Abstract:
:The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28 +/- 3.1 to 85 +/- 12.3 pmol/l (p less than 0.001) and this difference was maintained to 48 days. Plasma PYY correlates both with crypt cell production rate (CCPR) in the ileum and with plasma enteroglucagon levels. In a second study, PYY or saline was infused over a 12 day period. There were no significant changes in intestinal wet weight or CCPR in any part of the bowel studied. This indicates that it is unlikely that PYY exerts a major trophic effect on the gastrointestinal tract.
journal_name
Gutjournal_title
Gutauthors
Savage AP,Gornacz GE,Adrian TE,Ghatei MA,Goodlad RA,Wright NA,Bloom SRdoi
10.1136/gut.26.12.1353subject
Has Abstractpub_date
1985-12-01 00:00:00pages
1353-8issue
12eissn
0017-5749issn
1468-3288journal_volume
26pub_type
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