Abstract:
OBJECTIVES:Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN:Retrospective multinational study including SCN diagnosed between 1990 and 2014. RESULTS:2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2-200)), 9% had resection beyond 1 year of follow-up (3 years (1-20), size at diagnosis: 25 mm (4-140)) and 39% had no surgery (3.6 years (1-23), 25.5 mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1 year (n=1271), size increased in 37% (growth rate: 4 mm/year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCN's related mortality was 0.1% (n=1). CONCLUSIONS:After a 3-year follow-up, clinical relevant symptoms occurred in a very small proportion of patients and size slowly increased in less than half. Surgical treatment should be proposed only for diagnosis remaining uncertain after complete workup, significant and related symptoms or exceptionally when exists concern with malignancy. This study supports an initial conservative management in the majority of patients with SCN. TRIAL REGISTRATION NUMBER:IRB 00006477.
journal_name
Gutjournal_title
Gutauthors
Jais B,Rebours V,Malleo G,Salvia R,Fontana M,Maggino L,Bassi C,Manfredi R,Moran R,Lennon AM,Zaheer A,Wolfgang C,Hruban R,Marchegiani G,Fernández Del Castillo C,Brugge W,Ha Y,Kim MH,Oh D,Hirai I,Kimura W,Jang JYdoi
10.1136/gutjnl-2015-309638subject
Has Abstractpub_date
2016-02-01 00:00:00pages
305-12issue
2eissn
0017-5749issn
1468-3288pii
gutjnl-2015-309638journal_volume
65pub_type
杂志文章相关文献
GUT文献大全abstract:OBJECTIVE:Whether peginterferon α and ribavirin combination therapy reduces risk of hepatocellular carcinoma (HCC) or improves survival in patients dual-infected with hepatitis C virus (HCV) and hepatitis B virus (HBV) is unknown. Since it is ethically impossible to conduct a randomised trial to learn the long-term eff...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-304370
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Surveillance colonoscopy is widely recommended in patients with longstanding and extensive ulcerative colitis (UC) in order to detect colorectal neoplasia at an early stage. However, it still remains questionable whether surveillance colonoscopy effectively enables early detection of UC associated neoplasia....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.062059
更新日期:2005-09-01 00:00:00
abstract::This paper reports the association between severe, prolonged, watery diarrhoea and islet cell tumours of the pancreas. There appear to be significant differences between patients with these symptoms and those with the classical Zollinger-Ellison syndrome. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2.1.12
更新日期:1961-03-01 00:00:00
abstract::Chronic idiopathic constipation may be the result of an autonomic neuropathy. This hypothesis was tested in 23 constipated patients and 17 age matched controls, using the acetylcholine sweat spot test devised to test autonomic integrity in diabetes. Acetylcholine (0.01%) was injected in the dorsum of the foot painted ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.11.1539
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND AND AIMS:The risk of colorectal cancer is increased in ulcerative colitis (UC). Patients with UC have diverse colonoscopic appearances. Determining colonoscopic markers for cancer risk could allow patient risk stratification. PATIENTS AND METHODS:Following on from an earlier study which demonstrated a corre...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.038505
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND AND AIMS:In acute liver failure (ALF), the brain is exposed to high levels of ammonia. Human studies defining the clinical significance of ammonia in ALF are lacking. This prospective study evaluated the relationship of arterial ammonia levels at admission to complications and survival among patients with AL...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.061754
更新日期:2006-01-01 00:00:00
abstract::Based on a diary which was kept while preparing for and undergoing pan-proctocolectomy, the paper describes the process of coming to terms with an ileostomy. A number of stages in the process are identified: anticipation, reorientation, trauma, maintenance of selfimage and accommodation. The social-psychological strat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.1.81
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed medications, but they are associated with a number of serious adverse effects, including hypertension, cardiovascular disease, kidney injury and GI complications. OBJECTIVE:To develop a set of multidisciplinary recommenda...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2019-319300
更新日期:2020-04-01 00:00:00
abstract::It has been suggested, on the basis of impaired granulocyte migration to skin windows, that there is a fundamental granulocyte defect in Crohn's disease. In vitro tests of granulocyte function have, however, failed to confirm this. We have studied granulocyte migration to inflamed bowel in Crohn's disease using a new ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.4.378
更新日期:1985-04-01 00:00:00
abstract::Fasting and postprandial plasma concentrations of glycine and taurine conjugates of cholic, chenodeoxycholic, and deoxycholic acid were measured by a high pressure liquid chromatography-enzymatic assay in nine healthy subjects. The mean value of each bile acid concentration increased significantly (2.4-4.7 times) in t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.3.249
更新日期:1983-03-01 00:00:00
abstract::Helicobacter pylori possesses unusually high urease activity that lowers the urea concentration and raises the ammonium concentration of the gastric juice in infected people. The value of measuring urea and ammonium concentrations in gastric juice obtained during upper gastrointestinal endoscopy as a means of diagnosi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.9.973
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined. OBJECTIVE:To compare the performance of CE to VC for the detecti...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2016-313213
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Independent component analysis (ICA) of the electroencephalogram (EEG) overcomes many of the classical problems in EEG analysis. We used ICA to determine the brain responses to painful stimulation of the oesophagus. METHODS:Twelve subjects with a median age of 41 years were included. With a nasal e...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.2005.068460
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. OBJECTIVE:To explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease. DESIGN:The regulated miRNAs in human livers infected with hepatitis C virus were identified...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300717
更新日期:2012-11-01 00:00:00
abstract::A manometric method was developed to study the motor activity in the unprepared human colon, and the results in eight healthy subjects were compared with those obtained in the same subjects after bowel cleansing with a non-absorbable solution containing polyethylene glycol 4000 (PEG). A tube assembly (4.5 m long, 12 l...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.5.649
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND AND AIM:The aim of this study was to unravel the mechanisms responsible for the increased risk of gall stone disease in hypertriglyceridaemia (HTG) and to compare the effects of triglyceride lowering therapy by bezafibrate and fish oil on determinants of cholelithiasis (biliary lipid composition and gall bla...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.52.1.109
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Fresh fruit and vegetables exert multiple biological effects on the gastrointestinal mucosa. AIM:To assess whether apple extracts counteract oxidative or indomethacin induced damage to gastric epithelial cells in vitro and to rat gastric mucosa in vivo. METHODS:Apple extracts were obtained from freeze drie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.046292
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319693
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct cancers in terms of a number of clinical and epidemiological characteristics, complicating the design of clinical trials and biomarker developments. We analysed 1048 oesophageal tumour-germline pairs from both subtypes, to chara...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314607
更新日期:2018-10-01 00:00:00
abstract::Polyacrylamide gel electrophoresis of pure pancreatic juice from 14 healthy normal subjects, 11 chronic alcoholics without detectable pancreatic disease, 15 patients with pancreatitis, and two with cancer of the pancreas consistently demonstrated the presence of two variants of trypsinogen with different electrophoret...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.10.886
更新日期:1979-10-01 00:00:00
abstract:OBJECTIVES:National guidelines for the management of irritable bowel syndrome (IBS) recommend that psychological therapies should be considered, but their relative efficacy is unknown, because there have been few head-to-head trials. We performed a systematic review and network meta-analysis to try to resolve this unce...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321191
更新日期:2020-08-01 00:00:00
abstract::Clarithromycin, a new and well tolerated, acid stable macrolide antibiotic, has a similar antimicrobial spectrum to erythromycin but a better in vitro MIC90 (0.03 microgram/l-1) against Helicobacter pylori (H pylori). This study aimed at determining the eradication rate using clarithromycin 500 mg thrice daily and ome...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.3.323
更新日期:1994-03-01 00:00:00
abstract::To investigate further the cause of the pancreatic enlargment induced by orally ingested soybean trypsin inhibitor (STI), antibodies raised against STI and purified by affinity chromatography were used to localise dietary STI in the rat gut by fluorescent immunocytochemical methods. This technique permitted the clear ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.4.260
更新日期:1978-04-01 00:00:00
abstract::Family histories were obtained from 50 patients with adenocarcinoma of the colon or rectum in north-east Scotland. A comparable control group was similarly interviewed and in each group the case notes of the first degree relatives were studied where possible. Eight (16%) of the patients with cancer of the colon or rec...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.2.169
更新日期:1982-02-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive type of GI tumour, and it possesses deregulated cellular energetics. Although recent advances in PDAC biology have led to the discovery of recurrent genetic mutations in Kras, TP53 and SMAD4, which are related to this disease, clinical application...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2018-317163
更新日期:2020-05-01 00:00:00
abstract::p53 mutations are a common genetic finding in hepatocellular carcinoma from areas of high aflatoxin exposure. Recent small studies have shown that p53 gene mutations may be less common in areas with a low prevalence of hepatocellular carcinoma such as Great Britain. The protein product of mutant p53 can be detected im...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.1.98
更新日期:1994-01-01 00:00:00
abstract::There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid for...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.4.531
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. AIMS:To establish a new colitis associated neoplasia model in p53 deficie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.028779
更新日期:2004-05-01 00:00:00
abstract::Colorectal cancer is the second commonest cause of cancer death in the UK. An effective national screening programme is urgently required to reduce the substantial morbidity and mortality from the disease. The success of any screening programme will depend on the screening test detecting early Dukes's A carcinomas and...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.4.590
更新日期:1995-04-01 00:00:00
abstract::Fasting insulin, lipids and lipoproteins were measured in 22 middle aged female non-insulin dependent diabetics with gall stone disease (cases) and in 22 non-insulin dependent diabetics without gall stone disease (controls). The groups were matched for sex, age, obesity, and fasting glucose concentrations. No differen...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.3.344
更新日期:1990-03-01 00:00:00