SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation.

Abstract:

BACKGROUND AND AIMS:Inflammatory bowel disease (IBD) is initiated and perpetuated by a dysregulated immune response to unknown environmental antigens such as luminal bacteria in genetically susceptible hosts. SR-PSOX/CXCL16, a scavenger receptor that binds phosphatidylserine and oxidised lipoprotein, has both phagocytic activity and chemotactic properties. The aim of this study was to investigate the role of SR-PSOX/CXCL16 in patients with IBD and experimental murine colitis. METHODS:The serum levels of SR-PSOX/CXCL16 were measured in patients with IBD. The roles of SR-PSOX/CXCL16 in phagocytosis of bacterial components and cytokine production by macrophages from wild-type (WT) and SR-PSOX/CXCL16 knockout (KO) mice were assessed. Colitis was induced by administering dextran sulfate sodium (DSS) to WT and SR-PSOX/CXCL16 KO mice. Colonic inflammation was analysed by clinical, histological and immunological parameters. Finally, the effect of a monoclonal antibody (mAb) to SR-PSOX/CXCL16 on DSS-induced colitis and trinitrobenzene sulfonic acid-induced colitis models was evaluated. RESULTS:Serum levels of SR-PSOX/CXCL16 correlated significantly with the disease activity of patients with IBD. Ex vivo experiments showed that SR-PSOX/CXCL16 was involved in both phagocytosis of bacterial antigens and the T helper 1 immune response through the production of interleukin 12 and interferon γ. In vivo murine experiments demonstrated the upregulated gene expression of SR-PSOX/CXCL16 in inflamed colonic tissues and the predominant expression of SR-PSOX/CXCL16 on macrophages. SR-PSOX/CXCL16 KO mice were less susceptible to colonic inflammation than were their WT littermates. Administration of SR-PSOX/CXCL16 mAb ameliorated the condition in the two different experimental colitis models. CONCLUSIONS:SR-PSOX/CXCL16 plays a critical role in colonic inflammation and could be a potential therapeutic target for patients with IBD.

journal_name

Gut

journal_title

Gut

authors

Uza N,Nakase H,Yamamoto S,Yoshino T,Takeda Y,Ueno S,Inoue S,Mikami S,Matsuura M,Shimaoka T,Kume N,Minami M,Yonehara S,Ikeuchi H,Chiba T

doi

10.1136/gut.2010.221879

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1494-505

issue

11

eissn

0017-5749

issn

1468-3288

pii

gut.2010.221879

journal_volume

60

pub_type

杂志文章

相关文献

GUT文献大全
  • Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis.

    abstract:BACKGROUND:Surveillance colonoscopy is widely recommended in patients with longstanding and extensive ulcerative colitis (UC) in order to detect colorectal neoplasia at an early stage. However, it still remains questionable whether surveillance colonoscopy effectively enables early detection of UC associated neoplasia....

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2004.062059

    authors: Fujii S,Tominaga K,Kitajima K,Takeda J,Kusaka T,Fujita M,Ichikawa K,Tomita S,Ohkura Y,Ono Y,Imura J,Chiba T,Fujimori T

    更新日期:2005-09-01 00:00:00

  • Evaluation of differential disaccharide excretion in urine for non-invasive investigation of altered intestinal disaccharidase activity caused by alpha-glucosidase inhibition, primary hypolactasia, and coeliac disease.

    abstract:BACKGROUND/AIM:The reliability of a quantitative method for the non-invasive assessment of intestinal disaccharide hydrolysis was assessed. METHODS:Differential excretion of intact disaccharide, expressed as ratios of lactulose to appropriate hydrolysable disaccharides in urine collected following combined ingestion, ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.39.3.374

    authors: Bjarnason I,Batt R,Catt S,Macpherson A,Maxton D,Menzies IS

    更新日期:1996-09-01 00:00:00

  • Development and validation of a rapid, generic measure of disease control from the patient's perspective: the IBD-control questionnaire.

    abstract:INTRODUCTION:The use of patient reported outcome measures to support routine inflammatory bowel disease (IBD) care is not widespread and suggests that existing questionnaires lack relevance to day-to-day decisions or are too cumbersome to administer. We developed a simple, generic tool for capturing disease control fro...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2013-305600

    authors: Bodger K,Ormerod C,Shackcloth D,Harrison M,IBD Control Collaborative.

    更新日期:2014-07-01 00:00:00

  • Extra intestinal influences on exhaled breath hydrogen measurements during the investigation of gastrointestinal disease.

    abstract::During the clinical investigation of patients with gastrointestinal disease by exhaled breath hydrogen measurement, the occurrence of inexplicable variations in recorded hydrogen values led to a search for extra intestinal factors which were capable of adversely influencing breath hydrogen concentration and impairing ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.26.12.1349

    authors: Thompson DG,Binfield P,De Belder A,O'Brien J,Warren S,Wilson M

    更新日期:1985-12-01 00:00:00

  • Primary ileal villous atrophy is often associated with microscopic colitis.

    abstract::Three cases of apparent primary villous atrophy of the terminal ileum in women with chronic diarrhoea are reported. Eight cases have previously been reported in the literature. Clinical characteristics are the presence of severe chronic secretory diarrhoea with episodes of hypokalaemia combined with signs of ileal mal...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.41.4.561

    authors: Marteau P,Lavergne-Slove A,Lemann M,Bouhnik Y,Bertheau P,Becheur H,Galian A,Rambaud JC

    更新日期:1997-10-01 00:00:00

  • Low dose interferon alfa-2b for chronic hepatitis B in Asian countries.

    abstract::In a study of low dose interferon alfa-2b in 587 patients expected to show a good response to treatment, 76-87% patients in different countries had alanine amino-transferase activities returned to normal after four months' treatment, 49-72% were negative for hepatitis B virus (HBV)-DNA, 51-66% were negative for hepati...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1136/gut.34.2_suppl.s99

    authors: Mauracher E

    更新日期:1993-01-01 00:00:00

  • Omeprazole in the treatment of erosive oesophagitis refractory to high dose cimetidine and ranitidine.

    abstract::Forty five patients with refractory oesophagitis, defined as persisting erosive changes or ulceration despite a minimum of three months' treatment with cimetidine 3.2 g daily or ranitidine 0.9 g daily, were treated in an open trial with omeprazole 40 mg daily for up to eight weeks. Endoscopically defined healing was o...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.7.745

    authors: Bardhan KD,Morris P,Thompson M,Dhande DS,Hinchliffe RF,Jones RB,Daly MJ,Carroll NJ

    更新日期:1990-07-01 00:00:00

  • The predictive value of transabdominal ultrasonography in the diagnosis of biliary tract complications after orthotopic liver transplantation.

    abstract:BACKGROUND:In transplant recipients with choledococholedocostomy (CDCD), endoscopic retrograde cholangiopancreatography (ERCP) remains the gold standard for the diagnosis of biliary leak or strictures. Transabdominal ultrasonography (TAUS) has been used to screen patients with suspected biliary tract complications, pri...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.45.6.900

    authors: Hussaini SH,Sheridan MB,Davies M

    更新日期:1999-12-01 00:00:00

  • Effect of anticoagulants and NSAIDs on accuracy of faecal immunochemical tests (FITs) in colorectal cancer screening: a systematic review and meta-analysis.

    abstract:OBJECTIVE:Most colorectal cancer (CRC) screening programmes are nowadays based on faecal immunochemical testing (FIT). Eligible subjects often use oral anticoagulants (OACs) or non-steroidal anti-inflammatory drugs (NSAIDs), which could possibly stimulate bleeding from both benign and premalignant lesions in the colon....

    journal_title:Gut

    pub_type: 杂志文章,meta分析

    doi:10.1136/gutjnl-2018-316344

    authors: Nieuwenburg SAV,Vuik FER,Kruip MJHA,Kuipers EJ,Spaander MCW

    更新日期:2019-05-01 00:00:00

  • Risk factors for extensive ulcerative colitis and ulcerative proctitis: a population based case-control study.

    abstract::To examine socioeconomic factors, dietary and other personal habits, and medical history as risk factors for ulcerative colitis, we studied 167 (98%) of all prevalent cases of ulcerative colitis diagnosed in Uppsala county from 1945 to 1964 and 167 age and sex matched population controls. Ulcerative colitis patients w...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.32.12.1526

    authors: Samuelsson SM,Ekbom A,Zack M,Helmick CG,Adami HO

    更新日期:1991-12-01 00:00:00

  • SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer.

    abstract:OBJECTIVE:To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6. DESIGN:We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expres...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2017-314983

    authors: Wan L,Yu W,Shen E,Sun W,Liu Y,Kong J,Wu Y,Han F,Zhang L,Yu T,Zhou Y,Xie S,Xu E,Zhang H,Lai M

    更新日期:2019-01-01 00:00:00

  • First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying.

    abstract:BACKGROUND:Ethanol undergoes a first pass metabolism (FPM) in the stomach and liver. Gastric FPM of ethanol primarily depends on the activity of gastric alcohol dehydrogenase (ADH). In addition, the speed of gastric emptying (GE) may modulate both gastric and hepatic FPM of ethanol. AIMS:To study the effect of modulat...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.43.5.612

    authors: Oneta CM,Simanowski UA,Martinez M,Allali-Hassani A,Parés X,Homann N,Conradt C,Waldherr R,Fiehn W,Coutelle C,Seitz HK

    更新日期:1998-11-01 00:00:00

  • Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon.

    abstract:BACKGROUND:Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is k...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.52.6.840

    authors: Berrebi D,Maudinas R,Hugot JP,Chamaillard M,Chareyre F,De Lagausie P,Yang C,Desreumaux P,Giovannini M,Cézard JP,Zouali H,Emilie D,Peuchmaur M

    更新日期:2003-06-01 00:00:00

  • Intestinal permeability to polyethyleneglycol 600 in Crohn's disease. Peroperative determination in a defined segment of the small intestine.

    abstract::Ileal permeability to different sized polyethyleneglycols (590-942 dalton PEG) was investigated peroperatively in 11 patients with Crohn's disease and seven with colonic carcinoma. A 15 cm ileal segment was converted into a tied loop, in which the PEG's were deposited. Absorption from the ileal segment was then measur...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.29.2.196

    authors: Olaison G,Leandersson P,Sjödahl R,Tagesson C

    更新日期:1988-02-01 00:00:00

  • Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis.

    abstract:OBJECTIVE:Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity. METHODS:Experimental liver fibrosis in mice induced by bile duct ligation or CCl4 application was used to characterise the mechanisms determining failure of innate imm...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-311224

    authors: Hackstein CP,Assmus LM,Welz M,Klein S,Schwandt T,Schultze J,Förster I,Gondorf F,Beyer M,Kroy D,Kurts C,Trebicka J,Kastenmüller W,Knolle PA,Abdullah Z

    更新日期:2017-03-01 00:00:00

  • Autonomic dysfunction in gastrointestinal motility disorders.

    abstract::The records of 113 consecutive patients with a suspected gastrointestinal motility disorder referred between January 1988 and July 1991 were retrospectively reviewed. The aims were to identify the prevalence of autonomic dysfunction in those with or without associated neurological disease and to determine the diagnost...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.34.3.397

    authors: Bharucha AE,Camilleri M,Low PA,Zinsmeister AR

    更新日期:1993-03-01 00:00:00

  • Distribution and metabolism in healthy volunteers of disodium azodisalicylate, a potential therapeutic agent for ulcerative colitis.

    abstract::A series of experiments has been performed in healthy male volunteers to investigate the disposition of orally administered disodium azodisalicylate, a potentially useful drug for the treatment of ulcerative colitis. The drug was given by mouth in doses of up to 2 g a day for six weeks and there were no adverse effect...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.23.12.1081

    authors: Willoughby CP,Aronson JK,Agback H,Bodin NO,Truelove SC

    更新日期:1982-12-01 00:00:00

  • Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice.

    abstract:BACKGROUND AND AIMS:Interleukin-6 (IL-6) is a well-recognised mediator of liver disease and regeneration. However, the in vivo effects of IL-6 on enterocytes and the intestinal tract have not been elucidated. We sought to determine the in vivo effects of IL-6 on enterocytes. METHODS:Murine models of increased or absen...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2008.151175

    authors: Jin X,Zimmers TA,Zhang Z,Pierce RH,Koniaris LG

    更新日期:2010-02-01 00:00:00

  • Gastritis due to spiral shaped bacteria other than Helicobacter pylori: clinical, histological, and ultrastructural findings.

    abstract::An intensive histological search for Helicobacter pylori in gastric biopsy specimens has led to the detection of other spiral shaped bacteria in the human gastric mucosa. The clinical and morphological findings of 39 cases (0.25% of all gastric biopsies performed in the observation period) are reported for 34 patients...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.32.2.137

    authors: Heilmann KL,Borchard F

    更新日期:1991-02-01 00:00:00

  • Relation between gastric cancer and previous peptic ulcer disease.

    abstract:BACKGROUND:It is presently not well understood to what extent peptic ulcer and gastric cancer represent related diseases. AIMS:The objective of this study was to assess past occurrence of gastric and duodenal ulcers in patients with cancer of the gastric cardia or other parts of the stomach. METHODS:The association b...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.40.2.247

    authors: Molloy RM,Sonnenberg A

    更新日期:1997-02-01 00:00:00

  • Acute delta hepatitis without circulating HBsAg.

    abstract::Infection with the delta agent can only occur in the context of coexistent hepatitis B virus infection. We describe a patient in whom the clinical features of acute delta hepatitis developed when seroconversion from hepatitis B surface antigen to antibody had already occurred and diagnosis of recent acute hepatitis B ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.26.2.212

    authors: De Cock KM,Govindarajan S,Redeker AG

    更新日期:1985-02-01 00:00:00

  • Liver tolerance mediated by antigen presenting cells: fact or fiction?

    abstract::Possible mechanisms by which liver antigen presenting cells (APC) may facilitate tolerance induction are discussed. Tolerance may be facilitated by a distinctive combination of factors, linked to the unique anatomical and microenvironmental features of the liver. ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.52.8.1075

    authors: Lau AH,de Creus A,Lu L,Thomson AW

    更新日期:2003-08-01 00:00:00

  • Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas).

    abstract:OBJECTIVES:Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN:Retrospective multinational study including SCN diagnosed between 1990 and 2014. ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-309638

    authors: Jais B,Rebours V,Malleo G,Salvia R,Fontana M,Maggino L,Bassi C,Manfredi R,Moran R,Lennon AM,Zaheer A,Wolfgang C,Hruban R,Marchegiani G,Fernández Del Castillo C,Brugge W,Ha Y,Kim MH,Oh D,Hirai I,Kimura W,Jang JY

    更新日期:2016-02-01 00:00:00

  • Radiographic evaluation of pancreatico-jejunal shunts.

    abstract::This paper describes opacification and identification of two surgically constructed pancreatico-jujunal shunts. A fibreoptic panendoscope was used with retrograde injection via the ampulla of Vater (ERCP). This procedure makes possible more accurate anatomical evaluation and so more precise clinical appraisal of both...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.17.6.439

    authors: Miller EW,Goldberg HI,Goldberg SB,Shapiro H

    更新日期:1976-06-01 00:00:00

  • Anticomplement receptor activity in the serum of patients with primary biliary cirrhosis.

    abstract::Patients with primary biliary cirrhosis have a defect in the receptor mediated clearance of complement coated erythrocytes by fixed macrophages of the reticuloendothelial system. To investigate the probable mechanism of this defect peripheral blood monocytes were isolated from nine patients with primary biliary cirrho...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.27.3.324

    authors: Minuk GY,Vergalla J,Hanson RG,Hoofnagle JH,Frank MM,Jones EA

    更新日期:1986-03-01 00:00:00

  • Assessment of variceal pressure by continuous non-invasive endoscopic registration: a placebo controlled evaluation of the effect of terlipressin and octreotide.

    abstract::Octreotide has been proposed for the treatment of variceal bleeding. The effects on portal pressure, however, have been variable in published studies. As bleeding is more directly related to pressure in the varices, this study investigated the effect on variceal pressure of octreotide and terlipressin, a vasoactive dr...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.38.1.129

    authors: Nevens F,Van Steenbergen W,Yap SH,Fevery J

    更新日期:1996-01-01 00:00:00

  • Fetal mortality associated with cholestasis of pregnancy and the potential benefit of therapy with ursodeoxycholic acid.

    abstract::Cholestasis of pregnancy is associated with increased fetal morbidity and mortality and should be treated actively. The significance attached to pruritus in pregnancy is often minimal, but it is a cardinal symptom of cholestasis of pregnancy, which may have no other clinical features. Eight women with previous cholest...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.37.4.580

    authors: Davies MH,da Silva RC,Jones SR,Weaver JB,Elias E

    更新日期:1995-10-01 00:00:00

  • Empyema of the gall bladder - reappraisal of a neglected disease.

    abstract::Thirty two patients with empyema of the gall bladder were identified among 1327 cases of gall-bladder disease presenting to one hospital over a six year period. Abdominal pain had been present for a median of eight days and, in eight cases, for between one and four months. In a few cases, the disease was painless and ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.24.12.1183

    authors: Thornton JR,Heaton KW,Espiner HJ,Eltringham WK

    更新日期:1983-12-01 00:00:00

  • Computer aided positioning of manometric probe in the upper digestive tract.

    abstract::A method not needing fluoroscopic control for positioning a manometric probe in the gastroduodenal tract is described. It is based on hydrostatic pressure variations occurring at each recording port of a multichannel perfused probe after changes in patient's position. The data are fed into a computer and the schematic...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.29.7.1007

    authors: Bortolotti M,Bersani G

    更新日期:1988-07-01 00:00:00

  • Relation between GB virus C/hepatitis G virus and fulminant hepatic failure may be secondary to treatment with contaminated blood and/or blood products.

    abstract:BACKGROUND:The role of the recently discovered GB virus C (GBV-C)/hepatitis G virus in fulminant hepatic failure (FHF) has been debated. Although GBV-C RNA has been detected in many cases of FHF, recent data suggest that the relation between GBV-C and FHF may be accidental. AIMS:To retrospectively investigate the poss...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.44.2.274

    authors: Halasz R,Barkholt L,Lara C,Hultgren C,Ando Y,Broomé U,Fischler B,Nemeth A,Ericzon BG,Sönnerborg A,Sällberg M

    更新日期:1999-02-01 00:00:00