Why portal hypertensive varices bleed and bleed: a hypothesis.

abstract：:The variability in the orocaecal transit time as measured by the lactulose/breath hydrogen method has been studied for three conditions: lactulose given with a meal, subjects sitting; lactulose given with a meal, subjects semirecumbent; lactulose given in aqueous solution, subjects semirecumbent. Thirty three healthy ...

journal_title：Gut

authors： Staniforth DH,Rose D

更新日期：1989-02-01 00:00:00

abstract：:To examine socioeconomic factors, dietary and other personal habits, and medical history as risk factors for ulcerative colitis, we studied 167 (98%) of all prevalent cases of ulcerative colitis diagnosed in Uppsala county from 1945 to 1964 and 167 age and sex matched population controls. Ulcerative colitis patients w...

journal_title：Gut

authors： Samuelsson SM,Ekbom A,Zack M,Helmick CG,Adami HO

更新日期：1991-12-01 00:00:00

abstract：:Previous studies have suggested that profound inhibition of gastric acid secretion may increase exposure to potentially carcinogenic N-nitroso compounds. The aim of this study was to find out if the proton pump inhibitor omeprazole (20 mg daily) is associated with increased concentrations of potentially carcinogenic N...

journal_title：Gut

authors： Verdu E,Viani F,Armstrong D,Fraser R,Siegrist HH,Pignatelli B,Idström JP,Cederberg C,Blum AL,Fried M

更新日期：1994-04-01 00:00:00

abstract：:Although the development of endoscopic methods of treatment for biliary obstruction has proceeded rapidly in recent years, endoscopic retrograde cholangiopancreatographic (ERCP) services are patchily distributed. A recent survey by the British Society of Gastroenterology has shown that almost half the district general...

journal_title：Gut

authors： Gear MW,Dent NA,Colin-Jones DG,Lennard-Jones JH,Colley JR

更新日期：1990-10-01 00:00:00

abstract：:Six of 25 renal transplant recipients had a duodenal ulcer at endoscopy. Histamine concentration and the activity of histamine methyltransferase, the degrading enzyme of histamine, were measured in gastric mucosal biopsies obtained at endoscopy and compared with patients with duodenal ulcer but not undergoing transpla...

journal_title：Gut

authors： Timoney AG,Man WK,Spencer J,Taylor H,Williams G

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:To develop gene expression profiles that characterise KRAS-, BRAF- or PIK3CA-activated- tumours, and to explore whether these profiles might be helpful in predicting the response to the epidermal growth factor receptor (EGFR) pathway inhibitors better than mutation status alone. DESIGN:Fresh frozen tumour sa...

journal_title：Gut

authors： Tian S,Simon I,Moreno V,Roepman P,Tabernero J,Snel M,van't Veer L,Salazar R,Bernards R,Capella G

更新日期：2013-04-01 00:00:00

abstract：:Neurotensin is a tridecapeptide located mainly in the distal small intestine. The present study was carried out in order to investigate the neurotensin response after proximal small intestinal resection in the rat. After resection, the median plasma concentration of neurotensin like immunoreactivity (NTLI) was unchang...

journal_title：Gut

authors： Olsen PS,Pedersen JH,Poulsen SS,Yamashita Y,Kirkegaard P

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The effectiveness of surveillance for hepatocellular carcinoma (HCC) in the USA is largely unknown. The objective of this study was to evaluate the effectiveness of HCC surveillance in a national Veterans Administration (VA) practice setting, using the national VA hepatitis C virus (HCV) Clinical Ca...

journal_title：Gut

authors： El-Serag HB,Kramer JR,Chen GJ,Duan Z,Richardson PA,Davila JA

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Gastric carcinogenesis is a multifactorial, multistep process, in which chronic inflammation plays a major role. AIMS:In order to ascertain whether free radical mediated oxidative DNA damage is involved in such a process, concentrations of 8-hydroxydeoxyguanosine (8OHdG), a mutagenic/carcinogenic adduct, an...

journal_title：Gut

authors： Farinati F,Cardin R,Degan P,Rugge M,Mario FD,Bonvicini P,Naccarato R

更新日期：1998-03-01 00:00:00

abstract：:With oral and intravenous doses of metoclopramide there was no constant effect on the gastric emptying of test meals of glucose or sodium citrate, nor was secretion of acid by the stomach in response to test meals of glucose or sodium citrate affected. Apomorphine, in subnauseous doses (0.25 mg intravenously) slowed t...

journal_title：Gut

authors： Ramsbottom N,Hunt JN

更新日期：1970-12-01 00:00:00

abstract：:Intravenous cholangiograms were performed on 100 unselected nonicteric patients using methylglucamine ioglycamide (Biligram). Fifty patients received 10.5 g of contrast medium and 50 received 5.25 g of medium. The contrast medium was injected evenly over five minutes. Side effects were recorded in only 13% of patients...

journal_title：Gut

authors： Parkin GJ,Herlinger H

更新日期：1974-04-01 00:00:00

abstract：:The free primary amines present in the faeces of 44 infants (1-18 months) with gastroenteritis have been examined by field desorption mass spectrometry of the lactone form of their fluorescamine derivatives without their prior separation. p-Tyramine, 2-phenylethylamine, the diamines, putrescine and cadaverine and seve...

journal_title：Gut

authors： Murray KE,Adams RF,Earl JW,Shaw KJ

更新日期：1986-10-01 00:00:00

abstract：:To investigate the basis of subclinical alveolitis in patients with primary biliary cirrhosis, 10 primary biliary cirrhosis patients were studied by bronchoalveolar lavage. Both bronchoalveolar lavage lymphoid and non-lymphoid cell populations were analysed using immunocytological methods to determine their proportion...

journal_title：Gut

authors： Spiteri MA,Johnson M,Epstein O,Sherlock S,Clarke SW,Poulter LW

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:Suboptimal adenoma detection rate (ADR) at colonoscopy is associated with increased risk of interval colorectal cancer. It is uncertain how ADR might be improved. We compared the effect of leadership training versus feedback only on colonoscopy quality in a countrywide randomised trial. DESIGN:40 colonoscopy...

journal_title：Gut

authors： Kaminski MF,Anderson J,Valori R,Kraszewska E,Rupinski M,Pachlewski J,Wronska E,Bretthauer M,Thomas-Gibson S,Kuipers EJ,Regula J

更新日期：2016-04-01 00:00:00

abstract：:Faecal stream diversion may induce inflammatory changes in the defunctioned segment of the large intestine. These changes are predominantly mucosal, although confusing histological features including granulomas may be present. The pathology of 15 defunctioned rectal stumps has been studied. All patients had previously...

journal_title：Gut

authors： Warren BF,Shepherd NA,Bartolo DC,Bradfield JW

更新日期：1993-04-01 00:00:00

abstract：:Levels of clotting factors II, V, and VII were measured on admission and then daily in 12 patients with grade IV hepatic coma due to fulminant hepatic failure. Factor VII levels obtained within 36 hours of the development of grade IV coma were not of value in predicting which patients would subsequently recover consci...

journal_title：Gut

authors： Gazzard BG,Henderson JM,Williams R

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:There is a widespread notion that obesity leads to gastro-oesophageal reflux but scientific evidence of an association is limited and inconsistent. AIMS:To estimate the strength of the association between body mass and reflux symptoms, we performed a population based cross sectional interview study. SUBJEC...

journal_title：Gut

authors： Lagergren J,Bergström R,Nyrén O

更新日期：2000-07-01 00:00:00

abstract：:T-lymphocytic infiltration of the exocrine pancreas and liver in patients with chronic pancreatitis has suggested that cell mediated immune mechanisms may play a part in the pathogenesis of this disease. As expression of major histocompatibility (MHC) antigens is a prerequisite for organ specific autoimmunity, the exp...

journal_title：Gut

authors： Jalleh RP,Gilbertson JA,Williamson RC,Slater SD,Foster CS

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:Loss of surface maturation and cytonuclear atypia have been regarded as the pathological 'gold standard' for the diagnosis of oesophageal squamous cell intraepithelial neoplasia. However, there has been no satisfactory endomicroscopic method similar to this pathological approach to detect surface maturation a...

journal_title：Gut

authors： Li M,Zuo XL,Yu T,Gu XM,Zhou CJ,Li Z,Liu H,Ji R,Dong YY,Li CQ,Li YQ

更新日期：2013-11-01 00:00:00

abstract：:The effects of the methyl ester analogue of prostaglandin E1, misoprostol, on gastric epithelial cell proliferation were investigated in six dogs given 300 micrograms/kg/day of misoprostol orally for 11 weeks and in six control dogs given placebo for 11 weeks. Misoprostol treatment resulted in a 36% increase in stomac...

journal_title：Gut

authors： Goodlad RA,Madgwick AJ,Moffatt MR,Levin S,Allen JL,Wright NA

更新日期：1989-03-01 00:00:00

abstract：:Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is associated with a decline in physiological function and adaptive capacity. Altered GI physiology can affect the amount and types of nutrients digested and absorbed as well as impact the intestinal microbiota. The intestinal microb...

journal_title：Gut

authors： An R,Wilms E,Masclee AAM,Smidt H,Zoetendal EG,Jonkers D

更新日期：2018-12-01 00:00:00

abstract：:It has been reported that intestinal permeability to polyethylene glycol 400 is increased in patients with Crohn's disease and their apparently unaffected first degree relatives. Because of the implications that these findings have for the aetiology of Crohn's disease these studies were repeated. Patients with Crohn's...

journal_title：Gut

authors： Teahon K,Smethurst P,Levi AJ,Menzies IS,Bjarnason I

更新日期：1992-03-01 00:00:00

abstract：:The effects of low power (1-2 Watts), long exposure (30-400 seconds), interstitial Nd YAG laser therapy on dimethylhydrazine induced rat colonic neoplasms and normal rat colon have been studied. After a single exposure with appropriate laser parameters, dimethylhydrazine induced rat colonic neoplasms underwent coagula...

journal_title：Gut

authors： Matthewson K,Barton T,Lewin MR,O'Sullivan JP,Northfield TC,Bown SG

更新日期：1988-01-01 00:00:00

abstract：:Multinucleated giant cells are an important feature of the granulomatous reaction in Crohn's disease (CD) but their cellular origin is poorly understood. The aim of this study was to discover if intestinal macrophages are capable of generating multinucleated giant cells in vitro in response to cytokine stimulation. Hu...

journal_title：Gut

authors： Fais S,Pallone F

更新日期：1995-12-01 00:00:00

abstract：:An improved technique for the detection of alpha-gliadin sensitised mononuclear cells in the peripheral blood of untreated coeliac patients is described. This method is a modification of the direct LMIF assay, and involves exposure of lymphocytes to alpha-gliadin and the assay of the resultant lymphokine produced usin...

journal_title：Gut

authors： O'Farrelly C,Feighery C,Greally JF,Weir DG

更新日期：1982-01-01 00:00:00

abstract：:Evidence is presented which indicates a possible reduction in recognition capacity for tumour cell antigens (EB(2) Burkitt lymphoma cell line) by lymphocytes from some patients with longstanding but inactive Crohn's disease. Three out of seven patients tested also showed diminished or absent lymphocytotoxicity when th...

journal_title：Gut

authors： Maclaurin BP,Cooke WT,Ling NR

更新日期：1972-08-01 00:00:00

abstract：BACKGROUND:Ethanol undergoes a first pass metabolism (FPM) in the stomach and liver. Gastric FPM of ethanol primarily depends on the activity of gastric alcohol dehydrogenase (ADH). In addition, the speed of gastric emptying (GE) may modulate both gastric and hepatic FPM of ethanol. AIMS:To study the effect of modulat...

journal_title：Gut

authors： Oneta CM,Simanowski UA,Martinez M,Allali-Hassani A,Parés X,Homann N,Conradt C,Waldherr R,Fiehn W,Coutelle C,Seitz HK

更新日期：1998-11-01 00:00:00

abstract：:The nervous system in the intestine controls motility, secretion, sensory perception, and immune function. Peptidergic neurones with neurotransmitters such as substance P and nerve growth factors have been the main focus of neuroimmunomodulation research in the gut. This review summarises the present knowledge concern...

journal_title：Gut

authors： Straub RH,Wiest R,Strauch UG,Härle P,Schölmerich J

更新日期：2006-11-01 00:00:00

abstract：:In a study of low dose interferon alfa-2b in 587 patients expected to show a good response to treatment, 76-87% patients in different countries had alanine amino-transferase activities returned to normal after four months' treatment, 49-72% were negative for hepatitis B virus (HBV)-DNA, 51-66% were negative for hepati...

journal_title：Gut

authors： Mauracher E

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. DESIGN:384 single nucleotide po...

journal_title：Gut

authors： Wouters MM,Lambrechts D,Knapp M,Cleynen I,Whorwell P,Agréus L,Dlugosz A,Schmidt PT,Halfvarson J,Simrén M,Ohlsson B,Karling P,Van Wanrooy S,Mondelaers S,Vermeire S,Lindberg G,Spiller R,Dukes G,D'Amato M,Boeckxstaens

更新日期：2014-07-01 00:00:00