:00

abstract：:Using immune electron microscopy, an attempt has been made to visualise viral particles in Crohn's disease tissue and faeces. No particles resembling viruses were observed, but in the absence of a specific antiserum a negative result does not exclude the presence of a virus, particularly if it is sparsely distributed....

journal_title：Gut

authors： Whorwell PJ,Baldwin RC,Wright R

更新日期：1976-09-01 00:00:00

abstract：:Based on a diary which was kept while preparing for and undergoing pan-proctocolectomy, the paper describes the process of coming to terms with an ileostomy. A number of stages in the process are identified: anticipation, reorientation, trauma, maintenance of selfimage and accommodation. The social-psychological strat...

journal_title：Gut

authors： Kelly MP

更新日期：1987-01-01 00:00:00

abstract：:Blood ethanol concentrations after separate oral dosing and intravenous infusion of ethanol (0.15 g/kg) were measured in 16 control subjects and 13 subjects treated with ranitidine. All subjects underwent routine upper gastrointestinal endoscopy. Peak blood ethanol concentrations, and area under the blood ethanol/time...

journal_title：Gut

authors： Brown AS,Fiaterone JR,Day CP,Bennett MK,Kelly PJ,James OF

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Patients with irritable bowel syndrome (IBS) have reduced pain thresholds for rectal distension. In addition, the prevalence of sexual/physical abuse in referred IBS patients is high and is associated with greater pain reporting, poorer health status, and poorer outcome. This lead to a hypothesis that abuse ...

journal_title：Gut

authors： Ringel Y,Whitehead WE,Toner BB,Diamant NE,Hu Y,Jia H,Bangdiwala SI,Drossman DA

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND/AIMS:In 1998 the PPP2R1B gene encoding the A subunit of the serine/threonine protein phosphatase was identified as a putative tumour suppressor gene in lung and colon cancer in the chromosome region 11q22-24. The aim of the present study was to determine the type of alterations in primary rectal cancers as w...

journal_title：Gut

authors： Takagi Y,Futamura M,Yamaguchi K,Aoki S,Takahashi T,Saji S

更新日期：2000-08-01 00:00:00

abstract：:To examine socioeconomic factors, dietary and other personal habits, and medical history as risk factors for ulcerative colitis, we studied 167 (98%) of all prevalent cases of ulcerative colitis diagnosed in Uppsala county from 1945 to 1964 and 167 age and sex matched population controls. Ulcerative colitis patients w...

journal_title：Gut

authors： Samuelsson SM,Ekbom A,Zack M,Helmick CG,Adami HO

更新日期：1991-12-01 00:00:00

abstract：:Ten patients in whom cystic dystrophy developed in a heterotopic pancreas of the duodenal (nine patients) or gastric (one patient) wall are reported. All were young or middle aged white men, only two of whom were alcoholic. The symptoms were caused by intestinal or biliary stenosis, or both, secondary to the inflammat...

journal_title：Gut

authors： Fléjou JF,Potet F,Molas G,Bernades P,Amouyal P,Fékété F

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND/AIMS:Studies in animals suggest a physiological role for glucagon-like peptide-1-(7-36)-amide (GLP-1) in regulating satiety. The role of GLP-1 in regulating food intake in man has, however, not been investigated. Subjects-Sixteen healthy male subjects were examined in a double blind placebo controlled fashio...

journal_title：Gut

authors： Gutzwiller JP,Göke B,Drewe J,Hildebrand P,Ketterer S,Handschin D,Winterhalder R,Conen D,Beglinger C

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Watery stools are equated with rapid and hard stools with slow intestinal transit; however, the relation between stool form and transit through specific regions of the gut is not clear cut. In addition, more information is needed on interindividual variability of these measurements. AIM:To examine the relat...

journal_title：Gut

authors： Degen LP,Phillips SF

更新日期：1996-07-01 00:00:00

abstract：:p53 mutations are a common genetic finding in hepatocellular carcinoma from areas of high aflatoxin exposure. Recent small studies have shown that p53 gene mutations may be less common in areas with a low prevalence of hepatocellular carcinoma such as Great Britain. The protein product of mutant p53 can be detected im...

journal_title：Gut

authors： Collier JD,Carpenter M,Burt AD,Bassendine MF

更新日期：1994-01-01 00:00:00

abstract：:Earlier studies regarding possible primary immune disturbances participating in the pathogenesis of Crohn's disease yielded conflicting results. Peripheral blood lymphocyte subsets and lymphocyte proliferative responses to five soluble recall antigens and to the polyclonal stimulator phythaemagglutinin were therefore ...

journal_title：Gut

authors： D'Haens G,Hiele M,Rutgeerts P,Geboes K,Ceuppens JL

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND AND AIMS:A previous study suggested that the presence of myenteric plexitis in the proximal resection margins could be predictive of early endoscopic recurrence after ileocolonic or ileal resection for Crohn's disease (CD). The aim of the present study was to assess the predictive value of plexitis for early...

journal_title：Gut

authors： Sokol H,Polin V,Lavergne-Slove A,Panis Y,Treton X,Dray X,Bouhnik Y,Valleur P,Marteau P

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:A population based epidemiological study identified all the patients diagnosed with ulcerative colitis (UC) or Crohn's disease (CD) resident in the Florence area in the period 1978-1992. AIMS:To assess the mortality of unselected patients with inflammatory bowel disease (IBD) in a Mediterranean country. ME...

journal_title：Gut

authors： Palli D,Trallori G,Saieva C,Tarantino O,Edili E,D'Albasio G,Pacini F,Masala G

更新日期：1998-02-01 00:00:00

abstract：:The enteric nervous system of several species, including the mouse, rat, guinea pig and humans, contains cannabinoid CB1 receptors that depress gastrointestinal motility, mainly by inhibiting ongoing contractile transmitter release. Signs of this depressant effect are, in the whole organism, delayed gastric emptying a...

journal_title：Gut

authors： Pertwee RG

更新日期：2001-06-01 00:00:00

abstract：:Histochemical enzymatic studies were performed on 30 freshly resected large bowel carcinomas, 30 samples of normal colonic epithelium, and six samples of the histologically normal epithelium (so-called transitional epithelium) immediately adjacent to a carcinoma. Five enzymes were studied: nicotine adenine dinucleotid...

journal_title：Gut

authors： Marsden JR,Dawson IM

更新日期：1974-10-01 00:00:00

abstract：:An investigation of immunological parameters was conducted in 38 patients with Crohn's disease. The immunological tests employed included skin tests with dinitrochlorobenzene and a battery of common skin test antigens, lymphocyte transformation with phytohaemagglutinin and pokeweed mitogen, serum immunoglobulins, and ...

journal_title：Gut

authors： MacPherson BR,Albertini RJ,Beeken WL

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma cells express high levels of the antiapoptotic proteins Bcl-X(L) and Mcl-1 and are markedly chemo- and radioresistant. Mitochondria have emerged as central players in apoptosis. Antiapoptotic members of the Bcl-2 protein family localise to the outer mitochondrial membrane and regulate mito...

journal_title：Gut

authors： Okaro AC,Fennell DA,Corbo M,Davidson BR,Cotter FE

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment domain 9 (CARD9), a key innate immunity gene, is required to shape a normal gut microbiota. Card9-/- mice are more susceptible to the enteric mouse pathogen C...

journal_title：Gut

authors： Lamas B,Michel ML,Waldschmitt N,Pham HP,Zacharioudaki V,Dupraz L,Delacre M,Natividad JM,Costa GD,Planchais J,Sovran B,Bridonneau C,Six A,Langella P,Richard ML,Chamaillard M,Sokol H

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is associated with cardiovascular risk. The aim of this study was to determine the role of fatty liver in predicting coronary artery disease and clinical outcomes in patients undergoing coronary angiogram. METHOD...

journal_title：Gut

authors： Wong VW,Wong GL,Yip GW,Lo AO,Limquiaco J,Chu WC,Chim AM,Yu CM,Yu J,Chan FK,Sung JJ,Chan HL

更新日期：2011-12-01 00:00:00

abstract：:In a double-blind controlled trial amylopectin sulphate (Depepsen) had no significant advantage over placebo in the symptomatic treatment of duodenal ulcer. ...

journal_title：Gut

authors： Baron JH,Gribble RJ,Holdstock DJ,Misiewicz JJ

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:An increasing number of patients with severe or refractory ulcerative colitis involving only the rectum and sigmoid colon are being offered restorative proctocolectomy with ileal reservoir but very few data are available concerning the outcome for these patients. AIM:This study was designed to compare the o...

journal_title：Gut

authors： Samarasekera DN,Stebbing JF,Kettlewell MG,Jewell DP,Mortensen NJ

更新日期：1996-04-01 00:00:00

abstract：:It has been suggested that an intact vagal supply is essential for the normal function of the recptors in the duodenum and proximal small bowel, which influence the rate of gastric emptying. This paper reports the effect of vagal denervation on gastric emptying and also examines the site and mode of action of receptor...

journal_title：Gut

authors： Shahidullah M,Kennedy TL,Parks TG

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The authors have previously isolated a putative oncogene, eukaryotic initiation factor 5A2 (EIF5A2) from 3q26. In this study, EIF5A2 was characterised for its role in colorectal carcinoma (CRC) aggressiveness and underlying molecular mechanisms. METHODS:The expression dynamics of EIF5A2 were examin...

journal_title：Gut

authors： Zhu W,Cai MY,Tong ZT,Dong SS,Mai SJ,Liao YJ,Bian XW,Lin MC,Kung HF,Zeng YX,Guan XY,Xie D

更新日期：2012-04-01 00:00:00

abstract：:In 19 subjects (four controls, one gastric ulcer and 14 duodenal ulcer) maximal gastric secretion was evoked with histamine 0.13 mumol/kg/h (0.04 mg/kg/h) for two to two and a half hours. A slow intravenous bolus dose of 200 mg cimetidine was given at the beginning of the last hour. Gastric secretion was measured befo...

journal_title：Gut

authors： Melville RJ,Suleiman SI,Whitfield PF,Parkin JV,Nwabunike TO,Hobsley M

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We have previously shown that hypnosis can be used to study the effect of different emotions on the motility of the gastrointestinal tract. These studies demonstrated that both anger and excitement increased colonic motility while happiness led to a reduction. The purpose of this study was to ...

journal_title：Gut

authors： Houghton LA,Calvert EL,Jackson NA,Cooper P,Whorwell PJ

更新日期：2002-11-01 00:00:00

abstract：:Clarithromycin, a new and well tolerated, acid stable macrolide antibiotic, has a similar antimicrobial spectrum to erythromycin but a better in vitro MIC90 (0.03 microgram/l-1) against Helicobacter pylori (H pylori). This study aimed at determining the eradication rate using clarithromycin 500 mg thrice daily and ome...

journal_title：Gut

authors： Logan RP,Gummett PA,Schaufelberger HD,Greaves RR,Mendelson GM,Walker MM,Thomas PH,Baron JH,Misiewicz JJ

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The effectiveness of surveillance for hepatocellular carcinoma (HCC) in the USA is largely unknown. The objective of this study was to evaluate the effectiveness of HCC surveillance in a national Veterans Administration (VA) practice setting, using the national VA hepatitis C virus (HCV) Clinical Ca...

journal_title：Gut

authors： El-Serag HB,Kramer JR,Chen GJ,Duan Z,Richardson PA,Davila JA

更新日期：2011-07-01 00:00:00

abstract：:To determine the optimum bile acid regimen for rapid gall stone dissolution, 48 gall stone patients were divided into four groups of 12 according to stone diameter and were randomly allocated to receive one of four treatment regimens: bedtime or mealtime chenodeoxycholic acid (CDCA, 12 mg/kg/day) and bedtime or mealti...

journal_title：Gut

authors： Jazrawi RP,Pigozzi MG,Galatola G,Lanzini A,Northfield TC

更新日期：1992-03-01 00:00:00