Role of intracellular Ca2+ and the calmodulin messenger system in pepsinogen secretion from isolated rabbit gastric mucosa.

abstract：:Using 24 hour pH monitoring as a reference standard, the usefulness of the acid perfusion (AP) test in predicting gastro-oesophageal reflux disease (GORD) was assessed in 71 non-cardiac chest pain (NCCP) patients and 23 endoscopic oesophagitis patients. Of the 71 NCCP patients, 35 had a positive AP test (of whom 20 ha...

journal_title：Gut

authors： Hewson EG,Sinclair JW,Dalton CB,Wu WC,Castell DO,Richter JE

更新日期：1989-03-01 00:00:00

abstract：:In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within ...

journal_title：Gut

authors： Gebbers JO,Ferguson DJ,Mason C,Kelly P,Jewell DP

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:Osteoporosis and fractures are frequently encountered in patients with Crohn's disease. In order to prevent fractures, treatment with bone protecting drugs appears warranted early in the course of bone disease when bone loss is not yet prominent. We therefore aimed to demonstrate a beneficial effect on bone d...

journal_title：Gut

authors： van Bodegraven AA,Bravenboer N,Witte BI,Dijkstra G,van der Woude CJ,Stokkers PC,Russel MG,Oldenburg B,Pierik M,Roos JC,van Hogezand RA,Dik VK,Oostlander AE,Netelenbos JC,van de Langerijt L,Hommes DW,Lips P,Dutch Initiat

更新日期：2014-09-01 00:00:00

abstract：:The radio-telemetering capsule (radio-pill) has been used to study the return of motility in the small bowel after vagotomy with a drainage procedure, gastric operations not involving vagotomy, and non-gastric operations. Small intestinal movements returned in about 10 hours after vagotomy, about four hours after the ...

journal_title：Gut

authors： ROSS B,WATSON BW,KAY AW

更新日期：1963-03-01 00:00:00

abstract：BACKGROUND AND AIM:There are few data on the course of Helicobacter pylori infection in asymptomatic subjects. The aim of this study was to assess the effect of eradication therapy on the development of dyspeptic and gastro-oesophageal reflux disease in a cohort of asymptomatic individuals observed over a prolonged per...

journal_title：Gut

authors： Vaira D,Vakil N,Rugge M,Gatta L,Ricci C,Menegatti M,Leandro G,Holton J,Russo VM,Miglioli M

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:Current diagnostic methods for gastro-oesophageal reflux disease (GORD) have moderate sensitivity/specificity and can be invasive and expensive. Pepsin detection in saliva has been proposed as an 'office-based' method for GORD diagnosis. The aims of this study were to establish normal values of salivary pepsi...

journal_title：Gut

authors： Hayat JO,Gabieta-Somnez S,Yazaki E,Kang JY,Woodcock A,Dettmar P,Mabary J,Knowles CH,Sifrim D

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Previous studies of anticipation in familial pancreatic cancer have been small and subject to ascertainment bias. Our aim was to determine evidence for anticipation in a large number of European families. PATIENTS AND METHODS:A total of 1223 individuals at risk from 106 families (264 affected individuals) w...

journal_title：Gut

authors： McFaul CD,Greenhalf W,Earl J,Howes N,Neoptolemos JP,Kress R,Sina-Frey M,Rieder H,Hahn S,Bartsch DK,European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC).,German National Case Collection for Familial

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed medications, but they are associated with a number of serious adverse effects, including hypertension, cardiovascular disease, kidney injury and GI complications. OBJECTIVE:To develop a set of multidisciplinary recommenda...

journal_title：Gut

authors： Szeto CC,Sugano K,Wang JG,Fujimoto K,Whittle S,Modi GK,Chen CH,Park JB,Tam LS,Vareesangthip K,Tsoi KKF,Chan FKL

更新日期：2020-04-01 00:00:00

abstract：:Evidence is presented which indicates a possible reduction in recognition capacity for tumour cell antigens (EB(2) Burkitt lymphoma cell line) by lymphocytes from some patients with longstanding but inactive Crohn's disease. Three out of seven patients tested also showed diminished or absent lymphocytotoxicity when th...

journal_title：Gut

authors： Maclaurin BP,Cooke WT,Ling NR

更新日期：1972-08-01 00:00:00

abstract：:A technique for obtaining needle aspiration cytology specimens from upper gastrointestinal lesions at endoscopy is described. The validity of the technique was initially confirmed by applying it to resected gastric carcinomas. Thirty seven endoscopically visualised lesions were then sampled by forceps biopsy, brush an...

journal_title：Gut

authors： Ingoldby CJ,Mason MK,Hall RI

更新日期：1987-09-01 00:00:00

abstract：:A method of in vivo calculation of liver volume using a gamma camera and a 1600 or 4096 channel analyser is described. Topographically, the maximum thickness giving the highest counts in matrix data in the right anterior oblique projection is measured as the maximum breadth in the right posterior oblique projection. T...

journal_title：Gut

authors： Fujii M,Mukai T,Yamamoto T,Wakisaka G

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:This is a consensus developed by a group of expert endoscopists aiming to standardise the preparation, process and endoscopic procedural steps for diagnosis of early upper gastrointestinal (GI) cancers. METHOD:The Delphi method was used to develop consensus statements through identification of clinical ques...

journal_title：Gut

authors： Chiu PWY,Uedo N,Singh R,Gotoda T,Ng EKW,Yao K,Ang TL,Ho SH,Kikuchi D,Yao F,Pittayanon R,Goda K,Lau JYW,Tajiri H,Inoue H

更新日期：2019-02-01 00:00:00

abstract：:Some patients with the Zollinger-Ellison syndrome appear to have hypergastrinaemia and hyperplasia of the antral G cells but no tumour. This subgroup has been classified as Zollinger-Ellison syndrome type 1. We have treated such a patient by vagotomy and antrectomy, the fasting plasma gastrin and acid secretion subseq...

journal_title：Gut

authors： Cowley DJ,Dymock IW,Boyes BE,Wilson RY,Stagg BH,Lewin MR,Polak JM,Pearse AG

更新日期：1973-01-01 00:00:00

abstract：:The case of a 44-year-old woman is reported. The diagnosis after the appropriate tests and laparotomy was ACTH-secreting 'apudoma' of the gallbladder. This is a rare tumour and this case is believed to be the first reported of an ectopic hormone producing tumour from this side. ...

journal_title：Gut

authors： Spence RW,Burns-Cox CJ

更新日期：1975-06-01 00:00:00

abstract：OBJECTIVE:Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV ...

journal_title：Gut

authors： La Bella T,Imbeaud S,Peneau C,Mami I,Datta S,Bayard Q,Caruso S,Hirsch TZ,Calderaro J,Morcrette G,Guettier C,Paradis V,Amaddeo G,Laurent A,Possenti L,Chiche L,Bioulac-Sage P,Blanc JF,Letouze E,Nault JC,Zucman-Rossi

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND AND AIM:The treatment of ulcerative colitis (UC) with 5-aminosalicylic acid (5-ASA) does not have the same therapeutic effect in all patients. We tested the hypothesis that the effectiveness of the drug is related to its mucosal concentration. PATIENTS:Twenty one UC patients receiving oral 5-ASA (2.4-3.2 g/...

journal_title：Gut

authors： Frieri G,Giacomelli R,Pimpo M,Palumbo G,Passacantando A,Pantaleoni G,Caprilli R

更新日期：2000-09-01 00:00:00

abstract：:On the basis of circumstantial clinical and experimental evidence, it has been suggested that enteroglucagon (EG) may act as an enterotrophic factor. This study was undertaken to evaluate the effects of long term in vivo immunoneutralisation of EG, using monoclonal antibodies to EG, on the hyperplastic ileal response ...

journal_title：Gut

authors： Gregor M,Menge H,Stössel R,Riecken EO

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:An increasing number of patients with severe or refractory ulcerative colitis involving only the rectum and sigmoid colon are being offered restorative proctocolectomy with ileal reservoir but very few data are available concerning the outcome for these patients. AIM:This study was designed to compare the o...

journal_title：Gut

authors： Samarasekera DN,Stebbing JF,Kettlewell MG,Jewell DP,Mortensen NJ

更新日期：1996-04-01 00:00:00

abstract：:The problems associated with recurrent Crohn's disease were examined in a series of 168 patients who had undergone primary resection for this condition at the General Infirmary at Leeds from 1939 to 1968 inclusive. The overall recurrence rate was 34.2%. The risk of recurrence was less in patients with involvement main...

journal_title：Gut

authors： De Dombal FT,Burton I,Goligher JC

更新日期：1971-07-01 00:00:00

abstract：BACKGROUND:Saccharomyces boulardii is a non-pathogenic yeast which exerts trophic effects on human and rat small intestinal mucosa. AIMS:To examine the effects of S boulardii on ileal adaptation after proximal enterectomy in rats. METHODS:Wistar rats, aged eight weeks, underwent 60% proximal resection or transection ...

journal_title：Gut

authors： Buts JP,De Keyser N,Marandi S,Hermans D,Sokal EM,Chae YH,Lambotte L,Chanteux H,Tulkens PM

更新日期：1999-07-01 00:00:00

abstract：:Dysphagia in a 79 year old lady was caused by a giant polypoid tumour in mid-oesophagus. Surgery was not appropriate. Shrinkage of the tumour and its eventual detachment were achieved by stopping its blood supply by YAG laser photocoagulation of the tumour stalk. Good, temporary palliation of the dysphagia was achieve...

journal_title：Gut

authors： Richardson D,Wyatt JI,Miloszewski KJ

更新日期：1992-08-01 00:00:00

abstract：:In 19 subjects (four controls, one gastric ulcer and 14 duodenal ulcer) maximal gastric secretion was evoked with histamine 0.13 mumol/kg/h (0.04 mg/kg/h) for two to two and a half hours. A slow intravenous bolus dose of 200 mg cimetidine was given at the beginning of the last hour. Gastric secretion was measured befo...

journal_title：Gut

authors： Melville RJ,Suleiman SI,Whitfield PF,Parkin JV,Nwabunike TO,Hobsley M

更新日期：1985-08-01 00:00:00

abstract：:Since pancreatobiliary diversion probably stimulates pancreatic growth by increasing cholecystokinin secretion, the effect of the cholecystokinin antagonist CR-1409 on this adaptive response was tested. Male Wistar rats (n = 108) weighing 220-250g were randomised to receive either pancreatobiliary diversion (n = 60) o...

journal_title：Gut

authors： Watanapa P,Efa EF,Beardshall K,Calam J,Sarraf CE,Alison MR,Williamson RC

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Helicobacter pylori (H pylori) infection is a major risk factor in the development of distal gastric adenocarcinoma. Development of the invasive phenotype is associated with the phenomenon of epithelial:mesenchymal transition (EMT). Soluble heparin-binding epidermal growth factor (HB-EGF) has been i...

journal_title：Gut

authors： Yin Y,Grabowska AM,Clarke PA,Whelband E,Robinson K,Argent RH,Tobias A,Kumari R,Atherton JC,Watson SA

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is a therapy recalcitrant disease with the worst survival rate of common solid tumours. Preclinical models that accurately reflect the genetic and biological diversity of PDAC will be important for delineating features of tumour biology and therapeutic vulnerabilities. ...

journal_title：Gut

authors： Knudsen ES,Balaji U,Mannakee B,Vail P,Eslinger C,Moxom C,Mansour J,Witkiewicz AK

更新日期：2018-03-01 00:00:00

abstract：:HLA antigens and various aspects of atopy were studied in 42 Finnish children and adolescents with coeliac disease, and the results were compared with findings of recent population studies. The HLA associations were as expected: relative risks for coeliac disease in individuals with HLA-B8, DR3, and DR7 were 8 . 0, 18...

journal_title：Gut

authors： Verkasalo M,Tiilikainen A,Kuitunen P,Savilahti E,Backman A

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Somatostatin has been used to prevent pancreatitis after endoscopic retrograde cholangiopancreatography but its effect on acute non-biliary pancreatitis is still unclear. AIM:The purpose of this study was to evaluate the function of the sphincter of Oddi (SO) and the effect of somatostatin on patients with ...

journal_title：Gut

authors： Lai KH,Lo GH,Cheng JS,Fu MT,Wang EM,Chan HH,Wang YY,Hsu PI,Lin CK

更新日期：2001-12-01 00:00:00

abstract：:Calcium palmitate occurred in 20% of the gallstones studied in this laboratory by x-ray diffraction and was the most important crystalline constituent after the different forms of cholesterol and calcium carbonate. Only one calculus contained alpha-palmitic acid. The gallstones came from America, England, Australia, S...

journal_title：Gut

authors： Sutor DJ

更新日期：1970-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Little is known about the epidemiology of malignant digestive endocrine tumours. The aim of this study was to report on their incidence and management in a well defined population. METHODS:Data were obtained from the population based Digestive Cancer Registry of Burgundy (France) over a 24 year per...

journal_title：Gut

authors： Lepage C,Bouvier AM,Phelip JM,Hatem C,Vernet C,Faivre J

更新日期：2004-04-01 00:00:00

abstract：:Psychological treatments are increasingly being used to help patients with the irritable bowel syndrome (IBS), but the efficacy of such treatments is still debated. This review indicates that there are three ways in which they might have been effective in published studies to date; relating bowel symptoms to stress, s...

journal_title：Gut

authors： Creed F,Guthrie E

更新日期：1989-11-01 00:00:00