Laparoscopic biliary and gastric bypass: a useful adjunct in the treatment of carcinoma of the pancreas.

Abstract:

:Over 90% of patients with inoperable carcinoma of the pancreas are successfully palliated by endoscopic retrograde cholangiopancreatography and stent insertion. Treatment of the residual 10% of patients often entails a laparotomy, which is difficult to justify when median survival of these patients is only 150 days. Laparoscopic biliary and gastric bypass offers a less invasive alternative than open surgery with shorter hospital stay and more rapid return to normal activity. Between August 1991 and March 1994, 16 patients (median age 69 years, range 31-85) had laparoscopic bypass surgery. The indications for surgery were gastric outlet obstruction at initial presentation (n = 4), blocked biliary stent (n = 8), and metastatic tumour at laparoscopy (n = 4). Surgery took the form of cholecystjejunostomy (n = 7), gastroenterostomy (n = 5), both procedures (n = 3), and failed operation (n = 1). Operative duration was 75 minutes (range 45-190) and hospital stay four days (range 3-33) and all apart from two patients were discharged from hospital in seven days or less. Morbidity occurred in two patients (13%) in the form of a cerebrovascular accident and delayed gastric emptying. Median survival in 10 patients who have died is 201 days (range 20-525). Laparoscopic biliary and gastric bypass is possible in most patients in whom endoscopic stenting has failed and in those who subsequently develop gastric outlet obstruction. Hospital stay is shorter than after open surgery and recovery more rapid.

journal_name

Gut

journal_title

Gut

authors

Rhodes M,Nathanson L,Fielding G

doi

10.1136/gut.36.5.778

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

778-80

issue

5

eissn

0017-5749

issn

1468-3288

journal_volume

36

pub_type

杂志文章

相关文献

GUT文献大全
  • Dietary nucleotides and gut mucosal defence.

    abstract::The informational aspects of nucleic acid synthesis have attracted much more attention than the quantitative significance of DNA, rRNA, tRNA, and nucleotide synthesis. Animal and human studies suggest that in energetic terms, 5-10% of the energy used in synthesising tissue protein is expended in manufacturing an appro...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.35.1_suppl.s46

    authors: Grimble GK

    更新日期:1994-01-01 00:00:00

  • The cardiac sphincter in the cat.

    abstract::A study of the function of the lower end of the oesophagus in the cat confirms that it behaves as a true physiological sphincter, even though histological evidence for such a structure is absent. Sphincteric action is a function of the circular muscle fibres in the lowest 2 cm. of the oesophagus. Reflex changes in ton...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2.3.252

    authors: CLARK CG,VANE JR

    更新日期:1961-09-01 00:00:00

  • Is gastric cancer preventable?

    abstract::Gastric cancer is a major health burden worldwide and prevention is the most promising strategy to control the disease. The available scientific evidence indicates that curing Helicobacter pylori infection results in a modest retardation of the precancerous process but does not prevent all cancers. Individuals at the ...

    journal_title:Gut

    pub_type: 评论,杂志文章,评审

    doi:10.1136/gut.2004.039834

    authors: Correa P

    更新日期:2004-09-01 00:00:00

  • Diagnostic utility of reflux disease symptoms.

    abstract::Symptom assessment, by structured interview or questionnaire, is central to the diagnosis of gastro-oesophageal reflux disease (GORD). However, empiric support for the diagnostic utility of reflux symptom measures is lacking. Reliable reflux symptom questionnaires have been developed with content validity. These quest...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.2003.034280

    authors: Shaw M

    更新日期:2004-05-01 00:00:00

  • Bone marrow transplantation improves hepatic fibrosis in Abcb4-/- mice via Th1 response and matrix metalloproteinase activity.

    abstract:OBJECTIVE:Reports on the effects of bone marrow-derived cells on hepatic fibrosis are contradictory. Impaired fibrosis but increased inflammation has recently been demonstrated 10 weeks after bone marrow transplantation (BM-Tx) in Abcb4-/- mice. It is hypothesised that BM-Tx might have long-term therapeutic potential b...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2011-300608

    authors: Roderfeld M,Rath T,Pasupuleti S,Zimmermann M,Neumann C,Churin Y,Dierkes C,Voswinckel R,Barth PJ,Zahner D,Graf J,Roeb E

    更新日期:2012-06-01 00:00:00

  • What activates visceral afferents?

    abstract::Vagal and spinal afferents represent the information superhighways that convey sensory information from the gut to the central nervous system. These afferents are sensitive to both mechanical and chemical stimuli. Vagal afferents terminate in the muscle layers and in the mucosa. Muscle afferents are activated at physi...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2003.033415

    authors: Grundy D

    更新日期:2004-03-01 00:00:00

  • Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas).

    abstract:OBJECTIVES:Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN:Retrospective multinational study including SCN diagnosed between 1990 and 2014. ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-309638

    authors: Jais B,Rebours V,Malleo G,Salvia R,Fontana M,Maggino L,Bassi C,Manfredi R,Moran R,Lennon AM,Zaheer A,Wolfgang C,Hruban R,Marchegiani G,Fernández Del Castillo C,Brugge W,Ha Y,Kim MH,Oh D,Hirai I,Kimura W,Jang JY

    更新日期:2016-02-01 00:00:00

  • Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo.

    abstract:BACKGROUND:Fresh fruit and vegetables exert multiple biological effects on the gastrointestinal mucosa. AIM:To assess whether apple extracts counteract oxidative or indomethacin induced damage to gastric epithelial cells in vitro and to rat gastric mucosa in vivo. METHODS:Apple extracts were obtained from freeze drie...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2004.046292

    authors: Graziani G,D'Argenio G,Tuccillo C,Loguercio C,Ritieni A,Morisco F,Del Vecchio Blanco C,Fogliano V,Romano M

    更新日期:2005-02-01 00:00:00

  • Optimum dosage of ispaghula husk in patients with irritable bowel syndrome: correlation of symptom relief with whole gut transit time and stool weight.

    abstract::To determine the optimum dose of ispaghula husk in patients with irritable bowel syndrome (IBS) and to assess the correlation, if any between the relief in patients' symptoms and the whole gut transit time, and the increase in stool weight, a two part study was carried out. In part 1, 14 male patients were given ispag...

    journal_title:Gut

    pub_type: 临床试验,杂志文章

    doi:10.1136/gut.28.2.150

    authors: Kumar A,Kumar N,Vij JC,Sarin SK,Anand BS

    更新日期:1987-02-01 00:00:00

  • Transit through the gut measured by analysis of a single stool.

    abstract::A method is described for measuring transit time through the gut which requires the collection of only one stool. A dose of 20 radio-opaque markers is given to the subject on each of three consecutive days with breakfast, each dose of marker being of a different type. The first stool passed after rising on the fourth ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.17.3.219

    authors: Cummings JH,Wiggins HS

    更新日期:1976-03-01 00:00:00

  • Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice.

    abstract:OBJECTIVE:Cathepsin K is a lysosomal cysteine protease that has pleiotropic roles in bone resorption, arthritis, atherosclerosis, blood pressure regulation, obesity and cancer. Recently, it was demonstrated that cathepsin K-deficient (Ctsk(-/-) ) mice are less susceptible to experimental autoimmune arthritis and enceph...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2011-300076

    authors: Sina C,Lipinski S,Gavrilova O,Aden K,Rehman A,Till A,Rittger A,Podschun R,Meyer-Hoffert U,Haesler R,Midtling E,Pütsep K,McGuckin MA,Schreiber S,Saftig P,Rosenstiel P

    更新日期:2013-04-01 00:00:00

  • HLA antigens and atopy in children with coeliac disease.

    abstract::HLA antigens and various aspects of atopy were studied in 42 Finnish children and adolescents with coeliac disease, and the results were compared with findings of recent population studies. The HLA associations were as expected: relative risks for coeliac disease in individuals with HLA-B8, DR3, and DR7 were 8 . 0, 18...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.24.4.306

    authors: Verkasalo M,Tiilikainen A,Kuitunen P,Savilahti E,Backman A

    更新日期:1983-04-01 00:00:00

  • A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma.

    abstract:OBJECTIVE:Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity. DESIGN:By utilising large ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2012-304037

    authors: Chan TH,Lin CH,Qi L,Fei J,Li Y,Yong KJ,Liu M,Song Y,Chow RK,Ng VH,Yuan YF,Tenen DG,Guan XY,Chen L

    更新日期:2014-05-01 00:00:00

  • In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy.

    abstract:BACKGROUND:Mouse models of colitis and cancer are indispensable for our understanding of the pathogenesis of these diseases. In the past, mice had to be sacrificed in order to analyse colitis activity and tumour development. We have developed a safe method for high resolution endoscopic monitoring of living mice. METH...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2004.061283

    authors: Becker C,Fantini MC,Wirtz S,Nikolaev A,Kiesslich R,Lehr HA,Galle PR,Neurath MF

    更新日期:2005-07-01 00:00:00

  • Potential difference across the normal and the abnormal gastric mucosa in man.

    abstract::The mucosal potential difference in the body of the stomach was measured in 18 patients with gastric ulcers, five with gastritis, and three with pernicious anaemia. The results were compared with those of 12 normal volunteers. Significantly lower than normal levels were found in the groups of patients with gastric ulc...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.17.12.993

    authors: Hossenbocus A,Fitzpatrick P,Colin-Jones DG

    更新日期:1976-12-01 00:00:00

  • Serum amylase and serum lipase levels in man after administration of secretin and pancreozymin.

    abstract::A simple evocative test has been used to study pancreatic function. Serial estimations of amylase and lipase in blood serum are made at intervals up to six hours and again at 24 hours after injecting intravenously standard doses of secretin and pancreozymin. The results of 213 tests on a normal group, in pancreatic di...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.1.2.125

    authors: BURTON P,HAMMOND EM,HARPER AA,HOWAT HT,SCOTT JE,VARLEY H

    更新日期:1960-06-01 00:00:00

  • Serum gastrin in duodenal ulcer. I. Basal levels and effect of food and atropine.

    abstract::Fasting serum gastrin has been measured by radioimmunoassay in 72 patients with duodenal ulcer and compared with that in normals, patients with gastric ulcer, and with the Zollinger-Ellison syndrome. The mean (+/- SEM) gastrin levels were 15.7 +/- 1.5 pg/ml in the duodenal ulcer group, 32.1 +/- 4.3 pg/ml in normals, 1...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.12.11.899

    authors: Korman MG,Soveny C,Hansky J

    更新日期:1971-11-01 00:00:00

  • Diverticulitis of the right colon--experience from Hong Kong.

    abstract::Diverticulitis affects the right side of the colon more commonly than the left side in the Far East. A consecutive series of 35 patients (mean age 44 years) with right sided diverticulitis seen at this hospital is presented. All had localised pain in the right iliac fossa but systemic upset was uncommon. All but one w...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.33.4.547

    authors: Markham NI,Li AK

    更新日期:1992-04-01 00:00:00

  • Fate of pancreatic nodules induced by raw soya flour in rats.

    abstract::We have previously shown that rats fed raw soya flour (RSF) for more than four months develop hyperplastic foci of pancreatic acinar cells, which undergo malignant change if feeding RSF is continued throughout the life of the animals. The tendency to undergo malignant change is augmented by the additional use of a gen...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.28.suppl.207

    authors: McGuinness EE,Morgan RG,Wormsley KG

    更新日期:1987-01-01 00:00:00

  • Short chain fatty acids dilate isolated human colonic resistance arteries.

    abstract::Colonic biopsy specimens were obtained from patients undergoing surgery for carcinoma of the rectum. Colonic resistance arteries (internal diameter 178-345 microns) were dissected out under the microscope and mounted in a microvascular myograph capable of measuring isometric tension development. Experiments were desig...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.12.1391

    authors: Mortensen FV,Nielsen H,Mulvany MJ,Hessov I

    更新日期:1990-12-01 00:00:00

  • Duodenal mucosal architecture in non-specific and ulcer-associated duodenitis.

    abstract::This study was done to determine the severity and extent of abnormalities of duodenal mucosal architecture in non-specific (non-ulcerative) and ulcer-associated duodenitis. The effect of successful treatment with cimetidine on these changes has also been assessed. A method of microdissection and measurement of villus ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.22.8.637

    authors: Hasan M,Sircus W,Ferguson A

    更新日期:1981-08-01 00:00:00

  • Risk factors for extensive ulcerative colitis and ulcerative proctitis: a population based case-control study.

    abstract::To examine socioeconomic factors, dietary and other personal habits, and medical history as risk factors for ulcerative colitis, we studied 167 (98%) of all prevalent cases of ulcerative colitis diagnosed in Uppsala county from 1945 to 1964 and 167 age and sex matched population controls. Ulcerative colitis patients w...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.32.12.1526

    authors: Samuelsson SM,Ekbom A,Zack M,Helmick CG,Adami HO

    更新日期:1991-12-01 00:00:00

  • Effect of somatostatin on the sphincter of Oddi in patients with acute non-biliary pancreatitis.

    abstract:BACKGROUND:Somatostatin has been used to prevent pancreatitis after endoscopic retrograde cholangiopancreatography but its effect on acute non-biliary pancreatitis is still unclear. AIM:The purpose of this study was to evaluate the function of the sphincter of Oddi (SO) and the effect of somatostatin on patients with ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.49.6.843

    authors: Lai KH,Lo GH,Cheng JS,Fu MT,Wang EM,Chan HH,Wang YY,Hsu PI,Lin CK

    更新日期:2001-12-01 00:00:00

  • Gastric, pancreatic, and biliary responses to meals in hyperthyroidism.

    abstract::Upper gastrointestinal function in response to a mixed nutrient meal was evaluated in hyperthyroid patients, both before and after therapy, and in healthy controls. Gastric secretion, gastric emptying, and pancreatic secretion were all normal and normally integrated postprandially in the hyperthyroid patients. Bile ac...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.8.695

    authors: Miller LJ,Owyang C,Malagelada JR,Gorman CA,Go VL

    更新日期:1980-08-01 00:00:00

  • Occupational distribution of inflammatory bowel disease among German employees.

    abstract::Previous reports have shown that both Crohn's disease and ulcerative colitis affect people in white collar occupations associated with higher income and higher social class more frequently than other groups in the population. This study sought to carry these analyses one step further and investigate the distribution o...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.9.1037

    authors: Sonnenberg A

    更新日期:1990-09-01 00:00:00

  • To be or not to be--an incretin or enterogastrone?

    abstract::Glucagon-like peptide 1 does not comfortably fulfil the criterion of a gut derived factor responsible for an enhanced meal related insulin response; it appears logical to add the definition of a "physiological incretin hormone". ...

    journal_title:Gut

    pub_type: 评论,杂志文章

    doi:10.1136/gut.2005.071787

    authors: Horowitz M,Nauck MA

    更新日期:2006-02-01 00:00:00

  • Oestrus and gasric secretion in the dog.

    abstract::Marked decreases in 24-hour Heidenhain pouch secretion, lasting from nine to 18 days, were observed in five mongrel bitches during periods of naturally occurring oestrus. Neither oophorectomy nor control celiotomy caused significant change in Heidenhain pouch secretion in bitches who were not experiencing oestrus. The...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.11.10.855

    authors: Landor JH,Wild RA

    更新日期:1970-10-01 00:00:00

  • Visceral sensation and emotion: a study using hypnosis.

    abstract:BACKGROUND AND OBJECTIVES:We have previously shown that hypnosis can be used to study the effect of different emotions on the motility of the gastrointestinal tract. These studies demonstrated that both anger and excitement increased colonic motility while happiness led to a reduction. The purpose of this study was to ...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.51.5.701

    authors: Houghton LA,Calvert EL,Jackson NA,Cooper P,Whorwell PJ

    更新日期:2002-11-01 00:00:00

  • Split-dose preparation for colonoscopy increases adenoma detection rate: a randomised controlled trial in an organised screening programme.

    abstract:OBJECTIVE:Although a split regimen of bowel preparation has been associated with higher levels of bowel cleansing, it is still uncertain whether it has a favourable effect on the adenoma detection rate (ADR). The present study was aimed at evaluating whether a split regimen was superior to the traditional 'full-dose, d...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/gutjnl-2015-310685

    authors: Radaelli F,Paggi S,Hassan C,Senore C,Fasoli R,Anderloni A,Buffoli F,Savarese MF,Spinzi G,Rex DK,Repici A

    更新日期:2017-02-01 00:00:00

  • Diffuse enterochromaffin-like (ECL) cell hyperplasia and multiple gastric carcinoids: a complication of pernicious anaemia.

    abstract::A man with long-standing pernicious anaemia developed multiple gastric carcinoid tumours with a background of diffuse enterochromaffin-like cell hyperplasia. There is evidence that enterochromaffin-like cells synthesis and store histamine and that their proliferation is stimulated by high serum gastrin levels. Gastric...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.22.3.237

    authors: Hodges JR,Isaacson P,Wright R

    更新日期:1981-03-01 00:00:00