British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.

abstract：:In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within ...

journal_title：Gut

authors： Gebbers JO,Ferguson DJ,Mason C,Kelly P,Jewell DP

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVES:No trial has compared non-bismuth quadruple 'sequential' and 'concomitant' regimens in settings with increasing clarithromycin rates. The study aims to compare the effectiveness and safety of these therapies for Helicobacter pylori treatment. DESIGN:Prospective randomised clinical trial in 11 Spanish hospit...

journal_title：Gut

authors： McNicholl AG,Marin AC,Molina-Infante J,Castro M,Barrio J,Ducons J,Calvet X,de la Coba C,Montoro M,Bory F,Perez-Aisa A,Forné M,Gisbert JP,Participant Centres.

更新日期：2014-02-01 00:00:00

abstract：:Twenty one patients with diabetic peripheral neuropathy, 18 with idiopathic faecal incontinence and 11 normal controls were studied with techniques of mucosal electrosensitivity, rectal distension for the quantitative assessment of anorectal sensation, and manometric and electromyographic tests for the assessment of a...

journal_title：Gut

authors： Rogers J,Levy DM,Henry MM,Misiewicz JJ

更新日期：1988-06-01 00:00:00

abstract：:This paper reviews the experience gained over the past few years in two techniques of liver support, charcoal haemoperfusion and polyacrylonitrile membrane haemodialysis. Problems with charcoal haemoperfusion have centred around platelet aggregation and hypertension, and new carbon preparations with a variety of diffe...

journal_title：Gut

authors： Williams R

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Many lines of evidence suggest that T helper cell type 1 (Th1) immune responses predominate in Crohn's disease (CD). Recently, a novel transcription factor T-box expressed in T cells (T-bet) has been reported as the master regulator of Th1 development. This study was designed to investigate the role...

journal_title：Gut

authors： Matsuoka K,Inoue N,Sato T,Okamoto S,Hisamatsu T,Kishi Y,Sakuraba A,Hitotsumatsu O,Ogata H,Koganei K,Fukushima T,Kanai T,Watanabe M,Ishii H,Hibi T

更新日期：2004-09-01 00:00:00

abstract：:A 90 year old woman with alveolar rhabdomyosarcoma of the gall bladder is described. The patient died with tumour metastasis four months after diagnosis despite complete excision of the tumour. The histological, immunohistochemical, and ultrastructural features of the tumour are summarised and published works are revi...

journal_title：Gut

authors： al-Jaberi TM,al-Masri N,Tbukhi A

更新日期：1994-06-01 00:00:00

abstract：:On three occasions, a 63 year old housewife with hyperthyroidism developed a reaction which included fever, pruritus, malaise, and, on one occasion, jaundice one to 17 days after taking carbimazole. Challenge with carbimazole was followed within 12 hours by abdominal pain, pruritus, and increased serum transaminase le...

journal_title：Gut

authors： Lunzer M,Huang SN,Ginsburg J,Ahmed M,Sherlock S

更新日期：1975-11-01 00:00:00

abstract：:Pouchitis may complicate the construction of an ileal pouch after colectomy for ulcerative colitis (UC) but not familial adenomatous polyposis (FAP). To examine whether differences in eicosanoid metabolism might explain why pouchitis is largely confined to UC patients, this study compared arachidonic acid stimulated r...

journal_title：Gut

authors： Gertner DJ,Rampton DS,Madden MV,Talbot IC,Nicholls RJ,Lennard-Jones JE

更新日期：1994-10-01 00:00:00

abstract：:Both hog gastrin and synthetic gastrin stimulate the cardiac sphincter to increase tone and augment the resistance to reflux. Endogenous gastrin has a similar effect, and gastrin also stimulates the secretion of acid which has also been found to increase the resistance of the sphincter, but the effect of gastrin appea...

journal_title：Gut

authors： Giles GR,Mason MC,Humphries C,Clark CG

更新日期：1969-09-01 00:00:00

abstract：:Cholecystokinin (CCK) release and gall bladder emptying in response to a fatty meal are completely abolished in coeliac disease. To determine the effect of lipid digestion on CCK release and gall bladder motility, six patients with untreated coeliac disease and a flat jejunal mucosa were studied on two separate days. ...

journal_title：Gut

authors： Hopman WP,Rosenbusch G,Hectors MP,Jansen JB

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVES:Novel imaging methods based on specific molecular targets to detect both established neoplasms and their precursor lesions are highly desirable in cancer medicine. Previously, we identified claudin-4, an integral constituent of tight junctions, as highly expressed in various gastrointestinal tumours includin...

journal_title：Gut

authors： Neesse A,Hahnenkamp A,Griesmann H,Buchholz M,Hahn SA,Maghnouj A,Fendrich V,Ring J,Sipos B,Tuveson DA,Bremer C,Gress TM,Michl P

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. AIMS:To study the effect of glyceryl trinitrate, a nitr...

journal_title：Gut

authors： Greaves R,Miller J,O'Donnell L,McLean A,Farthing MJ

更新日期：1998-03-01 00:00:00

abstract：:The biomechanical properties of the oesophageal wall were investigated in a rabbit model using a four electrode impedance technique. A specially designed probe with the electrodes inside a low pressure expandable insulating latex balloon was introduced in the oesophagus. Stepwise inflation and deflation was done for a...

journal_title：Gut

authors： Gregersen H,Jensen LS,Djurhuus JC

更新日期：1988-12-01 00:00:00

abstract：:We determined the ionic composition of faecal fluid from 13 patients with Crohn's disease limited to the colon, 10 with diffuse ulcerative colitis, and eight with ulcerative proctitis. The Crohn's and colitis groups had similar proportions of colon surface involved radiographically and similar 24 hour faecal weights. ...

journal_title：Gut

authors： Schilli R,Breuer RI,Klein F,Dunn K,Gnaedinger A,Bernstein J,Paige M,Kaufman M

更新日期：1982-04-01 00:00:00

abstract：:Plasminogen activator activity was studied in bile and perfusate during extracorporeal pig liver perfusion. Plasminogen activator activity in bile was up to 58 times greater than in perfusate. A high level of plasminogen activator activity in bile was also found after the addition of urokinase to the perfusate. These ...

journal_title：Gut

authors： Jedrychowski A,Parbhoo SP,Hillenbrand P

更新日期：1972-01-01 00:00:00

abstract：OBJECTIVE:The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. DESIGN:384 single nucleotide po...

journal_title：Gut

authors： Wouters MM,Lambrechts D,Knapp M,Cleynen I,Whorwell P,Agréus L,Dlugosz A,Schmidt PT,Halfvarson J,Simrén M,Ohlsson B,Karling P,Van Wanrooy S,Mondelaers S,Vermeire S,Lindberg G,Spiller R,Dukes G,D'Amato M,Boeckxstaens

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Insulin-like growth factor (IGF) I receptor (IGF-Ir) signalling is required for carcinogenicity and proliferation of many tumours but this pathway has not been studied in detail in gastric cancer. We have previously shown successful therapy for colorectal, pancreatic, and lung cancer using recombina...

journal_title：Gut

authors： Min Y,Adachi Y,Yamamoto H,Imsumran A,Arimura Y,Endo T,Hinoda Y,Lee CT,Nadaf S,Carbone DP,Imai K

更新日期：2005-05-01 00:00:00

abstract：:Eighteen patients with achalasia of the cardia diagnosed by radiography, endoscopy, and manometry were subjected to forced pneumatic dilatation under fluoroscopic control. The procedure was uneventful in all but one patient who developed a pneumomediastinum which resolved on conservative management. A satisfactory res...

journal_title：Gut

authors： Lishman AH,Dellipiani AW

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND/AIMS:Studies in animals suggest a physiological role for glucagon-like peptide-1-(7-36)-amide (GLP-1) in regulating satiety. The role of GLP-1 in regulating food intake in man has, however, not been investigated. Subjects-Sixteen healthy male subjects were examined in a double blind placebo controlled fashio...

journal_title：Gut

authors： Gutzwiller JP,Göke B,Drewe J,Hildebrand P,Ketterer S,Handschin D,Winterhalder R,Conen D,Beglinger C

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Current diagnostic methods for gastro-oesophageal reflux disease (GORD) have moderate sensitivity/specificity and can be invasive and expensive. Pepsin detection in saliva has been proposed as an 'office-based' method for GORD diagnosis. The aims of this study were to establish normal values of salivary pepsi...

journal_title：Gut

authors： Hayat JO,Gabieta-Somnez S,Yazaki E,Kang JY,Woodcock A,Dettmar P,Mabary J,Knowles CH,Sifrim D

更新日期：2015-03-01 00:00:00

abstract：:Nutritional status and immune function were correlated with clinical features in 56 patients with Crohn's disease. These were divided arbitrarily into either undernourished or well nourished groups according to whether their midarm circumference was below or above 90% of ideal standard. Results were also compared with...

journal_title：Gut

authors： Harries AD,Danis VA,Heatley RV

更新日期：1984-05-01 00:00:00

abstract：OBJECTIVE:Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian of genome stability. Hp reduces the expression of the transcription factor USF1 shown to stabilise p53 in response to genotoxic stress. We investigated whether Hp-me...

journal_title：Gut

authors： Costa L,Corre S,Michel V,Le Luel K,Fernandes J,Ziveri J,Jouvion G,Danckaert A,Mouchet N,Da Silva Barreira D,Torres J,Camorlinga M,D'Elios MM,Fiette L,De Reuse H,Galibert MD,Touati E

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...

journal_title：Gut

authors： Hochart A,Gower-Rousseau C,Sarter H,Fumery M,Ley D,Spyckerelle C,Peyrin-Biroulet L,Laberenne JE,Vasseur F,Savoye G,Turck D,Epimad Group.

更新日期：2017-11-01 00:00:00

abstract：:Tumour cell membrane fatty acid composition was investigated using an animal model of colorectal carcinogenesis. Eighty six male Wistar rats were fed experimental diets containing either 5% saturated fat or 20% saturated fat. Colorectal tumours were induced by intraperitoneal injection of azoxymethane, and control rat...

journal_title：Gut

authors： Nicholson ML,Neoptolemos JP,Clayton HA,Talbot IC,Bell PR

更新日期：1991-04-01 00:00:00

abstract：:Thirty-two patients with diarrhoea, on average four years following truncal vagotomy and drainage, were studied. A comparison was made with 24 patients without postvagotomy diarrhoea. The incidence of bacterial colonization of the upper small intestine was no different in the two groups, though patients with a gastroe...

journal_title：Gut

authors： Browning GG,Buchan KA,Mackay C

更新日期：1974-08-01 00:00:00

abstract：:Increased concentrations of the soluble form of the interleukin 2 receptor have been observed in the sera of Crohn's disease and ulcerative colitis patients. In this study we have observed the spontaneous release of soluble interleukin 2 receptor by unstimulated, isolated normal and inflammatory bowel disease colonic ...

journal_title：Gut

authors： Schreiber S,Raedler A,Conn AR,Rombeau JL,MacDermott RP

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:There is a need for an improved biomarker for colorectal cancer (CRC) and advanced adenoma. We evaluated faecal microbial markers for clinical use in detecting CRC and advanced adenoma. DESIGN:We measured relative abundance of Fusobacterium nucleatum (Fn), Peptostreptococcus anaerobius (Pa) and Parvimonas mi...

journal_title：Gut

authors： Wong SH,Kwong TNY,Chow TC,Luk AKC,Dai RZW,Nakatsu G,Lam TYT,Zhang L,Wu JCY,Chan FKL,Ng SSM,Wong MCS,Ng SC,Wu WKK,Yu J,Sung JJY

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:Cryptogenic multifocal ulcerating stenosing enteritis (CMUSE) is an extremely rare, but devastating, disease of unknown aetiology. We investigated the genetic basis of this autosomal recessive condition in a pair of affected siblings who have 40-year histories of catastrophic gastrointestinal and extraintesti...

journal_title：Gut

authors： Brooke MA,Longhurst HJ,Plagnol V,Kirkby NS,Mitchell JA,Rüschendorf F,Warner TD,Kelsell DP,MacDonald TT

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Using genome-wide promoter methylation assay, B cell CLL/lymphoma 6 member B (BCL6B) was found to be preferentially methylated in cancer. A study was undertaken to examine the epigenetic regulation, biological function and clinical significance of BCL6B in gastric cancer (GC). METHODS:BCL6B promoter methylat...

journal_title：Gut

authors： Xu L,Li X,Chu ES,Zhao G,Go MY,Tao Q,Jin H,Zeng Z,Sung JJ,Yu J

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:This phase II, randomised, double-blind, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PF-00547659, a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion molecule (MAdCAM) to selectively reduce lymphocyte homing to the intestinal tract, i...

journal_title：Gut

authors： Sandborn WJ,Lee SD,Tarabar D,Louis E,Klopocka M,Klaus J,Reinisch W,Hébuterne X,Park DI,Schreiber S,Nayak S,Ahmad A,Banerjee A,Brown LS,Cataldi F,Gorelick KJ,Cheng JB,Hassan-Zahraee M,Clare R,D'Haens GR

更新日期：2018-10-01 00:00:00