Motor activity recorded in the unprepared colon of healthy humans.

abstract：OBJECTIVE:Exposure of the oesophageal mucosa to gastric acid and bile acids leads to the accumulation of reactive oxygen species (ROS), a known risk factor for Barrett's oesophagus and progression to oesophageal adenocarcinoma (OAC). This study investigated the functions of glutathione peroxidase 7 (GPX7), frequently s...

journal_title：Gut

authors： Peng D,Belkhiri A,Hu T,Chaturvedi R,Asim M,Wilson KT,Zaika A,El-Rifai W

更新日期：2012-09-01 00:00:00

abstract：:Electrical activity of the colon was investigated in six healthy volunteers and 22 patients presenting functional colonic disorders associated with pain, constipation, or diarrhoea. Myoelectrical activity during 10 hours, including two daily meals, was recorded from eight groups of nickel-chrome electrodes using a 1.5...

journal_title：Gut

authors： Bueno L,Fioramonti J,Ruckebusch Y,Frexinos J,Coulom P

更新日期：1980-06-01 00:00:00

abstract：:During the clinical investigation of patients with gastrointestinal disease by exhaled breath hydrogen measurement, the occurrence of inexplicable variations in recorded hydrogen values led to a search for extra intestinal factors which were capable of adversely influencing breath hydrogen concentration and impairing ...

journal_title：Gut

authors： Thompson DG,Binfield P,De Belder A,O'Brien J,Warren S,Wilson M

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Juvenile polyps occur in several Mendelian disorders, whether in association with gastrointestinal cancer alone (juvenile polyposis syndrome, JPS) or as part of known syndromes (Cowden, Gorlin, and Bannayan-Zonana) in association with developmental abnormalities, dysmorphic features, or extraintesti...

journal_title：Gut

authors： Bevan S,Woodford-Richens K,Rozen P,Eng C,Young J,Dunlop M,Neale K,Phillips R,Markie D,Rodriguez-Bigas M,Leggett B,Sheridan E,Hodgson S,Iwama T,Eccles D,Bodmer W,Houlston R,Tomlinson I

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:The aim of the study was to test the hypothesis that in the fasting state, proximal intestinal HCO3- absorption, which depends on villus Na+/H+ exchanger activity, is tonically inhibited by a cholinergic atropine sensitive mechanism. SUBJECTS:The experiments were performed in 34 healthy volunteers and in ei...

journal_title：Gut

authors： Mellander A,Sjövall H

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:There is a widespread notion that obesity leads to gastro-oesophageal reflux but scientific evidence of an association is limited and inconsistent. AIMS:To estimate the strength of the association between body mass and reflux symptoms, we performed a population based cross sectional interview study. SUBJEC...

journal_title：Gut

authors： Lagergren J,Bergström R,Nyrén O

更新日期：2000-07-01 00:00:00

abstract：:Electrogenic (Cl-) secretion was measured as the short circuit current (Isc, microA/cm2) across muscle-stripped sheets of jejunum and ileum incubated in vitro after removal from fed rats, rats starved for three days, and chronically undernourished rats (50% of fed control intake for 21 days). Concentration and Isc res...

journal_title：Gut

authors： Nzegwu HC,Levin RJ

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND AND AIMS:One of the key components of inflammation is changes in vascular structure and function. This suggests that the microcirculation may be a key target of Helicobacter pylori released factors. It has previously been shown in vivo that pooled H pylori extracts from duodenal ulcer/gastritis patients indu...

journal_title：Gut

authors： Kalia N,Bardhan KD,Atherton JC,Brown NJ

更新日期：2002-11-01 00:00:00

abstract：:The results of bile salt treatment in patients with radiolucent stones and a functioning gall bladder have been poor. In 42 of these patients awaiting cholecystectomy we determined the value of duodenal bile examination in predicting gall stone composition, and thus identifying those less likely to respond to bile sal...

journal_title：Gut

authors： Agarwal DK,Choudhuri G,Saraswat VA,Negi TS,Kapoor VK,Saxena R

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the association between concentra...

journal_title：Gut

authors： Amaral AF,Porta M,Silverman DT,Milne RL,Kogevinas M,Rothman N,Cantor KP,Jackson BP,Pumarega JA,López T,Carrato A,Guarner L,Real FX,Malats N

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The ground squirrel on a high cholesterol diet exhibits prolonged intestinal transit, a pathogenetic factor in cholesterol gallstone formation. AIMS:To examine the effect of a high cholesterol diet on the characteristics of the migrating myoelectrical complex (MMC) and the potential benefit of erythromycin....

journal_title：Gut

authors： Xu QW,Scott RB,Tan DT,Shaffer EA

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Many lines of evidence suggest that T helper cell type 1 (Th1) immune responses predominate in Crohn's disease (CD). Recently, a novel transcription factor T-box expressed in T cells (T-bet) has been reported as the master regulator of Th1 development. This study was designed to investigate the role...

journal_title：Gut

authors： Matsuoka K,Inoue N,Sato T,Okamoto S,Hisamatsu T,Kishi Y,Sakuraba A,Hitotsumatsu O,Ogata H,Koganei K,Fukushima T,Kanai T,Watanabe M,Ishii H,Hibi T

更新日期：2004-09-01 00:00:00

abstract：:The effects of corticotrophin and of cortisone, methyl prednisolone, and of aldosterone on the gastric secretion of dogs have been investigated. Juice was collected from dogs with denervated pouches under basal conditions and when stimulated with meat extract and with histamine. For each secretion the volume, viscosit...

journal_title：Gut

authors： CLARKE SD,NEILL DW,WELBOURN RB

更新日期：1960-03-01 00:00:00

abstract：:Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and derma...

journal_title：Gut

authors： Duggan JM,Dobson AJ,Johnson H,Fahey P

更新日期：1986-08-01 00:00:00

abstract：OBJECTIVE:In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. DESIGN:International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structu...

journal_title：Gut

authors： Scott AJ,Alexander JL,Merrifield CA,Cunningham D,Jobin C,Brown R,Alverdy J,O'Keefe SJ,Gaskins HR,Teare J,Yu J,Hughes DJ,Verstraelen H,Burton J,O'Toole PW,Rosenberg DW,Marchesi JR,Kinross JM

更新日期：2019-09-01 00:00:00

abstract：:The frequency of gastric Crohn's disease has been considered low. This study was undertaken to determine the prevalence of chronic gastritis and Helicobacter pylori infection in patients with Crohn's disease. Oesophagogastroduodenoscopy was performed on 62 consecutive patients suffering from ileocolonic Crohn's diseas...

journal_title：Gut

authors： Halme L,Kärkkäinen P,Rautelin H,Kosunen TU,Sipponen P

更新日期：1996-03-01 00:00:00

abstract：:A case is described of non-necrotizing, epithelioid cell granulomatous synovitis of the ankle of a 22-year-old man with Crohn's disease. It appears to be the first published example of granulomatous arthritis in association with Crohn's disease. ...

journal_title：Gut

authors： Lindström C,Wramsby H,Ostberg G

更新日期：1972-04-01 00:00:00

abstract：OBJECTIVES:Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct cancers in terms of a number of clinical and epidemiological characteristics, complicating the design of clinical trials and biomarker developments. We analysed 1048 oesophageal tumour-germline pairs from both subtypes, to chara...

journal_title：Gut

authors： Lin DC,Dinh HQ,Xie JJ,Mayakonda A,Silva TC,Jiang YY,Ding LW,He JZ,Xu XE,Hao JJ,Wang MR,Li C,Xu LY,Li EM,Berman BP,Phillip Koeffler H

更新日期：2018-10-01 00:00:00

abstract：:Marked decreases in 24-hour Heidenhain pouch secretion, lasting from nine to 18 days, were observed in five mongrel bitches during periods of naturally occurring oestrus. Neither oophorectomy nor control celiotomy caused significant change in Heidenhain pouch secretion in bitches who were not experiencing oestrus. The...

journal_title：Gut

authors： Landor JH,Wild RA

更新日期：1970-10-01 00:00:00

abstract：:Serrated polyps have been recognised in the last decade as important premalignant lesions accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical need for guidance on how to manage these lesions; however, the evidence base is limited. A working group was commission by the British Societ...

journal_title：Gut

authors： East JE,Atkin WS,Bateman AC,Clark SK,Dolwani S,Ket SN,Leedham SJ,Phull PS,Rutter MD,Shepherd NA,Tomlinson I,Rees CJ

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to protect against the development of colon cancer. However, the mechanism(s) by which NSAIDs exert their effects is not clear. AIMS:The aim of this study was to examine the effects of NSAIDs on mRNA expression of tumour suppressor adenomatou...

journal_title：Gut

authors： Kishimoto Y,Takata N,Jinnai T,Morisawa T,Shiota G,Kawasaki H,Hasegawa J

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:miR-21 was found to be overexpressed in the colon tissues and serum of patients with UC and colorectal cancer (CRC); however, the exact roles of miR-21 in colitis-associated CRC remain unclear. The aim of our study was to investigate the biological mechanisms of miR-21 in colitis-associated colon cancer (CAC)...

journal_title：Gut

authors： Shi C,Yang Y,Xia Y,Okugawa Y,Yang J,Liang Y,Chen H,Zhang P,Wang F,Han H,Wu W,Gao R,Gasche C,Qin H,Ma Y,Goel A

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The authors have previously isolated a putative oncogene, eukaryotic initiation factor 5A2 (EIF5A2) from 3q26. In this study, EIF5A2 was characterised for its role in colorectal carcinoma (CRC) aggressiveness and underlying molecular mechanisms. METHODS:The expression dynamics of EIF5A2 were examin...

journal_title：Gut

authors： Zhu W,Cai MY,Tong ZT,Dong SS,Mai SJ,Liao YJ,Bian XW,Lin MC,Kung HF,Zeng YX,Guan XY,Xie D

更新日期：2012-04-01 00:00:00

abstract：:Calcium palmitate occurred in 20% of the gallstones studied in this laboratory by x-ray diffraction and was the most important crystalline constituent after the different forms of cholesterol and calcium carbonate. Only one calculus contained alpha-palmitic acid. The gallstones came from America, England, Australia, S...

journal_title：Gut

authors： Sutor DJ

更新日期：1970-07-01 00:00:00

abstract：BACKGROUND:Lynch syndrome is caused by germline mismatch repair (MMR) gene mutations. The PREMM(1,2,6) model predicts the likelihood of a MMR gene mutation based on personal and family cancer history. OBJECTIVE:To compare strategies using PREMM(1,2,6) and tumour testing (microsatellite instability (MSI) and/or immunoh...

journal_title：Gut

authors： Kastrinos F,Steyerberg EW,Balmaña J,Mercado R,Gallinger S,Haile R,Casey G,Hopper JL,LeMarchand L,Lindor NM,Newcomb PA,Thibodeau SN,Syngal S,Colon Cancer Family Registry.

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:Corticosteroid has been established as the standard therapy for autoimmune pancreatitis (AIP), but the requirement for maintenance corticosteroid therapy is controversial. We conducted a randomised controlled trial to clarify the efficacy of maintenance corticosteroid therapy in patients with AIP. DESIGN:We ...

journal_title：Gut

authors： Masamune A,Nishimori I,Kikuta K,Tsuji I,Mizuno N,Iiyama T,Kanno A,Tachibana Y,Ito T,Kamisawa T,Uchida K,Hamano H,Yasuda H,Sakagami J,Mitoro A,Taguchi M,Kihara Y,Sugimoto H,Hirooka Y,Yamamoto S,Inui K,Inatomi O,

更新日期：2017-03-01 00:00:00

abstract：:The possibility that the mode of action of sulphasalazine and its active metabolite 5-amino-salicylic acid (5ASA) involves modification of toxic oxygen metabolite production by neutrophils has been investigated by measuring the effect of these drugs on luminol-dependent chemiluminescence, superoxide release and oxygen...

journal_title：Gut

authors： Williams JG,Hallett MB

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Hephaestin is a multicopper ferroxidase required for basolateral transport of iron from enterocytes. Sex linked anaemia (sla) mice have a defect in the release of iron from intestinal enterocytes into the circulation due to an interstitial deletion in the hephaestin gene (heph). RESULTS:We have demonstrated...

journal_title：Gut

authors： Kuo YM,Su T,Chen H,Attieh Z,Syed BA,McKie AT,Anderson GJ,Gitschier J,Vulpe CD

更新日期：2004-02-01 00:00:00

abstract：:The radio-telemetering capsule (radio-pill) has been used to study the return of motility in the small bowel after vagotomy with a drainage procedure, gastric operations not involving vagotomy, and non-gastric operations. Small intestinal movements returned in about 10 hours after vagotomy, about four hours after the ...

journal_title：Gut

authors： ROSS B,WATSON BW,KAY AW

更新日期：1963-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Independent component analysis (ICA) of the electroencephalogram (EEG) overcomes many of the classical problems in EEG analysis. We used ICA to determine the brain responses to painful stimulation of the oesophagus. METHODS:Twelve subjects with a median age of 41 years were included. With a nasal e...

journal_title：Gut

authors： Drewes AM,Sami SA,Dimcevski G,Nielsen KD,Funch-Jensen P,Valeriani M,Arendt-Nielsen L

更新日期：2006-05-01 00:00:00