Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling.

abstract：:Continued bleeding or early rebleeding is associated with a poor prognosis in patients with variceal haemorrhage. It is not clear why bleeding stops in some patients and continues or restarts in others. It is suggested that secondary haemodynamic changes in the splanchnic circulation after a bleed may contribute to th...

journal_title：Gut

authors： McCormick PA,Jenkins SA,McIntyre N,Burroughs AK

更新日期：1995-01-01 00:00:00

abstract：:Little is known about chronic constipation in infants, toddlers, and preschool children and longterm outcome after treatment. The symptoms of 174 children < or = 4 years of age, who were evaluated for chronic constipation, are reported in this study together with the long-term outcome in 90 of them. Initial symptoms w...

journal_title：Gut

authors： Loening-Baucke V

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Norovirus infection is the most frequent cause of infectious diarrhoea in the western world. This study aimed to characterise functionally and histomorphologically the diseased duodenum in human biopsies. METHODS:Norovirus infection was diagnosed by the Kaplan criteria and confirmed by PCR of stool samples....

journal_title：Gut

authors： Troeger H,Loddenkemper C,Schneider T,Schreier E,Epple HJ,Zeitz M,Fromm M,Schulzke JD

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Gluten-free diet (GFD) is the only management for coeliac disease (CD). Available methods to assess GFD compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause gut mucosal damage. We aimed to develop a method to determine gluten intake and monitor GFD compliance in p...

journal_title：Gut

authors： Moreno ML,Cebolla Á,Muñoz-Suano A,Carrillo-Carrion C,Comino I,Pizarro Á,León F,Rodríguez-Herrera A,Sousa C

更新日期：2017-02-01 00:00:00

abstract：:One-hundred-and-one normal neonates were examined manometrically in the first day of life to assess anorectal function. In order to overcome some of the difficulties in subjective interpretation of results, the stimuli used and the response pattern seen in the anal canal were measured. In the unstimulated state, all s...

journal_title：Gut

authors： Boston VE,Cywes S,Davies MR

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVE:The natural course of chronic hepatitis C varies widely. To improve the profiling of patients at risk of developing advanced liver disease, we assessed the relative contribution of factors for liver fibrosis progression in hepatitis C. DESIGN:We analysed 1461 patients with chronic hepatitis C with an estimat...

journal_title：Gut

authors： Rüeger S,Bochud PY,Dufour JF,Müllhaupt B,Semela D,Heim MH,Moradpour D,Cerny A,Malinverni R,Booth DR,Suppiah V,George J,Argiro L,Halfon P,Bourlière M,Talal AH,Jacobson IM,Patin E,Nalpas B,Poynard T,Pol S,Abel L,

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Major histocompatibility complex class II deficient (Aalpha0/0) mice have decreased CD4+ T cells, making them immunologically similar to patients with acquired immunodeficiency syndrome (AIDS). Both patients with AIDS and Aalpha0/0 mice have hypertrophic gastric folds. To clarify the mechanism of ga...

journal_title：Gut

authors： Fukui T,Nishio A,Okazaki K,Uza N,Ueno S,Kido M,Inoue S,Kitamura H,Kiriya K,Ohashi S,Asada M,Tamaki H,Matsuura M,Kawasaki K,Suzuki K,Uchida K,Fukui H,Nakase H,Watanabe N,Chiba T

更新日期：2006-05-01 00:00:00

abstract：:As relatively little is known of human colonic motor activity either in health, or in pathological conditions, we investigated mass movements in 14 chronically constipated patients and 18 healthy volunteers. Mass movements were recorded from proximal and distal colon during 24 h (12 noon-12 noon) by a colonoscopically...

journal_title：Gut

authors： Bassotti G,Gaburri M,Imbimbo BP,Rossi L,Farroni F,Pelli MA,Morelli A

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:It is postulated that high serum levels of insulin and insulin growth factor 1 (IGF-1) mediate obesity-associated carcinogenesis. The relationship of insulin, IGF-1 and IGF binding proteins (IGFBP) with Barrett's oesophagus (BO) has not been well examined. METHODS:Serum levels of insulin and IGFBPs in patie...

journal_title：Gut

authors： Greer KB,Thompson CL,Brenner L,Bednarchik B,Dawson D,Willis J,Grady WM,Falk GW,Cooper GS,Li L,Chak A

更新日期：2012-05-01 00:00:00

abstract：:Patients with primary biliary cirrhosis have a defect in the receptor mediated clearance of complement coated erythrocytes by fixed macrophages of the reticuloendothelial system. To investigate the probable mechanism of this defect peripheral blood monocytes were isolated from nine patients with primary biliary cirrho...

journal_title：Gut

authors： Minuk GY,Vergalla J,Hanson RG,Hoofnagle JH,Frank MM,Jones EA

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The early responses of the oesophageal mucosa to acid perfusion may predict subsequent pathology. Mucosal responses to luminal acid may result either from acid permeating through the mucosa or from other unknown transduction mechanisms. In order to better understand the dynamics of acid permeation i...

journal_title：Gut

authors： Tanaka S,Chu S,Hirokawa M,Montrose MH,Kaunitz JD

更新日期：2003-06-01 00:00:00

abstract：:The incidence of small intestinal colonization in unoperated duodenal ulcer patients was low and similar to that in the normal population. The majority of patients seven to 10 days following truncal vagotomy and drainage were colonized whereas none of a control group of patients following simple closure of a perforate...

journal_title：Gut

authors： Browning GG,Buchan KA,Mackay C

更新日期：1974-02-01 00:00:00

abstract：:Lymphocytes obtained after enzymatic digestion of intestinal biopsies from patients with coeliac disease were examined for the presence of gliadin specific antibody secreting cells by means of the ELISPOT technique. This technique permits enumeration of gliadin antibody secreting immunocytes, differentiated with regar...

journal_title：Gut

authors： Lycke N,Kilander A,Nilsson LA,Tarkowski A,Werner N

更新日期：1989-01-01 00:00:00

abstract：:This study determined the location and tissue density of cells immunoreactive for tumour necrosis factor alpha (TNF alpha) in intestinal specimens from 24 patients with chronic inflammatory bowel disease (15 with Crohn's disease, nine with ulcerative colitis) and 11 controls. There was significantly increased density ...

journal_title：Gut

authors： Murch SH,Braegger CP,Walker-Smith JA,MacDonald TT

更新日期：1993-12-01 00:00:00

abstract：:Faecal chymotrypsin was measured in patients with chronic pancreatitis and in healthy black urban and rural control subjects. In the patients, significantly lower values of faecal chymotrypsin were obtained (mean (SD) 2.4 1.79 U/g stool) whereas in urban control subjects, values were within the normal range (mean (SD)...

journal_title：Gut

authors： Riedel L,Walker AR,Segal I,Mohamed AE,Smyth AE,Daya B,Naik I

更新日期：1991-03-01 00:00:00

abstract：:The endothelins are a group of three related peptides with two receptor subtypes, ET(A) and ET(B). Following the discovery of endothelin 1 as a potent vasoconstrictor, there has been intense interest in the role of endothelin on vascular function in liver disease. Speculation on the role of endothelin in the pathogene...

journal_title：Gut

authors： Moore K

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Crohn's disease (CD) and ulcerative colitis (UC) are chronic multifactorial inflammatory bowel diseases (IBDs) with unknown aetiology, but a deregulated mucosal immune response to gut-derived bacterial antigens is thought to be involved. Toll-like receptor ligands, especially lipopolysaccharide (LPS...

journal_title：Gut

authors： Tuin A,Poelstra K,de Jager-Krikken A,Bok L,Raaben W,Velders MP,Dijkstra G

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Gastric acid secretion is downregulated by Helicobacter pylori infection and upregulated after its eradication, but the mechanisms are still unclear. We examined the effects of H pylori eradication on the number of parietal cells and on expression of molecules functioning in acid secretion in the hu...

journal_title：Gut

authors： Osawa H,Kita H,Ohnishi H,Hoshino H,Mutoh H,Ishino Y,Watanabe E,Satoh K,Sugano K

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVES:In order to maintain the mucosal barrier against luminal microorganisms the intestinal epithelial cells synthesise various broad-spectrum antimicrobial peptides including defensins and cathelicidins. Recent studies indicate that both may be deficient in Crohn's disease. To elucidate the possible functional c...

journal_title：Gut

authors： Nuding S,Fellermann K,Wehkamp J,Stange EF

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian of genome stability. Hp reduces the expression of the transcription factor USF1 shown to stabilise p53 in response to genotoxic stress. We investigated whether Hp-me...

journal_title：Gut

authors： Costa L,Corre S,Michel V,Le Luel K,Fernandes J,Ziveri J,Jouvion G,Danckaert A,Mouchet N,Da Silva Barreira D,Torres J,Camorlinga M,D'Elios MM,Fiette L,De Reuse H,Galibert MD,Touati E

更新日期：2020-09-01 00:00:00

abstract：:The motility of the descending colon was studied in nine patients before and after resection of the rectum for cancer. This operation parasympathectomises and generally also sympathectomises the remaining left colon. Motor activity was significantly reduced by sleep before and after surgery. There was also a reduction...

journal_title：Gut

authors： Catchpole BN

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Some cirrhotic patients with tense ascites who undergo paracentesis develop a circulatory dysfunction syndrome, manifested by an increase in plasma renin activity. Recently, a significant inverse correlation between postparacentesis changes in plasma renin activity and systemic vascular resistance has been d...

journal_title：Gut

authors： Cabrera J,Falcón L,Gorriz E,Pardo MD,Granados R,Quinones A,Maynar M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:TFF1 is a 6.5 kDa secreted protein that is expressed predominantly in normal gastric mucosa. It is coexpressed with mucins and it can form dimers via a free carboxy terminal cysteine residue. AIMS:To investigate the molecular forms of TFF1 that are present in normal human stomach and the association of the ...

journal_title：Gut

authors： Newton JL,Allen A,Westley BR,May FE

更新日期：2000-03-01 00:00:00

abstract：:All cases of Crohn's disease in the Nottingham area were ascertained and the date and place of domicile and work at the time of onset of symptoms noted. Applying the Knox and Pike and Smith tests for clustering of patients in time and space, no significant results were observed. Further analysis of differences in time...

journal_title：Gut

authors： Miller DS,Keighley A,Smith PG,Hughes AO,Langman MJ

更新日期：1975-06-01 00:00:00

abstract：:A patient presented with pruritus and recent elevation of aminotransferases. The case fulfilled most of the criteria for the diagnosis of autoimmune hepatitis and achieved clinical and complete biochemical response to steroid therapy. However, the liver biopsy specimen revealed an unusual histological pattern consisti...

journal_title：Gut

authors： Te HS,Koukoulis G,Ganger DR

更新日期：1997-08-01 00:00:00

abstract：:Small intestinal mucosa obtained from six fasting patients with cholera by a peroral biopsy technique was studied with the electron microscope. The cultures of their rectal swabs were all positive for Vibrio cholerae. In the absorptive cells, large pseudopod-like cytoplasmic processes with deformed microvilli or witho...

journal_title：Gut

authors： Asakura H,Tsuchiya M,Watanabe Y,Enomoto Y,Morita A

更新日期：1974-07-01 00:00:00

abstract：:A method is described for measuring transit time through the gut which requires the collection of only one stool. A dose of 20 radio-opaque markers is given to the subject on each of three consecutive days with breakfast, each dose of marker being of a different type. The first stool passed after rising on the fourth ...

journal_title：Gut

authors： Cummings JH,Wiggins HS

更新日期：1976-03-01 00:00:00

abstract：:Computed tomography detected the presence of dilated ducts in 15 of 18 cases with extrahepatic obstructive jaundice and demonstrated the obstructing lesion in 18 out of 25. The cause of the obstruction was detected in the absence of duct dilatation, and calculi which were radiolucent on conventional radiographs were d...

journal_title：Gut

authors： Morris A,Fawcitt RA,Wood R,Forbes WS,Isherwood I,Marsh MN

更新日期：1978-08-01 00:00:00

abstract：:Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD in isolation, but are of value in determining need for further investigation. Conclusive evidence for reflux on oesophageal testing include advanced grade erosive oesophagitis (LA grades C...

journal_title：Gut

authors： Gyawali CP,Kahrilas PJ,Savarino E,Zerbib F,Mion F,Smout AJPM,Vaezi M,Sifrim D,Fox MR,Vela MF,Tutuian R,Tack J,Bredenoord AJ,Pandolfino J,Roman S

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Hirschsprung's disease (HSCR) is a congenital disorder characterised by an absence of ganglion cells in the nerve plexuses of the lower digestive tract. Manifestation of the disease has been linked to mutations in genes that encode the crucial signals for the development of the enteric nervous system-the RET...

journal_title：Gut

authors： Garcia-Barceló M,Sham MH,Lui VC,Chen BL,Ott J,Tam PK

更新日期：2003-04-01 00:00:00