Is raised plasma peptide YY after intestinal resection in the rat responsible for the trophic response?

Abstract:

:The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28 +/- 3.1 to 85 +/- 12.3 pmol/l (p less than 0.001) and this difference was maintained to 48 days. Plasma PYY correlates both with crypt cell production rate (CCPR) in the ileum and with plasma enteroglucagon levels. In a second study, PYY or saline was infused over a 12 day period. There were no significant changes in intestinal wet weight or CCPR in any part of the bowel studied. This indicates that it is unlikely that PYY exerts a major trophic effect on the gastrointestinal tract.

journal_name

Gut

journal_title

Gut

authors

Savage AP,Gornacz GE,Adrian TE,Ghatei MA,Goodlad RA,Wright NA,Bloom SR

doi

10.1136/gut.26.12.1353

subject

Has Abstract

pub_date

1985-12-01 00:00:00

pages

1353-8

issue

12

eissn

0017-5749

issn

1468-3288

journal_volume

26

pub_type

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