Abstract:
:The problems associated with recurrent Crohn's disease were examined in a series of 168 patients who had undergone primary resection for this condition at the General Infirmary at Leeds from 1939 to 1968 inclusive. The overall recurrence rate was 34.2%. The risk of recurrence was less in patients with involvement mainly of large bowel rather than small. It was also affected by the age of the patient, being greatest in children or adolescents, less in adults, and least in those over 60 years of age. Recurrent disease was most commonly found in the small bowel proximal to an anastomosis, and usually manifested itself either in the first year or two after surgery or some five to 15 years later. Patients with ;early' recurrence had a shorter history of symptoms at operation, and a graver outlook than those with ;late' recurrence. The status of recurrent cases was much better than might have been anticipated in so far as nearly 70% of them were considered at review to be in very good or good general health. Moreover the risk of further recurrence after a second or third operation was found to be no greater than after a first operation.
journal_name
Gutjournal_title
Gutauthors
De Dombal FT,Burton I,Goligher JCdoi
10.1136/gut.12.7.519subject
Has Abstractpub_date
1971-07-01 00:00:00pages
519-27issue
7eissn
0017-5749issn
1468-3288journal_volume
12pub_type
杂志文章相关文献
GUT文献大全abstract::The epidemiology of hepatitis C virus (HCV) infection was studied in an English teaching hospital over an 18 month period. A total of 104 HCV antibody positive patients were referred for further investigation. They were divided into those diagnosed through screening (blood donors and intravenous drug abusers) and thos...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.2.269
更新日期:1996-02-01 00:00:00
abstract::The most reliable method of making a specific aetiological diagnosis of chronic viral hepatitis would be to identify virus specific cytotoxic T lymphocytes responsible for the killing of virus infected hepatocytes in each patient's liver. Unfortunately, this can not be proposed for routine diagnosis and surrogate test...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.2_suppl.s36
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Tumour necrosis factor (TNF) is a predominant cytokine produced in the gastric mucosa of patients with Helicobacter pylori infection. TNF induces apoptosis in a variety of cells. The soluble TNF receptors (sTNF-Rs) can be divided into sTNF-RI and sTNF-RII, both of which inhibit TNF activity. However, their p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.1.24
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Previous studies of anticipation in familial pancreatic cancer have been small and subject to ascertainment bias. Our aim was to determine evidence for anticipation in a large number of European families. PATIENTS AND METHODS:A total of 1223 individuals at risk from 106 families (264 affected individuals) w...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.065045
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:It is presently not well understood to what extent peptic ulcer and gastric cancer represent related diseases. AIMS:The objective of this study was to assess past occurrence of gastric and duodenal ulcers in patients with cancer of the gastric cardia or other parts of the stomach. METHODS:The association b...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.2.247
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:Escherichia coli is part of the normal gastrointestinal microflora which exerts a barrier effect against enteropathogens. Several E coli strains develop a protective effect against other Enterobacteriaceae. AIMS:Two E coli strains, EM0, a human faecal strain, and JM105 K-12 were tested for their ability to ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.1.47
更新日期:2001-07-01 00:00:00
abstract::In order to establish whether alcohol in amounts in amounts customarily imbibed during social drinking causes gastro-oesophageal reflux, 12 healthy young individuals, without symptoms of gastro-oesophageal reflux, were studied twice. Each time, distal oesophageal pH was monitored continuously for three hours after a s...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.19.4.336
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation and increased epithelial permeability. Both tumour necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) have been implicated in IBD. AIMS:To understand better the effects of these cytokines on epithelial cell ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.2.191
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Fresh fruit and vegetables exert multiple biological effects on the gastrointestinal mucosa. AIM:To assess whether apple extracts counteract oxidative or indomethacin induced damage to gastric epithelial cells in vitro and to rat gastric mucosa in vivo. METHODS:Apple extracts were obtained from freeze drie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.046292
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:The effect of histamine H2 receptor antagonists on gastric emptying is controversial. AIMS:To determine the effects of ranitidine, famotidine, and omeprazole on gastric motility and emptying. PATIENTS AND METHODS:Fifteen normal subjects underwent simultaneous antroduodenal manometry, electrogastrography (E...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.42.2.243
更新日期:1998-02-01 00:00:00
abstract:INTRODUCTION:In pancreatic cancer, preoperative biliary drainage (PBD) increases complications compared with surgery without PBD, demonstrated by a recent randomised controlled trial (RCT). This outcome might be related to the plastic endoprosthesis used. Metal stents may reduce the PBD-related complications risk. MET...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2014-308762
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND AIMS:A previous study suggested that the presence of myenteric plexitis in the proximal resection margins could be predictive of early endoscopic recurrence after ileocolonic or ileal resection for Crohn's disease (CD). The aim of the present study was to assess the predictive value of plexitis for early...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.177782
更新日期:2009-09-01 00:00:00
abstract::The variability in the orocaecal transit time as measured by the lactulose/breath hydrogen method has been studied for three conditions: lactulose given with a meal, subjects sitting; lactulose given with a meal, subjects semirecumbent; lactulose given in aqueous solution, subjects semirecumbent. Thirty three healthy ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.2.171
更新日期:1989-02-01 00:00:00
abstract::A case of spontaneous partial rupture of the normal large bowel causing a haemoperitoneum is described. No similar case appears to have been reported previously. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.4.321
更新日期:1960-12-01 00:00:00
abstract::Over 90% of patients with inoperable carcinoma of the pancreas are successfully palliated by endoscopic retrograde cholangiopancreatography and stent insertion. Treatment of the residual 10% of patients often entails a laparotomy, which is difficult to justify when median survival of these patients is only 150 days. L...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.5.778
更新日期:1995-05-01 00:00:00
abstract::This study reports on a group of 20 patients with an initial diagnosis of primary biliary cirrhosis (PBC) whose serum tested negative for antimitochondrial antibodies by immunofluorescence. All had a clinical history compatible with primary biliary cirrhosis, and results of biochemical, histological, and radiological ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.2.260
更新日期:1994-02-01 00:00:00
abstract::Lactulose H2 breath tests are widely used for quantifying carbohydrate malabsorption, but the validity of the commonly used technique (interval sampling of H2 concentrations) has not been systematically investigated. In eight healthy adults we studied the reproducibility of the technique and the accuracy with which 5 ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.1.37
更新日期:1990-01-01 00:00:00
abstract::Studies have been made of mucus glycoprotein biosynthesis in different regions of the lower gastrointestinal tract in normal patients and those with ulcerative colitis (UC), active or inactive, by means of 3H-glucosamine (3H-GlcNH2)--35S-sulphate double labelling of epithelial biopsy specimens under culture conditions...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.7.926
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian of genome stability. Hp reduces the expression of the transcription factor USF1 shown to stabilise p53 in response to genotoxic stress. We investigated whether Hp-me...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-318640
更新日期:2020-09-01 00:00:00
abstract::The effects of sulphasalazine, 5-aminosalicylic acid (5-ASA), and sulphapyridine on peroxidation of red cell membrane lipids, measured as malondialdehyde production, were assessed. Sulphasalazine and 5-ASA, at concentrations of 10(-5)-10(-3) M significantly inhibit lipid peroxidation, suggesting an antioxidant action ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.10.1156
更新日期:1991-10-01 00:00:00
abstract::The medication history of patients presenting with benign oesophageal stricture is compared with an age and sex matched control population selected from the community. Fifty five out of 151 consecutive admissions to a dysphagia clinic were found to have benign oesophageal stricture. Twenty six out of 53 (49%) had been...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.5.478
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:Gastric mucosal surface hydrophobicity (GMSH) is an essential component of the mucosal defence system that is decreased by Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs). Gastric ulcers occur predominantly in elderly subjects, and may thus reflect diminished mucosal resistance. AIMS:...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.4.465
更新日期:1998-10-01 00:00:00
abstract::Partial gastrectomy and intestinal resection significantly impaired glucose tolerance (p < 0.05) and significantly decreased the release of insulin by intravenous glucose (p < 0.05) or a meal of minced beef (p < 0.01). There was a significantly greater release of insulin one hour after oral glucose in the gastrectomy ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.11.871
更新日期:1972-11-01 00:00:00
abstract:PURPOSE:Despite recent advances in colorectal cancer (CRC) treatment, the prognosis of patients suffering from this malignancy still remains substandard, and metastatic recurrence following curative surgery is the leading cause of mortality. Therefore, it is imperative to identify prognostic markers to predict the clin...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309359
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Different acid and peptic related gastroduodenal diseases are associated with both increased gastric secretion and Helicobacter pylori infection. Patients with H pylori associated gastritis or duodenal ulcer have increased serum pepsinogen levels which decrease after eradication. The mechanisms of H pylori i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.1.13
更新日期:2002-01-01 00:00:00
abstract::The behaviour of basal and stimulated acid secretion, gastrin release, serum pepsinogen I, and gastric emptying of liquids was studied in 19 consecutive patients with Helicobacter pylori positive duodenal ulcer, over a follow up period of six months. Eleven patients were studied before and at three and six months afte...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.2.210
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Emerging evidence suggests that highly treatment-resistant tumour-initiating cells (TICs) play a central role in the pathogenesis of pancreatic cancer. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered to be a novel anticancer agent; however, recent studies have shown th...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.149039
更新日期:2009-07-01 00:00:00
abstract::The amylase/creatinine clearance ratio (Cam/Ccr ratio) was determined in 239 subjects. In 87 hospitalised patients without pancreatic disease (controls) the Cam/Ccr ratio was 3.02 +/- 0.69 (mean +/- ISD). The ratio was above the normal range in all patients with acute pancreatitis but was normal in those with chronic ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.9.703
更新日期:1977-09-01 00:00:00
abstract::Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral venous blood obtained at autopsy of sudden death victims within fou...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.10.1221
更新日期:1987-10-01 00:00:00
abstract:OBJECTIVE:Non-oxidative metabolism of ethanol (NOME) produces fatty acid ethyl esters (FAEEs) via carboxylester lipase (CEL) and other enzyme action implicated in mitochondrial injury and acute pancreatitis (AP). This study investigated the relative importance of oxidative and non-oxidative pathways in mitochondrial dy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-304058
更新日期:2014-08-01 00:00:00