Abstract:
:In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within epithelial cells and in subepithelial macrophages; there were numerous partially degranulated intraepithelial mast cells; and there was a marked increase in the proportion of IgE plasma cells within the lamina propria. Mucosal penetration by the organisms may be responsible for the unusual immune response. In one patient, treatment with antibiotics eliminated the spirochaetes and resulted in a clinical improvement. Spirochaetes should not always be considered as harmless commensals in the colon.
journal_name
Gutjournal_title
Gutauthors
Gebbers JO,Ferguson DJ,Mason C,Kelly P,Jewell DPdoi
10.1136/gut.28.5.588subject
Has Abstractpub_date
1987-05-01 00:00:00pages
588-93issue
5eissn
0017-5749issn
1468-3288journal_volume
28pub_type
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