Abstract:
OBJECTIVE:In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. DESIGN:International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structured, iterative, methodology based around a 1-day roundtable discussion was employed to derive expert consensus on key questions in microbiome-oncology research. RESULTS:Some 18 experts convened for the roundtable discussion and five key questions were identified regarding: (1) the relevance of dysbiosis/an altered gut microbiome to carcinogenesis; (2) potential mechanisms of microbiota-induced carcinogenesis; (3) conceptual frameworks describing how the human microbiome may drive carcinogenesis; (4) causation versus association; and (5) future directions for research in the field.The panel considered that, despite mechanistic and supporting evidence from animal and human studies, there is currently no direct evidence that the human commensal microbiome is a key determinant in the aetiopathogenesis of cancer. The panel cited the lack of large longitudinal, cohort studies as a principal deciding factor and agreed that this should be a future research priority. However, while acknowledging gaps in the evidence, expert opinion was that the microbiome, alongside environmental factors and an epigenetically/genetically vulnerable host, represents one apex of a tripartite, multidirectional interactome that drives carcinogenesis. CONCLUSION:Data from longitudinal cohort studies are needed to confirm the role of the human microbiome as a key driver in the aetiopathogenesis of cancer.
journal_name
Gutjournal_title
Gutauthors
Scott AJ,Alexander JL,Merrifield CA,Cunningham D,Jobin C,Brown R,Alverdy J,O'Keefe SJ,Gaskins HR,Teare J,Yu J,Hughes DJ,Verstraelen H,Burton J,O'Toole PW,Rosenberg DW,Marchesi JR,Kinross JMdoi
10.1136/gutjnl-2019-318556subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1624-1632issue
9eissn
0017-5749issn
1468-3288pii
gutjnl-2019-318556journal_volume
68pub_type
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