Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer.

abstract：:Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury, cholestasis and progressive fibrosis can culminate over time in an end-stage biliary cirrhosis. Both genetic and environmental influences are...

journal_title：Gut

authors： Hirschfield GM,Dyson JK,Alexander GJM,Chapman MH,Collier J,Hübscher S,Patanwala I,Pereira SP,Thain C,Thorburn D,Tiniakos D,Walmsley M,Webster G,Jones DEJ

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the association between concentra...

journal_title：Gut

authors： Amaral AF,Porta M,Silverman DT,Milne RL,Kogevinas M,Rothman N,Cantor KP,Jackson BP,Pumarega JA,López T,Carrato A,Guarner L,Real FX,Malats N

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Insulin resistance is a frequent feature of chronic hepatitis C. Whether insulin resistance could be the cause or consequence of steatosis and fibrosis is unknown. The ability of HCV genotype 3 to promote steatosis by itself provides an unique opportunity to answer this question. AIMS:The aim of the present...

journal_title：Gut

authors： Fartoux L,Poujol-Robert A,Guéchot J,Wendum D,Poupon R,Serfaty L

更新日期：2005-07-01 00:00:00

abstract：:The free primary amines present in the faeces of 44 infants (1-18 months) with gastroenteritis have been examined by field desorption mass spectrometry of the lactone form of their fluorescamine derivatives without their prior separation. p-Tyramine, 2-phenylethylamine, the diamines, putrescine and cadaverine and seve...

journal_title：Gut

authors： Murray KE,Adams RF,Earl JW,Shaw KJ

更新日期：1986-10-01 00:00:00

abstract：:Computed tomography detected the presence of dilated ducts in 15 of 18 cases with extrahepatic obstructive jaundice and demonstrated the obstructing lesion in 18 out of 25. The cause of the obstruction was detected in the absence of duct dilatation, and calculi which were radiolucent on conventional radiographs were d...

journal_title：Gut

authors： Morris A,Fawcitt RA,Wood R,Forbes WS,Isherwood I,Marsh MN

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:The mechanisms of aspirin induced gastroduodenal injury are not fully understood. Aspirin induces the release of reactive oxygen metabolites in animal models, which may contribute to mucosal injury. AIMS:To investigate the effects of aspirin administered with placebo or antioxidants on gastric mucosal react...

journal_title：Gut

authors： McAlindon ME,Muller AF,Filipowicz B,Hawkey CJ

更新日期：1996-04-01 00:00:00

abstract：:Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral venous blood obtained at autopsy of sudden death victims within fou...

journal_title：Gut

authors： Cummings JH,Pomare EW,Branch WJ,Naylor CP,Macfarlane GT

更新日期：1987-10-01 00:00:00

abstract：:125I-labelled human trypsin metabolism has been investigated in man. Three subjects received 125I-trypsin and 131I-albumin intravenously. Against a background secretin infusion (1 U/kg/h), trypsin decayed biexponentially from the serum with half-lives of 17.5, 21, and 24 minutes for the rapid disappearance phase and 5...

journal_title：Gut

authors： Lake-Bakaar G,Rubio CE,McKavanagh S,Potter BJ,Summerfield JA

更新日期：1980-07-01 00:00:00

abstract：OBJECTIVE:A high body mass index (BMI) is associated with an increased risk for severe liver disease. It is unclear if this risk differs across BMI categories, and if the association is partially attributed to development of type 2 diabetes mellitus (T2DM). DESIGN:We used register data from more than 1.2 million Swedi...

journal_title：Gut

authors： Hagström H,Tynelius P,Rasmussen F

更新日期：2018-08-01 00:00:00

abstract：:Four young Chinese women took daily doses of an unidentified 'Indian' herbal tea as treatment for psoriasis. Three (one of whom died), developed ascites, hepatomegaly and biochemical abnormalities within 19-45 days. The fourth patient discontinued herbal tea after 21 days when she developed a skin rash. Two patients h...

journal_title：Gut

authors： Kumana CR,Ng M,Lin HJ,Ko W,Wu PC,Todd D

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND AND AIM:To clarify the roles of Helicobacter pylori cytotoxin in gastric atrophy, the cytotoxin positive rate and cytotoxin activity in Fukui and Okinawa, where the prevalence of atrophic gastritis and gastric cancer risk are quite different, were studied. MATERIALS:Seventy three strains from Fukui and 51 f...

journal_title：Gut

authors： Ito S,Azuma T,Murakita H,Hirai M,Miyaji H,Ito Y,Ohtaki Y,Yamazaki Y,Kuriyama M,Keida Y,Kohli Y

更新日期：1996-12-01 00:00:00

abstract：:Epithelial cells shed from the intestinal villus in starved rats were trapped in mucus which the goblet cells were stimulated to secrete; the number of trapped cells per villus was counted in whole mounts of fixed Feulgen-stained specimens from three sites in the small intestine. Increase in the interval between stimu...

journal_title：Gut

authors： Clarke RM

更新日期：1970-12-01 00:00:00

abstract：:To examine socioeconomic factors, dietary and other personal habits, and medical history as risk factors for ulcerative colitis, we studied 167 (98%) of all prevalent cases of ulcerative colitis diagnosed in Uppsala county from 1945 to 1964 and 167 age and sex matched population controls. Ulcerative colitis patients w...

journal_title：Gut

authors： Samuelsson SM,Ekbom A,Zack M,Helmick CG,Adami HO

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:There is a widespread notion that obesity leads to gastro-oesophageal reflux but scientific evidence of an association is limited and inconsistent. AIMS:To estimate the strength of the association between body mass and reflux symptoms, we performed a population based cross sectional interview study. SUBJEC...

journal_title：Gut

authors： Lagergren J,Bergström R,Nyrén O

更新日期：2000-07-01 00:00:00

abstract：:Forty six patients with endoscopically diagnosed duodenal ulceration were randomly allocated to treatment with either sucralfate 1 g qds (n = 24) or cimetidine 200 mg tds and 400 mg nocte (n = 22). When the ulcers healed, a maintenance dose of sucralfate 1 g bd or cimetidine 400 mg nocte was given for one year (or unt...

journal_title：Gut

authors： Tovey FI,Husband EM,Yiu YC,Baker L,McPhail G,Lewin MR,Jayaraj AP,Clark CG

更新日期：1989-05-01 00:00:00

abstract：:Faecal stream diversion may induce inflammatory changes in the defunctioned segment of the large intestine. These changes are predominantly mucosal, although confusing histological features including granulomas may be present. The pathology of 15 defunctioned rectal stumps has been studied. All patients had previously...

journal_title：Gut

authors： Warren BF,Shepherd NA,Bartolo DC,Bradfield JW

更新日期：1993-04-01 00:00:00

abstract：:Previous reports have shown that both Crohn's disease and ulcerative colitis affect people in white collar occupations associated with higher income and higher social class more frequently than other groups in the population. This study sought to carry these analyses one step further and investigate the distribution o...

journal_title：Gut

authors： Sonnenberg A

更新日期：1990-09-01 00:00:00

abstract：:Coeliac disease is triggered by ingestion of wheat gliadin and is probably immune mediated. There is evidence by light microscopy that expression of class II major histocompatibility complex (MHC) molecules is increased in the small intestinal epithelium of patients with untreated coeliac disease and that gliadin can ...

journal_title：Gut

authors： Zimmer KP,Poremba C,Weber P,Ciclitira PJ,Harms E

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Genetic predisposition and gliadin exposure are known to be crucial factors in the development of coeliac disease. Circumstantial evidence suggests that other unidentified environmental factors may also be of pathogenetic importance. AIM:To define the relation between cigarette smoking and the risk of devel...

journal_title：Gut

authors： Snook JA,Dwyer L,Lee-Elliott C,Khan S,Wheeler DW,Nicholas DS

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:A population based epidemiological study identified all the patients diagnosed with ulcerative colitis (UC) or Crohn's disease (CD) resident in the Florence area in the period 1978-1992. AIMS:To assess the mortality of unselected patients with inflammatory bowel disease (IBD) in a Mediterranean country. ME...

journal_title：Gut

authors： Palli D,Trallori G,Saieva C,Tarantino O,Edili E,D'Albasio G,Pacini F,Masala G

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:Crohn's disease (CD) is associated with increased risk of small bowel cancer (SBC), but previous studies have been small. We aimed to examine the risk of incident SBC and death from SBC in patients with inflammatory bowel disease (IBD). DESIGN:In a binational, population-based cohort study from Sweden and De...

journal_title：Gut

authors： Axelrad JE,Olén O,Sachs MC,Erichsen R,Pedersen L,Halfvarson J,Askling J,Ekbom A,Sørensen HT,Ludvigsson JF

更新日期：2021-02-01 00:00:00

abstract：:Clinico-pathological features of 56 patients with primary gastric lymphoma were evaluated retrospectively. All cases were regraded according to a classification of Isaacson et al into high grade and low grade B-cell mucosa associated lymphoid tissue lymphoma. A third group of mixed grade was recognised in 11 patients ...

journal_title：Gut

authors： Castrillo JM,Montalban C,Obeso G,Piris MA,Rivas MC

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Hephaestin is a multicopper ferroxidase required for basolateral transport of iron from enterocytes. Sex linked anaemia (sla) mice have a defect in the release of iron from intestinal enterocytes into the circulation due to an interstitial deletion in the hephaestin gene (heph). RESULTS:We have demonstrated...

journal_title：Gut

authors： Kuo YM,Su T,Chen H,Attieh Z,Syed BA,McKie AT,Anderson GJ,Gitschier J,Vulpe CD

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:Gut microbiota and diet are known to contribute to human metabolism. We investigated whether the metagenomic gut microbiota composition and function changes over pregnancy are related to gestational diabetes mellitus (GDM) and can be modified by dietary supplements, fish oil and/or probiotics. DESIGN:The gut...

journal_title：Gut

authors： Mokkala K,Paulin N,Houttu N,Koivuniemi E,Pellonperä O,Khan S,Pietilä S,Tertti K,Elo LL,Laitinen K

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Colonoscopy is the current reference standard for the detection of colorectal neoplasia, but nevertheless adenomas remain undetected. The Endocuff, an endoscopic cap with plastic projections, may improve colonic visualisation and adenoma detection. The aim of this study was to compare the mean numbe...

journal_title：Gut

authors： van Doorn SC,van der Vlugt M,Depla A,Wientjes CA,Mallant-Hent RC,Siersema PD,Tytgat K,Tuynman H,Kuiken SD,Houben G,Stokkers P,Moons L,Bossuyt P,Fockens P,Mundt MW,Dekker E

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or ...

journal_title：Gut

authors： Higuchi S,Ahmad TR,Argueta DA,Perez PA,Zhao C,Schwartz GJ,DiPatrizio NV,Haeusler RA

更新日期：2020-09-01 00:00:00

abstract：:A case is described of a life threatening vasculitis of the small bowel leading to massive gastrointestinal haemorrhage which was apparently due to cytomegalovirus inclusion disease. Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine. This ...

journal_title：Gut

authors： Sackier JM,Kelly SB,Clarke D,Rees AJ,Wood CB

更新日期：1991-11-01 00:00:00

abstract：:Neurotensin is a tridecapeptide located mainly in the distal small intestine. The present study was carried out in order to investigate the neurotensin response after proximal small intestinal resection in the rat. After resection, the median plasma concentration of neurotensin like immunoreactivity (NTLI) was unchang...

journal_title：Gut

authors： Olsen PS,Pedersen JH,Poulsen SS,Yamashita Y,Kirkegaard P

更新日期：1987-09-01 00:00:00

abstract：:Using 24 hour pH monitoring as a reference standard, the usefulness of the acid perfusion (AP) test in predicting gastro-oesophageal reflux disease (GORD) was assessed in 71 non-cardiac chest pain (NCCP) patients and 23 endoscopic oesophagitis patients. Of the 71 NCCP patients, 35 had a positive AP test (of whom 20 ha...

journal_title：Gut

authors： Hewson EG,Sinclair JW,Dalton CB,Wu WC,Castell DO,Richter JE

更新日期：1989-03-01 00:00:00

abstract：:An improved technique for the detection of alpha-gliadin sensitised mononuclear cells in the peripheral blood of untreated coeliac patients is described. This method is a modification of the direct LMIF assay, and involves exposure of lymphocytes to alpha-gliadin and the assay of the resultant lymphokine produced usin...

journal_title：Gut

authors： O'Farrelly C,Feighery C,Greally JF,Weir DG

更新日期：1982-01-01 00:00:00