Managing radical surgery: notes from the patient's viewpoint.

abstract：:In a randomised clinical trial, patients with moderately active Crohn's disease received either prednisolone 0.5 mg/kg/day plus a normal diet, or an elemental diet plus oral framycetin, colistin and nystatin. Patients were assessed using the Crohn's disease activity index (CDAI), ESR, and faecal granulocyte excretion ...

journal_title：Gut

authors： Saverymuttu S,Hodgson HJ,Chadwick VS

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Pancreatic cancer is among the most dismal of human malignancies. Current therapeutic strategies are virtually ineffective in controlling advanced, metastatic disease. Recent evidence suggests that the Hedgehog signalling pathway is aberrantly reactivated in the majority of pancreatic cancers, and t...

journal_title：Gut

authors： Feldmann G,Habbe N,Dhara S,Bisht S,Alvarez H,Fendrich V,Beaty R,Mullendore M,Karikari C,Bardeesy N,Ouellette MM,Yu W,Maitra A

更新日期：2008-10-01 00:00:00

abstract：:An investigation of immunological parameters was conducted in 38 patients with Crohn's disease. The immunological tests employed included skin tests with dinitrochlorobenzene and a battery of common skin test antigens, lymphocyte transformation with phytohaemagglutinin and pokeweed mitogen, serum immunoglobulins, and ...

journal_title：Gut

authors： MacPherson BR,Albertini RJ,Beeken WL

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:The prevalence of portopulmonary hypertension (PPHTN) in patients with cirrhosis and refractory ascites is unknown. Its presence may preclude patients from receiving a transjugular intrahepatic portosystemic shunt or liver transplantation as a definitive treatment for their end stage cirrhosis. PURPOSE:To d...

journal_title：Gut

authors： Benjaminov FS,Prentice M,Sniderman KW,Siu S,Liu P,Wong F

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by perip...

journal_title：Gut

authors： Thoree VC,Golby SJ,Boursier L,Hackett M,Dunn-Walters DK,Sanderson JD,Spencer J

更新日期：2002-07-01 00:00:00

abstract：:The actions of hydrochloric acid, natural PGE1, PGE2 and a synthetic commercial PGE1 preparation, Enisoprost (Searle) on pepsinogen synthesis and secretion were studied in canine chief cell monolayer cultures. Hydrochloric acid, applied directly to the apical surface of chief cells using culture plate inserts (Millipo...

journal_title：Gut

authors： Defize J,Hunt RH

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVE:Gastric cancer is the third leading cause of cancer death worldwide and infection by Helicobacter pylori is the strongest risk factor. We have reported increased epidermal growth factor receptor (EGFR) phosphorylation in the H. pylori-induced human carcinogenesis cascade, and association with DNA damage. Our ...

journal_title：Gut

authors： Sierra JC,Asim M,Verriere TG,Piazuelo MB,Suarez G,Romero-Gallo J,Delgado AG,Wroblewski LE,Barry DP,Peek RM Jr,Gobert AP,Wilson KT

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To establish an appropriate steroid treatment regimen for autoimmune pancreatitis (AIP). METHODS:A retrospective survey of AIP treatment was conducted in 17 centres in Japan. The main outcome measures were rate of remission and relapse. RESULTS:Of 563 patients with AIP, 459 (82%) received steroid treatment....

journal_title：Gut

authors： Kamisawa T,Shimosegawa T,Okazaki K,Nishino T,Watanabe H,Kanno A,Okumura F,Nishikawa T,Kobayashi K,Ichiya T,Takatori H,Yamakita K,Kubota K,Hamano H,Okamura K,Hirano K,Ito T,Ko SB,Omata M

更新日期：2009-11-01 00:00:00

abstract：BACKGROUNDS AND AIMS:Telomerase is significantly reactivated in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). Our previous studies showed that the transactivation unit of HBV surface (S) gene, preS2, could upregulate human telomerase reverse transcriptase (hTERT) expression and telomerase activity ...

journal_title：Gut

authors： Luan F,Liu H,Gao L,Liu J,Sun Z,Ju Y,Hou N,Guo C,Liang X,Zhang L,Sun W,Ma C

更新日期：2009-11-01 00:00:00

abstract：:Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral venous blood obtained at autopsy of sudden death victims within fou...

journal_title：Gut

authors： Cummings JH,Pomare EW,Branch WJ,Naylor CP,Macfarlane GT

更新日期：1987-10-01 00:00:00

abstract：:Pancreatic secretion of lipase and chymotrypsin in response to elemental diets and a crushed food homogenate was studied in normal subjects. The solutions were infused at constant flow rates at the ligament of Treitz with polyethylene glycol as a nonabsorbable marker. A triple lumen tube was used, enabling collection ...

journal_title：Gut

authors： Vison N,Hecketsweiler P,Butel J,Bernier JJ

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND:The intestinal epithelium is covered by a continuous layer of mucus which is secreted by well differentiated epithelial cells. Disregulation of the expression of mucins has been reported to have possible implications in the neoplastic process which affects intestinal mucosae. It is well known that preneoplas...

journal_title：Gut

authors： Buisine MP,Devisme L,Savidge TC,Gespach C,Gosselin B,Porchet N,Aubert JP

更新日期：1998-10-01 00:00:00

abstract：:In a double-blind controlled trial amylopectin sulphate (Depepsen) had no significant advantage over placebo in the symptomatic treatment of duodenal ulcer. ...

journal_title：Gut

authors： Baron JH,Gribble RJ,Holdstock DJ,Misiewicz JJ

更新日期：1977-09-01 00:00:00

abstract：:Based on short recordings, the rectum has been shown to have contractions with a frequency of five to 10 cycles per minute and slow contractions at three cycles per minute. To define anorectal motility over a prolonged period of time, we have studied 12 healthy volunteers using a fine pressure sensitive anorectal prob...

journal_title：Gut

authors： Kumar D,Williams NS,Waldron D,Wingate DL

更新日期：1989-07-01 00:00:00

abstract：:This report assesses the value of cholinesterase (ChE) activity as an indicator of liver function and analyses its usefulness in the diagnosis of jaundice. A rapid method of determination has been used, and alterations in ChE activity in conditions other than liver disease have been studied to permit a fuller and more...

journal_title：Gut

authors： BURNETT W

更新日期：1960-12-01 00:00:00

abstract：BACKGROUND:The pre-malignant gastric lesions atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia (DYS) have long been identified as principal risk factors for gastric cancer. OBJECTIVE:To evaluate epidemiological time trends of pre-malignant gastric lesions in the Netherlands. METHODS:Patients with a fi...

journal_title：Gut

authors： de Vries AC,Meijer GA,Looman CW,Casparie MK,Hansen BE,van Grieken NC,Kuipers EJ

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:The reported cumulative risk of developing pouchitis in ulcerative colitis (UC) patients undergoing ileal pouch-anal anastomosis (IPAA) approaches 50% after 10 years. To date, no preoperative serological predictor of pouchitis has been found. AIMS:To assess whether preoperative perinuclear antineutrophil cy...

journal_title：Gut

authors： Fleshner PR,Vasiliauskas EA,Kam LY,Fleshner NE,Gaiennie J,Abreu-Martin MT,Targan SR

更新日期：2001-11-01 00:00:00

abstract：:For the first time the endoscopist has more than one option for the management of gastro-oesophageal varices. It is now feasible to select the appropriate therapy on the basis of the clinical setting. Acute injection sclerotherapy remains a quick and simple technique for the control of active bleeding from oesophageal...

journal_title：Gut

authors： Williams SG,Westaby D

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:Cryptogenic multifocal ulcerating stenosing enteritis (CMUSE) is an extremely rare, but devastating, disease of unknown aetiology. We investigated the genetic basis of this autosomal recessive condition in a pair of affected siblings who have 40-year histories of catastrophic gastrointestinal and extraintesti...

journal_title：Gut

authors： Brooke MA,Longhurst HJ,Plagnol V,Kirkby NS,Mitchell JA,Rüschendorf F,Warner TD,Kelsell DP,MacDonald TT

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The aetiology of Crohn's disease (CD) has been related to nucleotide-binding oligomerisation domain containing 2 (NOD2) and ATG16L1 gene variants. The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients with NOD2/ATG16L1-variant...

journal_title：Gut

authors： Gutiérrez A,Scharl M,Sempere L,Holler E,Zapater P,Almenta I,González-Navajas JM,Such J,Wiest R,Rogler G,Francés R

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Inflammatory bowel disease (IBD) is initiated and perpetuated by a dysregulated immune response to unknown environmental antigens such as luminal bacteria in genetically susceptible hosts. SR-PSOX/CXCL16, a scavenger receptor that binds phosphatidylserine and oxidised lipoprotein, has both phagocyti...

journal_title：Gut

authors： Uza N,Nakase H,Yamamoto S,Yoshino T,Takeda Y,Ueno S,Inoue S,Mikami S,Matsuura M,Shimaoka T,Kume N,Minami M,Yonehara S,Ikeuchi H,Chiba T

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Eradication of Barrett's mucosa by thermal or photoablation combined with high doses of proton pump inhibitors is a potentially attractive strategy in the management of this preneoplastic condition. However, major concerns of this method are the persistence of residual metaplastic glands beneath the new squa...

journal_title：Gut

authors： Van Laethem JL,Peny MO,Salmon I,Cremer M,Devière J

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The authors' goal was to measure pH at the gastric surface (pH₀) to understand how acid secretion affects the repair of microscopic injury to the gastric epithelium. METHODS:Microscopic gastric damage was induced by laser light, during confocal/two-photon imaging of pH-sensitive dyes (Cl-NERF, BCEC...

journal_title：Gut

authors： Demitrack ES,Aihara E,Kenny S,Varro A,Montrose MH

更新日期：2012-06-01 00:00:00

abstract：:We have studied B-lymphocyte function in 39 patients with Crohn's disease and 35 normal individuals using a reverse haemolytic plaque assay as the effector system. Ten patients had active Crohn's disease, the others being in an inactive state of the disease. Compared with normal individuals, the Crohn's disease patien...

journal_title：Gut

authors： Sieber G,Herrmann F,Zeitz M,Teichmann H,Rühl H

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:Despite intent to cure surgery with negative resection margins, locoregional recurrence is common in pancreatic cancer. AIMS:To determine whether detection of K-ras gene mutation in the histologically negative surgical margins of pancreatic cancer reflects unrecognised disease. PATIENTS:Seventy patients wh...

journal_title：Gut

authors： Kim J,Reber HA,Dry SM,Elashoff D,Chen SL,Umetani N,Kitago M,Hines OJ,Kazanjian KK,Hiramatsu S,Bilchik AJ,Yong S,Shoup M,Hoon DS

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic regenerative processes. The triggering receptor expressed on myeloid cells 2 (TREM-2) is predominantly expressed in hepatic non-parenchymal cells and i...

journal_title：Gut

authors： Esparza-Baquer A,Labiano I,Sharif O,Agirre-Lizaso A,Oakley F,Rodrigues PM,Zhuravleva E,O'Rourke CJ,Hijona E,Jimenez-Agüero R,Riaño I,Landa A,La Casta A,Zaki MYW,Munoz-Garrido P,Azkargorta M,Elortza F,Vogel A,Schabbaue

更新日期：2020-09-09 00:00:00

abstract：OBJECTIVE:To present comparative data about the performance of colorectal cancer (CRC) screening programmes in the European Union Member States (EU MSs). DESIGN:Cross-sectional study. We analysed key performance indicators-participation rate, positivity rate (PR), detection rate (DR) and positive predictive value for ...

journal_title：Gut

authors： Senore C,Basu P,Anttila A,Ponti A,Tomatis M,Vale DB,Ronco G,Soerjomataram I,Primic-Žakelj M,Riggi E,Dillner J,Elfström MK,Lönnberg S,Sankaranarayanan R,Segnan N

更新日期：2019-07-01 00:00:00

abstract：:An estimated 7.5 million individuals in England and Wales are actively infected with Helicobacter pylori and hence knowledge of local resistance rates is of growing importance. Also, information on strain resistance following treatment failure is crucial in selecting an appropriate regimen as the development of bacter...

journal_title：Gut

authors： Owen RJ

更新日期：2002-03-01 00:00:00

abstract：:Forty patients with endoscopically proven persistent duodenal ulcer who had been treated for six weeks with cimetidine (1 g/day) were randomly allocated to receive a further six weeks' treatment with cimetidine (1 g/day) or ranitidine (300 mg/day). Ulcers healed in 12 of 19 patients given cimetidine (63%) and in 13 of...

journal_title：Gut

authors： Quatrini M,Basilisco G,Bianchi PA

更新日期：1984-10-01 00:00:00

abstract：:An elderly woman with chronic ulcerative colitis who developed proximal muscle weakness, increased serum creatine phosphokinase activity, and histological and electromyographic abnormalities characteristic of polymyositis is described. Treatment with corticosteroids and 5-acetylsalicylic acid was followed by a remissi...

journal_title：Gut

authors： Chugh S,Dilawari JB,Sawhney IM,Dang N,Radotra BD,Chawla YK

更新日期：1993-04-01 00:00:00