The predictive value of transabdominal ultrasonography in the diagnosis of biliary tract complications after orthotopic liver transplantation.

abstract：BACKGROUND:Cyclooxygenase 2 (COX-2) and matrix metalloproteinases (MMPs) have been implicated in tissue injury and fibrogenesis in animal models but little is known regarding their role in hepatitis C virus (HCV) related liver disease in humans. AIMS:To characterise the intrahepatic expression pattern of COX-2 and MMP...

journal_title：Gut

authors： Núñez O,Fernández-Martínez A,Majano PL,Apolinario A,Gómez-Gonzalo M,Benedicto I,López-Cabrera M,Boscá L,Clemente G,García-Monzón C,Martín-Sanz P

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:Metabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remain...

journal_title：Gut

authors： Lim MY,You HJ,Yoon HS,Kwon B,Lee JY,Lee S,Song YM,Lee K,Sung J,Ko G

更新日期：2017-06-01 00:00:00

abstract：:By prolonged immunization of an inbred rat strain with isologous liver homogenate in Freund's complete adjuvant a low grade autoimmune ;cholangitis' with periductular fibrosis has been demonstrated. The lesion could be transferred to isogeneic animals by serial spleen cell injections and was associated with mild but v...

journal_title：Gut

authors： Maclaurin BP

更新日期：1971-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Pancreatic cancer is among the most dismal of human malignancies. Current therapeutic strategies are virtually ineffective in controlling advanced, metastatic disease. Recent evidence suggests that the Hedgehog signalling pathway is aberrantly reactivated in the majority of pancreatic cancers, and t...

journal_title：Gut

authors： Feldmann G,Habbe N,Dhara S,Bisht S,Alvarez H,Fendrich V,Beaty R,Mullendore M,Karikari C,Bardeesy N,Ouellette MM,Yu W,Maitra A

更新日期：2008-10-01 00:00:00

abstract：:We have previously shown that rats fed raw soya flour (RSF) for more than four months develop hyperplastic foci of pancreatic acinar cells, which undergo malignant change if feeding RSF is continued throughout the life of the animals. The tendency to undergo malignant change is augmented by the additional use of a gen...

journal_title：Gut

authors： McGuinness EE,Morgan RG,Wormsley KG

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Pigment epithelium-derived factor (PEDF), a non-inhibitory SERPIN with potent antiangiogenic activity, has been recently implicated in metabolism and adipogenesis, both of which are known to influence pancreatic cancer progression. Increased pancreatic fat in human pancreatic tumour correlates with ...

journal_title：Gut

authors： Grippo PJ,Fitchev PS,Bentrem DJ,Melstrom LG,Dangi-Garimella S,Krantz SB,Heiferman MJ,Chung C,Adrian K,Cornwell ML,Flesche JB,Rao SM,Talamonti MS,Munshi HG,Crawford SE

更新日期：2012-10-01 00:00:00

abstract：:Amino acid induced acid and gastrin responses during intragastric titration at pH 2.5 and 5.5 were compared in normal subjects and duodenal ulcer patients with G-cell hyperfunction. The latter were identified on the basis of raised basal or maximal acid outputs and increased gastrin responses to feeding. In normal sub...

journal_title：Gut

authors： Cooper RG,Dockray GJ,Calam J,Walker R

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:The mechanisms underlying the suppression of somatostatin dependent reflexes in Helicobacter pylori infection are not fully determined. The H pylori product N alpha-methylhistamine and inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha) may be responsible for the alterations in somatostat...

journal_title：Gut

authors： Beales IL,Calam J

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND/AIMS:By contrast with animal models, in most cases it is not possible to examine the systemic response in patients in the first hours after onset of acute pancreatitis. The aim was to determine whether endoscopic retrograde cholangiopancreaticography (ERP)-induced pancreatitis can be used as a human model fo...

journal_title：Gut

authors： Messmann H,Vogt W,Holstege A,Lock G,Heinisch A,von Fürstenberg A,Leser HG,Zirngibl H,Schölmerich J

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Endoscopic diagnosis of short segments of Barrett's epithelium (SSBE)' is difficult and its meaning in terms of the presence of specialised columnar epithelium (SCE) has not been prospectively evaluated. AIMS:To evaluate the prevalence of SCE in patients with an endoscopic diagnosis of SSBE and in individua...

journal_title：Gut

authors： Pereira AD,Suspiro A,Chaves P,Saraiva A,Glória L,de Almeida JC,Leitão CN,Soares J,Mira FC

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:Treatments with sequential therapy (SEQ) or bismuth quadruple (QUAD) therapy have been proposed as empirical firstline regimens for Helicobacter pylori. We compared the efficacy and tolerability of 10 day SEQ with 10 day modified QUAD as both firstline and secondline treatments for H pylori in a randomised cr...

journal_title：Gut

authors： Liu KS,Hung IF,Seto WK,Tong T,Hsu AS,Lam FY,But DY,Wong SY,Leung WK

更新日期：2014-09-01 00:00:00

abstract：:The effect of rebamipide, a novel antiulcer compound, on Helicobacter pylori activated neutrophil dependent in vitro gastric epithelial cell injury was investigated. Luminol dependent chemiluminescence (ChL), which detects toxic oxidants from neutrophils exhibited a 12-fold increase when the bacterial suspension of H ...

journal_title：Gut

authors： Suzuki M,Miura S,Mori M,Kai A,Suzuki H,Fukumura D,Suematsu M,Tsuchiya M

更新日期：1994-10-01 00:00:00

abstract：:TNM (tumour, node, metastases) staging has thus far been the most important guide to prognosis in patients with gastric cancer. Histological grading, in contrast, has not provided any additional information. Recently a novel grading system based on tubular differentiation and mucus production has been proposed, which ...

journal_title：Gut

authors： Martin IG,Dixon MF,Sue-Ling H,Axon AT,Johnston D

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Flares are a well known phenomenon during antiviral treatment for chronic hepatitis B. Little is known about the effect of flares on response. We investigated the timing and characteristics of flares, in relation to treatment response (hepatitis B e antigen loss). PATIENTS:A total of 266 patients, ...

journal_title：Gut

authors： Flink HJ,Sprengers D,Hansen BE,van Zonneveld M,de Man RA,Schalm SW,Janssen HL,HBV 99-01 Study Group.

更新日期：2005-11-01 00:00:00

abstract：:During the clinical investigation of patients with gastrointestinal disease by exhaled breath hydrogen measurement, the occurrence of inexplicable variations in recorded hydrogen values led to a search for extra intestinal factors which were capable of adversely influencing breath hydrogen concentration and impairing ...

journal_title：Gut

authors： Thompson DG,Binfield P,De Belder A,O'Brien J,Warren S,Wilson M

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori affects gastric epithelium integrity by acceleration of apoptosis. However, it remains unclear what product of the bacteria causes apoptosis, or whether or not the apoptosis is involved in the development of ulcers. AIMS:To elucidate the factor from H pylori that causes acceleration of a...

journal_title：Gut

authors： Kohda K,Tanaka K,Aiba Y,Yasuda M,Miwa T,Koga Y

更新日期：1999-04-01 00:00:00

abstract：:Earlier studies regarding possible primary immune disturbances participating in the pathogenesis of Crohn's disease yielded conflicting results. Peripheral blood lymphocyte subsets and lymphocyte proliferative responses to five soluble recall antigens and to the polyclonal stimulator phythaemagglutinin were therefore ...

journal_title：Gut

authors： D'Haens G,Hiele M,Rutgeerts P,Geboes K,Ceuppens JL

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immun...

journal_title：Gut

authors： Zhao Y,Shuen TWH,Toh TB,Chan XY,Liu M,Tan SY,Fan Y,Yang H,Lyer SG,Bonney GK,Loh E,Chang KTE,Tan TC,Zhai W,Chan JKY,Chow EK,Chee CE,Lee GH,Dan YY,Chow PK,Toh HC,Lim SG,Chen Q

更新日期：2018-10-01 00:00:00

abstract：:Gastric adaptation was impaired immediately after the performance of complete vagotomy in a series of 20 acute experiments in the dog. Preliminary isolation of the intact vagi in 10 of these animals produced alterations in adaptation similar to those seen after vagal division. It is concluded that alterations in gastr...

journal_title：Gut

authors： Carter DC,Whitfield HN,Macleod IB

更新日期：1972-11-01 00:00:00

abstract：OBJECTIVE:Adherent-invasive Escherichia coli (AIEC) are a leading candidate bacterial trigger for Crohn's disease (CD). The AIEC pathovar is defined by in vitro cell-line assays examining specific bacteria/cell interactions. No molecular marker exists for their identification. Our aim was to identify a molecular proper...

journal_title：Gut

authors： O'Brien CL,Bringer MA,Holt KE,Gordon DM,Dubois AL,Barnich N,Darfeuille-Michaud A,Pavli P

更新日期：2017-08-01 00:00:00

abstract：:A study of the function of the lower end of the oesophagus in the cat confirms that it behaves as a true physiological sphincter, even though histological evidence for such a structure is absent. Sphincteric action is a function of the circular muscle fibres in the lowest 2 cm. of the oesophagus. Reflex changes in ton...

journal_title：Gut

authors： CLARK CG,VANE JR

更新日期：1961-09-01 00:00:00

abstract：:p53 mutations are a common genetic finding in hepatocellular carcinoma from areas of high aflatoxin exposure. Recent small studies have shown that p53 gene mutations may be less common in areas with a low prevalence of hepatocellular carcinoma such as Great Britain. The protein product of mutant p53 can be detected im...

journal_title：Gut

authors： Collier JD,Carpenter M,Burt AD,Bassendine MF

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate whether patients with increased or decreased gastric motility can be differentiated from healthy volunteers by means of real time magnetic resonance imaging (MRI). PATIENTS AND METHODS:Ten healthy volunteers, 10 patients with gastroparesis, and 10 patients with function...

journal_title：Gut

authors： Ajaj W,Goehde SC,Papanikolaou N,Holtmann G,Ruehm SG,Debatin JF,Lauenstein TC

更新日期：2004-09-01 00:00:00

abstract：:4-Aminosalicylic acid (4-ASA) has been suggested as an effective treatment for both active and quiescent ulcerative colitis. 5-Aminosalicylic acid (5-ASA) is well accepted for the maintenance treatment of inactive ulcerative colitis. Moreover, recent studies suggest that 5-ASA may also be effective in maintaining remi...

journal_title：Gut

authors： Schreiber S,Howaldt S,Raedler A

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Teduglutide, a GLP-2 analogue, may restore intestinal structural and functional integrity by promoting repair and growth of the mucosa and reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS). This 24-week placebo-contr...

journal_title：Gut

authors： Jeppesen PB,Gilroy R,Pertkiewicz M,Allard JP,Messing B,O'Keefe SJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND AND AIMS:A low dietary folate intake can cause genomic DNA hypomethylation and may increase the risk of colorectal neoplasia. The hypothesis that folic acid supplementation increases DNA methylation in leucocytes and colorectal mucosa was tested in 31 patients with histologically confirmed colorectal adenoma...

journal_title：Gut

authors： Pufulete M,Al-Ghnaniem R,Khushal A,Appleby P,Harris N,Gout S,Emery PW,Sanders TA

更新日期：2005-05-01 00:00:00

abstract：:Bowel function was assessed in 51 subjects: 10 women and seven men who habitually consumed an omnivorous, vegetarian, or vegan diet. The subjects on these diets had a mean intake of fibre of 23 g, 37 g, and 47 g respectively. Mean transit times were variable and not significantly different between the groups. Vegans, ...

journal_title：Gut

authors： Davies GJ,Crowder M,Reid B,Dickerson JW

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Sulfhydryl (SH) compounds are essential in maintaining mucosal integrity in the gastrointestinal tract. A decrease in colonic mucosal SH compounds affects the redox status of the mucosa, resulting in vulnerability to further attacks. Therefore, there is a strong need for in vivo evaluation of SH compounds in...

journal_title：Gut

authors： Togashi H,Oikawa K,Adachi T,Sugahara K,Ito J,Takeda T,Watanabe H,Saito K,Saito T,Fukui T,Takeda H,Ohya H,Kawata S

更新日期：2003-09-01 00:00:00

abstract：:To examine socioeconomic factors, dietary and other personal habits, and medical history as risk factors for ulcerative colitis, we studied 167 (98%) of all prevalent cases of ulcerative colitis diagnosed in Uppsala county from 1945 to 1964 and 167 age and sex matched population controls. Ulcerative colitis patients w...

journal_title：Gut

authors： Samuelsson SM,Ekbom A,Zack M,Helmick CG,Adami HO

更新日期：1991-12-01 00:00:00

abstract：:In June 1990 a survey of members of the endoscopy section of the British Society of Gastroenterology showed that 47% of respondents were offering some form of open access gastroscopy (OAG). Only 10% offered true (non-censored) OAG. The survey was repeated in June 1994. The overall provision of OAG had risen to 74%, mo...

journal_title：Gut

authors： Silcock JG,Bramble MG

更新日期：1997-02-01 00:00:00